Research Record

• Biocatalytic oxyfunctionalization of unsaturated fatty acids to oxygenated chemicals via hydroxy fatty acids BIOTECHNOLOGY ADVANCES, 2025, v.79, 108510
  SCIE Scopus dColl.
• Enzymatic Cascade Transformation of Renewable C1 and C2 Alcohols into 3-Hydroxypropionaldehyde with a High Conversion Rate ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2025, v.13 no.7, 2694-2705
  SCIE Scopus dColl.
• Unveiling the biological activities of the microbial long chain hydroxy fatty acids as dual agonists of GPR40 and GPR120 Food Chemistry, 2025, v.465, 142010
  SCIE Scopus dColl.
• Biological Reaction Engineering for the Preparation of C9 Chemicals from Oleic Acid: 9-Aminononanoic Acid, 1,9-Nonanediol, 9-Amino-1-nonanol, and 1,9-Diaminononane ACS Catalysis, 2024, v.14 no.6, 4130-4138
  SCIE Scopus dColl.
• Biotransformation of C20- and C22-polyunsaturated fatty acids and fish oil hydrolyzates to R,R-dihydroxy fatty acids as lipid mediators using double-oxygenating 15R-lipoxygenase Green Chemistry, 2024, v.26 no.8, 4665-4676
  SCIE Scopus dColl.
• Exploring the fatty acid double bond hydration activities of Lacticaseibacillus rhamnosus strains Food Bioscience, 2024, v.57, 103571
  SCIE Scopus dColl.
• Lysolecithin-fatty acid liposomes as novel antibacterial agents to suppress the growth of periodontal Porphyromonas gingivalis Food Bioscience, 2024, v.59, 104059
  SCIE Scopus dColl.
• Structure modeling-based characterization of ChnD, the 6-hydroxyhexanoate dehydrogenase from Acinetobacter sp. strain NCIMB 9871 Journal of Biotechnology, 2024, v.392, 90-95
  SCIE Scopus dColl.
• Substrate-Binding Cavity Engineering of the Lipoxygenase from Pseudomonas aeruginosa to Produce 8S- and 11S-Hydroxyeicosatetraenoic Acids ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2024, v.13 no.1, 80-90
  SCIE Scopus dColl.
• Valorization of single-carbon chemicals by using carboligases as key enzymes Current Opinion in Biotechnology, 2024, v.85, 103047
  SCIE Scopus dColl.
• Efficient biotransformation of docosahexaenoic acid-rich oils into the lipid mediator resolvin D5 by cells expressing 15S-lipoxygenase using a bioreactor Bioresource Technology, 2023, v.388, 129750
  Scopus dColl.
• Engineering of two thiamine diphosphate-dependent enzymes for the regioselective condensation of C1-formaldehyde into C4-erythrulose International Journal of Biological Macromolecules, 2023, v.253, 127674
  SCIE Scopus dColl.
• Multilayer Engineering of an Escherichia coli-Based Biotransformation System to Exclusively Produce Glycolic Acid from Formaldehyde ACS Sustainable Chemistry and Engineering, 2023, v.11 no.3, 1078-1086
  SCIE Scopus dColl.
• Structural and functional characterization of a thermostable secretory phospholipase A2 from Sciscionella marina and its application in liposome biotransformation Acta crystallographica. Section D, Structural biology, 2023, v.79, 188-197
  SCIE Scopus dColl.
• Variability of oral/taste sensitivity to fat: An investigation of attribution from detection threshold methods with repeated measurements Food Research International, 2023, v.165, 112432
  SCIE Scopus dColl.
• Engineering of a bacterial outer membrane vesicle to a nano-scale reactor for the biodegradation of β-lactam antibiotics Journal of Biotechnology, 2022, v.356, 1-7
  SCIE Scopus dColl.
• Enzyme Access Tunnel Engineering in Baeyer-Villiger Monooxygenases to Improve Oxidative Stability and Biocatalyst Performance Advanced Synthesis and Catalysis, 2022, v.364 no.3, 555-564
  SCIE Scopus dColl.
