Ewha Researchers Discover Novel Therapeutic Strategy to Combat Alzheimer’s
Professor Yun Soo Bae and his research team from the Department of Life Sciences, College of Natural Sciences at Ewha Womans University, have unveiled a novel therapeutic strategy that suppresses oxidative stress and neuroinflammation—the core mechanisms driving the onset of Alzheimer’s disease—to enhance brain resilience. This groundbreaking achievement which presents an innovative approach toward conquering dementia, was published online in the prestigious international journal Advanced Science (IF = 14.1).
Alzheimer’s disease (AD) is closely associated with the activation of NADPH oxidase (Nox) isozymes. CRB-2131, a novel oxadiazole derivative, has been identified as a potent suppressor of Nox isozymes.
Both prophylactic administration (beginning at 3.5 months of age) and therapeutic administration (beginning at 6 months of age) of CRB-2131 for 10 weeks in 5XFAD mice significantly reduced hippocampal superoxide levels, lipid peroxidation, tau phosphorylation, and neuroinflammation.
CRB-2131 treatment increased the number of mature neurons, reduced apoptotic cell death among mature neurons, and elevated the population of immature neurons in the hippocampus.
Professor Bae stated, “This achievement opens a new paradigm in the development of Alzheimer’s therapeutics, and I hope it will pave the way for future clinical studies that can help address the global challenge of dementia.”
Jihyeon Lee , PhD | Professor Yun Soo Bae
View Published Paper: https://www.researchgate.net/publication/394532835_NADPH_Oxidase_Inhibition_Promotes_Brain_Resilience_by_Attenuating_Tauopathy_and_Neuroinflammation_in_Alzheimer's_Disease