이화여자대학교

In Hye Lee Associate Professor

Life Sciences/Department of Life Science

이인혜 프로필 사진 
Professor In Hye Lee has specialties in Metabolism and Aging research. She got a bachelor and PhD degree in Ewha Womans University. After she finished her PhD, she moved to USA to the find biological importance of Autophagy and Sirtuin biology. She was a federal government employee in National Institute of Health, USA before she got an appointment with Ewha Womans University. She is an assistant professor in Department of Life Science, College of Natural Science, Ewha Womans University since 2013. Her achievement was reported in the most prestigious journals, Science, Nature, Nature Medicine, PNAS, Cell Death Differentiation and so on.
  • Division Chair, HOKMA Scholars Program
  • Science Building C #208
  • 02-3277-3032
  • Research Interests
    • metabolism, aging, autophagy, cancer, cell death
Research Record
  • NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease ADVANCED SCIENCE, 2025, v.12 no.42, e05495
    SCIE Scopus dColl.
  • NADPH oxidase 4-SH3 domain-containing YSC84-like 1 complex participates liver inflammation and fibrosis Free Radical Biology and Medicine, 2025, v.227, 246-259
    SCIE Scopus dColl.
  • Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss BIOMOLECULES & THERAPEUTICS, 2025, v.33 no.1, 210-220
    SCIE Scopus KCI dColl.
  • Roles of Protein Post-Translational Modifications During Adipocyte Senescence INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2023, v.19 no.16, 5245-5256
    SCIE Scopus dColl.
  • Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases BMB REPORTS, 2023, v.56 no.4, 246-251
    SCIE Scopus KCI dColl.
  • Depletion of adipocyte becn1 leads to lipodystrophy and metabolic dysregulation Diabetes, 2021 , 182-195
    SCIE Scopus dColl.
  • Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway CANCERS, 2020, v.12 no.3, 605
    SCIE Scopus dColl.
  • SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation Cell Death and Differentiation, 2020, v.27 no.2, 482-496
    SCIE Scopus dColl.
  • Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFR/Src pathway LABORATORY INVESTIGATION, 2019, v.99 no.8, 1157-1172
    SCIE Scopus dColl.
  • Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51, 36
    SCIE Scopus KCI dColl.
  • Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide METABOLOMICS, 2019, v.15 no.10, 137
    SCIE Scopus dColl.
  • Mechanisms and disease implications of sirtuin-mediated autophagic regulation EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51, 102
    SCIE Scopus KCI dColl.
  • Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition Scientific Reports, 2018, v.8 no.1, 14379
    SCIE Scopus dColl.
  • Ahnak functions as a tumor suppressor via modulation of TGF beta/Smad signaling pathway ONCOGENE, 2014, v.33 no.38, 4675-4684
    SCIE Scopus dColl.
  • Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway. Oncogene, 2014, v.33 no.38, 4675-4684
    Scopus dColl.
  • [학술지논문] NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease ADVANCED SCIENCE, 2025, v.0 no.0 , 1-19
    SCIE
  • [학술지논문] NADPH oxidase 4-SH3 domain-containing YSC84-like 1 complex participates liver inflammation and fibrosis FREE RADICAL BIOLOGY AND MEDICINE, 2025, v.227 no.1 , 246-259
    SSCI
  • [학술지논문] Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss BIOMOLECULES & THERAPEUTICS, 2025, v.33 no.1 , 210-220
    SCIE
  • [학술지논문] Roles of Protein Post-Translational Modifications During Adipocyte Senescence INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2023, v.19 no.16 , 5245-5256
    SCIE
  • [학술지논문] Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases BMB REPORTS, 2023, v.56 no.4 , 246-251
    SCIE
  • [학술지논문] Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation DIABETES, 2021, v.70 no.1 , 182-195
    SCI
  • [저역서] Becker's world of the Cell, 10th Edition PEARSON, 2023, 893
  • [학술발표] MAAP deficiency Prevents from Metabolic Dysfunction-Associated Fatty Liver Diseases through Autophagy Regulation The Liver Weeks, 대한민국, 경주, 2025-05-30 The Liver Weeks Abstract book, 2025
  • [학술발표] MAAP is a new negative regulator of Autophagy in mTOR-independent manner Federation of Asian and Oceanian Biochemist and Molecular Biology, 대한민국, 부산, 2025-05-17 Federation of Asian and Oceanian Biochemist and Molecular Biology abstract book, 2025
  • [학술발표] PASK is a new negative regulator of Autophagy in mTOR-independent manner 제6회 KSBMB-KMPC 에너지 대사 분과 camp, 대한민국, 강릉, 2025-07-10 제6회 KSBMB-KMPC 에너지 대사 분과 camp program, 2025
  • [학술발표] PASK is a new negative regulator of autophagy in mTOR-independent manner EWHA-JWU-Ochanimuzu joint symposium , 일본, Tokyo, 2025-12-23 EWHA-JWU-Ochanimuzu joint symposium abstract book, 2025
  • [학술발표] PASK negatively regulates autophagy through mTOR-independent ULK1 degradation 11th International Symposium on Autophagy 2025, 호주, Lorne, 2025-11-17 11th International Symposium on Autophagy abstract book, 2025
  • [학술발표] Exploring the molecular connection between DNA Damage Response and Metabolism NHLBI Cardivascular Branch Meeting, 미국, Bethesda, 2022-12-07 NHLBI Cardivascular Branch Meeting abstract , 2022
  • [학술발표] Exploring the molecular mechanisms to connect between metabolism, cell death, and aging 제10회 한국분자세포생물학회 암미세환경연구분과 심포지엄, 대한민국, 대구, 2022-11-18 제10회 한국분자세포생물학회 암미세환경연구분과 심포지엄 초록집, 2022
  • [학술발표] Exploring the molecular mechanisms to connect metabolism, DNA Damage Response and Aging 단백질 생화학,바이오 의료 연구의 최신 연구지견회, 대한민국, 서울, 2022-09-15 단백질 생화학,바이오 의료 연구의 최신 연구지견회 초록집, 2022
  • [학술발표] Exploring the molecular mechanisms to connect metabolism, DNA damage response, and Aging Cell Bio 2022, 미국, 워싱턴 DC, 2022-12-06 American Socity of Cell Biology Abstract E-book, 2022
  • [학술발표] Finding the molecular connection between DNA Damage Response, Metabolism and Aging 대한생리학회, 대한민국, 서울, 2022-10-28 The Korean Journal of Physiology and Pharmacology, 2022, 46-47
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Courses

