김형래 명예교수
김형래 교수는 의학전문대학원(의과대학) 생화학교실소속 교수로 의학유전체 분야 보건의료연구정책 분야의 권위자다. 서울대학교에서 학사, 박사학위를 받았으며, 만성습관성질환의 유전적 배경과 유전적 소인이 식습관 운동습관 등 생활습관과 어떻게 상호작용하여 발병하고 진행하게 되는지, 그리고 이를 조절 가능한 유무형의 방법을 개발하여 질병 악화의 지연, 건강상태의 증진에 기여할 수 있는 것을 목표로 연구를 진행하고 있다. 2006년에는 의과대학 BK21사업단장, 2010년까지는 국립보건연구원의 유전체센터장 국립보건연구원장으로 재직하면서 한국의 인간유전체연구가 국제경쟁력있는 수준으로 도약하는데 기여하였다. 2011년부터 2014년까지 차세대맞춤의료유전체사업단장을 역임하면서 국제암컨소시엄인 ICGC에 가입 활동하게 함으로서 한국의 질병유전체연구의 국제화와 임상현장에 이식되는 유전체실용화에 크게 기여하였다. 2011년에는 한국유전체학회장, 2013년에는 생화학분자생물학회장을 역임하였다. 현재는 보건의료의 글로벌한 핫이슈인 만성질환-비만에 대한 연구로, 유전체학, 성격과 심리학, 수면-우울-인지저하, 신경-뇌이미징, 장내미생물-영양학 등의 의학부터 사회학까지 통섭하는 다학제연구를 연구를 수행 중에 있으며, 현재까지 총 90여편의 논문을 SCI급 국제학술지에 발표했다.
- 연구관심분야
- 만성질환의 발병, 진행, 예후예측 의 유전학적 연구, 만성질환의 발병 진행에 있어 유전적 배경과 행동습관의 상호작용, 행동습관과 성격특성과 상호작용과 성격특성의 유전체학, 정밀의료와 유전체분석기술, 참단의학기술과 사회
연구실적
- Association between gut microbiota and anxiety symptoms: A large population-based study examining sex differences Journal of Affective Disorders, 2023, v.333, 21-29
- A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids AMERICAN JOURNAL OF HUMAN GENETICS, 2022, v.109 no.8, 1366-1387
- Association Between Gut Microbiota and Depressive Symptoms: A Cross-Sectional Population-Based Study in South Korea Psychosomatic Medicine, 2022, v.84 no.7, 757-765
- Gut microbiota and the prevalence and incidence of renal stones Scientific Reports, 2022, v.12 no.1, 3732
- Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis Genome Biology, 2022, v.23 no.1, 268
- Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance Scientific Reports, 2022, v.12 no.1, 21842
- Sex-specific associations between gut microbiota and skeletal muscle mass in a population-based study Journal of Cachexia, Sarcopenia and Muscle, 2022, v.13 no.6, 2908-2919
- Whole-Genome Sequencing Reveals Age-Specific Changes in the Human Blood Microbiota Journal of Personalized Medicine, 2022, v.12 no.6, 939
- Correlation between Gut Microbiota and Six Facets of Neuroticism in Korean Adults JOURNAL OF PERSONALIZED MEDICINE, 2021, v.11 no.12, 1246
- Gut Microbiota Composition across Normal Range Prostate-Specific Antigen Levels JOURNAL OF PERSONALIZED MEDICINE, 2021, v.11 no.12, 1381
- Large-scale association analyses identify host factors influencing human gut microbiome composition Nature Genetics, 2021, v.53 no.2, 156-165
- Reversion of gut microbiota during the recovery phase in patients with asymptomatic or mild covid-19: Longitudinal study Microorganisms, 2021, v.9 no.6, 1237
- The power of genetic diversity in genome-wide association studies of lipids Nature, 2021, v.600 no.7890, 675-679
- Variants in NEB and RIF1 genes on chr2q23 are associated with skeletal muscle index in Koreans: genome-wide association study Scientific Reports, 2021, v.11 no.1, 2333
- Butler enables rapid cloud-based analysis of thousands of human genomes NATURE BIOTECHNOLOGY, 2020 , 288-
- Comprehensive molecular characterization of mitochondrial genomes in human cancers Nature Genetics, 2020, v.52 no.3, 342-352
- Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn's Disease: Results from the IMPACT Study JOURNAL OF CLINICAL MEDICINE, 2020, v.9 no.6, 1748
- Gut microbiota and metabolic health among overweight and obese individuals SCIENTIFIC REPORTS, 2020, v.10 no.1, 19417
- Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota JOURNAL OF CLINICAL MEDICINE, 2020, v.9 no.5, 1589
- Pan-cancer analysis of whole genomes NATURE, 2020, v.578 no.7793, 82-
- Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals Scientific Reports, 2020, v.10 no.1, 9179
- Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples Nature Communications, 2020, v.11 no.1, 4748
- Sex differences in oncogenic mutational processes Nature Communications, 2020, v.11 no.1, 4330
- Alterations of the Gut Microbiome in Chronic Hepatitis B Virus Infection Associated with Alanine Aminotransferase Level JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.2, 173
- Discovery of donor genotype associated with long-term survival of patients with hematopoietic stem cell transplantation in refractory acute myeloid leukemia LEUKEMIA & LYMPHOMA, 2019, v.60 no.7, 1775-1781
