이화여자대학교

So-Yeon Park Assistant Professor

Pharmaceutical Sciences / Industrial Pharmaceutical Science / Division of Pharmacy

박소연 프로필 사진 
So-Yeon Park specializes in drug discovery grounded in disease pathophysiology, pursuing phenotype-driven drug discovery that uses organoid models to identify therapeutic targets capable of reversing disease phenotypes.

She earned her B.S. in Pharmacy at Ewha Womans University and completed an integrated M.S./Ph.D. program at its Graduate School of Pharmaceutical Sciences, with doctoral work on the mechanisms of radioresistance based on bioinformatics. She subsequently served as a postdoctoral fellow and research assistant professor at the Gwangju Institute of Science and Technology (GIST) and as a senior researcher at the Center for Genome Engineering, Institute for Basic Science (IBS), where she conducted organoid gene-engineering research. She joined the College of Pharmacy at Ewha Womans University in 2024.

Her research centers on organoid-based target identification, drug screening, and the mechanisms of cancer metastasis and therapy resistance. Notably, she developed an anti-cancer peptide targeting Dysadherin—a novel biomarker linked to poor prognosis in colorectal cancer—elucidating its mechanism of action and securing granted patents (Theranostics, IF 15.9; top 3.1% in Medicine, Research & Experimental), and she defined the role of DCLK1 kinase activity in driving cancer recurrence using AI-based structural analyses and genome-engineered mouse models. Her broader work, including aberrant lipid-raft signaling in therapy-resistant cancer cell subpopulations and drug repositioning for recurrent and metastatic cancer, has appeared in leading international journals.

More recently, she has extended her work to therapeutic targeting of the link between cellular senescence and autophagy, showing that inhibiting the senescence factor p16INK4a restores autophagy and alleviates pulmonary fibrosis—findings published in Signal Transduction and Targeted Therapy (IF 81.2; top 0.3% in Biochemistry & Molecular Biology, 2025 JCR). She has also examined the molecular basis of cell competition in intestinal stem cell homeostasis and disease in Experimental and Molecular Medicine, and now focuses on drug-discovery methodologies that begin with the pathophysiology of intractable diseases such as colorectal cancer, intestinal inflammation, and pulmonary fibrosis.
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Research Record
  • [학술지논문] Targeting the senescence-autophagy axis for idiopathic pulmonary fibrosis therapy TRENDS IN PHARMACOLOGICAL SCIENCES, 2026, v.47 no.4 , 403-422
    SCIE
  • [학술지논문] Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer MOLECULAR CANCER, 2025, v.24 no.1 , 139-139
    SCIE
  • [학술지논문] GTSE1-driven ZEB1 stabilization promotes pulmonary fibrosis through the epithelial-to-mesenchymal transition MOLECULAR THERAPY, 2024, v.32 no.11 , 4138-4157
    SCIE
  • GTSE1-driven ZEB1 stabilization promotes pulmonary fibrosis through the epithelial-to-mesenchymal transition Molecular Therapy, 2024, v.32 no.11, 4138-4157
    SCIE Scopus dColl.
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Courses

  • 2026-2nd

    • Anatomy and Physiology Ⅱ

      • Subject No 38937Class No 01
      • 2Year ( 3Credit , 3Hour) Wed 3~3 (POSCO551) , Fri 2~2 (POSCO551)
      • Major Requisite

    • Anatomy and Physiology Ⅱ

      • Subject No 38937Class No 02
      • 2Year ( 3Credit , 3Hour) Wed 4~4 (POSCO555) , Fri 3~3 (POSCO555)
      • Major Requisite

    • Pharmaceutical Experiment Laboratory Ⅲ

      • Subject No 38980Class No 01
      • 4Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A313)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory Ⅲ

      • Subject No 38980Class No 02
      • 4Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A313)
      • Major Requisite
        • Syllabus(File)

    • Anatomy and Physiology Ⅱ

      • Subject No 39042Class No 01
      • 2Year ( 3Credit , 3Hour) Wed 5~5 (POSCO551) , Fri 4~4 (POSCO551)
      • Major Requisite

    • Pharmaceutical Experiment Laboratory Ⅲ

      • Subject No 39085Class No 01
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A313)
      • Major Requisite
        • Syllabus(File)

    • Organoid and Omics Technologies for Pharmaceutical Research

      • Subject No G19003Class No 01
      • Year ( 3Credit , 3Hour) Fri 6~7 (PHM-A204)

