Professor Hwi Young Kim from Department of Medicine Develops AI-based Model to Predict Risk of Hepatocellular...Professor Hwi Young Kim from Department of Medicine Develops AI-based Model to Predict Risk of Hepatocellular Carcinoma among Patients with Chronic Hepatitis B Professor Hwi Young Kim developed an AI-based model named “PLAN-B” to predict the risk of hepatocellular carcinoma among patients with chronic hepatitis B. The multinational and multi-institutional clinical study, conducted jointly with foreign and domestic researchers including a research team led by Professor Jeong-Hoon Lee from the Department of Internal Medicine at Seoul National University Hospital, is drawing attention as it is expected to demonstrate high practical utility in real clinical practice by improving the prediction accuracy of hepatocellular carcinoma risk among patients with chronic hepatitis B for which prediction and preparation are vital. In collaboration with researchers at home and abroad, research teams led by Professors Kim and Lee analyzed the data of a total of 13,508 patients with chronic hepatitis B from 18 institutions across South Korea and 11 institutions across Europe and North America, applying the data to AI-based machine learning algorithms to develop “PLAN-B,” which is a prediction model for the risk of hepatocellular carcinoma. “PLAN-B” is expected to be highly beneficial to practice as its prediction accuracy is significantly higher than that of existing prediction models. By providing more detailed analysis of hepatocellular carcinoma risk through a gradient-boosting machine algorithm, it will also contribute significantly to enabling treatment and patient management tailored to the characteristics of individual patients. First author Professor Kim remarked, “We developed a unique prediction model for hepatocellular carcinoma using artificial intelligence, and this study holds significant clinical implications as its efficacy was validated using large-scale patient data from the East and the West,” and explained, “PLAN-B will greatly help in identifying patients with high risk of hepatocellular carcinoma as well as those with very low risk.” PLAN-B was developed with support from “'Dr. Answer 2.0,” which is an AI-based precision medical solution development project. The research findings, titled “An Artificial Intelligence Model to Predict Hepatocellular Carcinoma Risk in Korean and Caucasian Patients with Chronic Hepatitis B,” were published in the online edition of Journal of Hepatology (IF = 25.083), a world-renowned academic journal in the field of gastrointestinal diseases and the official academic journal of the European Association of the Study of the Liver, on Friday, October 1. Professor Kim, an expert in liver diseases, is particularly recognized in the domestic and international academia for his outstanding research achievements in clinical epidemiologic studies and prediction model development for liver cancer, cirrhosis and fatty liver. He is also active as a member of the Publication Committee and the Public Relations Committee at the Korean Association for the Study of the Liver.
“Ewha Frontier 10–10 Project” to Lead the Future of Ewha Ewha Womans University announced the “Ewha Frontier 10–10 Project” to select a total of 20 project teams consisting of 10 teams each in leading research fields and future-oriented challenging research fields for its leap toward as a world-class research-oriented university on Tuesday, October 5. The “Ewha Frontier 10–10 Project,” aimed at enhancing Ewha’s competitiveness and consolidating its status as a research-oriented university under the capable leadership of President Eun Mee Kim, represents a core task for Ewha’s main objective of “Establishing an Environment Conducive to World-Class Research” under “Ewha Vision 2030+.” The project will be implemented with the aim to enhance Ewha’s external reputation by supporting leading and promising academic fields, securing outstanding faculty members, and generating innovative research outcomes. Based on the project, Ewha plans to solidify its status as a research-oriented university with world-class research capabilities. Ewha will select up to 10 project teams respectively in “leading research fields” and “future-oriented challenging fields,” which are areas with global competitiveness, and support each team with funding of 2 to 5 billion KRW for a total of three years. The selected project teams will conduct leading research with full support, such as the invitation of renowned scholars or outstanding faculty members, support for new researchers and graduate students, expansion of research environment and infrastructure, and support for international joint research and globalization. Through the project, Ewha plans to pioneer its own growth and prioritize future-oriented academic and research fields as well as establishing an environment conducive to world-class research based on its tradition of academic diversity encompassing liberal arts, social studies, arts and physical education, and convergence fields. The evaluation for project selection will be conducted between November and December, and the project’s full-scale implementation will commence in March 2022. Detailed information can be found in the project announcement by each college (or graduate school). Meanwhile, the Office of Research officially launched the “PURE service” (https://ewha.elsevierpure.com/) to disseminate and promote Ewha’s excellent research achievements. The service is a web-based solution provided by the global academic information analytics company Elsevier and is tailored for the promotion of research achievements and the implementation of marketing strategies by enhancing researchers’ convenience by providing the comprehensive management of research activities and achievements, visual research statistics based on a vast international academic database such as SCOPUS, and performance analysis sample reports for individual researchers or groups. Anyone who is interested in Ewha’s research performance and achievements can search for paper publication records, research activities, related statistics, and keywords by individual researchers on the PURE service’s official website. The launch of this service will enable the effective management of various research performance and achievements of individual researchers on a single platform. Vice President Lee Hyang-sook of the Office of Research remarked, “We expect that the PURE service will contribute to increasing the possibility of international joint research and convergence research in collaboration with the world’s leading research and academic institutions by maximizing the publicity and dissemination of our research achievements online, and enhancing the convenience of obtaining basic research performance data and reporting materials necessary for applying for and implementing external research projects.”
