Yonghyun Lee Associate Professor

Pharmaceutical Sciences/Division of Pharmacy/Industrial Pharmaceutical Science

이용현 프로필 사진
Prof. Yonghyun Lee, who works as an assistant professor, College of Pharmacy, Ewha Womans University, obtained his B.S. and Ph.D. from the College of Pharmacy at Pusan National University where he received his research training in medicinal chemistry and pharmaceutics. He further expanded his research toolbox as post-doctoral fellow in the laboratory of Prof. Sangyong Jon at KAIST (Korea Advanced Institute Science and Technology), where he developed innovative strategies based on bilirubin, a yellow bile pigment that is responsible for jaundice, for treatment and/or diagnosis of cancer and inflammation-related diseases. Since then, his research interests have moved from the development of novel materials to the specific modulation of the immune cells in the inflamed site or the tumor microenvironment by engineering immunity with nature-inspired targeted biomaterials. To explore these interests, he worked the immunoengineering laboratory of Prof. James Moon at the University of Michigan as a research Scientist. He published more than 40 SCI Journal Papers including Nature Materials, Angewandte Chemie, Advanced Science, Biomaterials, and etc. For his outstanding works, he has received many awards, including The Promising Young Scientist Award from the Korean Academy of Science and Technology. Currently, his research focuses on development of novel strategies, targeted-modulating gut microbiome, intestinal barriers, and/or immune systems for effective management of inflammation-related diseases (especially for inflammatory bowel diseases) and/or cancer. He also develop simple nano-drug delivery systems for delivery of anti-cancer agents or anti-inflammation agents. A long-term research goal of Lee Lab is to develop a revolutionary strategy that makes cancer tissue eradicated. His translational biomedical research utilizes tools of pharmaceutics, nanotechnology, biomaterials, drug delivery, and biomacromolecules and tissue engineering to achieve His goals.
  • Pharmaceutical Science Building B #304
  • 02-3277-3042
  • Research Interests
    • Nanomedicine, Anti-cancer treatment, Anti-inflammation treatment (IBD therapy), Immunotherapy, Gut microbiome
Research Record
  • Antioxidative Hyaluronic Acid-Bilirubin Nanomedicine Targeting Activated Hepatic Stellate Cells for Anti-Hepatic-Fibrosis Therapy ACS Nano, 2024, v.18 no.6, 4704-4716
    SCIE Scopus dColl.
  • Cancer cell-specific and pro-apoptotic SMAC peptide-doxorubicin conjugated prodrug encapsulated aposomes for synergistic cancer immunotherapy Journal of Nanobiotechnology, 2024, v.22 no.1, 109
    SCIE Scopus dColl.
  • Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy Nature Communications, 2023, v.14 no.1, 4771
    SCIE Scopus dColl.
  • Oral Nanomedicines for siRNA Delivery to Treat Inflammatory Bowel Disease Pharmaceutics, 2022, v.14 no.9, 1969
    SCIE Scopus dColl.
  • Smart pH-responsive nanomedicines for disease therapy Journal of Pharmaceutical Investigation, 2022, v.52 no.4, 427-441
    SCIE Scopus KCI dColl.
  • Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome ADVANCED DRUG DELIVERY REVIEWS, 2021, v.179, 114021
    SCIE Scopus dColl.
  • Recent progress in development and applications of second near-infrared (NIR-II) nanoprobes ARCHIVES OF PHARMACAL RESEARCH, 2021, v.44 no.2, 165-181
    SCIE Scopus KCI dColl.
  • Efficient Lymph Node-Targeted Delivery of Personalized Cancer Vaccines with Reactive Oxygen Species-Inducing Reduced Graphene Oxide Nanosheets ACS NANO, 2020, v.14 no.10, 13268-13278
    SCIE Scopus dColl.
  • Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis NATURE MATERIALS, 2020, v.19 no.1, 118-
    SCIE Scopus dColl.
  • PEGylated bilirubin-coated iron oxide nanoparticles as a biosensor for magnetic relaxation switching-based ros detection in whole blood Theranostics, 2020, v.10 no.5, 1997-2007
    SCIE Scopus dColl.
  • Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib PHARMACEUTICS, 2020, v.12 no.11, 1043
    SCIE Scopus dColl.
  • A Hybrid Platform Based on a Bispecific Peptide-Antibody Complex for Targeted Cancer Therapy ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, v.58 no.7, 2005-2010
    SCIE Scopus dColl.
  • Antibody-Assisted Delivery of a Peptide-Drug Conjugate for Targeted Cancer Therapy MOLECULAR PHARMACEUTICS, 2019, v.16 no.1, 165-172
    SCIE Scopus dColl.
  • [학술지논문] Antioxidative Hyaluronic Acid-Bilirubin Nanomedicine Targeting Activated Hepatic Stellate Cells for Anti-Hepatic-Fibrosis Therapy ACS NANO, 2024, v.18 no.6 , 4704-4716
    SCIE
  • [학술지논문] Cancer cell-specific and pro-apoptotic SMAC peptide-doxorubicin conjugated prodrug encapsulated aposomes for synergistic cancer immunotherapy Journal of Nanobiotechnology, 2024, v.22 no.1 , 1-19
    SCIE
  • [학술지논문] Hyaluronic Acid-Bilirubin Nanoparticles as a Tumor Microenvironment Reactive Oxygen Species-Responsive Nanomedicine for Targeted Cancer Therapy International journal of nanomedicine, 2024, v.19 no.1 , 4893-4906
    Scopus
  • [학술지논문] Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy NATURE COMMUNICATIONS, 2023, v.14 no.1 , 1-14
    SCIE
  • [학술지논문] Smart pH-responsive nanomedicines for disease therapy Journal of Pharmaceutical Investigation, 2022, v.52 no.4 , 427-441
    SCIE
  • [학술지논문] Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome ADVANCED DRUG DELIVERY REVIEWS, 2021, v.179 no.0 , 114021-114021
    SCI
  • [학술지논문] Recent progress in development and applications of second near-infrared (NIR-II) nanoprobes ARCHIVES OF PHARMACAL RESEARCH, 2021, v.44 no.2 , 165-181
    SCIE
  • [학술지논문] Efficient Lymph Node-Targeted Delivery of Personalized Cancer Vaccines with Reactive Oxygen Species-Inducing Reduced Graphene Oxide Nanosheets ACS NANO, 2020, v.14 no.10 , 13268-13278
    SCI
  • [학술지논문] Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis NATURE MATERIALS, 2020, v.19 no.1 , 118-118
    SCI
  • [학술지논문] PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood THERANOSTICS, 2020, v.10 no.5 , 1997-2007
    SCIE
  • [학술지논문] Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib PHARMACEUTICS, 2020, v.12 no.11 , 1043-1043
    SCIE
  • [학술지논문] A Hybrid Platform Based on a Bispecific Peptide-Antibody Complex for Targeted Cancer Therapy ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, v.58 no.7 , 2005-2010
    SCI
  • [학술지논문] Antibody-Assisted Delivery of a Peptide-Drug Conjugate for Targeted Cancer Therapy MOLECULAR PHARMACEUTICS, 2019, v.16 no.1 , 165-172
    SCIE
Courses
  • 2024-2nd

