Yun Soo Bae Professor
Life Sciences/Department of Life Science/College of Medicine
- Science Building A #A209
- 02-3277-2729
- Office hours
- 월 4-6시, 수 4-6시, 금 2-4시
Research Record
- A Natural Inhibitor, 1′S-1′-Acetoxychavicol Acetate, Against Testosterone-Induced Alopecia via NADPH Oxidase Regulation MOLECULES, 2025, v.30 no.10, 2246
- NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease ADVANCED SCIENCE, 2025, v.12 no.42, e05495
- NADPH oxidase 4-SH3 domain-containing YSC84-like 1 complex participates liver inflammation and fibrosis Free Radical Biology and Medicine, 2025, v.227, 246-259
- Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss BIOMOLECULES & THERAPEUTICS, 2025, v.33 no.1, 210-220
- The desulfinylation enzyme sulfiredoxin-1 attenuates HSC activation and liver fibrosis by modulating the PTPN12-NLRP3 axis Hepatology, 2025, v.82 no.1, 92-109
- Nox4-SH3YL1 complex is involved in diabetic nephropathy iScience, 2024, v.27 no.2, 108868
- Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia Experimental and Molecular Medicine, 2024, v.56 no.7, 1620-1630
- Ahnak is required to balance calcium ion homeostasis and smooth muscle development in the urinary system Cell and Bioscience, 2023, v.13 no.1, 108
- CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression Cancer Letters, 2022, v.525, 146-157
- Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease European Journal of Medicinal Chemistry, 2022, v.244, 114854
- NADPH oxidase inhibitor development for diabetic nephropathy through water tank model Kidney Research and Clinical Practice, 2022, v.41, S89-S98
- Nox4-IGF2 Axis Promotes Differentiation of Embryoid Body Cells Into Derivatives of the Three Embryonic Germ Layers Stem Cell Reviews and Reports, 2022, v.18 no.3, 1181-1192
- Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, v.53 no.3, 468-482
- Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells NEOPLASIA, 2021, v.23 no.9, 993-1001
- Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts Frontiers in Cell and Developmental Biology, 2021 , 571676
- Structural Requirements of 1-(2-Pyridinyl)-5-pyrazolones for Disproportionation of Boronic Acids MOLECULES, 2021, v.26 no.22, 6814
- APX-115, a pan-NADPH oxidase inhibitor, protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice FREE RADICAL BIOLOGY AND MEDICINE, 2020, v.161, 92-101
- Crystal structure determination of N- and O-alkylated tautomers of 1-(2-pyridinyl)-5-hydroxypyrazole Journal of Molecular Structure, 2020, v.1215, 128272
- Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors BIOMOLECULES & THERAPEUTICS, 2020, v.28 no.1, 25-33
- Intensive morphometric analysis of enormous alterations in skeletal bone system with micro-CT for AHNAK−/− mice Anatomical Science International, 2020, v.95 no.3, 323-333
- LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1 Cell Reports, 2020, v.33 no.3, 108245
- 2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate enhances thrombopoietin-induced megakaryocytic differentiation and plateletogenesis BMB REPORTS, 2019, v.52 no.7, 434-438
- Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis Cell Death and Differentiation, 2019, v.26 no.9, 1582-1599
- Oxidative activation of type III CD38 by NADPH oxidase-derived hydrogen peroxide in Ca2+ signaling FASEB JOURNAL, 2019, v.33 no.3, 3404-3419
- Pharmacokinetic Study of NADPH Oxidase Inhibitor Ewha-18278, a Pyrazole Derivative PHARMACEUTICS, 2019, v.11 no.9, 482
- The flagellin-TLR5-Nox4 axis promotes the migration of smooth muscle cells in atherosclerosis Experimental and Molecular Medicine, 2019, v.51 no.7, 78
- A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats PHARMACOLOGY, 2018, v.102 no.3-4, 180-189
- AHNAK loss in mice promotes type II pneumocyte hyperplasia and lung tumor development Molecular Cancer Research, 2018, v.16 no.8, 1287-1298
- Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition Scientific Reports, 2018, v.8 no.1, 14379
- Fc gamma R/ROS/CK2 alpha Is the Key Inducer of NF-kappa B Activation in a Murine Model of Asthma INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2018, v.175 no.1-2, 16-25
- Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States CELL REPORTS, 2018, v.23 no.9, 2667-2677
- A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: Possible role of peroxisomal and mitochondrial biogenesis Oncotarget, 2017, v.8 no.43, 74217-74232
- APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury LABORATORY INVESTIGATION, 2017, v.97 no.4, 419-431
