고광석(高光石) 교수
식품영양학과 /시스템헬스융합전공[대학원]
이화여자대학교 질병생리학 연구실(Ewha Nutritional Pathophysiology Laboratory, Ewha NPPL)은 분자생물학적인 방법과 빅데이터를 기반으로 질병의 발생과 예방, 건강기능식품의 안전성 평가 등의 연구를 진행하고 있습니다. 1. Molecular nutrition - 간질환 예방 및 조절 기전에 관한 연구 간은 인체의 영양소 대사와 독성 물질 제거 등 매우 중요한 기능을 담당하고 있습니다. 간암은 ‘침묵의 암’이라고 불릴 정도로 손상 정도에 비해 증상이 없는 질병 중 하나입니다. 자각증세가 심하지 않아 조기진단에 어려움이 있고 치료 시기를 놓질 경우 좋지 않은 예후를 보이게 됩니다. 본 연구실에서는 간 건강과 밀접한 관련이 있는 것으로 알려진 Prohibitin1 (PHB1)의 발현과 간 질환의 발생 기전을 밝히는데 주력하고 있습니다. - 간 오가노이드 개발 및 활용 연구 오가노이드란 인체 장기의 구조적 및 기능적 특성을 모방할 수 있는 3차원적 세포 배양 시스템을 말합니다. 전통적인 세포 배양 시스템은 in vivo 환경을 완벽하게 모방할 수 없으며, 동물실험은 경제적, 윤리적인 한계점을 가지고 있습니다. 따라서 간 오가노이드 구축은 2D culture의 제한점을 극복하고, 동물실험을 최소화하여 in vivo와 유사한 환경을 조성할 수 있다는 점에서 큰 이점이 있습니다. 본 연구실에서는 간 오가노이드를 이용하여 간 질환의 발생 기전 및 예측 바이오마커 개발 연구를 진행하고 있습니다. 또한 간 오가노이드를 이용한 건강기능식품의 안전성 및 독성 예측∙평가 시스템 개발하기 위한 연구를 진행하고 있습니다. 이는 기존에 안전성 및 독성 평가에 이용되고 있던 세포 주 실험과 동물실험을 대체하여 안전하게 인체에 적용할 수 있도록 하는 시스템 개발이 될 것이라 기대하고 있습니다. - 황 함유 아미노산의 간 보호 효과 구명 황 함유 아미노산 및 그 대사체는 methionine, cysteine과 함께 그 대사과정에서 생성되는 대사물로 S-adenosyl methionine (SAMe), taurine, glutathione과 같은 물질을 지칭합니다. 이 물질들은 체내에서 methyl group 전달 및 항산화 기능을 하는 것으로 알려져 있습니다. 항산화 기전은 간이 손상되었을 때 간을 보호하는 중요한 역할을 담당합니다. 황 함유 아미노산의 대사과정 중 생성되는 glutathione은 강력한 항산화 작용을 통해 간기능 회복 및 간 손상 예방에 효과가 있는 것으로 알려져 있습니다. 본 연구실에서는 glutathione의 전구체인 SAMe, cysteine, taurine과 같은 황 함유 아미노산 및 그 대사체와 대사과정에 도움을 주는 betaine 같은 물질의 섭취가 간 손상 및 간암에서 간 보호 효과를 낼 것으로 예상하고 관련 메커니즘에 대한 연구를 진행하고 있습니다. 2. Data science base nutrition - 다중 오믹스 분석(Multi-Omics Analysis) 기반 간질환 예측 바이오마커 개발 다중 오믹스 분석은 유전체(genome), 전사체(Transcriptome), 단백체(Proteome), 대사체(Metabolome) 등 다양한 분자 수준에서 생성된 여러 데이터들의 종합적인 분석을 의미합니다. 여러 종류의 오믹스를 동시 분석하고 종합하면 질병의 발생을 예측하거나 진단할 수 있습니다. 본 연구실에서는 Prohibitin1 발현 수준에 따라 변화하는 물질들의 변화를 확인하고 이를 통한 간질환의 발생 기전에 대한 연구를 진행하고 있습니다. 나아가 이러한 물질들을 통해 간 질환 민감성 (liver disease susceptibility)을 예측할 수 있는 바이오마커 개발 연구를 진행하고 있습니다. - 빅데이터 기반 개인 건강기능식품 안전성 평가 국민의 건강기능식품에 대한 수요가 증가함에 따라 건강기능식품의 중복 및 병용섭취가 이어지고 있습니다. 현재 건강기능식품의 중복/병용 섭취로 인한 안전성 평가방법이 부재한 상황이며, 다양한 식품 및 독성 등 데이터베이스들이 통합되어 있지 않습니다. 본 연구실에서는 대국민에게 균형 있는 건강기능식품 섭취의 방향성을 제공할 수 있도록 건강기능식품 빅데이터를 구축하고, 이를 기반으로 건강기능식품 중복/병용 섭취에 따른 부작용 예측 알고리즘을 개발하여 관련 시스템을 구축 및 보급하는 연구를 계획하고 있습니다. 3. 건강기능식품 규제정책 융복합 건강기능식품이란 건강기능식품과 일반식품을 일체형으로 만들어 동시에 섭취가 가능하도록 편의성을 높인 제품을 뜻합니다. 융복합 건강기능식품의 관심이 증가함에 따라 많은 업체에서 융복합 건강기능식품을 만들기 위해 노력하고 있습니다. 따라서 안전하게 운영될 수 있도록 위생교육, 안전점검, 컨설팅 등 지원이 필요합니다. 본 연구실에서는 융복합 건강기능식품 제조업소를 대상으로 점검 및 컨설팅을 진행하여 기준 규격 및 개정안 마련 연구를 진행하고 있습니다.
