이화여자대학교

Jang, Sunbok Associate Professor

Pharmaceutical Sciences / Division of Pharmacy / Graduate Program in Innovative Biomaterials Convergence / Industrial Pharmaceutical Science

장선복 프로필 사진 
Professor Sunbok Jang is a faculty member in Analytical Pharmacy at the College of Pharmacy. He received his B.S. in Chemistry from Yonsei University and his M.S. and Ph.D. in Pharmaceutical Sciences (Physical Pharmacy) from the College of Pharmacy, Seoul National University. He completed postdoctoral training at the National Institute of Diabetes and Digestive and Kidney Diseases (NIH) and at the HIV Center, University of Pittsburgh. He subsequently served as a Staff Research Scientist at the Hillman Cancer Center, University of Pittsburgh Medical Center, and as a Senior Scientist in the Structural Biology/Biophysics group at Hansoh Bio Pharmatech (Maryland, USA), where he engaged directly in drug discovery research.
His laboratory investigates how DNA repair proteins recognize and act upon DNA damage, using single-molecule real-time imaging together with in-cell live imaging to capture the dynamic interactions between repair factors and damaged DNA. By integrating analytical chemistry, biochemistry, molecular and cell biology, and structural biology, his group aims to redefine the molecular mechanisms of DNA repair pathways and to translate these insights into novel anticancer therapeutics.
Through this work, his team has demonstrated that UV-DDB serves as a key early damage sensor that not only detects DNA lesions but also recruits and stimulates downstream repair proteins—findings made possible by real-time single-molecule techniques. This platform is broadly extensible to a wide range of DNA repair proteins, enabling real-time mechanistic studies at the single-molecule level. His research has been published in leading international journals, including Nature Structural & Molecular Biology, Nature Communications, and Nucleic Acids Research.
  • sunbok.jang@ewha.ac.kr
  • Pharmaceutical Science Building B #113
  • 02-3277-3034
  • Research Interests
    • Genomic Integrity & Cancer & Aging, DNA repair (Nucleotide Excision Repair & Base Excision Repair), Single molecule analysis, Structural Biology, NMR & X-ray Crystallography
  • sdg03
  • sdg16
  • sdg05
Research Record
  • Anti-Obesity Effects of Pear Extract (Pyrus pyrifolia): Clinical Implications and Therapeutic Potential International Journal of Stem Cells, 2026, v.19 no.2, 242-255
    SCIE Scopus KCI dColl.
  • PoMA-10: a dual-action antiviral disrupting SARS-CoV-2 Spike-ACE2 interaction and protecting lung tissue FRONTIERS IN PHARMACOLOGY, 2026, v.17, 1755268
    SCIE Scopus dColl.
  • Advances in DNA damage detection: Current progress, challenges, and future directions TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2025, v.189, 118246
    SCIE Scopus dColl.
  • Cancer prognosis using base excision repair genes MOLECULES AND CELLS, 2025, v.48 no.2, 100186
    SCIE Scopus KCI dColl.
  • DNA repair and disease: insights from the human DNA glycosylase NEIL family EXPERIMENTAL AND MOLECULAR MEDICINE, 2025, v.57 no.3, 524-532
    SCIE Scopus KCI dColl.
  • XPC-RAD23B enhances UV-DDB binding to DNA to facilitate lesion search in nucleotide excision repair Nucleic Acids Research, 2025, v.53 no.11, gkaf463
    SCIE Scopus dColl.
  • Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy Coordination Chemistry Reviews, 2024, v.501, 215560
    SCIE Scopus dColl.
  • UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties Nucleic Acids Research, 2023, v.51 no.10, 4881-4898
    SCIE Scopus dColl.
  • Cooperative interaction between AAG and UV-DDB in the removal of modified bases Nucleic acids research, 2022, v.50 no.22, 12856-12871
    Scopus dColl.
  • [학술지논문] Anti-Obesity Effects of Pear Extract (Pyrus pyrifolia): Clinical Implications and Therapeutic Potential INTERNATIONAL JOURNAL OF STEM CELLS, 2026, v.19 no.0 , 242-255
    SCIE
  • [학술지논문] UV-DDB as a Dynamic Regulator Linking Base Excision and Nucleotide Excision Repair via AAG Interaction International Journal of Molecular Sciences, 2026, v.27 no.12 , 1-20
    SCIE
  • [학술지논문] Advances in DNA damage detection: Current progress, challenges, and future directions TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2025, v.189 no.1 , 1-10
    SCIE
  • [학술지논문] Cancer prognosis using base excision repair genes MOLECULES AND CELLS, 2025, v.48 no.2 , 1-9
    SCIE
  • [학술지논문] DNA repair and disease: insights from the human DNA glycosylase NEIL family EXPERIMENTAL AND MOLECULAR MEDICINE, 2025, v.57 no.3 , 524-532
    SCIE
  • [학술지논문] XPC-RAD23B enhances UV-DDB binding to DNA to facilitate lesion search in nucleotide excision repair NUCLEIC ACIDS RESEARCH, 2025, v.53 no.11 , 1-10
    SCIE
  • [학술지논문] UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties NUCLEIC ACIDS RESEARCH, 2023, v.51 no.10 , 4881-4898
    SCIE
  • [학술지논문] Cooperative interaction between AAG and UV-DDB in the removal of modified bases NUCLEIC ACIDS RESEARCH, 2022, v.50 no.22 , 12856-12871
    SCI
  • [학술지논문] Proteomic Analysis of Nuclear Hepatitis B Virus Relaxed Circular DNA-Associated Proteins Identifies UV-Damaged DNA Binding Protein as a Host Factor Involved in Covalently Closed Circular DNA Formation JOURNAL OF VIROLOGY, 2022, v.96 no.2 , 01360-21-01360-21
    SCI
  • [학술지논문] Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover NUCLEIC ACIDS RESEARCH, 2021, v.49 no.14 , 8177-8188
    SCI
  • [학술지논문] AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop NUCLEIC ACIDS RESEARCH, 2020, v.48 no.13 , 7345-7355
    SCI
  • [학술지논문] Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer DNA REPAIR, 2020, v.94 no.0 , 102860-102860
    SCI
  • [학술지논문] Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search NATURE COMMUNICATIONS, 2020, v.11 no.1 , 1356-1366
    SCI
  • [학술지논문] English NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2019, v.26 no.8 , 695-703
    SCI
  • [학술지논문] Structure and dynamics study of translation initiation factor 1 from Staphylococcus aureus suggests its RNA binding mode BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2017, v.1865 no.1 , 65-75
    SCI
  • [학술지논문] Substrate Specificity of SAMHD1 Triphosphohydrolase Activity Is Controlled by Deoxyribonucleoside Triphosphates and Phosphorylation at Thr592 BIOCHEMISTRY, 2016, v.55 no.39 , 5635-5646
    SCI
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Courses

