Pyung lim Han Professor Emeritus
Pyung-Lim Han is a professor at the Department of Brain & Cognitive Sciences, Ewha Womans University. And he is an expert on using an animal model of stress-depression in the molecular mechanism studies. He graduated from Seoul National University, Graduate School of Neuroscience Baylor College of Medicine in the United States learning and memory research in molecular biology Ph.D. on the subject. Since 2013, he is the President of the Society of neurodegenerative diseases and editor-in-chief of the Experimental Neurobiology(specializing in the International Journal of Neuroscience), and to date about 100 papers published in international journals SCI level. The main research topics include cognitive behavioral stress and stress-related depression, behavioral analysis of the function of regulatory factors, cognitive behavioral development of selective regulation and control technology.
Research Record
- Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer's Disease Cells, 2024, v.13 no.2
- Extracellular Vesicles Released by Lactobacillus paracasei Mitigate Stress-induced Transcriptional Changes and Depression-like Behavior in Mice EXPERIMENTAL NEUROBIOLOGY, 2023, v.32 no.5, 328-342
- Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice Experimental and Molecular Medicine, 2023, v.55 no.9, 2067-2082
- Behavioral Engagement With Playable Objects Resolves Stress-Induced Adaptive Changes by Reshaping the Reward System Biological Psychiatry, 2022, v.91 no.7, 676-689
- Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice Molecular Neurobiology, 2022, v.59 no.5, 2715-2728
- Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior MOLECULAR NEUROBIOLOGY, 2021, v.58 no.12, 6427-6442
- Humulus japonicus rescues autistic-like behaviours in the BTBR T+ Itpr3tf/J mouse model of autism Molecular Medicine Reports, 2021, v.23 no.6, A12
- Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits EXPERIMENTAL NEUROBIOLOGY, 2021, v.30 no.6, 415-429
- Hyperoxygenation Treatment Reduces Beta-amyloid Deposition via MeCP2-dependent Upregulation of MMP-2 and MMP-9 in the Hippocampus of Tg-APP/PS1 Mice EXPERIMENTAL NEUROBIOLOGY, 2021, v.30 no.4, 294-307
- Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice Nature Communications, 2021, v.12 no.1, 6682
- Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice Communications Biology, 2020, v.3 no.1, 292
- Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum EXPERIMENTAL NEUROBIOLOGY, 2019, v.28 no.3, 337-351
- Experimental Neurobiology: The Past, Present, and Future EXPERIMENTAL NEUROBIOLOGY, 2019, v.28 no.4, 447-450
- Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice EXPERIMENTAL NEUROBIOLOGY, 2019, v.28 no.2, 158-171
- Hyperoxygenation revitalizes Alzheimer’s disease pathology through the upregulation of neurotrophic factors Aging Cell, 2019, v.18 no.2, e12888
- Reciprocal interactions across and within multiple levels of monoamine and cortico-limbic systems in stress-induced depression: A systematic review NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2019, v.101, 13-31
- Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors Molecular Neurobiology, 2019, v.56 no.12, 8537-8556
- A Group of Descending Glutamatergic Neurons Activated by Stress in Corticolimbic Regions Project to the Nucleus Accumbens EXPERIMENTAL NEUROBIOLOGY, 2018, v.27 no.5, 387-396
- Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease KIDNEY INTERNATIONAL, 2018, v.93 no.2, 403-415
- Alarmin HMGB1 induces systemic and brain inflammatory exacerbation in post-stroke infection rat model CELL DEATH & DISEASE, 2018, v.9
- Effects of histone acetyltransferase inhibitors on l-DOPA-induced dyskinesia in a murine model of Parkinson's disease JOURNAL OF NEURAL TRANSMISSION, 2018, v.125 no.9, 1319-1331
- Proteomic Analysis of Hippocampus in a Mouse Model of Depression Reveals Neuroprotective Function of Ubiquitin C-terminal Hydrolase L1 (UCH-L1) via Stress-induced Cysteine Oxidative Modifications MOLECULAR & CELLULAR PROTEOMICS, 2018, v.17 no.9, 1803-1823
