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College of Natural Sciences

Daekee Lee Professor

Life Sciences/Department of Life Science

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Lee, Daekee is a professor at the Graduate School of Life Sciences/Biology and is conducting research on the function of genes in the carcinogenesis. He received his Ph.D. from the Department of Molecular Biology at Seoul National University, and as a postdoctoral researcher and full-time researcher at Vanderbilt Medical School and University of North Carolina in the United States, conducting research in the field of cancer biology using mouse genetics. Since 2005, he has been examining the effects of anticancer target genes on cell proliferation and death at Ewha Womans University. He also seeks to discover new genes affecting colon cancer proliferation and metastasis, and discover new target therapeutic genes by making mouse models using CRISPR/Cas9 gene editing technology and discovering the functions and mechanisms of new genes through cell-level studies.
  • Science Building C #411
  • 02-3277-4368
  • Research Interests
    • Colrectal cancer, Metastasis, Gene editing, EGFR siganling, Apoptosis
Research Record
  • STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells Molecular Oncology, 2020, v.14 no.8, 1850-1867
    SCIE Scopus dColl.
  • Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium-Induced Colitis CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2023, v.16 no.3, 411-429
    SCIE Scopus dColl.
  • Tumor-Promoting Role of GNA14 in Colon Cancer Development Cancers, 2023, v.15 no.18, 4572
    SCIE Scopus dColl.
  • Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells ONCOIMMUNOLOGY, 2022, v.11 no.1, 2015170
    SCIE Scopus dColl.
  • Stage-Dependent Changes of Visual Function and Electrical Response of the Retina in the rd10 Mouse Model FRONTIERS IN CELLULAR NEUROSCIENCE, 2022, v.16, 926096
    SCIE Scopus dColl.
  • Tetraspanin 7 regulates osteoclast function through association with the RANK/αvβ3 integrin complex Journal of Cellular Physiology, 2022, v.237 no.1, 846-855
    SCIE Scopus dColl.
  • ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos PLoS ONE, 2021, v.16 no.10-10월, e0259426
    SCIE Scopus dColl.
  • Pgc1α loss promotes lung cancer metastasis through epithelial-mesenchymal transition Cancers, 2021, v.13 no.8, 1772
    SCIE Scopus dColl.
  • WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury Gastroenterology, 2021, v.161 no.3, 953-9.67E17
    SCIE Scopus dColl.
  • A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model GENETICS, 2020, v.214 no.3, 691-702
    SCIE Scopus dColl.
  • Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation ONCOIMMUNOLOGY, 2020, v.9 no.1, 0
    SCIE Scopus dColl.
  • Kinase activity of ERBB3 contributes to intestinal organoids growth and intestinal tumorigenesis CANCER SCIENCE, 2020, v.111 no.1, 137-147
    SCIE Scopus dColl.
  • Tamoxifen-inducible cardiac-specific Cre transgenic mouse using VIPR2 intron Laboratory Animal Research, 2020, v.36 no.3, 260-267
    KCI dColl.
  • RACK1 interaction with c-Src is essential for osteoclast function Experimental and Molecular Medicine, 2019, v.51 no.7, 86
    SCIE Scopus KCI dColl.
  • Isolation and Functional Examination of the Long Non-Coding RNA Redrum Molecules and cells, 2018, v.41 no.2, 134-139
    Scopus dColl.
  • INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis Oncotarget, 2017, v.8 no.70, 115041-115053
    SCIE Scopus dColl.
  • Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells Nature Communications, 2017, v.8 no.1
    SCIE Scopus dColl.
  • Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon SCIENTIFIC REPORTS, 2016, v.6
    SCIE Scopus dColl.
  • Generation of various organ/tissue specific ERT2creERT2 transgenic mice TRANSGENIC RESEARCH, 2016, v.25 no.2, 225-226
    SCIE Scopus dColl.
  • NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells CANCER RESEARCH, 2016, v.76 no.4
    SCIE Scopus dColl.
  • The PGE2 EP3 receptor regulates diet-induced adiposity in male Mice Endocrinology, 2016, v.157 no.1, 220-232
    SCIE Scopus dColl.
  • The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors SCIENCE SIGNALING, 2015, v.8 no.379
    SCIE Scopus dColl.
  • Ahnak functions as a tumor suppressor via modulation of TGF beta/Smad signaling pathway ONCOGENE, 2014, v.33 no.38, 4675-4684
    SCIE Scopus dColl.
  • Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway. Oncogene, 2014, v.33 no.38, 4675-4684
    Scopus dColl.
  • ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells ONCOTARGET, 2014, v.5 no.13, 5138-5152
    SCIE Scopus dColl.
  • Quantitative analysis of a ubiquitin-dependent substrate using capillary electrophoresis with dual laser-induced fluorescence ELECTROPHORESIS, 2014, v.35 no.20, 2978-2985
    SCIE Scopus dColl.
  • [학술지논문] Tumor-Promoting Role of GNA14 in Colon Cancer Development CANCERS, 2023, v.15 no.18 , 4572-4572
    SCIE
  • [학술지논문] Kinase activity of ERBB3 contributes to intestinal organoids growth and intestinal tumorigenesis Cancer Science, 2020, v.111 no.1 , 137-147
    SCI
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Courses