  • 2026-2nd

    • Pharmaceutical Analysis Ⅱ

      • Subject No 38938Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 2~2 (PHM-A404) , Tue 4~4 (PHM-A404)
      • Major Requisite
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 38943Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 4~4 (HAK109)
        • 영문계획안

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 01
      • 4Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A300)
      • Major Requisite

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 02
      • 4Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A300)
      • Major Requisite

    • Pharmaceutical Experiment Laboratory Ⅳ

      • Subject No 38981Class No 03
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A300)
      • Major Requisite

    • Biopharmaceuticals Ⅱ

      • Subject No 39005Class No 01
      • 5Year ( 3Credit , 3Hour) Mon 4~4 (POSCO359) , Tue 5~5 (POSCO359)
      • Major Requisite
        • Syllabus(File)

    • Biopharmaceuticals Ⅱ

      • Subject No 39005Class No 02
      • 5Year ( 3Credit , 3Hour) Tue 4~4 (POSCO462) , Wed 3~3 (POSCO462)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Analysis Ⅱ

      • Subject No 39043Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO359) , Wed 2~2 (POSCO359)
      • Major Requisite
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 39048Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 4~4 (HAK109)
        • 영문계획안

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 39086Class No 01
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A300)
      • Major Requisite

    • Biopharmaceuticals Ⅱ

      • Subject No 39110Class No 01
      • 5Year ( 3Credit , 3Hour) Mon 3~3 (POSCO461) , Wed 4~4 (POSCO552)
        • Syllabus(File)

    • Advanced Analysis in Biochemistry 강의 계획서 상세보기

      • Subject No G16887Class No 01
      • Year ( 3Credit , 3Hour) Thu 2~3 (PHM-)

    • Seminar for Pharmaceutical Sciences Ⅱ 강의 계획서 상세보기

      • Subject No G16888Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A400)

    • Seminar for Pharmaceutical Sciences Ⅰ 강의 계획서 상세보기

      • Subject No G18238Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A400)