• Glyoxylate carboligase-based whole-cell biotransformation of formaldehyde into ethylene glycol via glycotaldehyde GREEN CHEMISTRY, 2022, v.24 no.1, 218-226
  SCIE Scopus dColl.
• Highly efficient oxidation of plant oils to C18 trihydroxy fatty acids by Escherichia coli co-expressing lipoxygenase and epoxide hydrolase GREEN CHEMISTRY, 2022, v.24 no.5, 2062-2072
  SCIE Scopus dColl.
• Substrate-binding Site Engineering of Candida antarctica Lipase B to Improve Selectivity for Synthesis of 1-monoacyl-sn-glycerols Biotechnology and Bioprocess Engineering, 2022, v.27 no.2, 234-243
  SCIE Scopus KCI dColl.
• Triplet–triplet annihilation-based photon-upconversion to broaden the wavelength spectrum for photobiocatalysis Scientific Reports, 2022, v.12 no.1, 9397
  SCIE Scopus dColl.
• Valorization of Soy Lecithin by Enzyme Cascade Reactions Including a Phospholipase A2, a Fatty Acid Double-Bond Hydratase, and/or a Photoactivated Decarboxylase Journal of Agricultural and Food Chemistry, 2022, v.70 no.35, 10818-10825
  SCIE Scopus dColl.
• Bacterial Outer Membrane Vesicles as Nano-Scale Bioreactors: A Fatty Acid Conversion Case Study ChemCatChem, 2021, v.13 no.19, 4080-4086
  SCIE Scopus dColl.
• Chemoenzymatic Cascade Conversion of Linoleic Acid into a Secondary Fatty Alcohol Using a Combination of 13S-Lipoxygenase, Chemical Reduction, and a Photo-Activated Decarboxylase ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, v.9 no.32, 10837-10845
  SCIE Scopus dColl.
• Enhancing acid tolerance of Escherichia coli via viroporin-mediated export of protons and its application for efficient whole-cell biotransformation Metabolic Engineering, 2021, v.67, 277-284
  SCIE Scopus dColl.
• Construction of an engineered biocatalyst system for the production of medium-chain α,ω-dicarboxylic acids from medium-chain ω-hydroxycarboxylic acids Biotechnology and Bioengineering, 2020, v.117 no.9, 2648-2657
  SCIE Scopus dColl.
• Design and engineering of whole-cell biocatalytic cascades for the valorization of fatty acids CATALYSIS SCIENCE & TECHNOLOGY, 2020, v.10 no.1, 46-64
  SCIE Scopus dColl.
• Discovery and Engineering of a Microbial Double-Oxygenating Lipoxygenase for Synthesis of Dihydroxy Fatty Acids as Specialized Proresolving Mediators ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2020, v.8 no.43, 16172-16183
  SCIE Scopus dColl.
• Engineering of a Microbial Cell Factory for the Extracellular Production of Catalytically Active Phospholipase A(2) of Streptomyces violaceoruber JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2020, v.30 no.8, 1244-1251
  SCIE Scopus KCI dColl.
• Genome-Scale Metabolic Network Reconstruction and In Silico Analysis of Hexanoic acid Producing Megasphaera elsdenii MICROORGANISMS, 2020, v.8 no.4, 539
  SCIE dColl.
• Increased Production of omega-Hydroxynonanoic Acid and alpha,omega-Nonanedioic Acid from Olive Oil by a Constructed Biocatalytic System JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, v.68 no.35, 9488-9495
  SCIE Scopus dColl.
• Multilayer Engineering of Enzyme Cascade Catalysis for One-Pot Preparation of Nylon Monomers from Renewable Fatty Acids ACS CATALYSIS, 2020, v.10 no.9, 4871-4878
  SCIE Scopus dColl.
• Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids Nature Communications, 2020, v.11 no.1, 2258
  SCIE Scopus dColl.
