이화여자대학교

Wan Kyu Kim Professor

Life Sciences/Life Sciences/College of Medicine/Bio-Information Science

김완규 프로필 사진 
Wankyu Kim received his PhD in Bioinformatics from the University of Cambridge in 2007. He is interested in diverse aspects of bioinformatics and systems biology including miRNA, chemical genomics, drug informatics, cancer genomics, and network biology. He developed many bioinformatic tools and published more than 25 scientific papers.
  • Department Chair, Bio-Information Science/Department Chair, Bioinformatics
  • Science Building A #A208
  • 02-3277-4132
Research Record
  • Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer Molecular Cancer, 2018, v.17 no.1, 175
    SCIE Scopus dColl.
  • 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis Nature Communications, 2024, v.15 no.1, 0
    SCIE Scopus dColl.
  • BEAR: A Novel Virtual Screening Method Based on Large-Scale Bioactivity Data JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, v.63 no.5
    SCIE Scopus dColl.
  • NecroX Improves Polyhexamethylene Guanidine-induced Lung Injury by Regulating Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress American journal of respiratory cell and molecular biology, 2023, v.69 no.1, 57-72
    Scopus dColl.
  • Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial Clinical and Molecular Hepatology, 2022, v.28 no.3, 497-509
    SCIE Scopus KCI dColl.
  • Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial Clinical and Molecular Hepatology, 2022, v.28 no.3, 497-509
    KCI dColl.
  • Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance CANCER RESEARCH, 2021, v.81 no.13, 3539-3553
    SCIE Scopus dColl.
  • Comprehensive Survey of Recent Drug Discovery Using Deep Learning INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, v.22 no.18, 9983
    SCIE Scopus dColl.
  • Enhanced Sensitivity of Nonsmall Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors to Phenformin: The Roles of a Metabolic Shift to Oxidative Phosphorylation and Redox Balance Oxidative Medicine and Cellular Longevity, 2021, v.2021, 5428364
    SCIE Scopus dColl.
  • Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer Oncogene, 2020, v.39 no.23, 4567-4580
    SCIE Scopus dColl.
  • Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation Proceedings of the National Academy of Sciences of the United States of America, 2020, v.117 no.33, 19982-19993
    Scopus dColl.
  • MiR-4435 is an UQCRB-related circulating miRNA in human colorectal cancer Scientific Reports, 2020, v.10 no.1, 2833
    SCIE Scopus dColl.
  • Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020 , 1831-1844
    SCIE Scopus KCI dColl.
  • Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation Nature Communications, 2020, v.11 no.1, 4343
    SCIE Scopus dColl.
  • Safe scarless cassette-free selection of genome-edited human pluripotent stem cells using temporary drug resistance Biomaterials, 2020, v.262, 120295
    SCIE Scopus dColl.
  • Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis Redox Biology, 2020, v.37, 101719
    SCIE Scopus dColl.
  • CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures Molecules and cells, 2019, v.42 no.3, 237-244
    SCIE Scopus KCI dColl.
  • CSgator: an integrated web platform for compound set analysis JOURNAL OF CHEMINFORMATICS, 2019, v.11, 17
    SCIE Scopus dColl.
  • Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data PHARMACEUTICS, 2019, v.11 no.8, 377
    SCIE Scopus dColl.
  • In silico drug repositioning: from large-scale transcriptome data to therapeutics ARCHIVES OF PHARMACAL RESEARCH, 2019, v.42 no.10, 879-889
    SCIE Scopus KCI dColl.
  • Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells FRONTIERS IN CHEMISTRY, 2019, v.7, 298