    • Seminar for Innovative Biomaterials Convergence Ⅲ 강의 계획서 상세보기

      • Subject No G18926Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A400)

    • Global Drug Discovery and Development

      • Subject No G19000Class No 01
      • Year ( 3Credit , 3Hour) Tue 6~7 (PHM-)
        • Syllabus(File)

  • 2026-1st

    • First-Year Seminar 강의 계획서 상세보기

      • Subject No 11401Class No 02
      • 1Year ( 1Credit , 1Hour) Thu 7~7

    • Introduction to Pharmaceutical Research

      • Subject No 38940Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Instrumental Analysis

      • Subject No 38950Class No 01
      • 3Year ( 3Credit , 3Hour) Wed 3~3 (POSCO359) , Thu 3~3 (POSCO359)
        • 영문계획안

    • Pharmaceutical Instrumental Analysis

      • Subject No 38950Class No 02
      • 3Year ( 3Credit , 3Hour) Wed 6~6 (POSCO359) , Thu 5~5 (POSCO359)
        • 영문계획안

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 01
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A300)
      • Major Requisite

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 02
      • 4Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A300)
      • Major Requisite

    • Honors Research Ⅰ

    • Pharmaceutical Instrumental Analysis

      • Subject No 39055Class No 01
      • 3Year ( 3Credit , 3Hour) Wed 4~4 (POSCO359) , Thu 2~2 (POSCO359)
        • 영문계획안

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 39086Class No 01
      • 4Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A300)
      • Major Requisite

    • Honors Research Ⅰ

    • Advanced Biotechnology Equipment and Experiments 강의 계획서 상세보기

      • Subject No G18929Class No 01
      • Year ( 3Credit , 3Hour) Tue 6~7 (PHM-A-400)
      • Classroom Changed

  • 2025-2nd

    • Advanced Pharmacy Practice and Research I

      • Subject No 37154Class No 02
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 02
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research Ⅲ

      • Subject No 37156Class No 02
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Honors research

    • Pharmaceutical Analysis Ⅱ

      • Subject No 38938Class No 01
      • 2Year ( 3Credit , 3Hour) Wed 4~4 (PHM-A104) , Thu 5~5 (POSCO453)
      • Major Requisite
        • 영문계획안

    • Pharmaceutical Analysis Ⅱ

      • Subject No 38938Class No 02
      • 2Year ( 3Credit , 3Hour) Wed 3~3 (PHM-A104) , Thu 4~4 (POSCO453)
      • Major Requisite
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 38943Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Tue 5~5 (HAK655)
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 38943Class No 02
      • 2Year ( 1.5Credit , 1.5Hour) Tue 3~3 (HAK852)
        • 영문계획안

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 01
      • 4Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A300)
      • Major Requisite

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 02
      • 4Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A300)
      • Major Requisite

    • Honors Research Ⅰ

    • Forensic Science 강의 계획서 상세보기

      • Subject No 38984Class No 01
      • 4Year ( 1.5Credit , 1.5Hour) Mon 3~3 (PHM-A400)

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 39048Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Tue 5~5 (HAK655)
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 39048Class No 02
      • 2Year ( 1.5Credit , 1.5Hour) Tue 3~3 (HAK852)
        • 영문계획안

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 39086Class No 01
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A300)
      • Major Requisite

    • Honors Research Ⅰ

    • Advanced Analysis in Biochemistry 강의 계획서 상세보기

      • Subject No G16887Class No 01
      • Year ( 3Credit , 3Hour) Thu 2~3 (PHM-A204)

  • 2025-1st

    • First-Year Seminar 강의 계획서 상세보기

      • Subject No 11401Class No 02
      • 1Year ( 1Credit , 1Hour) Thu 7~7

    • Pharmaceutical Analysis Ⅰ

      • Subject No 38930Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 2~2 (POSCO552) , Fri 3~3 (POSCO)
      • Major Requisite
        • 영문계획안

    • Pharmaceutical Analysis Ⅰ

      • Subject No 38930Class No 02
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO555) , Fri 4~4 (POSCO)
      • Major Requisite
        • 영문계획안

    • Introduction to Pharmaceutical Research

      • Subject No 38940Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 01
      • 4Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A300)
      • Major Requisite

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 38981Class No 02
      • 4Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A300)
      • Major Requisite

    • Honors Research Ⅰ

    • Pharmaceutical Instrumental Analysis 강의 계획서 상세보기

      • Subject No 39055Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A104) , Wed 5~5 (PHM-A100-1)