Ewha University-Industry Collaboration Foundation Concludes Technology Transfer Agreement for Cell Type–specific DeliverEwha University-Industry Collaboration Foundation Concludes Technology Transfer Agreement for Cell Type–specific Delivery of RNA Therapeutics The Ewha University-Industry Collaboration Foundation (EUICF) held a signing ceremony with EnhancedBio Inc. to join the technology transfer agreement for “lipid nanoparticles (LNP) for targeted delivery of RNA therapeutics into different types of cells” on Wednesday, September 15. The technology, developed by Professor Hyukjin Lee at the College of Pharmacy, enables the targeted delivery of RNA therapeutics to various types of cells by the formulation of lipid nanoparticles (LNP). The presenting technology has shown clinically relevant gene-transfer efficacy as well as good safety. Although this is a core technology that has already been used for the COVID-19 mRNA vaccines by Moderna and Pfizer, it represented an essential endeavor for biotech companies to secure their own LNP technology. The relevant core technology patents are mostly held by U.S. companies and other foreign companies. It is important to note that the presenting technology has been developed solely by a domestic research group and the patent (KR10-2198763) has been granted with this technology. The research team, led by Professor Lee at the College of Pharmacy, already transferred the patent of 246C10 LNP technology to EnhancedBio Inc. in May 2020 and two more follow-up patents will be transferred through this agreement. The agreement contains an advance payment, a milestone payment for the commencement of clinical trials, and royalties on sales, which are expected to add to the school’s revenue from the technology transfer fee. “The LNP platform technology for the delivery of RNA therapeutics will be a game-changer for non-viral gene therapy and can be applied widely to various RNA therapeutics including siRNA and mRNA that are currently on the market,” explained Professor Hyukjin Lee. “In particular, LNP for the cell-specific delivery of RNA therapeutics negates the disadvantage of current LNP technology and represents an extraordinary advancement that simultaneously guarantees the efficacy and safety of RNA therapeutics.” He also added, “We will actively participate in commercializing RNA therapeutics and making inroads into global markets through continued joint research and collaboration with EnhancedBio Inc., a company that develops anti-cancer therapeutics based on siRNA.” “This agreement is meaningful to Ewha in that the stability of the patent rights has been proved after the first technology transfer last year and a patent portfolio was established with the subsequent R&D outcomes, leading to a new patent technology for which the second technology transfer agreement was signed,” said EUICF President Lee Hyang-sook, who also added, “I hope this ceremony serves as an opportunity for Ewha Womans University and EnhancedBio Inc. to advance to the next step and take the lead in the global biotechnology market.” Ewha holds an extensive range of about 1,000 patents across various fields including the humanities, social sciences, entertainment, sports as well as science and technology. The EUICF actively supports the entire process of technology commercialization based on Ewha’s excellent research outcomes, from the creation of intellectual properties, to technology transfer and business launch. The EUICF will continuously endeavor to establish a virtuous cycle to generate profits from technology transfers, businesses creation, industry-university joint research, and recruitment linkages regarding outstanding technologies and patents held by Ewha and reinvesting such profits into research and development, amidst Ewha’s dedicated efforts to construct a creative research ecosystem conducive to world-class performance under the vision of “A Creative and Innovative Platform Leading to a Sustainable Society.”
