이화여자대학교

Hyunbo Shim Professor

Life Sciences/College of Medicine/Life Sciences

심현보 프로필 사진 
Prof. Hyunbo Shim (Department of Life Science) is an expert in antibody engineering. He received B.S. and M.S. degrees in chemistry from Seoul National University, and Ph.D. degree in bioorganic chemistry from Texas A&M university. In the Scripps Research Institute and XOMA Ltd., he performed research in antibody engineering. Currently his research interest includes the development of platform technologies for antibody engineering and the development of antibodies for therapeutic applications. The human antibody library technology from his laboratory has been licenced out to multiple pharmaceutical and biotech companies.
Research Record
  • 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis Nature Communications, 2024, v.15 no.1, 0
    SCIE Scopus dColl.
  • A single-domain antibody library based on a stability-engineered human VH3 scaffold Scientific Reports, 2024, v.14 no.1, 17747
    SCIE Scopus dColl.
  • A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants FRONTIERS IN IMMUNOLOGY, 2023, v.14, 1271508
    SCIE Scopus dColl.
  • Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis Biomedicines, 2023, v.11 no.10, 2844
    SCIE Scopus dColl.
  • A Fully‐Human Antibody Specifically Targeting a Membrane‐Bound Fragment of CADM1 Potentiates the T Cell‐Mediated Death of Human Small‐Cell Lung Cancer Cells International Journal of Molecular Sciences, 2022, v.23 no.13, 6895
    SCIE Scopus dColl.
  • A Novel Synthetic Antibody Library with Complementarity-Determining Region Diversities Designed for an Improved Amplification Profile International Journal of Molecular Sciences, 2022, v.23 no.11, 6255
    SCIE Scopus dColl.
  • An internalizing antibody targeting of cell surface GRP94 effectively suppresses tumor angiogenesis of colorectal cancer Biomedicine and Pharmacotherapy, 2022, v.150, 113051
    SCIE Scopus dColl.
  • Development and Characterization of Phage-Display-Derived Novel Human Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Biomedicines, 2022, v.10 no.12, 3274
    SCIE Scopus dColl.
  • An isoform of the oncogenic splice variant AIMP2-DX2 detected by a novel monoclonal antibody Biomolecules, 2020, v.10 no.6, 820
    SCIE Scopus dColl.
  • Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis Circulation, 2020 , 1736-1751
    SCIE Scopus dColl.
  • Bispecific antibodies and antibody–drug conjugates for cancer therapy: Technological considerations Biomolecules, 2020, v.10 no.3, 360
    SCIE Scopus dColl.
  • Development of human monoclonal antibody for claudin-3 overexpressing carcinoma targeting Biomolecules, 2020, v.10 no.1, 51
    SCIE Scopus dColl.
  • Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation Nature Communications, 2020, v.11 no.1, 4343
    SCIE Scopus dColl.
  • Antibody-based targeting of cell surface grp94 specifically inhibits cetuximab-resistant colorectal cancer growth Biomolecules, 2019, v.9 no.11, 681
    SCIE Scopus dColl.
  • Construction of rabbit immune antibody libraries Methods in Molecular Biology, 2018, v.1701, 133-146
    Scopus dColl.
  • A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In Vitro INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, v.18 no.3
    SCIE Scopus dColl.
  • Antibody Phage Display RECOMBINANT ANTIBODIES FOR INFECTIOUS DISEASES, 2017, v.1053, 21-34
    SCIE Scopus dColl.
  • Construction of a scFv library with synthetic, non-combinatorial CDR diversity Methods in Molecular Biology, 2017, v.1575, 15-29
    Scopus dColl.
  • Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer JOURNAL OF CANCER, 2017, v.8 no.8, 1347-1354
    SCIE Scopus dColl.
  • Development of a sandwich enzyme-linked immunosorbent assay for the detection of CD44v3 using exon v3-and v6-specific monoclonal antibody pairs JOURNAL OF IMMUNOLOGICAL METHODS, 2016, v.436, 22-28
    SCIE Scopus dColl.
  • Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions-Targeted siRNA delivery to pro-atherogenic endothelium in vivo Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection Nature Microbiology, 2016, v.2
    SCIE Scopus dColl.
  • Therapeutic Antibodies by Phage Display CURRENT PHARMACEUTICAL DESIGN, 2016, v.22 no.43, 6538-6559
    SCIE Scopus dColl.
  • A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity PLOS ONE, 2015, v.10 no.10
    SCIE Scopus dColl.
  • Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer PLOS ONE, 2015, v.10 no.7
    SCIE Scopus dColl.
  • Generation of a human antibody that inhibits TSPAN8-mediated invasion of metastatic colorectal cancer cells Biochemical and Biophysical Research Communications, 2015, v.468 no.4, 774-780
    SCIE Scopus dColl.
  • Synthetic approach to the generation of antibody diversity BMB REPORTS, 2015, v.48 no.9, 489-493
    SCIE KCI Scopus dColl.
  • Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, v.111 no.17, 6269-6274
    SCIE Scopus dColl.
  • [학술지논문] Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis BIOMEDICINES, 2023, v.11 no.10 , 2844-2844
    SCIE
  • [학술지논문] An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody BIOMOLECULES, 2020, v.10 no.6 , 820-820
    SCIE
  • [학술지논문] Development of human monoclonal antibody for claudin-3 overexpressing carcinoma targeting BIOMOLECULES, 2020, v.10 no.1 , 51-51
    SCIE
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Courses