- 식품영양학과장/글로벌식품영양연구소장
- 생활환경관 502-1호
- 02-3277-6859
- 연구관심분야
- 질병의 발생기전 연구, 멀티오믹스 및 빅데이터 기반 연구, 간기능 보호 및 암예방 연구, 아미노산 대사 연구, 규제과학 법률, 정책, 기반과학 연구
연구실적
- Novel effects of prohibitin 1 expression level on cholesterol and lipid homeostasis Journal of Nutritional Biochemistry, 2024, v.125, 109561
- Associations of Food Insecurity with Dietary Inflammatory Potential and Risk of Low Muscle Strength NUTRIENTS, 2023, v.15 no.5, 1120
- Inhibitory Effects of Wheat Sprouts Extract on RANKL-Induced Osteoclast Differentiation via Suppressing MAPK and NFATc1 Signaling Pathways Journal of Medicinal Food, 2023, v.26 no.7, 480-488
- Association between Use of Nutrition Labels and Risk of Chronic Kidney Disease: The Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2019 Nutrients, 2022, v.14 no.9, 1731
- Effects of Amino Acids Supplementation on Lipid and Glucose Metabolism in HepG2 Cells Nutrients, 2022, v.14 no.15
- The Relationship between Prohibitin 1 Expression, Hepatotoxicity Induced by Acetaminophen, and Hepatoprotection by S-Adenosylmethionine in AML12 Cells Journal of Microbiology and Biotechnology, 2022, v.32 no.11, 1447-1453
- Development of a Human Estrogen Receptor Dimerization Assay for the Estrogenic Endocrine-Disrupting Chemicals Using Bioluminescence Resonance Energy Transfer INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, v.18 no.16, 8875
- RNA-Seq Reveals Different Gene Expression in Liver-Specific Prohibitin 1 Knock-Out Mice Frontiers in Physiology, 2021, v.12, 717911
- Analysis and management of abnormal cases by multiple intake of Korean health functional foods Journal of the Korean Society of Food Science and Nutrition, 2020, v.49 no.5, 511-520
- Lipopolysaccharide-induced innate immune responses are exacerbated by Prohibitin 1 deficiency and mitigated by S-adenosylmethionine in murine macrophages PLOS ONE, 2020, v.15 no.11, e0241224
- Long-Term Feeding of Soy Protein Attenuates Choline Deficient-Induced Adverse Effects in Wild Type Mice and Prohibitin 1 Deficient Mice Response More Sensitively. Preventive Nutrition and Food Science, 2019, v.24 no.1, 32~40
- Long-term feeding of soy protein attenuates choline deficient-induced adverse effects in wild type mice and prohibitin 1 deficient mice response more sensitively Preventive Nutrition and Food Science, 2019, v.24 no.1, 32-40
- Analysis of consumption status of calcium with related factors in a Korean population: Based on data from the 2013∼2015 Korean National Health and Nutritional Examination Survey (KNHANES) Journal of the Korean Society of Food Science and Nutrition, 2018, v.47 no.3, 328-336
- Effects of Coffee Extracts with Different Roasting Degrees on Antioxidant and Anti-Inflammatory Systems in Mice NUTRIENTS, 2018, v.10 no.3
- 개인 맞춤형 건강진단을 위한 건강데이터 수집 모바일 플랫폼의 설계와 구현 데이타베이스연구, 2018, v.34 no.1, 59~68
- 대사증후군 예방을 위한 모바일 헬스 애플리케이션의 개인맞춤형 콘텐츠 개발 보건교육건강증진학회지, 2018, v.35 no.3, 25~40
- Antioxidative and Anti-Inflammatory Activities of Akebia quinata Extracts in an In Vitro Model of Acute Alcohol-Induced Hepatotoxicity JOURNAL OF MEDICINAL FOOD, 2017, v.20 no.9, 912-922
- Cellular Antioxidant and Anti-Inflammatory Effects of Coffee Extracts with Different Roasting Levels Journal of Medicinal Food, 2017, v.20 no.6, 626-635
- 성인의 만성질환 관련 건강위험행태요인 군집현상 분석 보건교육건강증진학회지, 2017, v.34 no.3, 21~31
- Dietary beet pulp decreases taurine status in dogs fed low protein diet 한국동물자원과학회지, 2016, v.58 no.8, 1~10
- Effect of beverage containing fermented akebia quinata extracts on alcoholic hangover Preventive Nutrition and Food Science, 2016, v.21 no.1, 9-13
- Effects of Morphological Characteristics of Muscle Fibers on Porcine Growth Performance and Pork Quality 한국축산식품학회지, 2016, v.36 no.5, 583~593
- Effects of Morphological Characteristics of Muscle Fibers on Porcine Growth Performance and Pork Quality KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, 2016, v.36 no.5, 583-593
- Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine on Glutathione Homeostasis in Ethanol-induced Acute Hepatotoxicity 대한암예방학회지, 2016, v.21 no.3, 164~172
