이수영(李秀榮) 교수

생명과학과[대학원] /의과대학 /생명과학전공

이수영 프로필 사진
이수영 교수는 고려대학교에서 박사학위를 받은 후, 미국 Rockefeller 대학에서 박사후 연구과정을 이수하였다. 현재 이화여대 자연대학 생명과학과 교수로 재직 중이며, 염증 및 노화 관련된 골격계 질환에서 염증, 선천면역 및 골대사 분야를 연구하고 있다. 2008년부터 2013년까지 국가지정연구실 책임자를 역임하였으며 현재까지 면역 및 뼈 연구분야에서 80여편에 이르는 논문을 국제 저명학술지에 발표하였다.
  • 멀티태스킹 대식세포 연구센터 소장
  • 종합과학관 C동 419호
  • 02-3277-3770
연구실적
  • 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis Nature Communications, 2024, v.15 no.1, 0
    SCIE Scopus dColl.
  • Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain Journal of Cellular Physiology, 2024, v.239 no.4, e31196
    SCIE Scopus dColl.
  • RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts Bone Research, 2024, v.12 no.1, 29
    SCIE Scopus dColl.
  • Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis Biomedicines, 2023, v.11 no.10, 2844
    SCIE Scopus dColl.
  • Differential Expression Patterns of Toll-like Receptors in COVID-19 Patients FRONTIERS IN BIOSCIENCE-LANDMARK, 2023, v.28 no.11, 307
    SCIE Scopus dColl.
  • IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes Experimental and Molecular Medicine, 2023, v.55 no.12, 2576-2585
    SCIE Scopus KCI dColl.
  • BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism Experimental and Molecular Medicine, 2022, v.54, 825-833
    KCI dColl.
  • BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism Experimental and Molecular Medicine, 2022, v.54 no.6, 825-833
    SCIE Scopus KCI dColl.
  • Pim1 promotes IFN-β production by interacting with IRF3 Experimental and Molecular Medicine, 2022, v.54, 1-12
    KCI dColl.
  • Tetraspanin 7 regulates osteoclast function through association with the RANK/αvβ3 integrin complex Journal of Cellular Physiology, 2022, v.237 no.1, 846-855
    SCIE Scopus dColl.
  • Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters NUCLEIC ACIDS RESEARCH, 2021, v.49 no.14, 8097-8109
    SCIE Scopus dColl.
  • Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts Nature Communications, 2021, v.12 no.1, 2258
    SCIE Scopus dColl.
  • Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression Acta Pharmaceutica Sinica B, 2020, v.10 no.3, 462-474
    SCIE Scopus dColl.
  • Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis Journal of Cellular Physiology, 2020, v.236 no.3, 0
    SCIE Scopus dColl.
  • Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for beta-catenin or MITF in colon cancer and melanoma cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.7, 1075-1089
    SCIE Scopus KCI dColl.
  • Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression FASEB JOURNAL, 2020, v.34 no.9, 12894-12906
    SCIE Scopus dColl.
  • GDNF secreted by pre-osteoclasts induces migration of bone marrow mesenchymal stem cells and stimulates osteogenesis BMB REPORTS, 2020 , 646-651
    SCIE Scopus KCI dColl.
  • Intensive morphometric analysis of enormous alterations in skeletal bone system with micro-CT for AHNAK−/− mice Anatomical Science International, 2020, v.95 no.3, 323-333
    SCIE Scopus dColl.
  • Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020 , 1831-1844
    SCIE Scopus KCI dColl.
  • Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation Nature Communications, 2020, v.11 no.1, 4343
    SCIE Scopus dColl.
  • Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss AGING-US, 2020, v.12 no.9, 8652-8668
    SCIE Scopus dColl.
  • Spi-C positively regulates RANKL-mediated osteoclast differentiation and function EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.4, 691-701
    SCIE Scopus KCI dColl.
  • C-Cbl negatively regulates TRAF6-mediated NF-B activation by promoting K48-linked polyubiquitination of TRAF6 CELLULAR & MOLECULAR BIOLOGY LETTERS, 2019, v.24, 29
    SCIE Scopus dColl.
  • Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis Journal of immunology (Baltimore, Md. : 1950), 2019, v.203 no.11, 2990-2999
    Scopus dColl.
  • RACK1 interaction with c-Src is essential for osteoclast function Experimental and Molecular Medicine, 2019, v.51 no.7, 86
    SCIE Scopus KCI dColl.
  • Metabolic alterations in the bone tissues of aged osteoporotic mice Scientific Reports, 2018, v.8 no.1
    SCIE Scopus dColl.
  • STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex CELL DEATH AND DIFFERENTIATION, 2018, v.25 no.8, 1364-1374
    SCIE Scopus dColl.
  • Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation MOLECULES AND CELLS, 2017, v.40 no.10, 706-713
    SCIE Scopus KCI dColl.
  • Euphorbia factor L1 inhibits osteoclastogenesis by regulating cellular redox status and induces Fas-mediated apoptosis in osteoclast Free Radical Biology and Medicine, 2017, v.112, 191-199
    SCIE Scopus dColl.
  • Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β Scientific Reports, 2017, v.7 no.1
    SCIE Scopus dColl.
  • Saturated fatty acid determination method using paired ion electrospray ionization mass spectrometry coupled with capillary electrophoresis ANALYTICA CHIMICA ACTA, 2017, v.984, 223-231
    SCIE Scopus dColl.
  • A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • A novel small-molecule PPI inhibitor targeting integrin alpha(v)beta(3)-osteopontin interface blocks bone resorption in vitro and prevents bone loss in mice BIOMATERIALS, 2016, v.98, 131-142
    SCIE Scopus dColl.
  • Accelerated lactate dehydrogenase activity potentiates osteoclastogenesis via NFATc1 signaling PLoS ONE, 2016, v.11 no.4
    SCIE Scopus dColl.
  • FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-kappa B JOURNAL OF MEDICINAL FOOD, 2016, v.19 no.12, 1196-1203
    SCIE Scopus KCI dColl.
  • Glycogen synthase kinase 3 beta in Toll-like receptor signaling BMB REPORTS, 2016, v.49 no.6, 305-310
    SCIE Scopus KCI dColl.
  • Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • ADP-ribosylation factor 1 regulates proliferation, migration, and fusion in early stage of osteoclast differentiation International Journal of Molecular Sciences, 2015, v.16 no.12, 29305-29314
    Scopus dColl.
  • Glycogen synthase kinase 3 beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production NATURE COMMUNICATIONS, 2015, v.6
    SCIE Scopus dColl.
  • NK cell function triggered by multiple activating receptors is negatively regulated by glycogen synthase kinase-3β Cellular Signalling, 2015, v.27 no.9, 1731-1741
    SCIE Scopus dColl.
  • The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors SCIENCE SIGNALING, 2015, v.8 no.379
    SCIE Scopus dColl.
  • Tight junction protein 1 is regulated by transforming growth factor-beta and contributes to cell motility in NSCLC cells BMB REPORTS, 2015, v.48 no.2, 115-120
    SCIE KCI Scopus dColl.
  • 2-(Trimethylammonium) Ethyl (R)-3-Methoxy-3-oxo-2-Stearamidopropyl Phosphate Suppresses Osteoclast Maturation and Bone Resorption by Targeting Macrophage-Colony Stimulating Factor Signaling MOLECULES AND CELLS, 2014, v.37 no.8, 628-635
    SCIE KCI Scopus dColl.
  • PKC beta Positively Regulates RANKL-Induced Osteoclastogenesis by Inactivating GSK-3 beta MOLECULES AND CELLS, 2014, v.37 no.10, 747-752
    SCIE KCI dColl.
  • TRP14 Inhibits Osteoclast Differentiation via Its Catalytic Activity MOLECULAR AND CELLULAR BIOLOGY, 2014, v.34 no.18, 3515-3524
    SCIE Scopus dColl.
  • [학술지논문] 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis NATURE COMMUNICATIONS, 2024, v.15 no.1 , 1024-1024
    SCIE
  • [학술지논문] Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain JOURNAL OF CELLULAR PHYSIOLOGY, 2024, v.239 no.4 , 1-13
    SCIE
  • [학술지논문] RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts BONE RESEARCH, 2024, v.12 no.1 , 1-14
    SCIE
  • [학술지논문] Pim1 promotes IFN-β production by interacting with IRF3 EXPERIMENTAL AND MOLECULAR MEDICINE, 2022, v.54 no.0 , 2092-2103
    SCI
  • [학술지논문] Tetraspanin 7 regulates osteoclast function through association with the RANK/alpha v beta 3 integrin complex JOURNAL OF CELLULAR PHYSIOLOGY, 2022, v.237 no.1 , 846-855
    SCI
  • [학술지논문] Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters NUCLEIC ACIDS RESEARCH, 2021, v.49 no.14 , 8097-8109
    SCI
  • [학술지논문] Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression FASEB JOURNAL, 2020, v.34 no.9 , 12894-12906
    SCI
  • [학술지논문] Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation NATURE COMMUNICATIONS, 2020, v.11 no.1 , 4343-4343
    SCI
  • [학술지논문] Glycogen Synthase Kinase 3 beta Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis JOURNAL OF IMMUNOLOGY, 2019, v.203 no.11 , 2990-2999
    SCI
  • [학술지논문] RACK1 interaction with c-Src is essential for osteoclast function EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51 no.7 , 86-86
    SCI
강의
  • 2023-2학기