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases PLOS ONE, 2019, v.14 no.9, e0222535
- Fecal Microbiota Differences According to the Risk of Advanced Colorectal Neoplasms JOURNAL OF CLINICAL GASTROENTEROLOGY, 2019, v.53 no.3, 197-203
- Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects PLOS ONE, 2019, v.14 no.3, e0213692
- Gut Microbiota and Risk of Persistent Nonalcoholic Fatty Liver Diseases JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.8, 1089
- Landscape of Actionable Genetic Alterations Profiled from 1,071 Tumor Samples in Korean Cancer Patients Cancer research and treatment : official journal of Korean Cancer Association, 2019, v.51 no.1, 211-222
- Oncogenic effects of germline variants in lysosomal storage disease genes GENETICS IN MEDICINE, 2019, v.21 no.12, 2695-2705
- Physiologic intestinal F-18-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer SCIENTIFIC REPORTS, 2019, v.9, 18273
- The Impact of Cholecystectomy on the Gut Microbiota: A Case-Control Study JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.1, 79
- The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.2, 230
- Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study JOURNAL OF CLINICAL MEDICINE, 2018, v.7 no.9, 282
- Association between Neutrophil-to-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study SCIENTIFIC REPORTS, 2018, v.8, 16031
- Correlation between gut microbiota and personality in adults: A cross-sectional study BRAIN BEHAVIOR AND IMMUNITY, 2018, v.69, 374-385
- Development of the variant calling algorithm, ADIScan, and its use to estimate discordant sequences between monozygotic twins NUCLEIC ACIDS RESEARCH, 2018, v.46 no.15, e92
- Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients MOLECULES AND CELLS, 2018, v.41 no.5, 465-475
- Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach Scientific Reports, 2018, v.8 no.1, 3284
- Integrated genome sizing (IGS) approach for the parallelization of whole genome analysis BMC Bioinformatics, 2018, v.19 no.1, 462
- Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative MICROBIOME, 2018, v.6, 101
- Rosacea and its association with enteral microbiota in Korean females EXPERIMENTAL DERMATOLOGY, 2018, v.27 no.1, 37-42
- Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort BMC Microbiology, 2017, v.17 no.1
- Gut microbiota and physiologic bowel F-18-FDG uptake EJNMMI RESEARCH, 2017, v.7
- HLAscan: genotyping of the HLA region using next-generation sequencing data BMC BIOINFORMATICS, 2017, v.18
- Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia BMC MEDICAL GENETICS, 2017, v.18
- Meta-analysis of genome-wide SNP- A nd pathway-based associations for facets of neuroticism Journal of Human Genetics, 2017, v.62 no.10, 903-909
- Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population PLOS ONE, 2017, v.12 no.3
- The effect of probiotics, antibiotics, and antipyretic analgesics on gut microbiota modification Journal of Bacteriology and Virology, 2017, v.47 no.1, 64-74
- Direct and Indirect Effects of Five Factor Personality and Gender on Depressive Symptoms Mediated by Perceived Stress PLOS ONE, 2016, v.11 no.4
- SLC29A1 (ENT1) polymorphisms and outcome of complete remission in acute myeloid leukemia Cancer Chemotherapy and Pharmacology, 2016, v.78 no.3, 1-8
- Association between personality traits and sleep quality in young Korean women PLoS ONE, 2015, v.10 no.6
- Background Intestinal F-18-FDG Uptake Is Related to Serum Lipid Profile and Obesity in Breast Cancer Patients PLOS ONE, 2015, v.10 no.11
- Cytidine deaminase polymorphisms and worse treatment response in normal karyotype AML Journal of Human Genetics, 2015, v.60 no.12, 749-754
- Family-Based Association Study of Pulmonary Function in a Population in Northeast Asia PLOS ONE, 2015, v.10 no.10
- GWA meta-analysis of personality in Korean cohorts Journal of Human Genetics, 2015, v.60 no.8, 455-460
- Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome HUMAN REPRODUCTION, 2015, v.30 no.3, 723-731
- Genomic profile of AML-ETO rearranged acute myeloid leukemia CANCER RESEARCH, 2015, v.75