- Effects of extract of lactic acid bacteria culture media on quality characteristics of pork loin and antimicrobial activity against pathogenic bacteria during cold storage Journal of the Korean Society of Food Science and Nutrition, 2016, v.45 no.10, 1476-1480
- Effects of oleanolic acid and hederagenin on acute alcohol-induced hepatotoxicity in mice Journal of the Korean Society of Food Science and Nutrition, 2016, v.45 no.3, 307-312
- Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, v.291 no.46, 24148-24159
- Protective Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine Against Lipopolysaccharide or Polyinosinic-polycytidylic Acid-induced Acute Hepatotoxicity 대한암예방학회지, 2016, v.21 no.3, 152~163
- Relationship between Broca index of late school-aged children and their mothers’ eating, cooking, and exercise habit Journal of the Korean Society of Food Science and Nutrition, 2016, v.45 no.10, 1488-1496
- 어머니의 식습관, 요리습관 및 운동습관과 학령기 후기 아동의 Broca 체질량지수와의 상관관계 연구 한국식품영양과학회지, 2016, v.45 no.10, 1488~1496
- 유산균 배양액 추출액의 항병원성균 효과 및 냉장저장 육제품의 품질에 미치는 효과 한국식품영양과학회지, 2016, v.45 no.10, 1476~1480
- Effects of various garlic (Allium sativum) extracts on cholesterol synthesis in HepG2 cells Journal of the Korean Society of Food Science and Nutrition, 2015, v.44 no.12, 1779-1784
- Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases Mediators of Inflammation, 2015, v.2015
- Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice FREE RADICAL BIOLOGY AND MEDICINE, 2014, v.68, 148-158
- Protective effects of Akebia quinata fruit extract on acute alcohol-induced hepatotoxicity in mice Korean Journal of Food Science and Technology, 2014, v.46 no.5, 622-629
- 대중매체 식품영양정보에 대한 성인 여성의 요구도 조사 대한지역사회영양학회지, 2014, 제19권 6호, 550-557
- [학술지논문] Effect of Ginseng (Panax ginseng, Meyer) Leaf Extract on the Gene Expression of Enzymes Involved in Metabolism of Ethanol, Glucose and Lipid in HepG2 Hepatocytes 건강기능식품미래포럼 학술지, 2024, v.4 no.3 , 1-12
- [학술지논문] Novel effects of prohibitin 1 expression level on cholesterol and lipid homeostasis JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2024, v.125 no.1 , 109561-109569
- [학술지논문] Associations of Food Insecurity with Dietary Inflammatory Potential and Risk of Low Muscle Strength NUTRIENTS, 2023, v.15 no.5 , 1-14
- [학술지논문] Inhibitory Effects of Wheat Sprouts Extract on RANKL-Induced Osteoclast Differentiation via Suppressing MAPK and NFATc1 Signaling Pathways JOURNAL OF MEDICINAL FOOD, 2023, v.26 no.7 , 480-488
- [학술지논문] Organoid Establishment of Long-Term Culture Using Primary Mouse Hepatocytes and Evaluation of Liver Function Preventive Nutrition and Food Science, 2023, v.28 no.3 , 360-369
- [학술지논문] Association between Use of Nutrition Labels and Risk of Chronic Kidney Disease: The Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2019 NUTRIENTS, 2022, v.14 no.9 , 1731-1731
- [학술지논문] Effects of Amino Acids Supplementation on Lipid and Glucose Metabolism in HepG2 Cells NUTRIENTS, 2022, v.14 no.15 , 1-13
- [학술지논문] Saturated Fatty Acid-Induced Impairment of Hepatic Lipid Metabolism Is Worsened by Prohibitin 1 Deficiency in Hepatocytes JOURNAL OF MEDICINAL FOOD, 2022, v.25 no.8 , 845-852
- [학술지논문] The Relationship between Prohibitin 1 Expression, Hepatotoxicity Induced by Acetaminophen, and Hepatoprotection by S-Adenosylmethionine in AML12 Cells Journal of Microbiology and Biotechnology, 2022, v.32 no.11 , 1447-1453
- [학술지논문] Development of a Human Estrogen Receptor Dimerization Assay for the Estrogenic Endocrine-Disrupting Chemicals Using Bioluminescence Resonance Energy Transfer INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, v.18 no.16 , 1-13
- [학술지논문] We Are Not Informed Enough Food Supplements and Biomaterials for Health, 2021, v.1 no.4 , 1-2
- [학술지논문] Lipopolysaccharide-induced innate immune responses are exacerbated by Prohibitin 1 deficiency and mitigated by S-adenosylmethionine in murine macrophages PLOS ONE, 2020, v.15 no.11 , 0241224-0241224
- [학술지논문] 국내 건강기능식품의 복수 섭취에 따른 이상사례 신고 내용 분석 및 관리 방안 Journal of the Korean Society of Food Science and Nutrition, 2020, v.49 no.5 , 511-520