• Understanding the molecular properties of the E1 subunit (SucA) of alpha-ketoglutarate dehydrogenase complex from Vibrio vulnificus for the enantioselective ligation of acetaldehydes into (R)-acetoin CATALYSIS SCIENCE & TECHNOLOGY, 2020, v.10 no.1, 79-85
  SCIE Scopus dColl.
• Whole-Cell Photoenzymatic Cascades to Synthesize Long-Chain Aliphatic Amines and Esters from Renewable Fatty Acids Angewandte Chemie - International Edition, 2020, v.59 no.18, 7024-7028
  SCIE Scopus dColl.
• Characterization and application of chemical-resistant polyurethane-based enzyme and whole cell compartments Journal of Biotechnology, 2019, v.289, 31-38
  SCIE Scopus dColl.
• Cofactor specificity engineering of a long-chain secondary alcohol dehydrogenase from Micrococcus luteus for redox-neutral biotransformation of fatty acids CHEMICAL COMMUNICATIONS, 2019, v.55 no.96, 14462-14465
  SCIE Scopus dColl.
• Endocytosing Escherichia coli as a Whole-Cell Biocatalyst of Fatty Acids ACS Synthetic Biology, 2019, v.8 no.5, 1055-1066
  SCIE Scopus dColl.
• Enzymatic synthesis of new hepoxilins and trioxilins from polyunsaturated fatty acids Electronic supplementary information (ESI) available. See DOI: 10.1039/c9gc01031a GREEN CHEMISTRY, 2019, v.21 no.11, 3172-3181
  SCIE Scopus dColl.
• Enzyme Cascade Reactions for the Biosynthesis of Long Chain Aliphatic Amines from Renewable Fatty Acids ADVANCED SYNTHESIS & CATALYSIS, 2019, v.361 no.6, 1359-1367
  SCIE Scopus dColl.
• Esterification of Secondary Alcohols and Multi-hydroxyl Compounds by Candida antarctica Lipase B and Subtilisin BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2019, v.24 no.1, 41-47
  SCIE Scopus KCI dColl.
• Multi-Step Enzymatic Synthesis of 1,9-Nonanedioic Acid from a Renewable Fatty Acid and Its Application for the Enzymatic Production of Biopolyesters POLYMERS, 2019, v.11 no.10, 1690
  SCIE Scopus dColl.
• Multi-level engineering of Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the production of C9 chemicals from oleic acid METABOLIC ENGINEERING, 2019, v.54, 137-144
  SCIE Scopus dColl.
• Structural basis for the selective addition of an oxygen atom to cyclic ketones by Baeyer-Villiger monooxygenase from Parvibaculum lavamentivorans BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, v.512 no.3, 564-570
  SCIE Scopus dColl.
• -hydroxyundec-9-enoic acid induces apoptosis by ROS mediated JNK and P38 phosphorylation in breast cancer cell lines JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, v.119 no.1, 998-1007
  SCIE Scopus dColl.
• Enzyme/whole-cell biotransformation of plant oils, yeast derived oils, and microalgae fatty acid methyl esters into n-nonanoic acid, 9-hydroxynonanoic acid, and 1,9-nonanedioic acid Bioresource Technology, 2018, v.251, 288-294
  SCIE Scopus dColl.
• Improving catalytic activity of the Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the overproduction of (Z)-11-(heptanoyloxy) undec-9-enoic acid from ricinoleic acid SCIENTIFIC REPORTS, 2018, v.8
  SCIE Scopus dColl.
• Intracellular transformation rates of fatty acids are influenced by expression of the fatty acid transporter FadL in Escherichia coli cell membrane JOURNAL OF BIOTECHNOLOGY, 2018, v.281, 161-167
  SCIE Scopus dColl.
• Microbial synthesis of undec-9-enoic acid, heptyl ester from renewable fatty acids using recombinant Corynebacterium glutamicum-based whole-cell biocatalyst Process Biochemistry, 2018, v.66, 61-69
  SCIE Scopus dColl.