  • 2023-1학기

  • 2022-2학기

    • 면역학

      • 학수번호 20593분반 01
      • 3학년 ( 3학점 , 3시간) 화 3~3 (포361) , 목 2~2 (포361)
    • 일반생물학실험II

      • 학수번호 33333분반 01
      • 1학년 ( 1학점 , 1.5시간) 월 6~7 (종A202)
      • 집중이수(8주) 수업
    • 일반생물학실험II

      • 학수번호 33333분반 02
      • 1학년 ( 1학점 , 1.5시간) 수 6~7 (종A202)
      • 집중이수(8주) 수업
    • 분자의생물학

      • 학수번호 36336분반 01
      • 4학년 ( 3학점 , 3시간) 수 3~3 (종A) , 금 2~2 (101)
    • 생명과학세미나Ⅳ

      • 학수번호 G16931분반 01
      • 학년 ( 3학점 , 3시간) 목 3~4 (종C)
    • 생명과학연구Ⅱ

      • 학수번호 G16933분반 01
      • 학년 ( 3학점 , 3시간)
    • 면역학특론

      • 학수번호 G16953분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6 (종C)
  • 2022-1학기

    • 일반생물학

      • 학수번호 20412분반 01
      • 1학년 ( 3학점 , 3시간) 월 4~4 (포453) , 목 5~5 (포453)
    • 생명과학실험III

      • 학수번호 35313분반 01
      • 3학년 ( 2학점 , 3시간) 화 6~7 (종A202)
    • 생명과학실험III

      • 학수번호 35313분반 02
      • 3학년 ( 2학점 , 3시간) 금 6~7 (종A202)
    • 고급면역학

      • 학수번호 G16979분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6 (종C)
  • 2021-2학기

    • 면역학

      • 학수번호 20593분반 01
      • 3학년 ( 3학점 , 3시간) 화 3~3 , 목 2~2
    • 면역학특론

      • 학수번호 G16953분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6 (종C418)
  • 2021-1학기

    • 생명의신비

      • 학수번호 10066분반 01
      • 학년 ( 3학점 , 3시간) 화 3~3 , 금 3~3
      • 수강불가:자연대,엘텍공대,의대,간호대,약대 재학생 및 일반생물학, 일반생물학I,II 수강생
    • 일반생물학

      • 학수번호 20412분반 01
      • 1학년 ( 3학점 , 3시간) 월 3~3 , 수 2~2
      • 자연대,호크마대1, 팀티칭
    • 생명과학실험III

      • 학수번호 35313분반 01
      • 3학년 ( 2학점 , 3시간) 화 6~7 (종A205)
    • 생명과학실험III

      • 학수번호 35313분반 02
      • 3학년 ( 2학점 , 3시간) 목 6~7 (종A205)
    • 고급면역학

      • 학수번호 G16979분반 01
      • 학년 ( 3학점 , 3시간) 화 5~6 (종C418)
학력

고려대학교(서울) 농학박사(농화학과)