- [학술지논문] Long-term feeding of soy protein attenuates choline deficient-induced adverse effects in wild type mice and prohibitin 1 deficient mice response more sensitively Preventive Nutrition and Food Science, 2019, v.24 no.1 , 32-40
- [학술지논문] Analysis of consumption status of calcium with related factors in a Korean population: Based on data from the 2013∼2015 Korean National Health and Nutritional Examination Survey (KNHANES) Journal of the Korean Society of Food Science and Nutrition, 2018, v.47 no.3 , 328-336
- [학술지논문] Effects of Coffee Extracts with Different Roasting Degrees on Antioxidant and Anti-Inflammatory Systems in Mice NUTRIENTS, 2018, v.10 no.3 , 1-13
- [학술지논문] 개인 맞춤형 건강진단을 위한 건강데이터 수집 모바일 플랫폼의 설계와 구현 데이타베이스연구, 2018, v.34 no.1 , 59-68
- [학술지논문] 대사증후군 예방을 위한 모바일 헬스 애플리케이션의 개인맞춤형 콘텐츠 개발 보건교육건강증진학회지, 2018, v.35 no.3 , 25-40
- [학술지논문] Antioxidative and Anti-Inflammatory Activities of Akebia quinata Extracts in an In Vitro Model of Acute Alcohol-Induced Hepatotoxicity JOURNAL OF MEDICINAL FOOD, 2017, v.20 no.9 , 912-922
- [학술지논문] Cellular Antioxidant and Anti-Inflammatory Effects of Coffee Extracts with Different Roasting Levels JOURNAL OF MEDICINAL FOOD, 2017, v.20 no.6 , 626-635
- [학술지논문] 성인의 만성질환 관련 건강위험행태요인 군집현상 분석 보건교육건강증진학회지, 2017, v.34 no.3 , 21-31
- [학술지논문] Dietary beet pulp decreases taurine status in dogs fed low protein diet 한국동물자원과학회지, 2016, v.58 no.8 , 1-10
- [학술지논문] Effect of beverage containing fermented akebia quinata extracts on alcoholic hangover Preventive Nutrition and Food Science, 2016, v.21 no.1 , 9-13
- [학술지논문] Effects of Morphological Characteristics of Muscle Fibers on Porcine Growth Performance and Pork Quality KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES(한국축산식품학회지), 2016, v.36 no.5 , 583-593
- [학술지논문] Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine on Glutathione Homeostasis in Ethanol-induced Acute Hepatotoxicity 대한암예방학회지, 2016, v.21 no.3 , 164-172
- [학술지논문] Effects of extract of lactic acid bacteria culture media on quality characteristics of pork loin and antimicrobial activity against pathogenic bacteria during cold storage JOURNAL OF THE KOREAN SOCIETY OF FOOD SCIENCE AND NUTRITION(한국식품영양과학회지), 2016, v.45 no.10 , 1476-1480
- [학술지논문] Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, v.291 no.46 , 24148-24159
- [학술지논문] Protective Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine Against Lipopolysaccharide or Polyinosinic-polycytidylic Acid-induced Acute Hepatotoxicity 대한암예방학회지, 2016, v.21 no.3 , 152-163
- [학술지논문] Relationship between Broca index of late school-aged children and their mothers’ eating, cooking, and exercise habit JOURNAL OF THE KOREAN SOCIETY OF FOOD SCIENCE AND NUTRITION(한국식품영양과학회지), 2016, v.45 no.10 , 1488-1496
- [학술지논문] 마우스에서 oleanolic acid와 hedragenin이 급성 알코올성 간독성에 미치는 효과 Journal of the Korean Society of Food Science and Nutrition, 2016, v.45 no.3 , 307-312
- [학술지논문] Effects of various garlic (Allium sativum) extracts on cholesterol synthesis in HepG2 cells JOURNAL OF THE KOREAN SOCIETY OF FOOD SCIENCE AND NUTRITION(한국식품영양과학회지), 2015, v.44 no.12 , 1779-1784
- [학술지논문] Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases MEDIATORS OF INFLAMMATION, 2015, v.2015 no.276850 , 1-12
- [학술지논문] Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice FREE RADICAL BIOLOGY AND MEDICINE, 2014, v.68 no.0 , 148-158
- [학술지논문] Protective effects of Akebia quinata fruit extract on acute alcohol-induced hepatotoxicity in mice KOREAN JOURNAL OF FOOD SCIENCE AND TECHNOLOGY(한국식품과학회지), 2014, v.46 no.5 , 622-629
- [학술지논문] 대중매체 식품영양정보에 대한 성인 여성의 요구도 조사 대한지역사회영양학회지, 2014, v.19 no.6 , 550-557
- [학술지논문] Animal models of cholangiocarcinoma CURRENT OPINION IN GASTROENTEROLOGY, 2013, v.29 no.3 , 312-318
- [학술지논문] MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma JOURNAL OF CLINICAL INVESTIGATION, 2013, v.123 no.1 , 285-298
- [학술지논문] Protective Effects of Guava Pulp on Cholestatic Liver Injury ISRN Hepatology, 2013, v.2013 no.601071 , 1-11
- [학술지논문] Mechanism and Significance of Changes in Glutamate-Cysteine Ligase Expression during Hepatic Fibrogenesis JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, v.287 no.43 , 36341-36355
