Lyoo, In Kyoon Professor
Pharmaceutical Sciences/Industrial Pharmaceutical Science/Division of Pharmacy/Division of Brain & Cognitive Sciences
Professor Lyoo is a recognized researcher in stress resilience and posttraumatic stress disorder. Dr. Lyoo’s primary research has focused on brain mechanisms underlying psychiatric disorders using non-invasive imaging techniques, such as magnetic resonance imaging. He has published over one hundred and eighty papers in peer-reviewed journals including high-profile journals, which have broadened perspectives on identifying the populations that are more vulnerable to psychiatric disorders. In his decades-long career as a psychiatrist and neuroscientist, his enthusiasm slowly shifted from studying mental disorders to establishing boundaries between normality and disorder conditions. These experiences have expanded his research areas, including drug dependence, mood disorders, aging and geriatric conditions. He deeply appreciates a number of grant supports and awards from US NIH, Stanley Medical Research Institute, Brain and Behavior Research Foundation, and Korean governmental organizations.
- Director, Ewha Brain Institute
- Pharmaceutical Science Building A(Appenzeller Hall) #202
- 02-3277-6554
- Office hours
- 월요일 수요일 오후 5시-6시
Research Record
- Alterations in Brain Morphometric Networks and Their Relationship with Memory Dysfunction in Patients with Type 2 Diabetes Mellitus Experimental Neurobiology, 2024, v.33 no.2, 107-117
- Changes in Structural Covariance among Olfactory-related Brain Regions in Anosmia Patients Experimental Neurobiology, 2024, v.33 no.2, 99-106
- Identifying unique subgroups in suicide risks among psychiatric outpatients Comprehensive Psychiatry, 2024, v.131, 152463
- Impact of sleep disturbance in shift workers on hippocampal volume and psychomotor speed Sleep, 2024, v.47 no.9, zsae100
- Aberrant Resting-state Functional Connectivity in Complex Regional Pain Syndrome: A Network-based Statistics Analysis Experimental Neurobiology, 2023, v.32 no.2, 110-118
- Brain age prediction using combined deep convolutional neural network and multi-layer perceptron algorithms Scientific Reports, 2023, v.13 no.1, 22388
- Cerebral cortical thinning in brain regions involved in emotional regulation relates to persistent symptoms in subjects with posttraumatic stress disorder Psychiatry Research, 2023, v.327, 115345
- Disturbed insular functional connectivity and its clinical implication in patients with complex regional pain syndrome NEUROIMAGE-CLINICAL, 2023, v.38, 103440
- Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation European Archives of Psychiatry and Clinical Neuroscience, 2023, v.273 no.1, 99-111
- Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress Experimental Neurobiology, 2023, v.32 no.2, 91-101
- Overweight/Obesity-related microstructural alterations of the fimbria-fornix in the ABCD study: The role of aerobic physical activity PLoS ONE, 2023, v.18 no.7, e0287682
- Peripheral Markers of Suicidal Behavior: Current Findings and Clinical Implications Clinical Psychopharmacology and Neuroscience, 2023, v.21 no.4, 650-664
- Targeting the translationally controlled tumor protein by a monoclonal antibody improves allergic airway inflammation in mice Biomedicine and Pharmacotherapy, 2023, v.168, 115655
- Differential alterations in brain structural network organization during addiction between adolescents and adults Psychological Medicine, 2022
- Effect of Cannabinoids on Brain Metabolites: A Review of Animal and Human Studies Experimental and Clinical Psychopharmacology, 2022
- Gray matter volume reduction in the emotional brain networks in adults with anosmia Journal of Neuroscience Research, 2022, v.100 no.6, 1321-1330
- Altered functional activity in bipolar disorder: A comprehensive review from a large-scale network perspective Brain and Behavior, 2021, v.11 no.1, e01953
- Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation Scientific Reports, 2021, v.11 no.1, 2710
- Changes in Prefrontal Gamma-Aminobutyric Acid and Perfusion After the Computerized Relaxation Training in Women With Psychological Distress: A Preliminary Report Frontiers in Psychology, 2021, v.12, 569113
- Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study Human Psychopharmacology, 2021, v.36 no.2, e2767
- Effects of cytidine-5 '-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study JOURNAL OF PSYCHIATRIC RESEARCH, 2021, v.143, 215-221
- Elevating the level of hypoxia inducible factor may be a new potential target for the treatment of depression MEDICAL HYPOTHESES, 2021, v.146, 110398
- Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress Neurological Sciences, 2021, v.42 no.10
- Hippocampal subregional alterations and verbal fluency in the early stage of type 2 diabetes mellitus EUROPEAN JOURNAL OF NEUROSCIENCE, 2021, v.54 no.10, 7550-7559
- Prefrontal White Matter Abnormalities Associated With Pain Catastrophizing in Patients With Complex Regional Pain Syndrome Archives of Physical Medicine and Rehabilitation, 2021, v.102 no.2, 216-224
- A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms Nature Communications, 2020, v.11 no.1, 1898
- Decreased functional connectivity within the salience network after two-week morning bright light exposure in individuals with sleep disturbances: a preliminary randomized controlled trial Sleep Medicine, 2020, v.74, 66-72
- FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals Scientific reports, 2020, v.10 no.1, 3353
- Identification of Tendency to Alcohol Misuse From the Structural Brain Networks FRONTIERS IN SYSTEMS NEUROSCIENCE, 2020, v.14, 9
- Volume and shape analysis of the Hippocampus and amygdala in veterans with traumatic brain injury and posttraumatic stress disorder Brain Imaging and Behavior, 2020, v.14 no.5, 1850-1864
- Alterations in structural rich-club connectivity of the precuneus are associated with depressive symptoms among individuals with subjective memory complaints Cognitive, Affective and Behavioral Neuroscience, 2019, v.19 no.1, 73-87
- Altered functional connectivity in the fear network of firefighters with repeated traumatic stress BRITISH JOURNAL OF PSYCHIATRY, 2019, v.214 no.6, 347-353
- Diverging roles of the anterior insula in trauma-exposed individuals vulnerable or resilient to posttraumatic stress disorder Scientific Reports, 2019, v.9 no.1, 15539
- Low Prefrontal GABA Levels Are Associated With Poor Cognitive Functions in Professional Boxers FRONTIERS IN HUMAN NEUROSCIENCE, 2019, v.13, 193
- 비심인성 흉부 불편감을 가진 대상자에서 컴퓨터 기반 인지행동치료의 효과성 : 문헌 검토와 새로운 프로토콜 제안 생물정신의학, 2019, v.26 no.1, 1-7
- Altered attentional control over the salience network in complex regional pain syndrome Scientific Reports, 2018, v.8 no.1
- Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated learning MOLECULAR PSYCHIATRY, 2018, v.23 no.4, 1021-1030
- Brain structural changes in cynomolgus monkeys administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A longitudinal voxel-based morphometry and diffusion tensor imaging study PLOS ONE, 2018, v.13 no.1, e0189804
- Firefighters, posttraumatic stress disorder, and barriers to treatment: Results from a nationwide total population survey PLOS ONE, 2018, v.13 no.1, e0190630
- Hypoxia-Induced Neuroinflammation and Learning-Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine MOLECULAR NEUROBIOLOGY, 2018, v.55 no.11, 8738-8753
- Increased efficiency of brain connectivity networks in veterans with suicide attempts NEUROIMAGE-CLINICAL, 2018, v.20, 318-326
- Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users ADDICTION BIOLOGY, 2018, v.23 no.1, 327-336
- Negative Mood States Correlate with Laterobasal Amygdala in Collegiate Football Players BIOMED RESEARCH INTERNATIONAL, 2018 , 8142631