- Pathway Analysis Based on a Genome-Wide Association Study of Polycystic Ovary Syndrome PLOS ONE, 2015, v.10 no.8
- Pathway analysis of genome-wide association datasets of personality traits GENES BRAIN AND BEHAVIOR, 2015, v.14 no.4, 345-356
- Some personality traits converge gradually by long-term partnership through the lifecourse - Genetic and environmental structure of Cloninger's temperament and character dimensions Journal of Psychiatric Research, 2015, v.63, 43-49
- Association between Blood Lipid Levels and Personality Traits in Young Korean Women PLOS ONE, 2014, v.9 no.9
- Association between extraversion personality and abnormal glucose regulation in young Korean women ACTA DIABETOLOGICA, 2014, v.51 no.3, 421-427
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility NATURE GENETICS, 2014, v.46 no.3, 234-
- Genomic profile analysis of diffuse-type gastric cancers GENOME BIOLOGY, 2014, v.15
- Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts Genomics & Informatics, 2014, 제12권 4호, 195-202
- Personality Traits and Body Mass Index in a Korean Population PLOS ONE, 2014, v.9 no.3, Article ID e90516
- [학술지논문] Butler enables rapid cloud-based analysis of thousands of human genomes NATURE BIOTECHNOLOGY, 2020, v.38 no.3 , 288-288
- [학술지논문] Comprehensive molecular characterization of mitochondrial genomes in human cancers NATURE GENETICS, 2020, v.52 no.3 , 342-342
- [학술지논문] Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn's Disease: Results from the IMPACT Study JOURNAL OF CLINICAL MEDICINE, 2020, v.9 no.6 , 1748-1748
- [학술지논문] Gut microbiota and metabolic health among overweight and obese individuals SCIENTIFIC REPORTS, 2020, v.10 no.1 , 19417-19417
- [학술지논문] Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota JOURNAL OF CLINICAL MEDICINE, 2020, v.9 no.5 , 1589-1589
- [학술지논문] Pan-cancer analysis of whole genomes NATURE, 2020, v.578 no.7793 , 82-93
- [학술지논문] Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals SCIENTIFIC REPORTS, 2020, v.10 no.1 , 9179-9179
- [학술지논문] Alterations of the Gut Microbiome in Chronic Hepatitis B Virus Infection Associated with Alanine Aminotransferase Level JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.2 , 173-173
- [학술지논문] Characterization of the Blood Microbiota in Korean Females with Rosacea DERMATOLOGY, 2019, v.235 no.3 , 255-259
- [학술지논문] Discovery of donor genotype associated with long-term survival of patients with hematopoietic stem cell transplantation in refractory acute myeloid leukemia LEUKEMIA & LYMPHOMA, 2019, v.60 no.7 , 1775-1781
- [학술지논문] False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases PLOS ONE, 2019, v.14 no.9 , 0222535-0222535
- [학술지논문] Fecal Microbiota Differences According to the Risk of Advanced Colorectal Neoplasms JOURNAL OF CLINICAL GASTROENTEROLOGY, 2019, v.53 no.3 , 197-203
- [학술지논문] Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects PLOS ONE, 2019, v.14 no.3 , 1-15
- [학술지논문] Gut Microbiota and Risk of Persistent Nonalcoholic Fatty Liver Diseases JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.8 , 1089-1089
- [학술지논문] Oncogenic effects of germline variants in lysosomal storage disease genes GENETICS IN MEDICINE, 2019, v.21 no.12 , 2695-2705
- [학술지논문] Physiologic intestinal F-18-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer SCIENTIFIC REPORTS, 2019, v.9 no.0 , 18273-18273
- [학술지논문] The Impact of Cholecystectomy on the Gut Microbiota: A Case-Control Study JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.1 , 79-79
- [학술지논문] The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study JOURNAL OF CLINICAL MEDICINE, 2019, v.8 no.2 , 230-230
강의
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2021-1학기
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분자세포생물학I
- 학수번호 34353분반 01
- 2학년 ( 3학점 , 3시간) 수 4~5
- 전공필수 타전공생 수강 불가
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의학총론
- 학수번호 37588분반 01
- 1학년 ( 2.5학점 , 48시간)
- 전공필수 의학과 외 수강불가, 팀티칭, 자체시간표에 따라 운영
-
대사와영양
- 학수번호 37594분반 01
- 1학년 ( 2.5학점 , 52시간)
- 전공필수 의학과 외 수강불가, 팀티칭, 자체시간표에 따라 운영
-
학력
서울대학교 의학박사(의학과)