- [학술지논문] Recent advances of miRNA involvement in hepatocellular carcinoma and cholangiocarcinoma Open Journal of Internal Medicine, 2012, v.2 no.3 , 135-162
- [학술지논문] 황함유 아미노산의 간기능 보호 작용: 간세포암 예방의 가능성 한국식품과학회지, 2012, v.44 no.6 , 653-657
- [저역서] 2020 한국인 영양소 섭취기준 보건복지부, 2020, 274
- [저역서] 2015 한국인 영양소 섭취기준 보건복지부, 2015, 1118
- [학술발표] A Study on Safety Management support and institutionalization for Convergence Health functional foods 2024 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2024-10-24 Advances in Farm to Table Technologies for Human Health, 2024, 472-472
- [학술발표] Cross-Nutrient Database System: A Foundational Graph Database for Retrieving Information on Overlapping and Co-Administration of Pharmaceuticals and Dietary Supplements 2024 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2024-10-25 Advances in Farm to Table Technologies for Human Health, 2024, 568-568
- [학술발표] Data Collection for Predicting Safety Overlapping or Concurrent Intake of Functional Ingredients in Health Functional Foods 2024 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2024-10-24 Advances in Farm to Table Technologies for Human Health, 2024, 472-472
- [학술발표] Effect of Ginseng (Panax ginseng, Meyer) leaf extract on the gene expression of enzymes involved in metabolism of ethanol, glucose and lipid in HepG2 hepatocytes 2024 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2024-10-23 Advances in Farm to Table Technologies for Human Health, 2024, 458-458
- [학술발표] Exploring cutting-edge safety evaluation techniques for concurrent and combined intake utilizing big data analysis 2024 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2024-10-23 Advances in Farm to Table Technologies for Human Health, 2024, 147-147
- [학술발표] Is It Possible to Predict the Risks of Overlapping or Simultaneous Consumption of Health Functional Foods Using Big Data ? 2024 20th International Conference on Toxicogenomics, 대한민국, 인천, 2024-09-05 대한독성유전단백체학회초록집, 2024
- [학술발표] Prohibitin 1 is a Novel Regulator on Lipid and Cholesterol Metabolism in Liver Hepatocyte 2024 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2024-10-23 Advances in Farm to Table Technologies for Human Health, 2024, 457-457
- [학술발표] Relationship Between Metabolic Changes and Liver Health According to Prohibitin 1 Expression Level Nutrition 2024, 미국, Chicago, 2024-06-30 Current Development in Nutrition, 2024
- [학술발표] 복합건강기능식품 시험법 가이드라인 개발을 위한 현장 애로사항 조사 연구 2024 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2024-10-25 Advances in Farm to Table Technologies for Human Health, 2024, 541-541
- [학술발표] A Study on the Proposal for Convergence Health Functional Food Management System 2023 KoSFOST International Symposium and Annual Meeting, 대한민국, 서귀포시, 2023-06-30 Sustainable Food Innovation: A Bridge to the Future for All, 2023, 836-836
- [학술발표] Discovery of Biomarkers for the Diagnosis of Liver Disease Susceptibility by Omics Analysis in Liver Specific Prohibitin 1 Deficient Mice 2023 한국대사체학회 정기학술대회, 대한민국, 서울, 2023-04-07 2023 한국대사체학회 정기학술대회 및 제11차 정기총, 2023, 96-96
- [학술발표] Discovery of biomarkers for the diagnosis of liver disease susceptibility by metabolome analysis in liver specific Phb1 deficient mice 2023 KFN International Symposium and Annual Meeting, 대한민국, 부산, 2023-10-18 Sustainable Food System for a Healthy & Value-Oriented Life, 2023, 518-518
- [학술발표] Novel Effects of Prohibitin 1 Expression Level on Cholesterol and Lipid Homeostasis 2023 KFN International Symposium and Annual Meeting, 대한민국, 부산, 2023-10-18 Sustainable Food System for a Healthy & Value-Oriented Life, 2023, 518-518
- [학술발표] The Impact of the Expression Level of Prohibitin 1 on the Cholesterol Metabolism Nutrition 2023, 미국, Boston, 2023-07-24 Nutrition 2023, 2023
- [학술발표] 융복합 건강기능식품 탄생과 효율적 규제를 통한 건강기능식품의 다변화 2023 한국영양학회 추계국제학술대회, 대한민국, 서울, 2023-10-13 Understanding Metabolism: Scientific ADvances and Practical Applications, 2023, 46-47
- [학술발표] Hepatic Damage Sensitivity of Prohibitin 1 Deficient Mice and Relieving Effects of S-Adenosylmethionine 2022년도 제42회 한국운동영양학회 춘계학술대회, 대한민국, 서울, 2022-05-20 New Paradigms of Nutrition and Exercise to Improve Health and Sports Performance in the New Normal Era , 2022, 57-72