- C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxal) in the NOX1 complex BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, v.490 no.3, 594-600
- Fluorescence-reported allelic exchange mutagenesis reveals a role for Chlamydia trachomatis TmeA in invasion that is independent of host AHNAK Infection and Immunity, 2017, v.85 no.12, e00640-17
- NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection Scientific Reports, 2017, v.7 no.1
- A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase Scientific Reports, 2016, v.6
- AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to beta-adrenergic signalling SCIENTIFIC REPORTS, 2016, v.6
- Ahnak stimulates BMP2-mediated adipocyte differentiation through Smad1 activation Obesity, 2016, 6 JAN 2016
- Flagellin-induced NADPH oxidase 4 activation is involved in atherosclerosis Scientific Reports, 2016, v.6
- Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A(2) Deactivation INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2016, v.171 no.1, 61-70
- NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells CANCER RESEARCH, 2016, v.76 no.4
- Regulation of c-Myc expression by Ahnak promotes induced pluripotent stem cell generation Journal of Biological Chemistry, 2016, v.291 no.2, 752-761
- Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors BIOORGANIC & MEDICINAL CHEMISTRY, 2016, v.24 no.18, 4144-4151
- 2-(Trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34+ haematopoietic stem cells Journal of Tissue Engineering and Regenerative Medicine, 2015, v.9 no.4, 435-446
- Dual oxidase 2 is essential for house dust mite-induced pro-inflammatory cytokine production in human keratinocytes Experimental Dermatology, 2015, 21 Aug 2015
- Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak(-/-) Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure PLOS ONE, 2015, v.10 no.10
- Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells BMB Reports, 2015, v.48 no.12, 691-695
- 2-(Trimethylammonium) Ethyl (R)-3-Methoxy-3-oxo-2-Stearamidopropyl Phosphate Suppresses Osteoclast Maturation and Bone Resorption by Targeting Macrophage-Colony Stimulating Factor Signaling MOLECULES AND CELLS, 2014, v.37 no.8, 628-635
- Ahnak functions as a tumor suppressor via modulation of TGF beta/Smad signaling pathway ONCOGENE, 2014, v.33 no.38, 4675-4684
- Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway. Oncogene, 2014, v.33 no.38, 4675-4684
- Dual Oxidase 2 in Lung Epithelia Is Essential for Hyperoxia-Induced Acute Lung Injury in Mice ANTIOXIDANTS & REDOX SIGNALING, 2014, v.21 no.13, 1803-1818
- Hydrogen peroxide generated by DUOX1 regulates the expression levels of specific differentiation markers in normal human keratinocytes JOURNAL OF DERMATOLOGICAL SCIENCE, 2014, v.74 no.1, 56-63
- Nox4-Mediated Cell Signaling Regulates Differentiation and Survival of Neural Crest Stem Cells MOLECULES AND CELLS, 2014, v.37 no.12, 907-911
- Testosterone Stimulates Duox1 Activity through GPRC6A in Skin Keratinocytes JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, v.289 no.42, 28835-28845
Courses
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2025-2nd
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General Biology
- Subject No 20412Class No 01
- 1Year ( 3Credit , 3Hour) Wed 3~3 (SCI-AA) , Fri 2~2 (102)
-
Introduction to Cell Signaling
- Subject No 38212Class No 01
- 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO454) , Thu 6~6 (POSCO454)
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Research for Life Science Ⅱ
- Subject No G16933Class No 01
- Year ( 3Credit , 3Hour)
-
Special Topics in Advanced Biochemistry Ⅱ
- Subject No G16947Class No 01
- Year ( 3Credit , 3Hour) Tue 2~3 (SCI-C)
-
Cellular Signal Transduction
- Subject No G16997Class No 01
- Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C)
-
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2025-1st
-
General Biology Ⅰ
- Subject No 20413Class No 01
- 1Year ( 3Credit , 3Hour) Mon 2~2 (POSCO453) , Thu 3~3 (POSCO453)
-
Biochemistry
- Subject No 21963Class No 01
- 3Year ( 3Credit , 3Hour) Thu 4~5 (POSCO552)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
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Signal Transduction and Drug Discovery
- Subject No G16982Class No 01
- Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)
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2024-1st
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General Biology Ⅰ
- Subject No 20413Class No 01
