Professor Jong Ran Lee, a professor in the Department of Life Science is an expert in the research field of immunology and cell signaling. She received her Ph.D. from the University of Texas at Austin and has been studying immune cell differentiation, activation, and function. She has identified several novel proteins in the process of studying mechanisms for surface receptor-mediated sigal transduction in immune cells. She has focused on finding new roles of these proteins in relation to immune diseases and has published many papers in the prestigious international scientific journals.
T cells in ARAP-deficient mice present defective T cell receptor signaling and reduced severity in an experimentally-induced autoimmune diseaseFRONTIERS IN IMMUNOLOGY, 2025, v.16, 1556616
Over-Expression of p190RhoGEF Regulates the Formation of Atherosclerotic Plaques in the Aorta of ApoE−/− Mice via Macrophage PolarizationInternational Journal of Molecular Sciences, 2023, v.24 no.16, 12785
Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory ResponsesFrontiers in Immunology, 2022, v.13, 782475
Over-expression of p190RhoGEF enhances B-cell activation and germinal center formation in T-cell-dependent humoral immune responsesImmunology and Cell Biology, 2019, v.97 no.10, 877-887
Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiationExperimental and Molecular Medicine, 2012, v.44 no.2, 138-148
Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPKExperimental and Molecular Medicine, 2011, v.43 no.2, 101-110
[학술지논문] Competition between SLP76 and LAT for PLC gamma 1 binding in resting T cells
EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, v.40
, 2330-2339
SCI
[학술지논문] Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge
PHYTOMEDICINE, 2009, v.16
, 327-335
SCI
[학술지논문] Characterization of phenotypically distinct B-cell subsets and receptor-stimulated mitogen-activated protein kinase activation in human cord blood B cells
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, v.84
no.6
, 1557-1564
SCI
[학술지논문] Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator
BIOCHEMICAL JOURNAL, 2007, v.403
, 250-2
SCI
[학술지논문] Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase
FEBS LETTERS, 2004, v.575
no.1-3
, 35-40
SCI
[학술지논문] Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40(phox), a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase
JOURNAL OF IMMUNOLOGY, 2004, v.172
, 231-239
SCI
[학술지논문] Cutting Edge: Induced expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, following CD40 stimulation and WEHI 231 B cell activation
Journal of Immunology, Cutting Edge, 2003, v.170
no.1
, 19-23
SCI
[학술지논문] Reactive oxygen species play roles on B cell surface receptor CD40-mediated proximal and distal signaling events: Effects of an antioxidant, N-Acetyl-L-Cysteine treatment
Molecular and Cellular Biochemistry, 2003, v.252
no.1
, 1-7
SCI
[저역서] Encyclopedia of Signaling Molecules
Springer, 2012, 2171
[학술발표] The adaptor protein ARAP regulates LPS-induced inflammatory cytokine production in mouse dendritic cells via phosphoinositide-3 kinase pathwayKAI International Meeting 2023, 대한민국, 2023-09-14
KAI International Meeting 2023, 2023
[학술발표] A novel adaptor protein, ARAP, is required for dendritic cell functions8th Federation of Immunological Societies of Asia-Oceania (FiMSA) Congress, 대한민국, 부산, 2021-10-31
8th FIMSA Congress, 2021
[학술발표] Overexpression of p190RhoGEF in macrophage enhances the formation of atherosclerotic plaques in mouse aortaKABMB International Conference 2020, 대한민국, 서울, 2020-09-22
KABMB International Conference 2020, 2020
[학술발표] Role of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Myeloid Cells, 아일랜드, Killarney, County Kerry, 2016-04-12
Keystone Symposia Myelodi Cells, 2016, 62-62
[학술발표] Role of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in T Cell-Dependent B Cell ActivationB Cells at the Intersection of Innate and Adaptive Immunity, 스웨덴, Stockholm, 2016-05-31