Ewha Develops International Climate Risk Management Model with Financial Supervisory Service Ewha signed an industry-government-academia business agreement to develop an international climate risk management model named “Frontier-1.5D” in partnership with the Financial Supervisory Service (FSS), major Korean businesses and the British Embassy in Seoul. Frontier-1.5D, a collaborative effort by Ewha, the FSS, major Korean companies, and the British Embassy, is aimed at taking the initiative towards reaching a global consensus on limiting the average global temperature rise within 1.5℃ above the pre-industrial level (before 1850) and actively participating in climate risk management. The business agreement, as the first global collaboration effort involving financial supervisory authorities, businesses, academia and foreign embassies, is expected to present an exemplary case of international collaboration in the development of future climate risk management models. The business agreement signing ceremony held at the British Embassy on Monday, September 13 was attended by President Eun Mee Kim of Ewha Womans University, Governor Jeong Eun-bo of the Financial Supervisory Service, British Ambassador to South Korea Simon Smith, the UK’s High-Level Climate Action Champion for COP26 Nigel Topping, CEO Kim Jun of SK Innovation, CEO Choi Eun-seok of CJ Cheiljedang, CEO John Rim of Samsung Biologics, Chairman Yoon Jong-Kyoo of KB Financial Group, and Chairman Cho Yong-byoung of Shinhan Financial Group. The business agreement aims to mitigate climate-related uncertainties by developing a management model for climate risk, estimating the range of costs incurred by climate risk, and forecasting the losses faced by businesses and financial institutions following abnormal climate change and countermeasures such as carbon emission reduction. The development of a new model will make it possible to reduce management uncertainty, present methods of Environmental, Social and Corporate Governance (ESG), and attract foreign investors. Ewha has been taking the initiative in researching climate change and now aims to play a leading role in developing the aforementioned climate risk management model as the only education and research institution to have signed the business agreement. The six corporations will provide climate risk data for each business sector and the analysis thereof, while the British Embassy will assume an advisory role for the development of the climate risk model, and the FSS will play a coordinating role in sharing their knowhow and mediating cooperation among the participants. This joint industrial-government-academia project, which is based on the role of financial authorities in responding to a “Green Swan,” referring to unpredictable risks and threats brought by the climate change as defined by the Bank for International Settlements, is expected to contribute to enhancing the climate risk management capacity of stakeholders by coordinating their needs and capabilities.
Research Team Led by Professor Sangheon Lee Discovers the Secret of Atoms Hidden in Nanosynthesis A team of researchers led by Professor Sangheon Lee (Department of Chemical Engineering and Materials Science) has identified the mechanism through which surface ligands control the growth of nanomaterials by utilizing quantum mechanical modeling and atom probe tomography. The outcome of this research was published in Nature Communications on July 14 (Wed), 2021, titled “Three-dimensional Atomic Mapping of Ligands on Palladium Nanoparticles by Atom Probe Tomography.” The research was jointly conducted in collaboration with Professor Pyuck-Pa Choi (Department of Materials Science and Engineering at KAIST), and Ms. Jiwon Yu, who is currently a Ph.D. student at The University of Texas at Austin after receiving B.S. and M.S. from Ewha Womans University, made a significant contribution as a co-author. Ligands are long-chain organic molecules involved in the process of nanoparticle synthesis. It has been well known that ligands are anchored on the surface of nanoparticles, like spines of chestnuts and sea urchins, and play a key role in controlling the shape and various properties of nanoparticles. Therefore, ligand-based synthesis techniques have already been applied to mass production of some commercialized products, such as quantum dot displays. However, the scientific understanding of the mechanism by which ligands control the nanoparticle growth remained unknown due to the difficulty in direct characterization of the interaction between ligands and nanoparticles. For the first time in the world, the Ewha-KAIST joint research team succeeded in imaging the three-dimensional distribution of ligands over the surface of palladium nanoparticles using an atomic tomographic microscope. Then, the research team performed state-of-the-art quantum mechanical calculations and demonstrated that a specific combination of ligands leads to the formation of a specific shape of nanoparticles by selectively stabilizing specific facets of palladium nanoparticles. The physical insights and relevant technologies obtained through this experiment-theory joint research are expected to be directly applied to the design and manufacture of nanoparticles with superior properties. “The primary goal of my research is to understand the underlying mechanisms involved in the formation and behavior of new materials based on atomic-level understanding,” said Professor Lee. “This joint research is academically very important, as the presented results encompass all the previously reported conflicting results.” Professor Lee also acknowledged, “I am very fortunate to be able to make a world-class achievement by working with brilliant students and by taking full advantage of the excellent research infrastructure at Ewha Womans University.”