    • Biopharmaceutics

      • Subject No 22497Class No 03
      • 4Year ( 1.5Credit , 1.5Hour) Tue 3~3 (POSCO552)
      • Major Requisite
    • Clinical Immunology

      • Subject No 37131Class No 01
      • 4Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 01
      • 5Year ( 1.5Credit , 3Hour) Tue 6~9 (PHM-A214)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 02
      • 5Year ( 1.5Credit , 3Hour) Wed 6~9 (PHM-A214)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 03
      • 5Year ( 1.5Credit , 3Hour) Mon 6~9 (PHM-A214)
      • Major Requisite
    • Advanced Topics in Biomedical Nanoscience and Engineering

      • Subject No G17213Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (PHM-)
  • 2024-1st

    • Drug Delivery System

      • Subject No 36213Class No 01
      • 5Year ( 1.5Credit , 1.5Hour) Thu 4~4 (POSCO552)
      • Major Requisite
    • Drug Delivery System

      • Subject No 36213Class No 02
      • 5Year ( 1.5Credit , 1.5Hour) Thu 5~5 (POSCO552)
      • Major Requisite
    • Drug Delivery System

      • Subject No 36213Class No 03
      • 5Year ( 1.5Credit , 1.5Hour) Wed 5~5 (PHM-A400)
      • Major Requisite
    • Pharmaceutics

