Choi, Sun Professor
Pharmaceutical Sciences/Division of Pharmacy/Industrial Pharmaceutical Science
Dr. Sun Choi is a professor at the College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea. After Ph.D. in Medicinal Chemistry from the State University of New York at Buffalo, USA, she joined Prof. Richard B. Silverman’s laboratory in Department of Chemistry and Drug Discovery Program at Northwestern University, Evanston, IL, USA. From 2001 to 2005, she worked as a molecular modeler and computational chemist at the molecular design group in Tripos, Inc., St. Louis, MO, USA. Then, she joined Ewha Womans Univeristy as a faculty member, where she has been an associate professor since 2011. Her research focuses on the state-of-the-art technologies of computer-aided drug design, cheminformatics, computational medicinal chemistry, and biomolecular simulations. Based on these computational methods, she has been conducting multiple research projects targeting therapeutically important enzymes, GPCRs, and ion channels. Active interdisciplinary collaborations are on-going for drug discovery in various diseases such as cancer, virus, pain, cardiovascular disease, osteoporosis, etc. Since 2011, her lab has been designated as the National Leading Research Laboratory(NLRL) by the Korean government.
- Pharmaceutical Science Building B #114
- 02-3277-4503
- Office hours
- Anytime upon appointment
Research Record
- Fc engineered anti-virus therapeutic human IgG1 expressed in plants with altered binding to the neonatal Fc receptor Biotechnology Journal, 2024, v.19 no.3, 2300552
- Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites Cancer Communications, 2024, v.44 no.1, 47-75
- GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory Nature Communications, 2024, v.15 no.1, 5830
- The anticancer effect of metformin targets VDAC1 via ER-mitochondria interactions-mediated autophagy in HCC EXPERIMENTAL AND MOLECULAR MEDICINE, 2024, v.56 no.12, 2714-2725
- Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway Biomaterials Research, 2023, v.27 no.1, 23
- DMAP and TBPP-mediated synthesis of urea-substituted nucleobases and nucleosides Tetrahedron, 2023, v.140, 133472
- Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling Biophysical journal, 2023, v.122 no.3S1
- Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling ELIFE, 2023, v.12, RP90773
- On the classical reaction rate and the first-time problems of Brownian motion Physica A: Statistical Mechanics and its Applications, 2023, v.622, 128823
- Structure-Activity Relationships of Truncated 1′-Homologated Carbaadenosine Derivatives as New PPARγ/δ Ligands: A Study on Sugar Puckering Affecting Binding to PPARs Journal of Medicinal Chemistry, 2023, v.66 no.7, 4961-4978
- Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD) Biochemical Society Transactions, 2022, v.50 no.1, 241-252
- CHARMM-GUI Enhanced Sampler for various collective variables and enhanced sampling methods PROTEIN SCIENCE, 2022, v.31 no.11, e4446
- Discovery of (E)-3-(3-((2-Cyano-4' -dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis JOURNAL OF MEDICINAL CHEMISTRY, 2022, v.65 no.14, 9974-10000
- GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2AAdenosine Receptor Journal of Medicinal Chemistry, 2022, v.65 no.17, 11648-11657
- Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step Organic Chemistry Frontiers, 2022
- 2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists Bioorganic and Medicinal Chemistry Letters, 2021, v.48, 128266
- Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors JOURNAL OF MEDICINAL CHEMISTRY, 2021, v.64 no.2, 958-979
- Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift Journal of Medicinal Chemistry, 2021, v.64 no.1, 370-384
- Emerging computational approaches for the study of regio- And stereoselectivity in organic synthesis Organic Chemistry Frontiers, 2021, v.8 no.18, 5165-5181
- N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application THERANOSTICS, 2021, v.11 no.16, 8092-8111
- Recent applications of deep learning methods on evolutionand contact-based protein structure prediction International Journal of Molecular Sciences, 2021, v.22 no.11, 6032
- Structural Characterization of Receptor-Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, v.22 no.6, 3241
- Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A(3) Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary JOURNAL OF MEDICINAL CHEMISTRY, 2021, v.64 no.17, 12525-12536