Research Team of Professor Kim TaeSoo Publishes Findings in Nucleic Acids Research, a World-renowned Academic JournalResearch Team of Professor Kim TaeSoo Publishes Findings in Nucleic Acids Research, a World-renowned Academic Journal A research team including Professor Kim TaeSoo at the Department of Life Science under the College of Natural Sciences discovered a new expression regulation mechanism of cryptic noncoding RNA within gene bodies. The results of this study, participated in by Dr. Lee Bo Bae of the Life Science major as the first author, were published in a SCI journal, Nucleic Acids Research (IF 16.971, within the top 2.5%), on July 28 (Wed). With the implementation of the Human Genome Project, scientists across the world believed that causes of incurable diseases that entail changes in DNA sequencing could be determined through understanding the function of all protein coding genes in the human genome. However, subsequent studies proved that transcription occurs not only in genes that encode proteins but also in DNA sequence (noncoding DNA), which does not encode proteins, leading to the conclusion that there exist a vast number of noncoding RNAs whose functions are unknown. These noncoding RNAs, which have come to receive significant attention recently, play key roles in the regulation of cell function, differentiation and death, and are known to be closely related to various diseases. Professor Kim TaeSoo’s research team selected noncoding RNAs which were uniquely expressed in cells under continuous environmental shifts and investigated their regulation mechanism, the results of which were already published in Nature Communications in 2016. Since then, the research team has conducted a follow-up study focusing on the expression patterns of genes within cells and those of noncoding RNAs depending on environmental changes. Gene expression is determined by “promoters,” DNA sequences to which transcription factors bind themselves. The Ewha research team carried out an experiment to substitute a certain gene’s original core promoters with those from genes that are differentially expressed. Through the experiment, the team identified that an increase in the activity of core promoters leads to a decrease in the expression of cryptic noncoding RNAs from internal cryptic promoters, as shown in the figure. Based on this, the research team newly found that promoter strength and transcription elongation factors play important roles in the regulation of noncoding RNAs expressed within gene bodies. Professor Kim TaeSoo expressed his high expectations, remarking “This study demonstrated for the first time that gene expression and noncoding RNA expression are strongly correlated. This will lead to the proposal of a new research direction on the regulation of noncoding RNA expression, which serves a key function within cells.” He added, “In addition, research on the expression regulation of cancer cell-specific noncoding RNAs will make it possible to understand the mechanism of carcinogenesis induced by noncoding RNAs, with the aim to develop a new biomarker and to suggest treatment targets.”
Professor Sun Choi’s Joint Research Team Identifies a New Development Mechanism Behind Liver Cancer and Designs...Professor Sun Choi’s Joint Research Team Identifies a New Development Mechanism Behind Liver Cancer and Designs Peptides with Efficacy Against Hepatocellular Carcinoma A joint research team including Professor Sun Choi of the Department of Pharmacy as a co-corresponding author identified a mechanism underlying hepatic fibrosis and hepatoma based on the signaling activation of the tumor protein c-Src and the cell membrane protein TM4SF5. They also succeeded in designing peptides (small protein fragments) that inhibit carcinogenesis by blocking protein-protein interactions between TM4SF5 and c-Src, which efficacy was verified through animal testing. The results of this study were published in a top world-renowned academic journal, Theranostics (IF 11.556, JCR top 3.22% in the Medicine, Research & Experimental category), on July 6 (Tue), 2021. Professor Sun Choi’s research team in collaboration with Professor Jung Weon Lee from Seoul National University College of Pharmacy conducted research on the correlation between liver diseases and the cell membrane protein TM4SF5, which transmits signals by binding to intra- and extra-cellular proteins,. In the landmark of this profitable collaboration, they also recently published an article in Cell Metabolism (IF 27.287, JCI top 1.69% in the Endocrinology & Metabolism category) identifying that, although the expression of TM4SF5 was insignificant in normal liver tissue, it increased under inflammatory metabolic disorders and inflammatory diseases to play a critical role in developing fatty liver, fatty hepatitis, and hepatoma. In this study, the research team discovered a new mechanism for c-Src signaling, a typical tumor protein that appears in various cancer cells, to be activated by binding to the membrane protein TM4SF5. The C-terminal tail of TM4SF5 binds to the inactive form of c-Src in the cytoplasm, recruiting c-Src at the cell membrane. This complex further binds with phosphatase that activates the tumor protein. In summary, the team newly found that the tumor protein c-Src can be activated at the cell membrane through its association with the membrane protein TM4SF5, even if it does not possess the ability to remain at the membrane, for example, by binding to fat molecules. Furthermore, through molecular modeling and point-mutation studies, the research