- 1Year ( 3Credit , 3Hour) Mon 4~4 (POSCO453) , Thu 5~5 (POSCO453)
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Biochemistry Ⅰ
- Subject No 33716Class No 03
- 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO366) , Wed 2~2 (POSCO366)
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Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
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Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
-
Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
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Biology of Reactive Oxygen Species Ⅰ
- Subject No G16942Class No 01
- Year ( 3Credit , 3Hour) Tue 3~4 (SCI-C)
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Special Topics in Advanced Biochemistry Ⅰ
- Subject No G16946Class No 01
- Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)
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2023-2nd
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Introduction to Cell Signaling 강의 계획서 상세보기
- Subject No 38212Class No 01
- 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO160) , Thu 6~6 (POSCO160)
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Research for Life ScienceⅡ
- Subject No G16933Class No 01
- Year ( 3Credit , 3Hour)
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Redox RegulationⅠ
- Subject No G16944Class No 01
- Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C)
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Cellular Signal Transduction
- Subject No G16997Class No 01
- Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
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2023-1st
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Biochemistry 강의 계획서 상세보기
- Subject No 21963Class No 01
- 3Year ( 3Credit , 3Hour) Mon 3~4 (EDU-)
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Experiments in Life Sciences I 강의 계획서 상세보기
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
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Experiments in Life Sciences I 강의 계획서 상세보기
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
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Experiments in Life Sciences I 강의 계획서 상세보기
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
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Experiments in Life Sciences I 강의 계획서 상세보기
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
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Experiments in Life Sciences I 강의 계획서 상세보기
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
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Redox RegulationⅡ
- Subject No G16945Class No 01
- Year ( 3Credit , 3Hour) Tue 3~4 (SCI-C)
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2022-2nd
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Introductory Biology
- Subject No 10066Class No 01
- Year ( 3Credit , 3Hour) Mon 3~3 , Thu 4~4
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General Biology
- Subject No 20412Class No 03
- 1Year ( 3Credit , 3Hour) Tue 4~4 (SCI-AA) , Fri 5~5 (101)
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Introduction to Cell Signaling
- Subject No 38212Class No 01
- 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO361) , Thu 6~6 (POSCO361)
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Research for Life ScienceⅣ
- Subject No G16935Class No 01
- Year ( 3Credit , 3Hour)
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Biology of Reactive Oxygen SpeciesⅡ
- Subject No G16943Class No 01
- Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C)
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2022-1st
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Biochemistry
- Subject No 21963Class No 01
- 3Year ( 3Credit , 3Hour) Wed 5~5 (EDU-) , Fri 6~6 (461)
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Biochemistry I
- Subject No 33716Class No 03
- 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO366) , Wed 2~2 (POSCO366)
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Experiments in Life Sciences I
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
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Life Science SeminarⅠ
- Subject No G16928Class No 01
- Year ( 3Credit , 3Hour) Thu 3~4 (-)
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Biology of Reactive Oxygen SpeciesⅠ
- Subject No G16942Class No 01
- Year ( 3Credit , 3Hour) Tue 3~4 (-)
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Academic Background
Korea Advanced Institute of Science & Technology 이학박사(생물공학과)