Keystone symposia B cells at the Intersection of Innate and Adaptive Immunity, 2016, 65-65
[학술발표] Function of a novel adaptor protein ARAP in T cell adhesion2012 KSBMB Annual Meeting, 대한민국, 서울, 2012-05-31
2012 생화학분자생물학회 연례국제학술대회 초록집, 2012
[학술발표] No.084 Over-expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, in mouse dendritic cells negatively regulates cellular responses to bacterial lipopolysaccharideChina Tregs 2012, 중국, Shanghai, 2012-10-14
Programs and Abstracts booklet, 2012, 131-132
[학술발표] A novel adaptor protein, activation-dependent, raft-recruited ADAP-like phosphoprotein, ARAP, plays an active role in T cell activation14th International Congress of Immunology, 일본, Kobe, 2010-08-23
International Immunology August 2010 Volume 22 supplement No. 1. i42 PP-004-22, 2010
[학술발표] Functional characterization of a new adaptor molecule in T cell activation2010년 대한면역학회 추계학술대회, 대한민국, 서울, 2010-11-18
2010년 대한면역학회 추계학술대회 초록집, 2010, 36-36
[학술발표] Functional studies of a novel adaptor protein, ARAP, in T cell receptor signaling2010년 대한면역학회 추계학술대회, 대한민국, 서울, 2010-11-18
2010년 대한면역학회 추계학술대회 초록집, 2010, 106-106
[학술발표] Functional studies of dendritic cells after bacterial infection in p190RhoGEF transgenic mice2010년 대한면역학회 추계학술대회, 대한민국, 서울, 2010-11-19
2010년 대한면역학회 추계학술대회 초록집, 2010, 163-163
[학술발표] Negative role of an adaptor protein, Odin in T cell receptor signaling 2010년 대한면역학회 추계학술대회 , 대한민국, 서울, 2010-11-18
2010년 대한면역학회 추계학술대회 초록집, 2010, 109-109
[학술발표] RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, functions in T cell-dependent immune responses14th International Congress of Immunology, 일본, Kobe, 2010-08-25
International Immunology August 2010 Volume 22 supplement No. 1. iii51 WS/PP-050-05, 2010
[학술발표] A new role of SLP-76 adaptor protein in the signaling cascade of phosphoinositide 3-kinase in T cells대한면역학회 제58차 춘계학술대회, 대한민국, 2009-05-01
대한면역학회 제58차 춘계학술대회 초록집, 2009
[학술발표] A region homologous to the P1 domain of SLP76 in LAT associates with PLC1 in SLP76-deficient Jurkat T cells2009년 대한면역학회 추계학술대회, 대한민국, 서울, 2009-11-09
2009년 대한면역학회 추계학술대회 초록집, 2009
[학술발표] Characterization of the production of reactive oxygen species by 5-lipoxygenase in CD40 signaling in B cells대한면역학회 제58차 춘계학술대회, 대한민국, 2009-05-01
대한면역학회 제58차 춘계학술대회 초록집, 2009
[학술발표] Constitutive interaction between LAT and PLCgamma1 in SLP76-deficient T cells2009년도 한국분자세포생물학회 정기학술대회, 대한민국, 서울, 2009-10-15
2009년도 한국분자세포생물학회 정기학술대회 초록집, 2009, 207-207
[학술발표] Functional studies of novel adaptors isolated from the analysis of raft proteins after T cell receptor activation2009년 대한면역학회 추계학술대회, 대한민국, 서울, 2009-11-09
2009년 대한면역학회 추계학술대회 초록집, 2009
[학술발표] In vivo function of p190RhoGEF in T cell-dependent immune responses2009년 대한면역학회 추계학술대회, 대한민국, 서울, 2009-11-09
2009년 대한면역학회 추계학술대회 초록집, 2009
[학술발표] Novel adaptor proteins being tyrosine-phosphorylated and raft-recruited in T cell activation2009년도 한국분자세포생물학회 정기학술대회, 대한민국, 서울, 2009-10-15
2009년도 한국분자세포생물학회 정기학술대회 초록집, 2009, 207-207
[학술발표] Role of a Rho A-specific guanine nucleotide exchange factor, p190RhoGEF, in mouse dendritic cells2009년 대한면역학회 추계학술대회, 대한민국, 서울, 2009-11-09
2009년 대한면역학회 추계학술대회 초록집, 2009
[학술발표] Role of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, in CD40-induced B cell maturation and differentiation2009년 대한면역학회 추계학술대회, 대한민국, 서울, 2009-11-09
2009년 대한면역학회 추계학술대회 초록집, 2009
[학술발표] Analysis of B cell subset and CD40-mediated signaling in human cord blood B cellsThe 9th ICCB & The 20th Annual Conference of the KSMCB, 대한민국, 서울, 2008-10-09
KSBCB & ICCB 2008 초록집, 2008, 363-363
[학술발표] Association of the B cell linker protein with the p85 subunit of phosphoinositide 3-Kinase대한면역학회 (57th Fall Conference), 대한민국, 서울, 2008-11-13
대한면역학회 초록집, 2008, 170-170
[학술발표] CD40 signaling in B cell maturation and differentiationThe 65th KSBMB Annual Meeting , 대한민국, Seoul, 2008-05-09
KSBMB Abstract Book, 2008, 174-174