team identified the atomic-level details of the binding process between TM4SF5 and c-Src, including the designed peptides with the ability to disrupt their binding. The team predicted that these peptide fragments, which resemble the C-terminal tail of TM4SF5, would intercept the c-Src action by competing against the actual TM4SF5, thus disrupting the binding of the two cell proteins. By conjugating with specific viral sequences, that help to infiltrate into cells, the designed peptides were confirmed to be effective in animal models. By actually injecting these peptide fragments into cells and tumor-infested laboratory mice, the team identified that both, the development of liver cancer and its metastasis to the lungs were inhibited. The research team emphasized the significance of this study, noting that “By identifying the molecular mechanism of hepatic fibrosis and hepatoma based on the signaling activation of the tumor protein aided by and the cell membrane protein, we obtained key information to control the activation of the tumor protein by disrupting the binding between the two proteins. This study will be expected to serve as a starting point in developing of safe peptide biomedicines that can prevent the development of liver diseases, including hepatoma.” This study was the result of a nice collaboration conducted by Professor Sun Choi at Ewha and Professor Jung Weon Lee at Seoul National University College of Pharmacy (co-corresponding authors), and participated in by Professor Yoonji Lee (co-first author) at Chung-Ang University College of Pharmacy who received bachelor’s, master’s and doctorate degrees at Ewha Womans University College of Pharmacy and served as an instructor at the University of Texas Southwestern Medical Center in the U.S.
Ewha Research Institute for Basic Sciences Selected as a Recipient of the Autonomous Priority Research Institute ProgramEwha Research Institute for Basic Sciences Selected as a Recipient of the Autonomous Priority Research Institute Program in Science and Engineering The Ewha Research Institute for Basic Sciences (BSRI, Director: Professor Kim Dong Ha) was selected as a recipient organization of the “Autonomous Priority Research Institute Program in Science and Engineering,” which is supported by the Ministry of Education (MOE) and the National Research Foundation (NRF) of Korea. Subsequent to its recent selections as a grantee of major institutes’ research projects, the BSRI has achieved meaningful outcomes in growing as a research institute with the capacity to lead the development of core technology in basic sciences and the training of talented individuals in science and engineering, thereby contributing to solidifying Ewha’s status as an excellent research-oriented university. The MOE selects a university Priority Research Institute with the aim to develop a university-affiliated research institute that is well-equipped with the commitment to promote basic sciences at the university level, a competent director, and a sound operational foundation into a research hub in the field of basic sciences within the university. In particular, the ministry has been carrying out the “Autonomous Priority Research Institute Program” since 2019, in order to plan and support “creative and challenging studies in the field of basic sciences”, “studies with medium- and long-term growth potential”, and “independent studies by competent and rising researchers”, in order to provide them with a steady supply of research funding, and to enhance the autonomy of researcher-driven studies. With its selection as a grantee of this project, the BSRI will receive an annual research fund of 1.21 billion KRW for up to nine years (3+3+3 years), amounting to a total of 10.89 billion KRW. The Autonomous Priority Research Institute Program focuses on promoting the enhancement of a research institute’s capacity to plan research support programs, manage research, discover and train researchers, and conduct research by supporting the institute to operate a “small-scale and seed-type research support program” for the development of basic sciences under the responsibility of a director with an aptitude for not only research, but also research management and organizational management, such as leadership within the university. Ewha has led NT and BT convergence studies through aggressive investments in education and research infrastructure to become a leader in the fields of basic and applied sciences, and its selection as the recipient of research projects in various fields, from the Science Research Center (SRC) in 1998 to the Priority Research Institute Program and Core-Facility. Based on this basic sciences infrastructure, the institute plans to lead basic and source research through the interdisciplinary convergence of basic sciences to address core issues of the future, such as climate change, aging society, and super-connected society. Professor Kim Dong Ha in the Department of Chemistry and Nanoscience at College of Natural Sciences evaluated the significance of the selection, commenting, “Our selection as a recipient of the Autonomous Research Institute Program, in collaboration with Ewha’s other research institutes selected for the Priority Research Institute, Science Research Center (SRC), and Core-Facility Center, laid a foundation for the establishment of the best research institute in Korea to contribute to the enhancement of national competitiveness through the development of basic sciences and the hub of educating science personnel to lead the development of basic sciences.”