• Regiospecific Conversion of Lipids and Fatty Acids through Enzymatic Cascade Reactions Lipid Modification by Enzymes and Engineered Microbes, 2018 , 139-155
  Scopus dColl.
• Simultaneous Enzyme/Whole-Cell Biotransformation of C18 Ricinoleic Acid into (R)-3-Hydroxynonanoic Acid, 9-Hydroxynonanoic Acid, and 1,9-Nonanedioic Acid Advanced Synthesis and Catalysis, 2018, v.360 no.4, 696-703
  SCIE Scopus dColl.
• Structural and Biochemical Characterization of the Curcumin-Reducing Activity of CurA from Vibrio vulnificus JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, v.66 no.40, 10608-10616
  SCIE Scopus dColl.
• Bioprocess engineering to produce 9-(nonanoyloxy) nonanoic acid by a recombinant Corynebacterium glutamicum-based biocatalyst Journal of Industrial Microbiology and Biotechnology, 2017, v.44 n.9, 1-11
  SCIE Scopus dColl.
• Co-expression of two heterologous lactate dehydrogenases genes in Kluyveromyces marxianus for L-lactic acid production Journal of Biotechnology, 2017, v.241, 81-86
  SCIE Scopus dColl.
• Comparison of biochemical properties of the original and newly identified oleate hydratases from Stenotrophomonas maltophilia Applied and Environmental Microbiology, 2017, v.83 no.9
  SCIE Scopus dColl.
• Engineering Escherichia coli BL21 genome to improve the heptanoic acid tolerance by using CRISPR-Cas9 system BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2017, v.22 no.3, 231-238
  SCIE Scopus KCI dColl.
• Gene cloning of an efficiency oleate hydratase from Stenotrophomonas nitritireducens for polyunsaturated fatty acids and its application in the conversion of plant oils to 10-hydroxy fatty acids Biotechnology and Bioengineering, 2017, v.114 no.1, 74-82
  SCIE Scopus dColl.
• 3 '-UTR engineering to improve soluble expression and fine-tuning of activity of cascade enzymes in Escherichia coli SCIENTIFIC REPORTS, 2016, v.6
  SCIE Scopus dColl.
• Activation of the Glutamic Acid-Dependent Acid Resistance System in Escherichia coli BL21(DE3) Leads to Increase of the Fatty Acid Biotransformation Activity PLOS ONE, 2016, v.11 no.9
  SCIE Scopus dColl.
• Chemo-enzymatic synthesis of 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid GREEN CHEMISTRY, 2016, v.18 no.4, 1089-1095
  SCIE Scopus dColl.
• Combined Biocatalytic and Chemical Transformations of Oleic Acid to ω-Hydroxynonanoic Acid and α,ω-Nonanedioic Acid Advanced Synthesis and Catalysis, 2016, v.358 no.19, 3084-3092
  SCIE Scopus dColl.
• Engineering of Baeyer-Villiger monooxygenase-based Escherichia coli biocatalyst for large scale biotransformation of ricinoleic acid into (Z)-11-(heptanoyloxy)undec-9-enoic acid Scientific Reports, 2016, v.6
  SCIE Scopus dColl.
• Preparation of 11-hexyloxy-9-undecenoic acid from crude castor oil hydrolysates by recombinant Escherichia coli expressing alcohol dehydrogenase and Baeyer-Villiger monooxygenase Process Biochemistry, 2016, v.51 no.3
  SCIE Scopus dColl.
• Simultaneous Enzyme/Whole-Cell Biotransformation of Plant Oils into C9 Carboxylic Acids ACS CATALYSIS, 2016, v.6 no.11, 7547-7553
  SCIE Scopus dColl.
• Adding value to plant oils and fatty acids: Biological transformation of fatty acids into omega-hydroxycarboxylic, alpha,omega-dicarboxylic, and omega-aminocarboxylic acids JOURNAL OF BIOTECHNOLOGY, 2015, v.216, 158-166
  SCIE Scopus dColl.