    • Pharmaceutical Experiment Laboratory Ⅳ 강의 계획서 상세보기

      • Subject No 39086Class No 01
      • 4Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A300)
      • Major Requisite

    • Honors Research Ⅰ

    • Methods for Biochemical Researches

  • 2024-2nd

    • Pharmaceutical Instrumental Analysis 강의 계획서 상세보기

      • Subject No 37130Class No 02
      • 4Year ( 3Credit , 3Hour) Mon 4~4 (POSCO160) , Wed 2~2 (PHM-A404)

    • Advanced Pharmacy Practice and Research I

      • Subject No 37154Class No 01
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 01
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research Ⅲ

      • Subject No 37156Class No 01
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

    • Honors research

    • Pharmaceutical Analysis Ⅱ

      • Subject No 38938Class No 01
      • 2Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A404) , Thu 6~6 (POSCO161)
      • Major Requisite
        • 영문계획안

    • Pharmaceutical Analysis Ⅱ

      • Subject No 38938Class No 02
      • 2Year ( 3Credit , 3Hour) Tue 6~6 (PHM-A404) , Thu 5~5 (POSCO151)
      • Major Requisite
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 38943Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Wed 5~5 (HAK655)
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 38943Class No 02
      • 2Year ( 1.5Credit , 1.5Hour) Thu 4~4 (POSCO)
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 39048Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Wed 5~5 (HAK655)
        • 영문계획안

    • Academic Writing in Pharmaceutical Sciences

      • Subject No 39048Class No 02
      • 2Year ( 1.5Credit , 1.5Hour) Thu 4~4 (POSCO)
        • 영문계획안

    • Advanced Analysis in Biochemistry 강의 계획서 상세보기

      • Subject No G16887Class No 01
      • Year ( 3Credit , 3Hour) Fri 2~3 (PHM-)
      • Classroom Changed

  • 2024-1st

    • First-Year Seminar 강의 계획서 상세보기

      • Subject No 11401Class No 02
      • 1Year ( 1Credit Thu 7~7

    • Honors research

    • Pharmaceutical Analysis Ⅰ

      • Subject No 38930Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO552) , Fri 2~2 (POSCO451)
      • Major Requisite
        • 영문계획안

    • Pharmaceutical Analysis Ⅰ

      • Subject No 38930Class No 02
      • 2Year ( 3Credit , 3Hour) Mon 2~2 (POSCO451) , Fri 3~3 (POSCO451)
      • Major Requisite
        • 영문계획안

    • Pharmaceutical Instrumental Analysis 강의 계획서 상세보기

      • Subject No 38950Class No 01
      • 3Year ( 3Credit , 3Hour) Mon 5~5 (POSCO555) , Thu 3~3 (POSCO)

    • Pharmaceutical Instrumental Analysis

      • Subject No 38950Class No 02
      • 3Year ( 3Credit , 3Hour) Wed 2~2 (PHM-A400) , Thu 6~6 (PHM-A104)
        • 영문계획안

    • Pharmaceutical Analysis Ⅰ

      • Subject No 39035Class No 01
      • 2Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A100-1) , Thu 2~2 (PHM-A100-1)
      • Major Requisite
        • 영문계획안

    • Introduction to Pharmaceutical Research

      • Subject No 39045Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A100-1)
        • Syllabus(File)

    • Pharmaceutical Instrumental Analysis 강의 계획서 상세보기

      • Subject No 39055Class No 01
      • 3Year ( 3Credit , 3Hour) Mon 5~5 (POSCO555) , Thu 3~3 (POSCO)

    • Pharmaceutical Instrumental Analysis

      • Subject No 39055Class No 02
      • 3Year ( 3Credit , 3Hour) Wed 2~2 (PHM-A400) , Thu 6~6 (PHM-A104)
        • 영문계획안

  • 2023-2nd

  • 2023-1st

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Academic Background

Seoul Nat'l Univ. 약학박사 (제약학과)

YONSEI UNIVERSITY 이학사 (화학과 )

Work Experience

Hansoh Bio Pharmatech 2020-12-01 ~ 2022-02-28

Univ. of Pittsburgh 2016-05-18 ~ 2020-11-30

Univ. of Pittsburgh 2015-05-17 ~ 2016-05-17

미국국립보건원(NIH) 2012-05-14 ~ 2015-05-13

서울대 2009-09-01 ~ 2012-05-13

Internal Awards

강의우수2025-09-01