[학술발표] Characterization of phenotypically distinct B cell subsets and receptor-stimulated mitogen-activated protein kinase activation in human cord blood B cells대한면역학회 (57th Fall Conference), 대한민국, 서울, 2008-11-13
대한면역학회 초록집, 2008, 120-120
[학술발표] Constitutive interaction of PLCg1 with SLP-76 in T cells at resting states is required for the prevention of PLCg1 binding to LAT대한면역학회 (57th Fall Conference), 대한민국, 서울, 2008-11-13
대한면역학회 초록집, 2008, 171-171
[학술발표] Correlation of p190RhoGEF expression and B cell maturation/differentiationThe 9th ICCB & The 20th Annual Conference of the KSMCB, 대한민국, 서울, 2008-10-09
KSMCB & ICCB 2008 초록집, 2008, 363-363
[학술발표] Role of SLP-76 and LAT in the phosphoinositide 3-kinase signaling pathway in activated T cellsThe 9th ICCB & The 20th Annual Conference of the KSMCB, 대한민국, 서울, 2008-10-09
KSMCB & ICCB 2008, 2008, 365-365
[학술발표] Tyrosine-phosphorylation-dependent interaction of the adaptor protein BLNK with the p85 subunit of phosphoinositide 3-kinaseThe 9th ICCB & The 20th Annual Conference of the KSMCB, 대한민국, 서울, 2008-10-09
KSMCB & ICCB 2008 초록집, 2008, 365-365
[학술발표] Analysis of a signaling complex containing PLC-gamma1 and adaptor proteins, LAT and SLP-76 in T cells19th FAOBMB Seoul Conference, 대한민국, Seoul, 2007-05-29
[학술발표] CD40 signaling by production of reactive oxygen species through 5-lipoxygenase pathway in human B cells19th FAOBMB Seoul Conference, 대한민국, Seoul, 2007-05-28
[학술발표] RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, regulates CD40-mediated final stage of B cell maturation and differentiation.Keystone Symposia, Biology of B cells in Health and Disease, 캐나다, Banff, 2007-02-08
[학술발표] Anti-diabetic effect of the major active components isolated from Salvia miltiorrhiza Bunge by an analysis of the effect on insulin receptor signaling.대한약학회, 대한민국, 서울, 2006-11-06
[학술발표] Correlation of p190RhoGEF expression and B cell activation/maturationKeystone Symposia (Lymphocyte Activation and Signaling), 미국, Colorado , 2006-01-08
[학술발표] Role of SLP-76 and LAT in the phosphoinositide 3-kinase signaling pathway in activated T cellsKeystone Symposia (Lymphocyte Activation and Signaling), 미국, Colorado, 2006-01-08
[학술발표] Signaling events through CD40 in B cell activation and maturationConvention of The Pharmaceutical Society of Korea, 대한민국, 서울, 2005-04-18
[학술발표] A new role of the adaptor protein SLP-76 in the phosphoinositide 3-kinase signaling pathway in activated T cellsKorean Society for Biochemistry and Molecular Biology , 대한민국, 서울, 2004-05-28
[학술발표] Alternative CD40 signaling pathway for the production of reactive oxygen species and the activation of p38 mitogen-activated protein kinase using 5-lipoxygenase12th International Congress of Immunology, 캐나다, Montreal, 2004-07-20
[학술발표] Alternative pathway for the CD40-induced production of reactive oxygen species using 5-lipoxygenase in human B lymphocytesKorean Society for Biochemistry and Molecular Biology, 대한민국, 서울, 2004-05-28
[학술발표] Anti-diabetic pentacyclic triterpenoids from leaves of Campsis grandiflora by an analysis of the effect on insulin receptor signalingThe Pharmaceutical Society of Korea, 대한민국, 서울, 2004-10-22
[학술발표] Anti-diabetic potential of ginsenosides, the major active components of ginseng by an analysis of the effect on insulin receptor signalingThe Pharmaceutical Society of Korea, 대한민국, 서울, 2004-10-22
[학술발표] Direct association of an adaptor protein SLP-76 with p85 subunit of phosphoinositide 3-kinase as a new role in T cell activation고사리 세포신호전달 심포지움, 대한민국, 2004-01-30
[학술발표] Induced expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, in the B cell maturation by CD40Korean Society for Biochemistry and Molecular Biology, 대한민국, 서울, 2004-05-28
[학술발표] Generation of reactive oxygen species after CD40 stimulation in B lymphocytes고사리 세포신호전달 심포지움, 대한민국, 2003-01-24
[학술발표] Ligand-stimulated induction of CD40 and TRAF3 in human aortic endothelial and smooth muscle cellInternational Symposium on New Horizons of Biomedicine, 대한민국, 서울, 2003-10-30