- Advances in Molecular Dynamics Simulations and Enhanced Sampling Methods for the Study of Protein Systems INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, v.21 no.17, 6339
- Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2-Catalyzed Intramolecular [3+2] Cycloaddition Angewandte Chemie, 2020, v.132 no.31, 12932-12936
- Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2-Catalyzed Intramolecular [3+2] Cycloaddition Angewandte Chemie - International Edition, 2020, v.59 no.31, 12832-12836
- Multiscale Molecular Modeling in G Protein-Coupled Receptor (GPCR)-Ligand Studies BIOMOLECULES, 2020, v.10 no.4, 631
- Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design JOURNAL OF MEDICINAL CHEMISTRY, 2019, v.62 no.17, 8011-8027
- Importance of protein dynamics in the structure-based drug discovery of class A G protein-coupled receptors (GPCRs) Current Opinion in Structural Biology, 2019, v.55, 147-153
- In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach Journal of the American Chemical Society, 2019, v.141 no.3, 1366-1372
- Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction as a Key Step Organic Letters, 2019, v.21 no.14, 5471-5474
- Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling CELL METABOLISM, 2019, v.29 no.6, 1306-
- Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy THERANOSTICS, 2019, v.9 no.22, 6412-6423
- 4-Aminophenyl acetamides and propanamides as potent transient receptor potential vanilloid 1 (TRPV1) ligands BIOORGANIC & MEDICINAL CHEMISTRY, 2018, v.26 no.15, 4509-4517
- Adaptable Small Ligand of CYP1 Enzymes for Use in Understanding the Structural Features Determining Isoform Selectivity ACS Medicinal Chemistry Letters, 2018, v.9 no.12, 1247-1252
- Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery MOLECULES, 2018, v.23 no.8, 1963
- Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug Design FRONTIERS IN PHARMACOLOGY, 2018, v.9
- Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, v.107, 1650-1658
- Integrated Ligand and Structure-Based Investigation of Structural Requirements for Silent Information Regulator 1 (SIRT1) Activation CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2018, v.18 no.27, 2313-2324
- Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region Bioorganic and Medicinal Chemistry, 2018, v.26 no.5, 1035-1049
- Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations JOURNAL OF MEDICINAL CHEMISTRY, 2018, v.61 no.1, 1-46
- Structural and Biochemical Characterization of the Curcumin-Reducing Activity of CurA from Vibrio vulnificus JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, v.66 no.40, 10608-10616
- Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors BIOORGANIC & MEDICINAL CHEMISTRY, 2018, v.26 no.12, 3133-3144
- Understanding G protein-coupled receptor allostery via molecular dynamics simulations: Implications for drug discovery Methods in Molecular Biology, 2018, v.1762, 455-472
- Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer’s Agents Based on Rational Design Journal of Medicinal Chemistry, 2017, v.60 no.6, 2573-2590
- Expediting the design, discovery and development of anticancer drugs using computational approaches Current Medicinal Chemistry, 2017, v.24 no.42, 4753-4778
- In silico prediction of multiple-category classification model for cytochrome P450 inhibitors and non-inhibitors using machine-learning method SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2017, v.28 no.10 SI, 863-874
- MLACP: machine-learning-based prediction of anticancer peptides ONCOTARGET, 2017, v.8 no.44, 77121-77136
- N-6-Substituted 5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation JOURNAL OF MEDICINAL CHEMISTRY, 2017, v.60 no.8, 3422-3437
- Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, v.27 no.18, 4383-4388
- t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists BIOORGANIC & MEDICINAL CHEMISTRY, 2017, v.25 no.8, 2451-2462
- 2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists Bioorganic and Medicinal Chemistry, 2016, v.24 no.6, 1231-1240
- A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase SCIENTIFIC REPORTS, 2016, v.6, 22389
- Design, synthesis, and anticancer activity of C8-substituted-4′-thionucleosides as potential HSP90 inhibitors Bioorganic and Medicinal Chemistry, 2016, v.24 no.16, 3418-3428
- Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template Bioorganic and Medicinal Chemistry Letters, 2016, v.26 no.15, 3603-3607
- Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases MOLECULES, 2016, v.21 no.8
- Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors BIOORGANIC & MEDICINAL CHEMISTRY, 2016, v.24 no.18, 4144-4151