• Biotransformation of Linoleic Acid into Hydroxy Fatty Acids and Carboxylic Acids Using a Linoleate Double Bond Hydratase as Key Enzyme ADVANCED SYNTHESIS & CATALYSIS, 2015, v.357 no.42038, 408-416
  SCIE Scopus dColl.
• Biotransformation of oleic acid into 10-ketostearic acid by recombinant Corynebacterium glutamicum-based biocatalyst BIOTECHNOLOGY LETTERS, 2015, v.37 no.5, 1101-1106
  SCIE Scopus dColl.
• Cyclohexanone-induced stress metabolism of Escherichia coli and Corynebacterium glutamicum Biotechnology and Bioprocess Engineering, 2015, v.20 no.6, 1088-1098
  SCIE KCI Scopus dColl.
• Display of membrane proteins on the heterologous caveolae carved by caveolin-1 in the Escherichia coli cytoplasm Enzyme and Microbial Technology, 2015, v.79-80, 55-62
  SCIE Scopus dColl.
• Enzyme fusion for whole-cell biotransformation of long-chain sec-alcohols into esters APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, v.99 no.15, 6267-6275
  SCIE Scopus dColl.
• Expression Levels of Chaperones Influence Biotransformation Activity of Recombinant Escherichia Coli Expressing Micrococcus Luteus Alcohol Dehydrogenase and Pseudomonas Putida Baeyer-Villiger Monooxygenase BIOTECHNOLOGY AND BIOENGINEERING, 2015, v.112 no.5, 889-895
  SCIE Scopus dColl.
• Fatty acid hydration activity of a recombinant Escherichia coli-based biocatalyst is improved through targeting the oleate hydratase into the periplasm Biotechnology Journal, 2015, v.10 no.12
  SCIE Scopus dColl.
• Microbial Synthesis of Plant Oxylipins from gamma-Linolenic Acid through Designed Biotransformation Pathways JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, v.63 no.10, 2773-2781
  SCIE Scopus dColl.
• Production of 13S-hydroxy-9(Z)-octadecenoic acid from linoleic acid by whole recombinant cells expressing linoleate 13-hydratase from Lactobacillus acidophilus Journal of Biotechnology, 2015, v.208, 1-10
  SCIE Scopus dColl.
• Whole Cell Bioconversion of Ricinoleic Acid to 12-Ketooleic Acid by Recombinant Corynebacterium glutamicum-Based Biocatalyst JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2015, v.25 no.4, 452-458
  SCIE KCI Scopus dColl.
• A biosynthetic pathway for hexanoic acid production in Kluyveromyces marxianus Journal of Biotechnology, 2014, v.182-183, 30-36
  Scopus dColl.
• Engineering the substrate-binding domain of an esterase enhances its hydrolytic activity toward fatty acid esters PROCESS BIOCHEMISTRY, 2014, v.49 no.12, 2101-2106
  SCIE Scopus dColl.
• Genome-scale metabolic network reconstruction and in silico flux analysis of the thermophilic bacterium Thermus thermophilus HB27 MICROBIAL CELL FACTORIES, 2014, v.13, Article ID 61
  SCIE Scopus dColl.
• High temperature stimulates acetic acid accumulation and enhances the growth inhibition and ethanol production by Saccharomyces cerevisiae under fermenting conditions APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2014, v.98 no.13, 6085-6094
  SCIE Scopus dColl.
• Microbial Synthesis of Medium-Chain ,-Dicarboxylic Acids and -Aminocarboxylic Acids from Renewable Long-Chain Fatty Acids ADVANCED SYNTHESIS & CATALYSIS, 2014, v.356 no.8, 1782-1788
  SCIE Scopus dColl.
• Production of omega-hydroxyundec-9-enoic acid and n-heptanoic acid from ricinoleic acid by recombinant Escherichia coli-based biocatalyst PROCESS BIOCHEMISTRY, 2014, v.49 no.4, 617-622
  SCIE Scopus dColl.