[학술발표] Protein kinase activation and B lymphocyte population in human cord blood mononuclear cellInternational Symposium on New Horizons of Biomedicine, 대한민국, 서울, 2003-10-29
[학술발표] RhoA-specific guanine nucleotide exchange factor, p190RhoGEF and WEHI 231 B cell activation고사리 세포신호전달 심포지움, 대한민국, 2003-01-24
[학술발표] Role of SLP-76 interaction with p85, a subunit of phosphatidylinositol 3-kinase in T cell activationThe American Association of Immunologists Annual Meeting, 미국, Denver, 2003-05-09
[학술발표] Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of NADPH oxidase.The American Association of Immunologists Annual Meeting, 미국, Denver, 2003-05-08
[학술발표] SLP-76 interaction with p85, a subunit of phosphatidylinositol 3-kinase고사리 세포신호전달 심포지움, 대한민국, 2003-01-24
[학술발표] 수용체 신호기전의 고찰을 통한 제대혈 B 림파구 특성 연구2003년 보건의료기술진흥사업 연구발표회, 대한민국, 서울, 2003-12-05
[학술발표] Characterization of SLP-76 interaction with p85, a subunit of phosphatidylinositol 3-kinase한국분자˙세포생물학회 추계학술대회, 대한민국, 서울, 2002-10-17
[학술발표] Differential activation of kinases following B cell antigen and/or CD40 receptor ligation in human cord blood mononuclear cellsWorld Congress of the International Society of Hematology, 대한민국, 서울, 2002-08-25
[학술발표] Induced expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, following CD40 stimulation and WEHI 231 B cell activationGordon Research Conference , 미국, Andover, NH, 2002-08-20
[학술발표] Molecular adapter SLP-76 associates with p85 subunit of phosphatidylinositol 3-kinase through tyrosine phosphorylation고사리 세포신호전달 심포지움, 대한민국, 2002-02-01
[학술발표] T 세포 신호전달물질로서의 활성산소종의 역할과학기술부 지원 2001 이화여자대학연구기반확충사업 연구발표, 대한민국, 서울, 2002-08-15
[학술발표] Two separate pathways for the generation of reactive oxygen species after CD40 stimulation in B lymphocytes한국분자˙세포생물학회 추계학술대회, 대한민국, 서울, 2002-10-17
[학술발표] CD40-induced Up-regulation of p190RhoGEF, a RhoA-specific Guanine Nucleotide Exchange Factor, Mediates B Cell Activation한국분자, 세포생물학회 추계학술대회, 대한민국, 서울, 2001-10-11
[학술발표] Molecular Adapter SLP-76 Associates with p85 Subunit of Phosphatidylinositol 3-Kinase through Tyrosine Phosphorylation한국분자, 세포생물학회 추계학술대회, 대한민국, 서울, 2001-10-11
[학술발표] Reactive Oxygen Species Mediate Cellular Functions of CD40 Signaling in WEHI 231 B cells한국분자, 세포생물학회 추계학술대회, 대한민국, 서울, 2001-10-11
[학술발표] Reactive Oxygen Species Mediate p38 MAP Kinase Activation and p190RhoGEF Expression by B Cell Surface Receptor CD40 Cross-linking제43차 대한면역학회, 2001년 한국 BRM학회 통합추계학술대회, 대한민국, 서울, 2001-11-29
[학술발표] Reactive Oxygen Species-dependent p38 Mitogen-activated Protein Kinase Activation by CD40 Requires NADPH Oxidase or 5-Lipoxygenase Activity in B cells한국분자, 세포생물학회 추계학술대회, 대한민국, 서울, 2001-10-11
[학술발표] SLP-76 결합 단백질들의 기능 분석에 의한 T 세포 활성화 조절기전 연구2001년도 보건의료기술진흥사업 연구발표회, 대한민국, 서울, 2001-12-07
[학술발표] T 세포 신호전달물질로서의 활성산소종의 역할과학기술부 지원 2000 이화여자대학연구기반확충사업 연구발표, 대한민국, 서울, 2001-08-21
[학술발표] B cell surface receptor, CD40, cross-linking activates p38 mitogen-activated protein kinase through the generation of reactive oxygen species.40th Annual Meeting American Society for Cell Biology 초록집, 미국, San Francisco, 2000-12-09
[학술발표] Inducible expression of membrane-bound catalase enhances protein tyrosine phosphorylation and cell death by surface receptor stimulation in Jurkat T cells.제12차 한국분자생물학회 추계학술대회 초록집, 대한민국, 서울, 2000-10-12
[학술발표] Reactive oxygen species are involved in the up-regulation of several proteins following ligation of surface receptor CD40 on WEHI231 B cell line.40th Annual Meeting The American Society for Cell Biology , 미국, San Francisco, 2000-12-09
[학술발표] Extracellular signal-regulated kinase, but not c-Jun NH2-terminal kinase, activation correlates with surface IgM-mediated apoptosis in the WEHI 231 B cell line.6th IUBMB Seoul Conference, 대한민국, 서울, 1999-10-10
[학술발표] Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice1999년 한국분자생물학회 추계학술대회, 대한민국, 서울, 1999-10-25