- The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3 BIOORGANIC & MEDICINAL CHEMISTRY, 2016, v.24 no.21, 5036-5046
- Ultraslow Water-Mediated Transmembrane Interactions Regulate the Activation of A(2A) Adenosine Receptor BIOPHYSICAL JOURNAL, 2016, v.111 no.6, 1180-1191
- 5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression Bioorganic and Medicinal Chemistry, 2015, v.23 no.21, 7069-7078
- 6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists Bioorganic and Medicinal Chemistry Letters, 2015, v.25 no.4
- Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling EXPERIMENTAL DERMATOLOGY, 2015, v.24 no.7, 503-509
- Communication over the Network of Binary Switches Regulates the Activation of A(2A) Adenosine Receptor PLOS COMPUTATIONAL BIOLOGY, 2015, v.11 no.2
- Polymodal Transient Receptor Potential Vanilloid Type 1 Nocisensor: Structure, Modulators, and Therapeutic Applications Advances in Protein Chemistry and Structural Biology, 2015, 4 JAN 2016
- Role of computer-aided drug design in modern drug discovery Archives of Pharmacal Research, 2015, 25 JUL 2015
- Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists Bioorganic and Medicinal Chemistry, 2015, v.23 no.21, 6844-6854
- Structure-Activity Relationships of Neplanocin A Analogues as S -Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities Journal of Medicinal Chemistry, 2015, v.58 no.12, 5108-5120
- The cell shape-determining Csd6 protein from Helicobacter pylori constitutes a new family of L, D-carboxypeptidase Journal of Biological Chemistry, 2015, v.290 no.41, 25103-25117
- Total synthesis of the putative structure of the proposed Banyasin A Frontiers in Chemistry, 2015, v.3
- Transient receptor potential vanilloid type 1 antagonists: a patent review (2011-2014) EXPERT OPINION ON THERAPEUTIC PATENTS, 2015, v.25 no.3, 291-318
- alpha-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, v.25 no.11, 2326-2330
- 2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists Bioorganic and Medicinal Chemistry Letters, 2014, v.24 no.16
- 2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4- methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists Bioorganic and Medicinal Chemistry Letters, 2014, v.24 no.16, 4044-4047
- Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, v.24 no.1, 382-385
- Mapping the intramolecular signal transduction of G-protein coupled receptors PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2014, v.82 no.5, 727-743
- Promiscuous gating modifiers target the voltage sensor of Kv7.2, TRPV1, and Hv1 cation channels FASEB Journal, 2014, v.28 no.6, 2591-2602
- Structural basis of the phosphorylation dependent complex formation of neurodegenerative disease protein Ataxin-1 and RBM17 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, v.449 no.4, 399-404
- Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N-6-Substituted-(N)-Methanocarba-nucleosides as A(3) Adenosine Receptor Antagonists and Partial Agonists JOURNAL OF MEDICINAL CHEMISTRY, 2014, v.57 no.4, 1344-1354
- [학술지논문] Advances in Molecular Dynamics Simulations and Enhanced Sampling Methods for the Study of Protein Systems INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, v.21 no.17 , 6339-6359
- [학술지논문] Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2-Catalyzed Intramolecular [3+2] Cycloaddition ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, v.59 no.31 , 12832-12836
- [학술지논문] Multiscale Molecular Modeling in G Protein-Coupled Receptor (GPCR)-Ligand Studies BIOMOLECULES, 2020, v.10 no.4 , 631-643
- [학술발표] Introduction of My Career Path as a Scienctist in the Interdisciplinary and International Research KWSE Smart Sister Program, 대한민국, 2020-10-24 KWSE Smart Sister Program, 2020
- [학술발표] Molecular Modeling and Computer-Aided Drug Design (CADD), and their Applications to Drug Discovery 전남대학교 약학대학 초청세미나, 대한민국, 2020-01-08 전남대학교 약학대학 초청세미나, 2020
- [학술발표] Molecular Modeling and Computer-Aided Drug Design (CADD), and their Applications to Drug Discovery 숭실대학교 생명정보학과 세미나, 대한민국, 2020-10-15 숭실대학교 생명정보학과 세미나, 2020
Courses
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2023-2nd
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Medicinal Chemistry II 강의 계획서 상세보기
- Subject No 36210Class No 01
- 5Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A400) , Thu 5~5 (PHM-A400)
- Major Requisite
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Medicinal Chemistry II 강의 계획서 상세보기
- Subject No 36210Class No 02
- 5Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A400) , Fri 5~5 (PHM-A400)