  • 2026-1st

  • 2025-2nd

    • Advanced Pharmacy Practice and Research I

      • Subject No 37154Class No 01
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 01
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research Ⅲ

      • Subject No 37156Class No 01
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Anatomy and Physiology Ⅱ

    • Anatomy and Physiology Ⅱ

    • Pharmaceutical Experiment Laboratory Ⅲ 강의 계획서 상세보기

      • Subject No 38980Class No 01
      • 4Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A303-1)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory Ⅲ 강의 계획서 상세보기

      • Subject No 38980Class No 02
      • 4Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A303-1)
      • Major Requisite
        • Syllabus(File)

    • Honors Research Ⅰ

    • Anatomy and Physiology Ⅱ

    • Pharmaceutical Experiment Laboratory Ⅲ 강의 계획서 상세보기

      • Subject No 39085Class No 01
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A303-1)
      • Major Requisite
        • Syllabus(File)

    • Honors Research Ⅰ

  • 2025-1st

    • Honors research

    • Anatomy and Physiology Ⅰ

      • Subject No 38929Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Wed 4~4 (PHM-A104)
      • Major Requisite
        • Syllabus(File)

    • Anatomy and Physiology Ⅰ

      • Subject No 38929Class No 02
      • 2Year ( 1.5Credit , 1.5Hour) Wed 3~3 (POSCO552)
      • Major Requisite
        • Syllabus(File)

    • Introduction to Pharmaceutical Research

      • Subject No 38940Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
      • Major Requisite
        • Syllabus(File)

    • Pathophysiology 강의 계획서 상세보기

      • Subject No 38949Class No 01
      • 3Year ( 3Credit , 3Hour) Mon 2~2 (POSCO551) , Fri 3~3 (POSCO555)
      • Major Requisite
        • Syllabus(File)

    • Pathophysiology 강의 계획서 상세보기

      • Subject No 38949Class No 02
      • 3Year ( 3Credit , 3Hour) Mon 4~4 (POSCO152) , Fri 5~5 (POSCO555)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory Ⅲ

      • Subject No 38980Class No 01
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A303-1)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory Ⅲ

      • Subject No 38980Class No 02
      • 4Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A303-1)
      • Major Requisite
        • Syllabus(File)

    • Honors Research Ⅰ

    • Anatomy and Physiology Ⅰ

      • Subject No 39034Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Wed 5~5 (POSCO552)
      • Major Requisite
        • Syllabus(File)

    • Pathophysiology 강의 계획서 상세보기

      • Subject No 39054Class No 01
      • 3Year ( 3Credit , 3Hour) Mon 3~3 (POSCO551) , Fri 4~4 (POSCO555)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory Ⅲ

      • Subject No 39085Class No 01
      • 4Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A303-1)
      • Major Requisite
        • Syllabus(File)

    • Honors Research Ⅰ

  • 2024-2nd

  • 2024-1st

    • Pathophysiology

    • Pathophysiology

    • Pathophysiology

    • Anatomy and Physiology Ⅰ 강의 계획서 상세보기

      • Subject No 38929Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Wed 3~3 (POSCO552)
      • Major Requisite
        • Syllabus(File)

    • Anatomy and Physiology Ⅰ 강의 계획서 상세보기

      • Subject No 38929Class No 02
      • 2Year ( 1.5Credit , 1.5Hour) Wed 4~4 (POSCO552)
      • Major Requisite
        • Syllabus(File)

    • Introduction to Pharmaceutical Research

      • Subject No 38940Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
      • Major Requisite
        • Syllabus(File)

    • Pathophysiology

    • Pathophysiology

    • Anatomy and Physiology Ⅰ 강의 계획서 상세보기

      • Subject No 39034Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Wed 2~2 (POSCO552)
      • Major Requisite
        • Syllabus(File)

    • Introduction to Pharmaceutical Research

      • Subject No 39045Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A100-1)
        • Syllabus(File)

    • Pathophysiology

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Academic Background

Ewha Womans University 약학박사(약학과)

Ewha Womans University 약학사(약학과)

Work Experience

기초과학연구원(IBS) 2022-03-01 ~ 2024-02-29

광주과학기술원(GIST) 2020-09-01 ~ 2022-02-28

광주과학기술원(GIST) 2017-09-01 ~ 2020-08-31

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