이화여자대학교

Hyun Ae Woo Professor

Pharmaceutical Sciences/Division of Pharmacy/Industrial Pharmaceutical Science

우현애 프로필 사진 
Dr. Hyun Ae Woo is an assistant professor of the Graduate School of Pharmaceutical Sciences. She attended Ewha Womans University, majoring Pharmacy, and receiving a B.S. degree in 1997 and M.S. degree in 1999. She received her Ph.D. in Division of Molecular Life Sciences, from Ewha Womans University in 2005. Her research has focused on the elucidation of the role of reactive oxygen species and antioxidant enzymes in cell signaling. She was rewarded the Society for Free Radical Research Asia for Young Scientist in 2006. And she also received the Bioneer New Generation Investigator Award in 2010, and the Fellowship of the Korean LOREAL-UNESCO Women Life Science Award in 2011.
Research Record
  • Mitochondrial Peroxiredoxin III Protects against Non-Alcoholic Fatty Liver Disease Caused by a Methionine-Choline Deficient Diet ANTIOXIDANTS, 2023, v.12 no.1, 9
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  • Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1β mRNA Expression International Journal of Molecular Sciences, 2022, v.23 no.10, 5331
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  • Novel Small Molecule Inhibitors Targeting the IL-6/STAT3 Pathway or IL-1β Molecules, 2022, v.27 no.9, 2696
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  • Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver Science Advances, 2021, v.7 no.9, eabf4398
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  • Maturation of Mitochondrially Targeted Prx V Involves a Second Cleavage by Mitochondrial Intermediate Peptidase That Is Sensitive to Inhibition by H2O2 ANTIOXIDANTS, 2021, v.10 no.3, 346
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  • Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer British Journal of Cancer, 2021, v.125 no.8, 1146-1157
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  • Redox Regulation of PTEN by Peroxiredoxins ANTIOXIDANTS, 2021, v.10 no.2, 302
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  • The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver Free Radical Biology and Medicine, 2021, v.162, 141-148
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  • Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice ANTIOXIDANTS, 2020, v.9 no.8, 769
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  • Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway World journal of gastroenterology, 2020, v.26 no.3, 291-306
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  • Multiple functions of 2-Cys peroxiredoxins, I and II, and their regulations via post -translational modifications FREE RADICAL BIOLOGY AND MEDICINE, 2020, v.152, 107-115
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  • Peroxiredoxin 3 has important roles on arsenic trioxide induced apoptosis in human acute promyelocytic leukemia cell line via hyperoxidation of mitochondrial specific reactive oxygen species Molecules and Cells, 2020, v.43 no.9, 813-820
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  • Redox regulation of tumor suppressor PTEN in cell signaling Redox Biology, 2020, v.34, 101553
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  • Regulation of Autophagy Is a Novel Tumorigenesis-Related Activity of Multifunctional Translationally Controlled Tumor Protein CELLS, 2020, v.9 no.1, 257
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  • Constituents of the leaves and twigs of Elaeagnus umbellata and their proliferative effects on human keratinocyte HaCaT cells Fitoterapia, 2019, v.139, 104374
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  • Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, v.2019, 2828493
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  • Peroxiredoxin5 Controls Vertebrate Ciliogenesis by Modulating Mitochondrial Reactive Oxygen Species Antioxidants and Redox Signaling, 2019, v.30 no.14, 1731-1745
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  • Peroxiredoxin 5 regulates adipogenesis-attenuating oxidative stress in obese mouse models induced by a high-fat diet FREE RADICAL BIOLOGY AND MEDICINE, 2018, v.123, 27-38
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  • Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, v.19 no.6
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  • The Role of Peroxiredoxins in the Transduction of H2O2 Signals ANTIOXIDANTS & REDOX SIGNALING, 2018, v.28 no.7, 537-557
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  • Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells Bioorganic and Medicinal Chemistry Letters, 2017, v.27 no.14, 3065-3070
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  • PI3K-mTOR-S6K Signaling Mediates Neuronal Viability via Collapsin Response Mediator Protein-2 Expression FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, v.10
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  • Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, v.137 no.6, 1333-1342
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  • Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide Free Radical Biology and Medicine, 2017, v.112, 277-286
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  • TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway AUTOPHAGY, 2017, v.13 no.5, 820-833
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  • Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-kappa B-Dependent Pathway, Leading to Modulation of Apoptosis INFECTION AND IMMUNITY, 2016, v.84 no.9, 2541-2554
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  • Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-I kappa B Kinase-NF-kappa B Pathways in Dendritic Cells INFECTION AND IMMUNITY, 2016, v.84 no.8, 2162-2174
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  • Identification of cytoprotective constituents of the flower buds of Tussilago farfara against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells Archives of Pharmacal Research, 2016, v.39 no.4, 1-7
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  • MITOCHONDRIAL SPECIFIC ROS HYPEROXIDATION VIA PEROXIREDOXIN III HAS IMPORTANT ROLES ON ARSENIC TRIOXIDE INDUCED APOPTOSIS IN ACUTE PROMYELOCYTIC LEUKEMIA HAEMATOLOGICA, 2016, v.101, 672-672
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  • A New 9,10-Dihydrophenanthrene and Cell Proliferative 3,4-delta-Dehydrotocopherols from Stemona tuberosa MOLECULES, 2015, v.20 no.4, 5965-5974
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  • Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression JOURNAL OF CELL BIOLOGY, 2015, v.210 no.1, 23-33
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  • EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling Cellular and molecular life sciences : CMLS, 2015, v.72 no.10, 2023-2039
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  • Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, v.111 no.33, 12043-12048
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  • Peroxiredoxin 3 has a crucial role in the contractile function of skeletal muscle by regulating mitochondrial homeostasis FREE RADICAL BIOLOGY AND MEDICINE, 2014, v.77, 298-306
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  • Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, v.111 no.17, 6269-6274
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Academic Background

Ewha Womans University 약학박사(분자생명과학부)