- Striatal Inhibition of MeCP2 or TSC1 Produces Sociability Deficits and Repetitive Behaviors EXPERIMENTAL NEUROBIOLOGY, 2018, v.27 no.6, 539-549
- Alarmin HMGB1 induces systemic and brain inflammatory exacerbation in post-stroke infection rat model JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2017, v.37, 386-386
- Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors Molecular Neurobiology, 2017 , 1-14
- Immunohistochemical Localization of Translationally Controlled Tumor Protein in Axon Terminals of Mouse Hippocampal Neurons EXPERIMENTAL NEUROBIOLOGY, 2017, v.26 no.2, 82-89
- Metagenome analysis of bodily microbiota in a mouse model of Alzheimer disease using bacteria-derived membrane vesicles in blood Experimental Neurobiology, 2017, v.26 no.6, 369-379
- Rapid assessment of microbiota changes in individuals with autism spectrum disorder using bacteria-derived membrane vesicles in urine Experimental Neurobiology, 2017, v.26 no.5, 307-317
- Chronic stress and moderate physical exercise prompt widespread common activation and limited differential activation in specific brain regions NEUROCHEMISTRY INTERNATIONAL, 2016, v.99, 252-261
- Erratum to: Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress Molecular Neurobiology, 2016, 7 Oct 2016, 1-2
- Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors EXPERIMENTAL NEUROBIOLOGY, 2016, v.25 no.6, 307-317
- Intranasal Delivery of RGD Motif-Containing Osteopontin Icosamer Confers Neuroprotection in the Postischemic Brain via alpha(v)beta(3) Integrin Binding MOLECULAR NEUROBIOLOGY, 2016, v.53 no.8, 5652-5663
- Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress Molecular Neurobiology, 2016, 2 Sep 2016, 1-12
- Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors Molecular Neurobiology, 2016, 23 Nov 2016, 1-15
- Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors Experimental Neurobiology, 2016, v.25 no.4, 163~173
- Physical exercise counteracts stress-induced upregulation of melanin-concentrating hormone in the brain and stress-induced persisting anxiety-like behaviors Experimental Neurobiology, 2016, v.25 no.4, 163-173
- Reversal of an Unconditioned Behavioral Preference for Specific Food Pellets by Intervention of Whisker Sensory Inputs Experimental Neurobiology, 2016, v.25 no.2, 79~85
- Reversal of an unconditioned behavioral preference for specific food pellets by intervention of whisker sensory inputs Experimental Neurobiology, 2016, v.25 no.2, 79-85
- Robust neuroprotective effects of intranasally delivered iNOS siRNA encapsulated in gelatin nanoparticles in the postischemic brain NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, v.12 no.5, 1219-1229
- STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance EXPERIMENTAL AND MOLECULAR MEDICINE, 2016, v.48
- Antidepressant effects of exercise are produced via suppression of hypocretin/orexin and melanin-concentrating hormone in the basolateral amygdala Neurobiology of Disease, 2015, v.79, 59-69
- G9a-Mediated Regulation of OXT and AVP Expression in the Basolateral Amygdala Mediates Stress-Induced Lasting Behavioral Depression and Its Reversal by Exercise Molecular Neurobiology, 2015
- Nitric Oxide Induction of Parkin Translocation in PTEN-induced Putative Kinase 1 (PINK1) Deficiency FUNCTIONAL ROLE OF NEURONAL NITRIC OXIDE SYNTHASE DURING MITOPHAGY JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, v.290 no.16, 10325-10335
- Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death Cell Death and Differentiation, 2015, 24 JUL 2015
- Physiological parameters in the blood of a murine stress-induced depression model before and after repeated passive exercise Endocrinology and Metabolism, 2015, v.30 no.3, 371-380
- Stable G protein-effector complexes in striatal neurons: Mechanism of assembly and role in neurotransmitter signaling eLife, 2015, v.4 no.42309, 1-21
- TRH and TRH receptor system in the basolateral amygdala mediate stress-induced depression-like behaviors Neuropharmacology, 2015, v.97, 346-356
- Adenylyl cyclase-5 in the dorsal striatum function as a molecular switch for the generation of behavioral preferences for cue-directed food choices MOLECULAR BRAIN, 2014, v.7