- Prefronto-temporal white matter microstructural alterations 20 years after the diagnosis of type 1 diabetes mellitus PEDIATRIC DIABETES, 2018, v.19 no.3, 478-485
- Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus Diabetologia, 2017, v.60 no.7, 1207-1217
- Diagnostic potential of multimodal neuroimaging in posttraumatic stress disorder PLoS ONE, 2017, v.12 no.5
- Immunohistochemical localization of translationally controlled tumor protein in axon terminals of mouse hippocampal neurons Experimental Neurobiology, 2017, v.26 no.2, 82-89
- Lipopolysaccharide (LPS)-stimulated iNOS induction is increased by glucosamine under normal glucose conditions but is inhibited by glucosamine under high glucose conditions in macrophage cells Journal of Biological Chemistry, 2017, v.292 no.5, 1724-1736
- Network attributes underlying intellectual giftedness in the developing brain Scientific Reports, 2017, v.7 no.1, 11321
- Psychometric Properties of the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) in Public First Responders Substance Use and Misuse, 2017, v.52 no.8, 1069-1075
- Recovery from Posttraumatic Stress Requires Dynamic and Sequential Shifts in Amygdalar Connectivities Neuropsychopharmacology, 2017, v.42 no.2, 454-461
- The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network FRONTIERS IN HUMAN NEUROSCIENCE, 2017, v.11
- 탈수초화 동물 모델과 1H 자기공명분광영상 생물정신의학, 2017, v.24 no.1, 1-9
- A tryptamine-paeonol hybridization compound inhibits LPS-mediated inflammation in BV2 cells NEUROCHEMISTRY INTERNATIONAL, 2016, v.100, 35-43
- Effects of Creatine Monohydrate Augmentation on Brain Metabolic and Network Outcome Measures in Women With Major Depressive Disorder Biological Psychiatry, 2016, 15 DEC 2015
- Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial AMERICAN JOURNAL OF CHINESE MEDICINE, 2016, v.44 no.3, 489-514
- Prefrontal Cortical Thickness Deficit in Detoxified Alcohol-dependent Patients Experimental Neurobiology, 2016, v.25 no.6, 333
- Subregional Shape Alterations in the Amygdala in Patients with Panic Disorder PLOS ONE, 2016, v.11 no.6
- Using a Tablet Device to Compensate for Underestimation of Cognitive Function due to Impaired Dominant Hand Function in Stroke Patients International Journal of Human-Computer Interaction, 2016, 33, 1-5
- Functional connectivity of insula, basal ganglia, and prefrontal executive control networks during hypoglycemia in type 1 diabetes Journal of Neuroscience, 2015, v.35 no.31, 11012-11023
- MR images of mouse brain using clinical 3T MR scanner and 4CH-Mouse coil JOURNAL OF THE KOREAN PHYSICAL SOCIETY, 2015, v.67 no.1, 237-242
- Predisposition to and effects of methamphetamine use on the adolescent brain Molecular Psychiatry, 2015, v.20 no.12, 1516-1524
- Validation of the Athens Insomnia Scale for screening insomnia in South Korean firefighters and rescue workers Quality of Life Research, 2015, v.24 no.10, 2391-2395
- Validation of the Korean version of the Connor-Davidson Resilience Scale-2 in firefighters and rescue workers COMPREHENSIVE PSYCHIATRY, 2015, v.59, 123-128
- 뇌과학 분야 기능적 연결체학의 발전 : 외상후스트레스장애를 중심으로 생물정신의학, 2015, v.22 no.3, 101-108
- Neurocognitive Changes and Their Neural Correlates in Patients with Type 2 Diabetes Mellitus Endocrinology and Metabolism, 2014, 제29권 2호, 112-121
- Neurocognitive changes and their neural correlates in patients with type 2 diabetes mellitus Endocrinology and Metabolism, 2014, v.29 no.2, 112-121
- The mental health sequelae of traumatic head injury in South Vietnamese ex-political detainees who survived torture COMPREHENSIVE PSYCHIATRY, 2014, v.55 no.7, 1626-1638
- [학술지논문] Altered attentional control over the salience network in complex regional pain syndrome SCIENTIFIC REPORTS, 2018, v.8 no.0 , 7466-7466
- [학술지논문] Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated learning MOLECULAR PSYCHIATRY, 2018, v.23 no.4 , 1021-1030