- [학술발표] Organoid Establishment for Long-Term Culture using Primary Mouse Hepatocytes and Evaluation of Liver Function as a Health Functional Food Test Model 2022 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2022-10-21 New Frontiers for Green Biotechnology in Food Science and Nutrition, 2022, 380-380
- [학술발표] Prohibitin 1 affects cell cycle signaling associated with hydrogen peroxide oxidative stress 2022 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2022-10-21 New Frontiers for Green Biotechnology in Food Science and Nutrition, 2022, 628-628
- [학술발표] 한국형 건강기능식품 섭취 실태조사를 통한 한국 성인의 건강기능식 품으로부터의 영양·기능성분 섭취량 추정 2022 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2022-10-21 New Frontiers for Green Biotechnology in Food Science and Nutrition , 2022, 543-543
- [학술발표] Development for early diagnosis of liver disease using metabolite changes in liver-specific Phb1 deficient mice 2021 KFN International Symposium and Annual Meeting, 대한민국, 부산, 2021-10-29 Tailored to Fit: Food & Nutrition in New Era, 2021
- [학술발표] Prohibitin 1 can protect hepatocytes against Acetaminophen toxicity in AML 12 cells 2020 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2020-10-23 Health Aging & Sustainable Life, 2020, 218-219
- [학술발표] Analysis of abnormal cases by multiple intake of health functional foods 2019 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2019-10-23 The 4th Industrial Revolution: The ROle of Food & Nutritional Sciences, 2019, 232-232
- [학술발표] BRET (Bioluminescence Resonance Energy Transfer)-based Androgen Binding Asay Detection Androgenic CHemical Compounds in Foods and Related Materials 2019 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2019-10-25 The 4th Industrial Revolution: The Role of Food & Nutritional Sciences, 2019, 435-436
- [학술발표] Effects of Branched Chain Amino Acids Supplementation on Lipid and Glucose Metabolism in HepG2 Cells 2019 KFN International Symposium and Annual Meeting, 대한민국, 서귀포시, 2019-10-24 The 4th Industrial Revolution: The Role of Food & Nutritional Sciences, 2019, 364-365
- [학술발표] Power of Sulfur Containing Amino Acids: in Liver 한국독성학회 2019 제35차 정기학술대회, 대한민국, 서귀포시, 2019-11-04 Bridging Modern Toxicology to DIsease Prevention, 2019
- [학술발표] Prohibitin 1 deficiency causes impairment of lipid metabolism and the disruption is deteriorated by excessive palmitic acids in hepatocytes Nutrition 2019, 미국, Baltimore, 2019-06-10 Nutrition 2019, 2019
- [학술발표] Depletion of Prohibitin 1 Maintains Low Glutathione Level Despite Treatment of S-Adenosylmethionine and Its Combination with Taurine and/or Betaine Nutrition 2018, 미국, Boston, 2018-06-11 Where the Best in Science & Health Meet, 2018
- [학술발표] Immunity and Amino Acids The 19th Congress of PENSA 2018, 대한민국, 서울, 2018-06-16 Innovative Nutrition in GLobal Health, 2018, 49-49
- [학술발표] Modulation of the LPS-Induced Inflammatory Responses by Prohibitin 1 and S-Adenosylmethionine in RAW 264.7 Cells 2018 KFN International Symposium and Annual Meeting, 대한민국, 부산, 2018-11-01 Food, Nutrition and Health: Human Microbiome, 2018, 494-494
- [학술발표] Modulation of the LPS-induced inflammatory responses by prohibitin 1 in RAW 264.7 cells 2018 KoSFoST International Symposium and Annual Meeting, 대한민국, 부산, 2018-06-29 KoSFoST Beyond 50 Years: Review the New in Food Science, 2018, 680-680
- [학술발표] 4.0시대의 식품영양 2017 KFN International Symposium and Annual Meeting, 대한민국, 경주, 2017-11-09 Tranlational Food & Nutrition Research for Healthy Life, 2017, 108-108
- [학술발표] Changing anti-inflammatory effects of coffee extracts with different levels of roasting KoSFoST International Symposium and Annual Meeting, 대한민국, 제주, 2017-06-23 The role of food scientists & food industries for food security, 2017, 520-520
- [학술발표] Immunity and Amino Acids 2017 한국임상영양학회 하계학술대회, 대한민국, 서울, 2017-07-01 고령화시대의 임상영양관리, 2017, 59-59
- [학술발표] Cellular antioxidant effects of coffee extracts with different roasting degrees 2016 KOSFOST International Symposium and Annual Meeting, 대한민국, 대구, 2016-08-18 Food Science for Daily Living via Innovation and Convergence, 2016, 53-53