- Major Requisite
-
Medicinal Chemistry II 강의 계획서 상세보기
- Subject No 36210Class No 03
- 5Year ( 3Credit , 3Hour) Wed 3~3 (PHM-A400) , Fri 3~3 (PHM-A400)
- Major Requisite
-
Medicinal Chemistry II 강의 계획서 상세보기
- Subject No 36210Class No 04
- 5Year ( 3Credit , 3Hour) Wed 3~3 (PHM-A400) , Fri 3~3 (PHM-A400)
- Major Requisite
-
Pharmaceutical Experiment Laboratory IV 강의 계획서 상세보기
- Subject No 37127Class No 01
- 4Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A309)
- Major Requisite
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Pharmaceutical Experiment Laboratory IV 강의 계획서 상세보기
- Subject No 37127Class No 02
- 4Year ( 1.5Credit , 3Hour) Tue 6~7 (PHM-A309)
- Major Requisite
-
Pharmaceutical Experiment Laboratory IV 강의 계획서 상세보기
- Subject No 37127Class No 03
- 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
- Major Requisite
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2023-1st
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Organic Chemistry of Drug Action
- Subject No 22574Class No 01
- 4Year ( 1.5Credit , 1.5Hour) Mon 3~3 (PHM-A400)
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Organic Chemistry of Drug Action
- Subject No 22574Class No 02
- 4Year ( 1.5Credit , 1.5Hour) Wed 3~3 (PHM-A400)
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Medicinal Chemistry Ⅰ 강의 계획서 상세보기
- Subject No 36202Class No 01
- 5Year ( 3Credit , 3Hour) Tue 4~4 (PHM-A400) , Thu 3~3 (PHM-A400)
- Major Requisite
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Medicinal Chemistry Ⅰ 강의 계획서 상세보기
- Subject No 36202Class No 02
- 5Year ( 3Credit , 3Hour) Tue 3~3 (PHM-A400) , Thu 6~6 (PHM-A400)
- Major Requisite
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Medicinal Chemistry Ⅰ 강의 계획서 상세보기
- Subject No 36202Class No 03
- 5Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A400) , Fri 6~6 (PHM-A404)
- Major Requisite
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Medicinal Chemistry Ⅰ 강의 계획서 상세보기
- Subject No 36202Class No 04
- 5Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A400) , Fri 6~6 (PHM-A404)
- Major Requisite
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Pharmaceutical Experiment Laboratory IV 강의 계획서 상세보기
- Subject No 37127Class No 01
- 4Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A309)
- Major Requisite
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Pharmaceutical Experiment Laboratory IV 강의 계획서 상세보기
- Subject No 37127Class No 02
- 4Year ( 1.5Credit , 3Hour) Tue 6~7 (PHM-A309)
- Major Requisite
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Pharmaceutical Experiment Laboratory IV 강의 계획서 상세보기
- Subject No 37127Class No 03
- 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
- Major Requisite
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Introduction to Pharmaceutical Research 강의 계획서 상세보기
- Subject No 38940Class No 01
- 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
- Major Requisite
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Molecular Modeling for Drug Discovery
- Subject No G16852Class No 01
- Year ( 3Credit , 3Hour) Fri 2~3 (PHM-A204)
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2022-2nd
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Medicinal Chemistry II
- Subject No 36210Class No 01
- 5Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A104) , Thu 4~4 (PHM-A104)
- Major Requisite
-
Medicinal Chemistry II
- Subject No 36210Class No 02
- 5Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A104) , Fri 5~5 (PHM-A400)
- Major Requisite
-
Medicinal Chemistry II
- Subject No 36210Class No 03
- 5Year ( 3Credit , 3Hour) Wed 3~3 (PHM-A400) , Fri 4~4 (PHM-A400)
- Major Requisite
-
Medicinal Chemistry II
- Subject No 36210Class No 04
- 5Year ( 3Credit , 3Hour) Wed 3~3 (PHM-A400) , Fri 4~4 (PHM-A400)
- Major Requisite
-
Pharmaceutical Experiment Laboratory IV
- Subject No 37127Class No 01
- 4Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A309)
- Major Requisite
-
Pharmaceutical Experiment Laboratory IV
- Subject No 37127Class No 02
- 4Year ( 1.5Credit , 3Hour) Tue 6~7 (PHM-A309)
- Major Requisite
-
Pharmaceutical Experiment Laboratory IV
- Subject No 37127Class No 03
- 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
- Major Requisite
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Drug Design
- Subject No G16894Class No 01
- Year ( 3Credit , 3Hour) Tue 2~3 (PHM-A-204)
- Classroom Changed
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Academic Background
State University of New York at Buffalo Ph.D.(Medicinal Chemistry)
Ewha Womans University 약학사(제약학과)