- [학술지논문] Brain structural changes in cynomolgus monkeys administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A longitudinal voxel-based morphometry and diffusion tensor imaging study PLOS ONE, 2018, v.13 no.1 , 0189804-0189804
- [학술지논문] Firefighters, posttraumatic stress disorder, and barriers to treatment: Results from a nationwide total population survey PLOS ONE, 2018, v.13 no.1 , 0190630-0190630
- [학술지논문] Hypoxia-Induced Neuroinflammation and Learning-Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine MOLECULAR NEUROBIOLOGY, 2018, v.55 no.11 , 8738-8753
- [학술지논문] Negative Mood States Correlate with Laterobasal Amygdala in Collegiate Football Players BIOMED RESEARCH INTERNATIONAL, 2018, v.2018 no.2018 , 1-11
- [학술지논문] Prefronto-temporal white matter microstructural alterations 20 years after the diagnosis of type 1 diabetes mellitus PEDIATRIC DIABETES, 2018, v.19 no.3 , 478-485
- [학술지논문] Network attributes underlying intellectual giftedness in the developing brain SCIENTIFIC REPORTS, 2017, v.7 no.1 , 11321-11321
- [학술지논문] The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network FRONTIERS IN HUMAN NEUROSCIENCE, 2017, v.11 no.400 , 1-10
- [학술지논문] Effects of Creatine Monohydrate Augmentation on Brain Metabolic and Network Outcome Measures in Women With Major Depressive Disorder BIOLOGICAL PSYCHIATRY, 2016, v.80 no.6 , 439-447
- [학술지논문] Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial AMERICAN JOURNAL OF CHINESE MEDICINE, 2016, v.44 no.3 , 489-514
- [학술지논문] 소방공무원과 구조대원에서 한국어판 Post-Traumatic Stress Disorder Checklist의 신뢰도와 타당도 생물정신의학, 2016, v.23 no.1 , 29-36
- [학술지논문] Validation of the Korean version of the Connor-Davidson Resilience Scale-2 in firefighters and rescue workers COMPREHENSIVE PSYCHIATRY, 2015, v.59 no.1 , 123-128
Courses
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2025-1st
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Introduction to Pharmaceutical Research
- Subject No 38940Class No 01
- 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
- Major Requisite
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Pathophysiology 강의 계획서 상세보기
- Subject No 38949Class No 01
- 3Year ( 3Credit , 3Hour) Mon 2~2 (POSCO551) , Fri 3~3 (POSCO555)
- Major Requisite
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Pathophysiology 강의 계획서 상세보기
- Subject No 38949Class No 02
- 3Year ( 3Credit , 3Hour) Mon 4~4 (POSCO152) , Fri 5~5 (POSCO555)
- Major Requisite
-
Pathophysiology 강의 계획서 상세보기
- Subject No 39054Class No 01
- 3Year ( 3Credit , 3Hour) Mon 3~3 (POSCO551) , Fri 4~4 (POSCO555)
- Major Requisite
-
Understanding of Neuroimaging Techniques and Hands-on Experiences 1 강의 계획서 상세보기
- Subject No G17742Class No 01
- Year ( 3Credit , 3Hour) Tue 7~8 (I-EDU602)
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2024-2nd
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Application of Molecular-Network Neuroimaging in Neuropsychopharmacology 강의 계획서 상세보기
- Subject No G17212Class No 01
- Year ( 3Credit , 3Hour) Fri 7~8 (-108)
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2023-2nd
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Physiology 강의 계획서 상세보기
- Subject No 33950Class No 01
- 3Year ( 3Credit , 3Hour) Mon 5~5 (POSCO551) , Thu 6~6 (POSCO551)
- Major Requisite
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Physiology 강의 계획서 상세보기
- Subject No 33950Class No 02
- 3Year ( 3Credit , 3Hour) Mon 4~4 (POSCO551) , Thu 4~4 (POSCO551)
- Major Requisite
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Physiology 강의 계획서 상세보기
- Subject No 33950Class No 03
- 3Year ( 3Credit , 3Hour) Mon 6~6 (POSCO551) , Thu 5~5 (POSCO551)
- Major Requisite
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Advanced Pharmacy Practice and Research I 강의 계획서 상세보기
- Subject No 37154Class No 01
- 6Year ( 4Credit , 200Hour)
- Major Requisite
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Advanced Pharmacy Practice and Research Ⅱ 강의 계획서 상세보기