- [학술발표] Hepato-Protective effects of sulfur containing amino acids mixtures against anti-bacterial or anti-viral challenges 2016년 한국노인과학학술대회, 대한민국, 서울, 2016-11-25 초고령사히 대응 고령친화환경 전략, 2016, 474-475
- [학술발표] Antibacterial Effectts of the Culture Supplement of Selected Lactobacilli Strains 2015 KFN International Symposium and Annual Meeting, 대한민국, Pyeongchang, 2015-08-24 Phytonutrients and Healthy Foods, 2015
- [학술발표] Correlation between prohibitin1 gene expression and susceptibility of liver disease through human liver tissue analysis 20th International Conference on Annual Meeting of Korean Society of Cancer Prevention, 대한민국, 서울, 2015-12-10 20th International Conference on Annual Meeting of Korean Society of Cancer Prevention, 2015, 94-94
- [학술발표] Effects of garlin (Allium sativum) extracts on cellular choleterol synthesis of HepG2 with different extraction method 2015 한국영양학회 추계학술대회 및 제50차 정기총회, 대한민국, 서울, 2015-11-06 Nutrition and Omics: CHallenges and Breakthrough, 2015
- [학술발표] Extract of Mammea lonifolia Planch and Triana Fruit Induces APoptosis in Human Colon Cancer by a Mitochondria Pathway 2015 KFN International Symposium and Annual Meeting, 대한민국, Pyeongchang, 2015-08-24 Phytonutrients and Healthy Foods, 2015
- [학술발표] Possibility of cancer prevention of Prohibitin1 UKC2015, 미국, Atlanta, 2015-07-30 UKC2015 Conference Proceedings, 2015
- [학술발표] Possibilty of cancer prevention of prohibitin1 2015 한국영양학회 추계학술대회 및 제50차 정기총회, 대한민국, 서울, 2015-11-06 Nutrition and Omics: Challenges and Breakingthrough, 2015, 148-156
- [학술발표] Amino Acids Fight to Sarcopenia 2014년 2차 근감소증 심포지엄, 대한민국, 서울, 2014-01-25 대한근감소증연구회 2014년 2차 근감소증 심포지엄, 2014, 71-75
- [학술발표] Developing an Integrated Multi-Disciplinary Healthcare Application for Elderly Disease Management 2014 Fifth International Conference on Information Science and Application, 대한민국, 서울, 2014-06-06 ICISA 2014, 2014, 600-601
- [학술발표] Effect of Extract of Lactic Acid Bacteria Culture Media on Quality Characteristics of Pork Loin and Antimicrobial Activity of Listeria monocytogenes during Cold Storage 2014 한국식품과학회 제81차 학술대회 및 정기총회, 대한민국, 광주, 2014-08-26 2014 Annual Meeting of KOSFOST: Creative Food Science for the future, 2014, 401-401
- [학술발표] Extract of Akebia quinata has a therapeutic role as anti-inflammatory and antioxidant in alcohol injury mouse hepatocyte 2014 International Symposium and Annual Meeting of KFN, 대한민국, 대전, 2014-10-29 2014 International Symposium and Annual: Lifelong Health and Welness from Nutrition and Food, 2014, 399-399
- [학술발표] Prohibitin1 regulates H19 and insulin-like growth factor 2 expression in hepatocytes and liver Experimental Biology 2014, 미국, San Doego, 2014-04-28 EB2014, 2014, 71-71
- [학술발표] Tumor Suppressor Function of Prohibitin1 through Regulating Insulin-like Growth Factor II mRNA-binding Protein3 Osaek Symposium, 대한민국, 강원도, 2014-07-04 Osaek Symposium, 2014, 19-19
- [학술발표] A new candidate helper for healthy liver, Prohibitin1 2013 한국식품과학회 Annual Meeting, 대한민국, 천안, 2013-08-28 Innovations in Food Science for Human Well-Being, 2013, 33-33
- [학술발표] Effects of Akebia Quinata extracts with antioxidants activity and hepatoprotective function on mouse liver 2013 한국영양학회 추계학술대회, 대한민국, 서울, 2013-11-08 2013 한국영양학회 추계학술대회: 염증과영양, 2013, 520-520
- [학술발표] Prohibitin1, Re-visit as a tumor-suppressor of liver cancer Canada-Korea Conference, 캐나다, Whistler, 2012-08-07 Canada-Korean Conference 2012, 2012, 55-55
- [학술발표] 황함유 아미노산: 그 중요성에 대한 재조명 한국동물자원과학괴 학술발표회, 대한민국, 대전, 2012-06-28 Proceedings of 2012 Annual Congress of KSAST, 2012, 113-121
강의
-
2024-2학기
-
식품영양분석실험
- 학수번호 36599분반 01
- 1학년 ( 3학점 , 4.5시간) 수 4~6 (생활403)
- 속강,실험안전교육수강필수,1학년우선전공(2~4학년수강가능)
-
-
2024-1학기
-
1학년세미나(신산업융합대)
- 학수번호 11222분반 06
- 1학년 ( 1학점 월 7~7
- 새내기의 맛집 탐방, 그리고 과학/생활관 502-1호, 이대/신촌 맛집
-
생애주기영양학
- 학수번호 22719분반 01
- 3학년 ( 3학점 , 3시간) 월 3~3 (생활216) , 수 2~2 (생활216)
-
단백질아미노산의건강
- 학수번호 G18810분반 01
- 학년 ( 3학점 , 3시간) 수 4~5 (생활607)
-
-
2023-2학기
-
식품영양분석실험Ⅰ 강의 계획서 상세보기
- 학수번호 36599분반 01
- 1학년 ( 3학점 , 4.5시간) 목 3~5 (생활403)
- 실험실안전교육 필수. 1학년 우선 전공. 2-4 학년 수강 가능.
