연구실적

• [학술지논문] Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver SCIENCE ADVANCES, 2021, v.7 no.9 , 4398-4398
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• Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood–brain-barrier penetration and tumor microenvironment modulation Journal of Nanobiotechnology, 2023, v.21 no.1, 253
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• Efficient Delivery of Globotriaosylceramide Synthase siRNA using Polyhistidine-Incorporated Lipid Nanoparticles Macromolecular Bioscience, 2023, v.23 no.4, 2200423
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• Engineered Lipid Nanoparticles for the Treatment of Pulmonary Fibrosis by Regulating Epithelial-Mesenchymal Transition in the Lungs Advanced Functional Materials, 2023, v.33 no.7, 2209432
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• Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics Experimental and Molecular Medicine, 2023, v.55 no.10, 2085-2096
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• In vivo genome editing for hemophilia B therapy by the combination of rebalancing and therapeutic gene knockin using a viral and non-viral vector Molecular Therapy - Nucleic Acids, 2023, v.32, 161-172
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• In vivo genome editing using 244-cis LNPs and low-dose AAV achieves therapeutic threshold in hemophilia A mice Molecular Therapy Nucleic Acids, 2023, v.34, 102050
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• Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications Advanced Drug Delivery Reviews, 2023, v.200, 114990
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• Novel piperazine-based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety Bioengineering and Translational Medicine, 2023, v.8 no.6, e10556
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• Anisotropic Plasmonic Gold Nanorod-Indocyanine Green@Reduced Graphene Oxide-Doxorubicin Nanohybrids for Image-Guided Enhanced Tumor Theranostics ACS Omega, 2022, v.7 no.17, 15186-15199
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• Artificial primary-miRNAs as a platform for simultaneous delivery of siRNA and antisense oligonucleotide for multimodal gene regulation Journal of Controlled Release, 2022, v.349, 983-991
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• In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy SCIENCE ADVANCES, 2022, v.8 no.3, eabj6901
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• Protein-RNA interaction guided chemical modification of Dicer substrate RNA nanostructures for superior in vivo gene silencing Journal of Controlled Release, 2022, v.343, 57-65
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• mRNA vaccines: the most recent clinical applications of synthetic mRNA Archives of Pharmacal Research, 2022, v.45 no.4, 245-262
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• Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver SCIENCE ADVANCES, 2021, v.7 no.9, eabf4398
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• Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy ACS APPLIED MATERIALS & INTERFACES, 2021, v.13 no.49, 58422-58433
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• The core composition of DNA block copolymer micelles dictates DNA hybridization properties, nuclease stabilities, and cellular uptake efficiencies NANOSCALE, 2021, v.13 no.32, 13758-13763
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• Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy BIOMATERIALS SCIENCE, 2020, v.8 no.4, 1101-1105
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• Combined hybrid structure of siRNA tailed IVT mRNA (ChriST mRNA) for enhancing DC maturation and subsequent anticancer T cell immunity Journal of Controlled Release, 2020, v.327, 225-234
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• Highly selective detection of single nucleotide polymorphism (SNP) using a dumbbell DNA probe with a gap-filling approach Journal of Industrial and Engineering Chemistry, 2020, v.88, 78-83
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• Nanoformulated Single-Stranded RNA-Based Adjuvant with a Coordinative Amphiphile as an Effective Stabilizer: Inducing Humoral Immune Response by Activation of Antigen-Presenting Cells Angewandte Chemie - International Edition, 2020, v.59 no.28, 11540-11549
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• Photocatalytic degradation of phenol using chemical vapor desposition graphene column Catalysts, 2020, v.10 no.11, 1-11
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• The impaired redox balance in peroxisomes of catalase knockout mice accelerates nonalcoholic fatty liver disease through endoplasmic reticulum stress FREE RADICAL BIOLOGY AND MEDICINE, 2020, v.148, 22-32
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• A dynamic DNA nanostructure with switchable and size-selective molecular recognition properties NANOSCALE, 2019, v.11 no.5, 2501-2509
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• Capillary Tube Based Molecular Diagnostic Test for Naked Eye Detection of Antibiotic Resistant Bacteria Advanced Materials Technologies, 2019, v.4 no.1, 1800375
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• Lamb wave-based molecular diagnosis using DNA hydrogel formation by rolling circle amplification (RCA) process Biosensors and Bioelectronics, 2019, v.142, 111496
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• Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, v.8 no.9, 1713-1717
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• Multicistronic IVT mRNA for simultaneous expression of multiple fluorescent proteins Journal of Industrial and Engineering Chemistry, 2019, v.80, 770-777