  • 2025-2nd

    • General Biology

      • Subject No 20412Class No 03
      • 1Year ( 3Credit , 3Hour) Mon 5~5 (POSCO365) , Wed 4~4 (POSCO365)
        • Syllabus(File)

    • Cell Biology Ⅱ

      • Subject No 34237Class No 02
      • 3Year ( 3Credit , 3Hour) Tue 2~2 (POSCO362) , Fri 3~3 (POSCO362)
      • team teaching
        • Syllabus(File)

    • Special Topics in Cell Biology Ⅰ

      • Subject No G16950Class No 01
      • Year ( 3Credit , 3Hour) Fri 4~5 (SCI-C)
        • Syllabus(File)

    • Advanced Cell Biology

      • Subject No G16993Class No 01
      • Year ( 3Credit , 3Hour) Tue 7~8 (SCI-C)
        • Syllabus(File)

    • Cellular Signal Transduction

      • Subject No G16997Class No 01
      • Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C)
        • Syllabus(File)

  • 2025-1st

    • First-Year Seminar

      • Subject No 10851Class No 09
      • 1Year ( 1Credit , 1Hour) Wed 7~7 (SCI-C208)
        • Syllabus(File)

    • General Biology

      • Subject No 20412Class No 03
      • 1Year ( 3Credit , 3Hour) Mon 3~3 (POSCO453) , Wed 2~2 (POSCO453)
        • Syllabus(File)

    • Cell Biology Ⅰ

      • Subject No 34229Class No 02
      • 3Year ( 3Credit , 3Hour) Mon 6~6 (POSCO360) , Wed 5~5 (POSCO360)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅲ

      • Subject No 35313Class No 01
      • 3Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅲ

      • Subject No 35313Class No 02
      • 3Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA203)
        • Syllabus(File)

    • Bioindustury in the 21st Century

      • Subject No 37713Class No 01
      • 4Year ( 1Credit , 1Hour) Fri 6~6 (POSCO363)
        • Syllabus(File)

    • Life Science Seminar Ⅲ

      • Subject No G16930Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (SCI-C)
        • Syllabus(File)

    • Special Topics in Cell Biology Ⅱ

      • Subject No G16951Class No 01
      • Year ( 3Credit , 3Hour) Fri 7~8 (SCI-C)
        • Syllabus(File)

    • Bio Technology

      • Subject No G16974Class No 01
      • Year ( 3Credit , 3Hour) Fri 5~6 (SCI-C)
        • Syllabus(File)

  • 2024-2nd

    • General Biology

      • Subject No 20412Class No 05
      • 1Year ( 3Credit , 3Hour) Wed 3~3 (POSCO452) , Fri 2~2 (POSCO452)
        • Syllabus(File)

    • Cell Biology Ⅱ

      • Subject No 34237Class No 02
      • 3Year ( 3Credit , 3Hour) Tue 6~6 (POSCO361) , Thu 4~4 (POSCO361)
        • Syllabus(File)

    • Introduction to Cell Signaling

      • Subject No 38212Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO361) , Thu 6~6 (POSCO361)
        • Syllabus(File)

    • Special Topics in Cell Biology Ⅰ

      • Subject No G16950Class No 01
      • Year ( 3Credit , 3Hour) Fri 4~5 (SCI-C)
        • Syllabus(File)