- Subject No 37155Class No 01
- 6Year ( 4Credit , 200Hour)
- Major Requisite
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Advanced Pharmacy Practice and Research Ⅲ 강의 계획서 상세보기
- Subject No 37156Class No 01
- 6Year ( 4Credit , 200Hour)
- Major Requisite
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Anatomy and Physiology Ⅱ 강의 계획서 상세보기
- Subject No 38937Class No 01
- 2Year ( 3Credit , 3Hour) Tue 2~2 (POSCO551) , Fri 3~3 (POSCO551)
- Major Requisite
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Anatomy and Physiology Ⅱ 강의 계획서 상세보기
- Subject No 38937Class No 02
- 2Year ( 3Credit , 3Hour) Tue 3~3 (POSCO551) , Fri 2~2 (POSCO551)
- Major Requisite
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Anatomy and Physiology Ⅱ 강의 계획서 상세보기
- Subject No 39042Class No 01
- 2Year ( 3Credit , 3Hour) Tue 4~4 (POSCO551) , Fri 4~4 (POSCO551)
- Major Requisite
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2023-1st
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Pathophysiology 강의 계획서 상세보기
- Subject No 37125Class No 01
- 4Year ( 3Credit , 3Hour) Mon 2~2 (POSCO551) , Thu 2~2 (POSCO551)
- Major Requisite
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Pathophysiology
- Subject No 37125Class No 02
- 4Year ( 3Credit , 3Hour) Mon 4~4 (POSCO551) , Thu 6~6 (POSCO551)
- Major Requisite
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Pathophysiology
- Subject No 37125Class No 03
- 4Year ( 3Credit , 3Hour) Mon 3~3 (POSCO551) , Thu 3~3 (POSCO551)
- Major Requisite
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Computational Medicine; Translating Models to Medicine 강의 계획서 상세보기
- Subject No 38920Class No 01
- Year ( 3Credit , 3Hour) Mon 3~4
- Major Requisite
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Anatomy and Physiology Ⅰ 강의 계획서 상세보기
- Subject No 38929Class No 01
- 2Year ( 1.5Credit , 1.5Hour) Mon 5~5 (POSCO551)
- Major Requisite
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Anatomy and Physiology Ⅰ 강의 계획서 상세보기
- Subject No 38929Class No 02
- 2Year ( 1.5Credit , 1.5Hour) Mon 6~6 (POSCO551)
- Major Requisite
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Introduction to Pharmaceutical Research 강의 계획서 상세보기
- Subject No 38940Class No 01
- 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
- Major Requisite
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Anatomy and Physiology Ⅰ 강의 계획서 상세보기
- Subject No 39034Class No 01
- 2Year ( 1.5Credit , 1.5Hour) Wed 3~3 (POSCO551)
- Major Requisite
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2022-2nd
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Advanced Pharmacy Practice and Research Ⅱ
- Subject No 37155Class No 01
- 6Year ( 4Credit , 200Hour)
- Major Requisite
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Current topics in Neurosciences
- Subject No G16013Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8 (I-EDU601)
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Understanding of Neuroimaging Techniques and Hands-on Experiences 2
- Subject No G17743Class No 01
- Year ( 3Credit , 3Hour) Mon 7~8 (I-EDU601)
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2022-1st
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Computational Medicine; Translating Models to Medicine
- Subject No 38920Class No 01
- Year ( 3Credit , 3Hour) Mon 3~4
- Major Requisite
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Brain & Cognitive Science Seminars 3
- Subject No G16256Class No 01
- Year ( 3Credit , 3Hour) Tue 7~8 (-)
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Understanding of Neuroimaging Techniques and Hands-on Experiences 1
- Subject No G17742Class No 01
- Year ( 3Credit , 3Hour) Fri 7~8 (-)
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Academic Background
Seoul Nat'l Univ. 의학박사(의학과)
Harvard University M.M.Sc.(Neuroscience)
Seoul Nat'l Univ. 의학사(의학과)