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• Tonsil-derived stem cells as a new source of adult stem cells WORLD JOURNAL OF STEM CELLS, 2019, v.11 no.8, 506-518
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• Catalytic degradation of phenols by recyclable CVD graphene films NANOSCALE, 2018, v.10 no.13, 5840-5844
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• Cellular uptake mechanism and comparative in vitro cytotoxicity studies of monomeric LMWP-siRNA conjugate Journal of Industrial and Engineering Chemistry, 2018, v.63, 103-111
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• Development of mRNA vaccines and their prophylactic and therapeutic applications NANO RESEARCH, 2018, v.11 no.10, 5173-5192
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• Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine BIOMATERIALS, 2018, v.156, 172-193
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• Enhanced Chemical Reactivity of Graphene by Fermi Level Modulation CHEMISTRY OF MATERIALS, 2018, v.30 no.16, 5602-5609
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• Enhanced intracellular delivery of macromolecules by melittin derivatives mediated cellular uptake Journal of Industrial and Engineering Chemistry, 2018, v.58, 290-295
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• Enzymatic Synthesis of Self-assembled Dicer Substrate RNA Nanostructures for Programmable Gene Silencing NANO LETTERS, 2018, v.18 no.7, 4279-4284
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• MMP-2-responsive fluorescent nanoprobes for enhanced selectivity of tumor cell uptake and imaging BIOMATERIALS SCIENCE, 2018, v.6 no.10, 2619-2626
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• Mechanochemical synthesis of fluorescent carbon dots from cellulose powders NANOTECHNOLOGY, 2018, v.29 no.16
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• Synergistic Nanozymetic Activity of Hybrid Gold Bipyramid-Molybdenum Disulfide Core@Shell Nanostructures for Two-Photon Imaging and Anticancer Therapy ACS Applied Materials and Interfaces, 2018, v.10 no.49, 42068-42076
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• The cutting-edge technologies of siRNA delivery and their application in clinical trials ARCHIVES OF PHARMACAL RESEARCH, 2018, v.41 no.9, 867-874
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• Aptamer-incorporated DNA Holliday junction for the targeted delivery of siRNA JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2017, v.56, 55-61
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• Artificial Chemical Reporter Targeting Strategy Using Bioorthogonal Click Reaction for Improving Active-Targeting Efficiency of Tumor MOLECULAR PHARMACEUTICS, 2017, v.14 no.5, 1558-1570
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• Effects of tumor microenvironments on targeted delivery of glycol chitosan nanoparticles Journal of Controlled Release, 2017, v.267, 223-231
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• Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound Journal of Controlled Release, 2017, v.263, 68-78
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• Hydrogel Based Biosensors for In Vitro Diagnostics of Biochemicals, Proteins, and Genes Advanced Healthcare Materials, 2017, v.6 no.12
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• In vitro and in vivo behavior of DNA tetrahedrons as tumor-targeting nanocarriers for doxorubicin delivery COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, v.157, 424-431
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• A Highly Sensitive Molecular Detection Platform for Robust and Facile Diagnosis of Middle East Respiratory Syndrome (MERS) Corona Virus Advanced Healthcare Materials, 2016, 22 June 2016
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• Bioorthogonal Copper Free Click Chemistry for Labeling and Tracking of Chondrocytes In Vivo Bioconjugate Chemistry, 2016, v.27 no.4, 927-936
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• Bioreducible Cationic Poly(amido amine)s for Enhanced Gene Delivery and Osteogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, v.12 no.5, 1023-1034
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• Dual delivery of biological therapeutics for multimodal and synergistic cancer therapies Advanced Drug Delivery Reviews, 2016, v.98, 113-133
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• Gold-based hybrid nanomaterials for biosensing and molecular diagnostic applications BIOSENSORS & BIOELECTRONICS, 2016, v.80, 543-559
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• Microfluidics-Based Pathogen Detection: A Highly Sensitive Molecular Detection Platform for Robust and Facile Diagnosis of Middle East Respiratory Syndrome (MERS) Corona Virus (Adv. Healthcare Mater. 17/2016) Advanced Healthcare Materials, 2016, v.5 no.17, 2146
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• Near-infrared light-responsive nanomaterials for cancer theranostics Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2016, v.8 no.1, 23-45
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• Non-invasive stem cell tracking in hindlimb ischemia animal model using bio-orthogonal copper-free click chemistry Biochemical and Biophysical Research Communications, 2016, v.479 no.4, 779-786
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• Oligonucleotide-based biosensors for in vitro diagnostics and environmental hazard detection Analytical and Bioanalytical Chemistry, 2016, 18 JAN 2016, 1-24
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• PEGylation and HAylation via catechol: alpha-Amine-specific reaction at N-terminus of peptides and proteins ACTA BIOMATERIALIA, 2016, v.43, 50-60