    • Advanced Cell Biology

      • Subject No G16993Class No 01
      • Year ( 3Credit , 3Hour) Tue 7~8 (SCI-C)
        • Syllabus(File)

  • 2024-1st

    • General Biology

      • Subject No 20412Class No 03
      • 1Year ( 3Credit , 3Hour) Mon 3~3 (POSCO453) , Wed 2~2 (POSCO453)
        • Syllabus(File)

    • General Biology Ⅰ

      • Subject No 20413Class No 01
      • 1Year ( 3Credit , 3Hour) Mon 4~4 (POSCO453) , Thu 5~5 (POSCO453)
        • Syllabus(File)

    • Cell Biology Ⅰ

      • Subject No 34229Class No 02
      • 3Year ( 3Credit , 3Hour) Mon 6~6 (POSCO360) , Wed 5~5 (POSCO360)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅲ

      • Subject No 35313Class No 01
      • 3Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA202)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅲ

      • Subject No 35313Class No 02
      • 3Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA202)
        • Syllabus(File)

    • Colloquium of Life Science Research

      • Subject No 36337Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 4~4 (POSCO161) , Fri 5~5 (POSCO161)
        • Syllabus(File)

    • Special Topics in Cell Biology Ⅱ

      • Subject No G16951Class No 01
      • Year ( 3Credit , 3Hour) Fri 7~8 (SCI-C)
        • Syllabus(File)

  • 2023-2nd

    • General Biology 강의 계획서 상세보기

      • Subject No 20412Class No 03
      • 1Year ( 3Credit , 3Hour) Mon 6~6 (SCI-AA) , Wed 5~5 (102)
        • Syllabus(File)

    • Cell Biology II

    • Life Science SeminarⅣ

      • Subject No G16931Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (SCI-C)
        • Syllabus(File)

    • Special Topics in Cell BiologyⅠ

      • Subject No G16950Class No 01
      • Year ( 3Credit , 3Hour) Fri 4~5 (SCI-C)
        • Syllabus(File)

    • Advanced Cell Biology

      • Subject No G16993Class No 01
      • Year ( 3Credit , 3Hour) Tue 7~8 (SCI-C)
        • Syllabus(File)

    • Cellular Signal Transduction

      • Subject No G16997Class No 01
      • Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
        • Syllabus(File)

  • 2023-1st

  • 2022-2nd

    • General Biology

      • Subject No 20412Class No 05
      • 1Year ( 3Credit , 3Hour) Mon 4~4 (SCI-AA) , Thu 5~5 (102)
        • Syllabus(File)

    • Cell Biology II

      • Subject No 34237Class No 02
      • 3Year ( 3Credit , 3Hour) Tue 6~6 (POSCO362) , Thu 4~4 (POSCO362)
        • Syllabus(File)

    • Advanced Experiments in Life Sciences Capstone Design II

      • Subject No 35830Class No 01
      • 4Year ( 2Credit , 3Hour) Sat 1~2 (SCI-AA205)
        • Syllabus(File)

    • Molecular Medical Science

      • Subject No 36336Class No 01
      • 4Year ( 3Credit , 3Hour) Wed 3~3 (SCI-AA) , Fri 2~2 (101)
        • Syllabus(File)

    • Life Science SeminarⅣ

      • Subject No G16931Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (SCI-C)
        • Syllabus(File)

    • Research for Life ScienceⅡ

    • Special Topics in Cell BiologyⅠ

      • Subject No G16950Class No 01
      • Year ( 3Credit , 3Hour) Fri 4~5 (SCI-C)
        • Syllabus(File)

  • 2022-1st

    • General Biology I

      • Subject No 20413Class No 03
      • 1Year ( 3Credit , 3Hour) Tue 4~4 (POSCO453) , Fri 5~5 (POSCO453)
        • Syllabus(File)

    • Cell Biology I

      • Subject No 34229Class No 03
      • 3Year ( 3Credit , 3Hour) Wed 6~6 (POSCO552) , Fri 4~4 (POSCO552)
        • Syllabus(File)

    • Cell BiologyIII

      • Subject No 37121Class No 01
      • 4Year ( 3Credit , 3Hour) Wed 3~3 (POSCO366) , Fri 2~2 (POSCO366)
        • Syllabus(File)

    • Life Science SeminarⅠ

      • Subject No G16928Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (-)
        • Syllabus(File)

    • Bio Technology

      • Subject No G16974Class No 01
      • Year ( 3Credit , 3Hour) Wed 5~6 (-)
        • Syllabus(File)
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Academic Background

Ewha Womans University 이학박사(분자생명과학)

Ewha Womans University 이학사(생물과학)

Work Experience

NIH 2005-10-01 ~ 2013-02-28

이화여대 2004-09-01 ~ 2005-09-30

College of medicine, University of Pittsburgh, USA 2020-11-01 ~ 2021-08-03