    SCIE Scopus dColl.
  • Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway SCIENTIFIC REPORTS, 2018, v.8, 12407
    SCIE Scopus dColl.
  • Selective Elimination of Culture-Adapted Human Embryonic Stem Cells with BH3 Mimetics STEM CELL REPORTS, 2018, v.11 no.5, 1244-1256
    SCIE Scopus dColl.
  • Drug Repositioning for Cancer Therapy Based on Large-Scale Drug-Induced Transcriptional Signatures PLOS ONE, 2016, v.11 no.3
    SCIE Scopus dColl.
  • Modulation of mRNA and lncRNA expression dynamics by the Set2-Rpd3S pathway Nature Communications, 2016, v.7
    SCIE Scopus dColl.
  • A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity PLOS ONE, 2015, v.10 no.10, e0141045
    SCIE Scopus dColl.
  • miRseqViewer: multi-panel visualization of sequence, structure and expression for analysis of microRNA sequencing data BIOINFORMATICS, 2015, v.31 no.4, 596-598
    SCIE Scopus dColl.
  • A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma NATURE GENETICS, 2014, v.46 no.4, 371-
    SCIE Scopus dColl.
  • Exome and transcriptome profiling of lung adenocarcinoma in female never-smokers CANCER RESEARCH, 2014, v.74 no.19
    SCIE Scopus dColl.
  • GEPdb: a database for investigating the ternary association of genotype, gene expression and phenotype BIOINFORMATICS, 2014, v.30 no.17, 2540-2542
    SCIE Scopus dColl.
  • IncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs BIOINFORMATICS, 2014, v.30 no.17, 2480-2485
    SCIE Scopus dColl.
  • gsGator : an integrated web platform for cross-species gene set analysis BMC BIOINFORMATICS, 2014, v.15, 13
    SCIE Scopus dColl.
  • [학술지논문] SARS-CoV-2 infection in severe asthma is associated with worsening of COVID-19 through respiratory NLRP3 inflammasome activation ALLERGY, 2023, v.10 no.1111 , 15452-15452
    SCIE
  • [학술지논문] Targeting Na-H exchanger 1 overcomes nuclear factor kappa B-mediated tumor resistance to radiotherapy NEOPLASIA, 2023, v.35 no.1 , 100862-100862
    SCIE
  • [학술지논문] Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial Clinical and molecular hepatology, 2022, v.28 no.3 , 497-509
    SCIE
  • [학술지논문] Crosstalk between YAP and TGF beta regulates SERPINE1 expression in mesenchymal lung cancer cells INTERNATIONAL JOURNAL OF ONCOLOGY, 2021, v.58 no.1 , 111-121
    SCI
  • [학술지논문] Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, v.117 no.33 , 19982-19993
    SCI
  • [학술지논문] MiR-4435 is an UQCRB-related circulating miRNA in human colorectal cancer SCIENTIFIC REPORTS, 2020, v.10 no.1 , 2833-2833
    SCI
  • [학술지논문] Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.11 , 1831-1844
    SCI
  • [학술지논문] Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation NATURE COMMUNICATIONS, 2020, v.11 no.1 , 4343-4343
    SCI
  • [학술지논문] CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures MOLECULES AND CELLS, 2019, v.42 no.3 , 237-244
    SCI
  • [학술지논문] CSgator: an integrated web platform for compound set analysis JOURNAL OF CHEMINFORMATICS, 2019, v.11 no.0 , 17-17
    SCIE
  • [학술지논문] Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data PHARMACEUTICS, 2019, v.11 no.8 , 377-377
    SCIE
  • [학술지논문] In silico drug repositioning: from large-scale transcriptome data to therapeutics ARCHIVES OF PHARMACAL RESEARCH, 2019, v.42 no.10 , 879-889
    SCIE
  • [학술지논문] Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells FRONTIERS IN CHEMISTRY, 2019, v.7 no.0 , 298-298
    SCIE
  • [학술발표] http://new.ksbmb.or.kr/academic_events_etc/academic_evt_main.php KSBMB International Conference 2019, 대한민국, 제주, 2019-06-04 KSBMB International Conference 2019, 2019
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Courses