- Biodegradable gelatin microspheres enhance the neuroprotective potency of osteopontin via quick and sustained release in the post-ischemic brain Acta Biomaterialia, 2014, v. 10 no. 7
- Ethyl Pyruvate Inhibits HMGB1 Phosphorylation and Release by Chelating Calcium MOLECULAR MEDICINE, 2014, v.20, 649-657
- Implementation of a Two-dimensional Behavior Matrix to Distinguish Individuals with Differential Depression States in a Rodent Model of Depression Experimental Neurobiology, 2014, 제23권 3호, 215-223
- Inhibition of Adenylyl Cyclase Type 5 Prevents L-DOPA-Induced Dyskinesia in an Animal Model of Parkinson's Disease JOURNAL OF NEUROSCIENCE, 2014, v.34 no.35, 11744-11753
- Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism BRAIN RESEARCH, 2014, v.1552, 72-81
- Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2014, v.8
- [학술지논문] Sphingomonas Paucimobilis-derived Extracellular Vesicles Reverse Aβ-induced Dysregulation of Neurotrophic Factors, Mitochondrial Function, and Inflammatory Factors through MeCP2-mediated Mechanism Experimental Neurobiology, 2025, v.34 no.1 , 20-33
- [학술지논문] Behavioral Engagement With Playable Objects Resolves Stress-Induced Adaptive Changes by Reshaping the Reward System BIOLOGICAL PSYCHIATRY, 2022, v.91 no.7 , 676-689
- [학술지논문] Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice MOLECULAR NEUROBIOLOGY, 2022, v.59 no.5 , 2715-2728
- [학술지논문] Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior MOLECULAR NEUROBIOLOGY, 2021, v.58 no.12 , 6427-6442
- [학술지논문] Humulus japonicus rescues autistic-like behaviours in the BTBR T+ Itpr3(tf)/J mouse model of autism MOLECULAR MEDICINE REPORTS, 2021, v.23 no.6 , 448-448
- [학술지논문] Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits EXPERIMENTAL NEUROBIOLOGY, 2021, v.30 no.6 , 415-429
- [학술지논문] Hyperoxygenation Treatment Reduces Beta-amyloid Deposition via MeCP2-dependent Upregulation of MMP-2 and MMP-9 in the Hippocampus of Tg-APP/PS1 Mice EXPERIMENTAL NEUROBIOLOGY, 2021, v.30 no.4 , 294-307
- [학술지논문] Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice NATURE COMMUNICATIONS, 2021, v.12 no.1 , 6682-6682
- [학술지논문] Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice Communications Biology, 2020, v.3 no.1 , 292-292
Courses
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2023-1st
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Laboratory Experiments in Brain and Cognitive Sciences I 강의 계획서 상세보기
- Subject No 37686Class No 01
- 2Year ( 3Credit , 4.5Hour) Wed 5~7 (ECOL215-2)
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Aging and geriatrics
- Subject No G14772Class No 01
- Year ( 3Credit , 3Hour) Thu 7~8
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Aging and Geriatrics
- Subject No G15690Class No 01
- Year ( 3Credit , 3Hour) Thu 7~8
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Advanced Neurochemistry
- Subject No G16015Class No 01
- Year ( 3Credit , 3Hour) Mon 5~6 (POSCO-460)
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2022-2nd
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Principles of Neuroscience
- Subject No 37585Class No 01
- 1Year ( 3Credit , 3Hour) Mon 4~4 (SCI-) , Thu 5~5 (102)
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Biological Psychology
- Subject No G16022Class No 01
- Year ( 3Credit , 3Hour) Tue 5~6 (POSCO-355)
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2022-1st
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Laboratory Experiments in Brain and Cognitive Sciences I
- Subject No 37686Class No 01
- 2Year ( 3Credit , 4.5Hour) Wed 5~7 (ECOL215-2)
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Aging and geriatrics
- Subject No G14772Class No 01
- Year ( 3Credit , 3Hour) Thu 7~8
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Aging and Geriatrics
- Subject No G15690Class No 01
- Year ( 3Credit , 3Hour) Thu 7~8
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Advanced Neurochemistry
- Subject No G16015Class No 01
- Year ( 3Credit , 3Hour) Mon 6~7 (-)
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