      • Subject No 37134Class No 01
      • 5Year ( 1.5Credit , 1.5Hour) Fri 4~4 (PHM-A404)
      • Major Requisite
    • Pharmaceutics

      • Subject No 37134Class No 02
      • 5Year ( 1.5Credit , 1.5Hour) Fri 5~5 (PHM-A404)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI 강의 계획서 상세보기

      • Subject No 37138Class No 01
      • 5Year ( 1.5Credit , 3Hour) Wed 6~9 (PHM-A214)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI 강의 계획서 상세보기

      • Subject No 37138Class No 02
      • 5Year ( 1.5Credit , 3Hour) Mon 6~9 (PHM-A214)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI 강의 계획서 상세보기

      • Subject No 37138Class No 03
      • 5Year ( 1.5Credit , 3Hour) Tue 6~9 (PHM-A214)
      • Major Requisite
    • Industrial Pharmacy & Administrative Pharmacy Practice

      • Subject No 37153Class No 03
      • 6Year ( 2.5Credit , 160Hour)
      • Major Requisite
    • Industrial Pharmacy & Administrative Pharmacy Practice

      • Subject No 37153Class No 04
      • 6Year ( 2.5Credit , 160Hour)
      • Major Requisite
    • Industrial Pharmacy & Administrative Pharmacy Practice

      • Subject No 37153Class No 05
      • 6Year ( 2.5Credit , 160Hour)
      • Major Requisite
    • Honors research

    • Introduction to Pharmaceutical Research

      • Subject No 38940Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
      • Major Requisite
  • 2023-2nd

    • Biopharmaceutics

      • Subject No 22497Class No 01
      • 4Year ( 1.5Credit , 1.5Hour) Fri 4~4 (PHM-A104)
      • Major Requisite
    • Biopharmaceutics

      • Subject No 22497Class No 02
      • 4Year ( 1.5Credit , 1.5Hour) Fri 5~5 (PHM-A104)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI 강의 계획서 상세보기

      • Subject No 37138Class No 01
      • 5Year ( 1.5Credit , 3Hour) Mon 6~9 (PHM-A214)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI 강의 계획서 상세보기

      • Subject No 37138Class No 02
      • 5Year ( 1.5Credit , 3Hour) Tue 6~9 (PHM-A214)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI 강의 계획서 상세보기

      • Subject No 37138Class No 03
      • 5Year ( 1.5Credit , 3Hour) Wed 6~9 (PHM-A214)
      • Major Requisite
    • Advanced Pharmacy Practice and Research I 강의 계획서 상세보기

      • Subject No 37154Class No 02
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Advanced Pharmacy Practice and Research I

      • Subject No 37154Class No 04
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Advanced Pharmacy Practice and Research I

      • Subject No 37154Class No 05
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Advanced Pharmacy Practice and Research Ⅱ 강의 계획서 상세보기

      • Subject No 37155Class No 02
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 04
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 05
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Advanced Pharmacy Practice and Research Ⅲ 강의 계획서 상세보기

      • Subject No 37156Class No 02
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Honors research

    • Advanced topics in Biomedical Nanoscience And Engineering

      • Subject No G17213Class No 01
      • Year ( 3Credit , 3Hour) Wed 4~5 (PHM-)
  • 2023-1st

  • 2022-2nd

    • Biopharmaceutics

      • Subject No 22497Class No 03
      • 4Year ( 1.5Credit , 1.5Hour) Wed 3~3 (POSCO)
      • Major Requisite
    • Biopharmaceutics

      • Subject No 22497Class No 04
      • 4Year ( 1.5Credit , 1.5Hour) Wed 3~3 (POSCO)
      • Major Requisite
    • Clinical Immunology

      • Subject No 37131Class No 02
      • 4Year ( 1.5Credit , 1.5Hour) Fri 5~5 (PHM-A404)
    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 02
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 04
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
    • Lab rotation Ⅰ

      • Subject No 38927Class No 01
      • 1Year ( 1.5Credit , 0Hour) Thu 7~7
    • Lab rotation Ⅰ

      • Subject No 38927Class No 02
      • 1Year ( 1.5Credit Thu 7~7
    • Lab rotation Ⅰ

      • Subject No 39032Class No 01
      • 1Year ( 1.5Credit , 0Hour) Thu 7~7
    • Advanced topics in Biomedical Nanoscience And Engineering