• Recent progress in development of synthetic biology platforms and metabolic engineering of Corynebacterium glutamicum JOURNAL OF BIOTECHNOLOGY, 2014, v.180, 43-51
  SCIE Scopus dColl.
• Stereospecific production of 9R-hydroxy-10E,12Z-octadecadienoic acid from linoleic acid by recombinant Escherichia coli cells expressing 9R-lipoxygenase from Nostoc sp SAG 25.82 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2014, v.104, 56-63
  SCIE Scopus dColl.
• ω-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells Biochemical and Biophysical Research Communications, 2014, v.448 no.3
  SCIE Scopus dColl.
• [학술지논문] Multilayer Engineering of an Escherichia coli-Based Biotransformation System to Exclusively Produce Glycolic Acid from Formaldehyde ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2023, v.11 no.3 , 1078-1086
  SCIE
• [학술지논문] Variability of oral/taste sensitivity to fat: An investigation of attribution from detection threshold methods with repeated measurements FOOD RESEARCH INTERNATIONAL, 2023, v.165 no.112432 , 1-11
  SCIE
• [학술지논문] Bacterial Outer Membrane Vesicles as Nano-Scale Bioreactors: A Fatty Acid Conversion Case Study CHEMCATCHEM, 2021, v.13 no.19 , 4080-4086
  SCIE
• [학술지논문] Chemoenzymatic Cascade Conversion of Linoleic Acid into a Secondary Fatty Alcohol Using a Combination of 13S-Lipoxygenase, Chemical Reduction, and a Photo-Activated Decarboxylase ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, v.9 no.32 , 10837-10845
  SCIE
• [학술지논문] Enhancing acid tolerance of Escherichia coli via viroporin-mediated export of protons and its application for efficient whole-cell biotransformation METABOLIC ENGINEERING, 2021, v.67 no.- , 277-284
  SCIE
• [학술지논문] Design and engineering of whole-cell biocatalytic cascades for the valorization of fatty acids CATALYSIS SCIENCE & TECHNOLOGY, 2020, v.10 no.1 , 46-64
  SCIE
• [학술지논문] Discovery and Engineering of a Microbial Double-Oxygenating Lipoxygenase for Synthesis of Dihydroxy Fatty Acids as Specialized Proresolving Mediators ACS SUSTAINABLE CHEMISTRY ENGINEERING, 2020, v.8 no.43 , 16172-16183
  SCIE
• [학술지논문] Increased Production of omega-Hydroxynonanoic Acid and alpha,omega-Nonanedioic Acid from Olive Oil by a Constructed Biocatalytic System JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, v.68 no.35 , 9488-9495
  SCI
• [학술지논문] Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids NATURE COMMUNICATIONS, 2020, v.11 no.1 , 1-8
  SCI
• [학술지논문] Understanding the molecular properties of the E1 subunit (SucA) of alpha-ketoglutarate dehydrogenase complex from Vibrio vulnificus for the enantioselective ligation of acetaldehydes into (R)-acetoin CATALYSIS SCIENCE & TECHNOLOGY, 2020, v.10 no.1 , 79-85
  SCIE
• [학술지논문] Whole-Cell Photoenzymatic Cascades to Synthesize Long-Chain Aliphatic Amines and Esters from Renewable Fatty Acids ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, v.59 no.18 , 7024-7028
  SCI
• [지적재산권] 슈도모나스 유래 리폭시게나아제 기반 재조합 대장균 및 이를 이용한 히드록시 지방산 및 이차 지방알콜 제조방법 Domestic : Patent , Registration , 10-2579073, 2023
• [지적재산권] 페리플라즘으로 분비되는 다이올 합성효소를 이용한 디하이드록시 지방산의 제조방법 Domestic : Patent , Registration , 10-2469656, 2022
• [지적재산권] 내열성 신규 포스포리파아제 A2 및 포스포리파아제 A2 생산방법 Domestic : Patent , Registration , 10-2227399, 2021