Professor Jo Il-hyun’s Research Team Publishes a Paper on Behavioral Patterns of Video-Based Online Learners in a World-Professor Jo Il-hyun’s Research Team Publishes a Paper on Behavioral Patterns of Video-Based Online Learners in a World-Renowned Academic Journal Amid the growing need to establish an environment for online teaching and learning due to the COVID-19 situation, Professor Jo Il-hyun’s research team gained recognition by publishing the results of their study on the behavioral patterns of online learners. In the world-renowned academic journal The Internet And Higher Education, Professor Jo’s team published a paper titled “Video learning analytics: Investigating behavioral patterns and learner clusters in video-based online learning,” which categorized behavioral patterns of learners by analyzing the big data of video-based online learning settings and analyzed academic performance by category. The study was conducted to obtain insights into learners’ behavioral patterns in video-based learning by employing “learning analytics.” Learning analytics is an intelligent convergence edutech that supports teaching and learning decision-making based on the measurement, collection, analysis, and prediction of big data generated in learning activities and contexts occurring in learning environments that are technologically mediated. The research team carried out one-on-one experiments on 72 college students utilizing “Learning Analytics for Prediction & Action (LAPA),” the EduTech Convergence Lab’s self-developed video player, and analyzed learners’ log data and academic performance recorded in the process of online learning, along with the learners’ general characteristics. The study was significant in both theoretical and practical aspects. First of all, it was theoretically meaningful in that the study identified learners’ patterns as demonstrated in the learning process, and automatically analyzed active and passive learners’ learning patterns using only log data. The study also gained attention as learners’ patterns and categories ascertained through the study offered experimental evidence in enriching the discussion on theoretical models suggested in prior studies. Professor Jo expressed his high expectations, commenting, “Our findings will allow educators, who are unable to observe learners face-to-face with the establishment of video-based education such as Zoom as the ‘new normal’ in the coronavirus pandemic era, to understand learners’ characteristics in order to apply differentiated instructional strategies and guidelines to teaching learners with different behavioral profiles.” The study was conducted with support from the National Research Foundation of Korea, jointly participated in by Professor Jo Il-hyun (corresponding author), and Dr. Yoon Mee-hyun (first author) and researcher Lee Jung-eun (co-author) at the EduTech Convergence Lab.
Research Team of Professor Bahn Hyo-kyung Publishes a Paper in IEEE Transactions on Industrial InformaticsResearch Team of Professor Bahn Hyo-kyung Publishes a Paper in IEEE Transactions on Industrial Informatics Professor Bahn Hyo-kyung, the Computer Science and Engineering major Yoo Suhyeon , Jo Yewon(co-first authors) A research team led by Professor Bahn Hyo-kyung from the Computer Science and Engineering major has succeeded in developing a scheduling technology that can immediately respond to sudden user inputs in real-time systems. This technology is expected to overcome the limitations of existing real-time systems that operate only in a predefined manner and instead respond immediately to sudden environmental changes while enabling power savings of 66.8% on average. Incorporating the findings of this study, a paper titled “Integrated scheduling of real-time and interactive tasks for configurable industrial systems” was published in the online edition of IEEE Transactions on Industrial Informatics. In particular, significant attention has been directed to the achievements of Yoo Su-hyeon and Jo Ye-won majoring in Computer Science and Engineering, incoming class of 2017, who participated in the study as co-first authors. A real-time system is a mission-critical system that requires each task to be processed within a given time. Unlike general purpose computers we commonly use, it refers to a system that does not allow a single error by determining the planning of hardware resources in advance. Concepts such as the Internet of Things (IoT), Smart Factory, and Cyber Physical System (CPS), which have recently come into the spotlight, are mostly real-time systems. There is increasing demand for these real-time systems to operate by accepting user inputs. However, real-time systems that process tasks in a predefined way and general purpose computer systems designed to handle irregular user inputs operate under very different hardware resource management methods, so integrating the two in a single system is a highly challenging research area. By tackling these problems, the research team led by Professor Bahn developed system management technologies that concurrently support real-time tasks and interactive tasks, and identified ways to simultaneously satisfy various requirements, such as ensuring deadlines for real-time tasks and response times for interactive tasks and reducing system power consumption, using an artificial intelligence technology called genetic algorithm (GA). Principal investigator Professor Bahn expressed his expectations, remarking that “This is a software source technology with high applicability as it can flexibly expand the functionality of real-time systems in various industrial settings in the era of the Fourth Industrial Revolution.”