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• Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs Journal of Controlled Release, 2016, v.243, 121-131
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• Technological development of structural DNA/RNA-based RNAi systems and their applications ADVANCED DRUG DELIVERY REVIEWS, 2016, v.104, 29-43
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• 고분자 전달체를 이용한 경폐 약물전달시스템 약 학 회 지, 2016, v.60 no.4, 173~179
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• A fibrin-supported myocardial organ culture for isolation of cardiac stem cells via the recapitulation of cardiac homeostasis BIOMATERIALS, 2015, v.48, 66-83
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• Cathepsin B Imaging to Predict Quality of Engineered Cartilage Macromolecular Bioscience, 2015, v.15 no.9, 1224-1232
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• Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo Journal of Controlled Release, 2015, 23 AUG 2015
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• Dendrimeric siRNA for efficient gene silencing Angewandte Chemie - International Edition, 2015, v.54 no.23, 6740-6744
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• DhITACT: DNA Hydrogel Formation by Isothermal Amplification of Complementary Target in Fluidic Channels ADVANCED MATERIALS, 2015, v.27 no.23, 3513-3517
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• Induced myogenic commitment of human chondrocytes via non-viral delivery of minicircle DNA JOURNAL OF CONTROLLED RELEASE, 2015, v.200, 212-221
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• Insulin induces phosphorylation of serine residues of translationally controlled tumor protein in 293T cells International Journal of Molecular Sciences, 2015, v.16 no.4, 7565-7576
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• Nanoparticle-Based Combination Therapy for Cancer Treatment CURRENT PHARMACEUTICAL DESIGN, 2015, v.21 no.22, 3158-3166
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• Near-infrared light-responsive nanomaterials for cancer theranostics Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2015, 2015
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• Osteogenic priming of mesenchymal stem cells by chondrocyte-conditioned factors and mineralized matrix CELL AND TISSUE RESEARCH, 2015, v.362 no.1, 115-126
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• Tonsil-derived Mesenchymal Stem Cells Ameliorate CCl4-induced Liver Fibrosis in Mice via Autophagy Activation SCIENTIFIC REPORTS, 2015, v.5
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• 3D Culture of Tonsil-Derived Mesenchymal Stem Cells in Poly(ethylene glycol)-Poly(L-alanine-co-L-phenyl alanine) Thermogel ADVANCED HEALTHCARE MATERIALS, 2014, v.3 no.11, 1782-1791
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• Biofunctional porous anodized titanium implants for enhanced bone regeneration JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, v.102 no.10, 3639-3648
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• Controlling mechanical properties of bio-inspired hydrogels by modulating nano-scale, inter-polymeric junctions BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 2014, v.5, 887-894
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• Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells CHEMICAL COMMUNICATIONS, 2014, v.50 no.87, 13388-13390
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• Erratum: Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells (Chemical Communications (2014) DOI: 10.1039/c4cc07155g) Chemical Communications, 2014, v.50 no.88, 13616
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• Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications ARCHIVES OF PHARMACAL RESEARCH, 2014, v.37 no.1, 53-59
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• Nanobiomaterials for pharmaceutical and medical applications ARCHIVES OF PHARMACAL RESEARCH, 2014, v.37 no.1, 1-3
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• PH/redox/photo responsive polymeric micelle via boronate ester and disulfide bonds with spiropyran-based photochromic polymer for cell imaging and anticancer drug delivery European Polymer Journal, 2014, v.57, 1-10
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• Pyrogallol 2-Aminoethane: A Plant Flavonoid-Inspired Molecule for Material-Independent Surface Chemistry ADVANCED MATERIALS INTERFACES, 2014, v.1 no.4
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• Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates CHEMICAL COMMUNICATIONS, 2014, v.50 no.86, 13049-13051
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• Tunable and selective detection of cancer cells using a betainized zwitterionic polymer with BODIPY and graphene oxide NEW JOURNAL OF CHEMISTRY, 2014, v.38 no.6, 2225-2228
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• Bio-inspired catechol chemistry: A new way to develop a re-moldable and injectable coacervate hydrogel Chemical Communications, 2012, v.48 no.97, 11895-11897
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• Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery Nature Nanotechnology, 2012, v.7 no.6, 389-393
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• [학술지논문] Engineered Lipid Nanoparticles for the Treatment of Pulmonary Fibrosis by Regulating Epithelial-Mesenchymal Transition in the Lungs ADVANCED FUNCTIONAL MATERIALS, 2023, v.33 no.7 , 2209432-2209432
  SCIE
• [지적재산권] TCTP-PTD를 포함하는 유전자 전달체 국내 : 특허, 등록, 10-1595152, 2016
• [지적재산권] 생분해성 중합체, 이의 제조 방법, 이를 포함하는 유전자 전달 시스템 국내 : 특허, 등록, 10-1577893, 2015
• [지적재산권] 표적 유전자 검출용 미세 유동 장치, 이의 제조방법 및 이를 이용한 검출 방법 국내 : 특허, 출원
• [지적재산권] 핵산 나노구조체의 대량생산방법 및 이의 약물전달체로서의 활용 국내 : 특허, 출원
• [지적재산권] 펩타이드 국내 : 특허, 등록