-
영양학특론
- 학수번호 G17729분반 01
- 학년 ( 3학점 , 3시간) 수 2~3 (생활508)
-
-
2023-1학기
-
1학년세미나(신산업융합대) 강의 계획서 상세보기
- 학수번호 11222분반 10
- 1학년 ( 1학점 수 7~7
- 새내기의 맛집 탐방, 그리고 과학 / 생활관 502-1호
-
생애주기영양학 강의 계획서 상세보기
- 학수번호 22719분반 01
- 3학년 ( 3학점 , 3시간) 월 6~6 (생활511) , 수 5~5 (생활511)
-
영양병태생리학
- 학수번호 G17201분반 01
- 학년 ( 3학점 , 3시간) 월 3~4 (생활607)
-
-
2022-2학기
-
식품영양분석실험I
- 학수번호 36599분반 01
- 1학년 ( 3학점 , 4.5시간) 목 3~5 (생활403)
- 실험실안전교육 필수. 1학년 우선 전공. 2-4 학년 수강 가능.
-
영양학특론
- 학수번호 G17729분반 01
- 학년 ( 3학점 , 3시간) 수 5~6 (생활607)
-
-
2022-1학기
-
호크마세미나
- 학수번호 11302분반 30
- 1학년 ( 1학점 수 7~7
- 새내기의 맛집 탐방, 그리고 과학 / 장소: 교수연구실 (생활환경관 502-1호) Zoom 이대/신촌 맛집
-
생애주기영양학
- 학수번호 22719분반 01
- 3학년 ( 3학점 , 3시간) 월 6~6 (생활511) , 수 5~5 (생활511)
- 영어강의
-
단백질영양과대사
- 학수번호 G13242분반 01
- 학년 ( 3학점 , 3시간) 월 3~4
-
맞춤영양학
- 학수번호 CN562분반 01
- 학년 ( 3학점 , 3시간) 월 8~9 (캠)
- 교수변경
-
-
2021-2학기
-
식품영양분석실험I
- 학수번호 36599분반 01
- 1학년 ( 3학점 , 4.5시간) 화 2~2 (생활114) , 화 3~4 (생활403)
- 영어강의 속강
-
영양학특론
- 학수번호 G17729분반 01
- 학년 ( 3학점 , 3시간) 월 2~3
-
-
2021-1학기
-
호크마세미나
- 학수번호 11302분반 33
- 1학년 ( 1학점 수 7~7
- 새내기의 맛집 탐방, 그리고 과학 / 교수연구실(생활환경관 502-1호) Zoom
-
창의융합형글로벌리더로가는길
- 학수번호 11307분반 01
- 1학년 ( 3학점 , 3시간) 수 6~7
- 팀티칭, 전면 온라인
-
생애주기영양학
- 학수번호 22719분반 01
- 3학년 ( 3학점 , 3시간) 월 3~3 , 수 2~2
- 영어강의
-
영양병태생리학
- 학수번호 G17201분반 01
- 학년 ( 3학점 , 3시간) 화 5~6 (생활511)
-
학력
University of California, Davis Ph.D.(Nutritional Biology)
고려대학교(서울) 농학석사(응용동물과학)
고려대학교(서울) 농학사(응용동물과학)
경력
식품영양학과장 2023-08-01 ~ 2025-07-31
글로벌식품영양연구소장 2023-08-01 ~ 2025-07-31
호크마교양대학부학장 2019-08-01 ~ 2021-07-31
Univ. of Southern California, Pos-doc. 2007-02-01 ~ 2012-02-29