  • 2025-1st

    • General Biology

      • Subject No 20412Class No 01
      • 1Year ( 3Credit , 3Hour) Wed 3~3 (POSCO452) , Fri 2~2 (POSCO452)
        • Syllabus(File)

    • Genetics

      • Subject No 30249Class No 01
      • 2Year ( 3Credit , 3Hour) Tue 7~7 (POSCO465) , Fri 6~6 (POSCO465)
        • Syllabus(File)

    • General Biology : Laboratory Work Ⅰ

      • Subject No 33332Class No 01
      • 1Year ( 1Credit , 1.5Hour) Mon 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology : Laboratory Work Ⅰ

      • Subject No 33332Class No 02
      • 1Year ( 1Credit , 1.5Hour) Wed 5~5 (SCI-AA203)
        • Syllabus(File)

    • Molecular Biology Ⅱ

      • Subject No 35825Class No 01
      • 3Year ( 3Credit , 3Hour) Mon 5~5 (POSCO361) , Wed 4~4 (POSCO361)
        • Syllabus(File)

    • Colloquium of Life Science Research

      • Subject No 36337Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 4~4 (POSCO452) , Fri 5~5 (POSCO452)
        • Syllabus(File)

    • Life Science Seminar Ⅲ

      • Subject No G16930Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (SCI-C)
        • Syllabus(File)

  • 2024-2nd

    • General Biology

      • Subject No 20412Class No 05
      • 1Year ( 3Credit , 3Hour) Wed 3~3 (POSCO452) , Fri 2~2 (POSCO452)
        • Syllabus(File)

    • Molecular Biology Ⅰ

      • Subject No 20600Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 5~5 (POSCO452) , Wed 4~4 (POSCO452)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
        • Syllabus(File)

    • Special Topics in Developmental Genetics Ⅱ

      • Subject No G16955Class No 01
      • Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)
        • Syllabus(File)

  • 2024-1st

    • General Biology

      • Subject No 20412Class No 01
      • 1Year ( 3Credit , 3Hour) Wed 3~3 (POSCO452) , Fri 2~2 (POSCO452)
        • Syllabus(File)

    • Genetics

      • Subject No 30249Class No 01
      • 2Year ( 3Credit , 3Hour) Tue 4~4 (POSCO363) , Fri 5~5 (POSCO363)
        • Syllabus(File)

    • General Biology: Laboratory Work Ⅰ

      • Subject No 33332Class No 01
      • 1Year ( 1Credit , 1.5Hour) Mon 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology: Laboratory Work Ⅰ

      • Subject No 33332Class No 02
      • 1Year ( 1Credit , 1.5Hour) Wed 6~6 (SCI-AA203)
        • Syllabus(File)

    • Molecular Biology Ⅱ

      • Subject No 35825Class No 03
      • 3Year ( 3Credit , 3Hour) Wed 3~3 (POSCO465) , Fri 2~2 (POSCO465)
        • Syllabus(File)

    • Colloquium of Life Science Research

      • Subject No 36337Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 4~4 (POSCO161) , Fri 5~5 (POSCO161)
        • Syllabus(File)

    • Special Topics in Advanced Biochemistry Ⅰ

      • Subject No G16948Class No 01
      • Year ( 3Credit , 3Hour) Mon 3~4 (SCI-C418)
        • Syllabus(File)

  • 2023-2nd

  • 2023-1st

  • 2022-2nd

    • Molecular Biology I

      • Subject No 20600Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 2~2 (POSCO361) , Thu 3~3 (POSCO361)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA203)
        • Syllabus(File)

    • Special Topics in Developmental Genetics Ⅱ

      • Subject No G16955Class No 01
      • Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)
        • Syllabus(File)

    • Human Disease Model Phenomics

      • Subject No G17003Class No 01
      • Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
        • Syllabus(File)

  • 2022-1st

    • General Biology I

      • Subject No 20413Class No 04
      • 1Year ( 3Credit , 3Hour) Tue 2~2 (POSCO453) , Fri 3~3 (POSCO453)
        • Syllabus(File)

    • Genetics

      • Subject No 30249Class No 01
      • 2Year ( 3Credit , 3Hour) Wed 3~3 (POSCO453) , Fri 2~2 (POSCO453)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 01
      • 1Year ( 1Credit , 1.5Hour) Mon 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 02
      • 1Year ( 1Credit , 1.5Hour) Tue 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 03
      • 1Year ( 1Credit , 1.5Hour) Wed 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 04
      • 1Year ( 1Credit , 1.5Hour) Fri 6~6 (SCI-AA203)
        • Syllabus(File)

    • Molecular Biology II

      • Subject No 35825Class No 02
      • 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO362) , Thu 6~6 (POSCO362)
        • Syllabus(File)

    • Colloquium of Life Science Research

      • Subject No 36337Class No 01
      • 3Year ( 3Credit , 3Hour) Mon 3~3 (SCI-AA) , Wed 2~2 (101)
        • Syllabus(File)
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Academic Background

Seoul Nat'l Univ. 이학박사(분자생물학과)

Work Experience

노스캐롤라이나주립대 연구원 2000-07-01 ~ 2005-06-30

Vanderbilt University 1998-05-01 ~ 2000-06-30

List