      • Subject No G17213Class No 01
      • Year ( 3Credit , 3Hour) Tue 5~6 (PHM-)
  • 2022-1st

    • Drug Delivery System

      • Subject No 36213Class No 01
      • 5Year ( 1.5Credit , 1.5Hour) Tue 3~3 (PHM-A400)
      • Major Requisite
    • Drug Delivery System

      • Subject No 36213Class No 02
      • 5Year ( 1.5Credit , 1.5Hour) Thu 5~5 (PHM-A404)
      • Major Requisite
    • Drug Delivery System

      • Subject No 36213Class No 03
      • 5Year ( 1.5Credit , 1.5Hour) Thu 2~2 (PHM-A400)
      • Major Requisite
    • Drug Delivery System

      • Subject No 36213Class No 04
      • 5Year ( 1.5Credit , 1.5Hour) Thu 2~2 (PHM-A400)
      • Major Requisite
    • Pharmaceutics

      • Subject No 37134Class No 01
      • 5Year ( 1.5Credit , 1.5Hour) Fri 6~6
      • Major Requisite
    • Pharmaceutics

      • Subject No 37134Class No 02
      • 5Year ( 1.5Credit , 1.5Hour) Fri 5~5
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 01
      • 5Year ( 1.5Credit , 3Hour) Thu 6~7 (PHM-A206)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 02
      • 5Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A206)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 03
      • 5Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A206)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 04
      • 5Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A206)
      • Major Requisite
    • Industrial Pharmacy & Administrative Pharmacy Practice

      • Subject No 37153Class No 03
      • 6Year ( 2.5Credit , 160Hour)
      • Major Requisite
    • Industrial Pharmacy & Administrative Pharmacy Practice

      • Subject No 37153Class No 04
      • 6Year ( 2.5Credit , 160Hour)
      • Major Requisite
  • 2021-2nd

    • Biopharmaceutics

      • Subject No 22497Class No 03
      • 4Year ( 1.5Credit , 1.5Hour) Wed 2~2
      • Major Requisite
    • Biopharmaceutics

      • Subject No 22497Class No 04
      • 4Year ( 1.5Credit , 1.5Hour) Wed 2~2
      • Major Requisite
    • Clinical Immunology

      • Subject No 37131Class No 02
      • 4Year ( 1.5Credit , 1.5Hour) Fri 5~5
    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 02
      • 6Year ( 4Credit
      • Major Requisite
    • Advanced topics in Biomedical Nanoscience And Engineering

      • Subject No G17213Class No 01
      • Year ( 3Credit , 3Hour) Tue 5~6 (-)
  • 2021-1st

    • Drug Delivery System

      • Subject No 36213Class No 01
      • 5Year ( 1.5Credit , 1.5Hour) Wed 4~4
      • Major Requisite
    • Drug Delivery System

      • Subject No 36213Class No 02
      • 5Year ( 1.5Credit , 1.5Hour) Thu 3~3
      • Major Requisite
    • Drug Delivery System

      • Subject No 36213Class No 03
      • 5Year ( 1.5Credit , 1.5Hour) Wed 2~2
      • Major Requisite
    • Pharmaceutics

      • Subject No 37134Class No 01
      • 5Year ( 1.5Credit , 1.5Hour) Mon 2~2
      • Major Requisite
    • Pharmaceutics

      • Subject No 37134Class No 02
      • 5Year ( 1.5Credit , 1.5Hour) Fri 5~5
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 01
      • 5Year ( 1.5Credit , 3Hour) Wed 5~6 (PHM-A206)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 02
      • 5Year ( 1.5Credit , 3Hour) Mon 5~6 (PHM-A206)
      • Major Requisite
    • Pharmaceutical Experiment Laboratory VI

      • Subject No 37138Class No 03
      • 5Year ( 1.5Credit , 3Hour) Thu 5~6 (PHM-A206)
      • Major Requisite
    • Industrial Pharmacy & Administrative Pharmacy Practice

      • Subject No 37153Class No 04
      • 6Year ( 2.5Credit
      • Major Requisite
    • Honors research

      • Subject No 37803Class No 01
      • 4Year ( 1Credit , 1Hour)
    • Seminar for Pharmaceutical Sciences I

      • Subject No G16848Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A400)
Work Experience

University of Michigan 2017-04-01 ~ 2020-02-29

한국과학기술원(KAIST) 2012-03-01 ~ 2017-03-31