학력

경력

연구분야

Advanced Biomaterials and Drug Delivery

We are interested in developing novel biomaterials for drug delivery and tissue engineering. Some of the projects that we are most interested in are

1. Sustained release of protein drugs,
2. Novel regio-specific PEGylation for therapeutic proteins,
3. Natural polymer based hydrogels for cell therapy and drug delivery.
4. Preparation of Induced Pluripotent Stem (IPS) cells by non-viral gene delivery systems

It is important that our materials are designed to be non-cytotoxic, non-immunogenic, and biodegradable.

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NanoBio and Theragnosis Technology

We are developing multi-functional nanoparticles for various applications. Drug, imaging, or biosensor molecules are incorporated within our nanoparticles. We aim to develop Nanobiotechnolgy that can efficiently and safely target particular tissues and organs to give therapeutic effects

1. Gene Delivery System (pDNA, mRNA, and siRNA delivery)
2. Anti-Cancer Drug Delivery System (water insoluble small molecule delivery)
3. Molecular Imaging System (ROS sensing, ECM degrading enzyme sensitive imaging probe)
4. Inorganic nanoparticles for biomedical sensors and probes

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Nucleic Acid Nanotechnology

We are motivated by the potential of DNA Nanotechnology to improve the fields of drug delivery. Not only the structural interests of DNA nano-assembly, we want to move forward to apply this novel materials and approaches to treat various diseases. Of particular interest to us is the targeting of cancer and stem cells

1. Programmable Self-assembly of DNA/RNA Nanoparticles
2. Self-replicating Nucleic Acid Nanoparticles
3. Screening of Targeting Ligands as well as evaluating Cell Penetrating Peptides
4. Dip-pen Nano-lithography using DNA/RNA molecular ink

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