  • 2024-2nd

    • General Biology

      • Subject No 20412Class No 03
      • 1Year ( 3Credit , 3Hour) Mon 5~5 (SCI-AA) , Wed 4~4 (102)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅱ

      • Subject No 35312Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
        • Syllabus(File)

    • Human Genome Sequence Data Analysis

      • Subject No G17226Class No 01
      • Year ( 3Credit , 3Hour) Mon 3~4 (SCI-C515)
        • Syllabus(File)

  • 2023-1st

  • 2022-2nd

    • Molecular Biology I

      • Subject No 20600Class No 03
      • 2Year ( 3Credit , 3Hour) Mon 2~2 (POSCO362) , Thu 3~3 (POSCO362)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA203)
        • Syllabus(File)

    • Integrative Biology SeminarⅡ

      • Subject No G16967Class No 01
      • Year ( 3Credit , 3Hour) Mon 3~4 (SCI-C515)
        • Syllabus(File)

  • 2022-1st

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 01
      • 1Year ( 1Credit , 1.5Hour) Mon 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 02
      • 1Year ( 1Credit , 1.5Hour) Tue 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 03
      • 1Year ( 1Credit , 1.5Hour) Wed 6~6 (SCI-AA203)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 04
      • 1Year ( 1Credit , 1.5Hour) Fri 6~6 (SCI-AA203)
        • Syllabus(File)

    • Molecular Biology II

      • Subject No 35825Class No 03
      • 3Year ( 3Credit , 3Hour) Tue 5~5 , Thu 6~6
        • Syllabus(File)

    • System Biology

      • Subject No 36338Class No 01
      • 4Year ( 3Credit , 3Hour) Tue 3~3 , Thu 2~2
        • Syllabus(File)

    • Advanced Molecular Biology

      • Subject No G16977Class No 01
      • Year ( 3Credit , 3Hour) Tue 5~6 (SCI-C)
        • Syllabus(File)

  • 2021-2nd

    • Molecular Biology I

      • Subject No 20600Class No 03
      • 2Year ( 3Credit , 3Hour) Mon 2~2 (POSCO453) , Thu 3~3 (POSCO453)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA203)
        • Syllabus(File)

    • Experiments in Life Sciences II

      • Subject No 35312Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA203)
        • Syllabus(File)

    • Genome Informatics

      • Subject No G17016Class No 01
      • Year ( 3Credit , 3Hour) Mon 3~4 (SCI-C-515)
        • Syllabus(File)

  • 2021-1st

    • Introductory Biology

      • Subject No 10066Class No 01
      • Year ( 3Credit , 3Hour) Tue 3~3 , Fri 3~3
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 01
      • 1Year ( 1Credit , 1.5Hour) Mon 6~6 (SCI-AA202)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 02
      • 1Year ( 1Credit , 1.5Hour) Tue 6~6 (SCI-AA202)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 03
      • 1Year ( 1Credit , 1.5Hour) Wed 6~6 (SCI-AA202)
        • Syllabus(File)

    • General Biology: Laboratory Work I

      • Subject No 33332Class No 04
      • 1Year ( 1Credit , 1.5Hour) Fri 6~6 (SCI-AA202)
        • Syllabus(File)

    • Molecular Biology II

      • Subject No 35825Class No 03
      • 3Year ( 3Credit , 3Hour) Tue 3~3 (POSCO453) , Thu 2~2 (POSCO453)
        • Syllabus(File)

    • System Biology

      • Subject No 36338Class No 01
      • 4Year ( 3Credit , 3Hour) Mon 3~3 (POSCO363) , Wed 2~2 (POSCO363)
        • Syllabus(File)

    • Advanced Molecular Biology

      • Subject No G16977Class No 01
      • Year ( 3Credit , 3Hour) Tue 5~6 (SCI-C)
        • Syllabus(File)
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Academic Background

University of Cambridge Ph.D.(생명정보학)

Seoul Nat'l Univ. 이학석사(미생물학과)

Seoul Nat'l Univ. 이학사(미생물학과)