  • 2024-2nd

    • General Biology

      • Subject No 20412Class No 03
      • 1Year ( 3Credit , 3Hour) Mon 5~5 (SCI-AA) , Wed 4~4 (102)
        • Syllabus(File)

    • Biochemistry Ⅱ

      • Subject No 35824Class No 02
      • 2Year ( 3Credit , 3Hour) Tue 4~4 (POSCO362) , Fri 5~5 (POSCO362)
        • Syllabus(File)

    • Research for Life Science Ⅱ

    • Antibody Engineering & Immunotherapy

      • Subject No G16994Class No 01
      • Year ( 3Credit , 3Hour) Mon 3~4 (SCI-C)
        • Syllabus(File)

    • Biological Chemistry and Education

      • Subject No BI352Class No 01
      • Year ( 3Credit , 3Hour) Thu 8~9 (EDU-)
        • Syllabus(File)

  • 2024-1st

    • Biochemistry

      • Subject No 21963Class No 01
      • 3Year ( 3Credit , 3Hour) Thu 4~5 (EDU-A202)
        • Syllabus(File)

    • Biochemistry Ⅰ

      • Subject No 33716Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO361) , Wed 2~2 (POSCO361)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
        • Syllabus(File)

    • Colloquium of Life Science Research

      • Subject No 36337Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 4~4 (POSCO161) , Fri 5~5 (POSCO161)
        • Syllabus(File)

    • Experiment Theory for Life Sciences Ⅰ

      • Subject No G16968Class No 01
      • Year ( 3Credit , 3Hour) Mon 7~8 (SCI-C)
        • Syllabus(File)

  • 2023-2nd

  • 2023-1st

  • 2021-2nd

    • Biochemistry

      • Subject No 21963Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 4~4 (EDU-A313) , Wed 4~4 (EDU-A313)
        • Syllabus(File)

    • Biochemistry II

      • Subject No 35824Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 4~4 (POSCO451) , Thu 5~5 (POSCO451)
        • Syllabus(File)

    • Antibody Engineering & Immunotherapy

      • Subject No G16994Class No 01
      • Year ( 3Credit , 3Hour) Thu 6~7 (SCI-C)
        • Syllabus(File)

  • 2021-1st

    • Introductory Biology

      • Subject No 10066Class No 01
      • Year ( 3Credit , 3Hour) Tue 3~3 , Fri 3~3
        • Syllabus(File)

    • General Biology I

      • Subject No 20413Class No 01
      • 1Year ( 3Credit , 3Hour) Tue 2~2 , Fri 3~3
        • Syllabus(File)

    • Biochemistry I

      • Subject No 33716Class No 01
      • 2Year ( 3Credit , 3Hour) Wed 3~3 (POSCO363) , Fri 2~2 (POSCO363)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Thu 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Fri 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Thu 4~5 (SCI-AA205)

    • Research for Life ScienceⅢ

    • Experiment Theory for Life SciencesⅠ

      • Subject No G16968Class No 01
      • Year ( 3Credit , 3Hour) Mon 7~8 (SCI-C)
        • Syllabus(File)

    • Bio Technology

      • Subject No G16974Class No 01
      • Year ( 3Credit , 3Hour) Wed 5~6 (SCI-C)
        • Syllabus(File)

    • Experiment Theory for Life SciencesⅠ

      • Subject No G17775Class No 01
      • Year ( 3Credit , 3Hour) Mon 7~8 (SCI-C)
        • Syllabus(File)
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Academic Background

Texas A&M University Ph.D.(화학)