이화여자대학교

Hyun-seok Kim Associate Professor

Life Sciences/Life Sciences

김현석 프로필 사진 
Professor Hyun-Seok Kim, who was joined in Department of Life Science, Ewha Womans University at March 2012, has worked to understand the mechanisms of aging and tumorigenesis. After Ph.D course from Dept. biochemistry, College of Medicine, University of Hallym, he joined in National Institute of Health, USA at 2003 as postdoc fellow, and then moved to Medical center of Vanderbilt as research professor at 2010. His major field is the research of molecular mechanisms about aging, metabolism, and aging-related diseases through acetylation/deacetylation of proteins within cell. Until now, he has published about 20 international papers with SCI, and among many studies, some were published on Cancer Cell and Cell Metabolism, one of the most famous journal in the field of Cancer and Metabolism, respectively. In recent, he got the outstanding paper award from NIH, USA based on his work.
  • Department Chair, Bioinspired Science
  • Science Building C #321
  • 02-3277-3439
Research Record
  • Reversible acetylation modulates p54nrb/NONO-mediated expression of the interleukin 8 gene Biochemical and Biophysical Research Communications, 2022, v.622, 50-56
    SCIE Scopus dColl.
  • Intracellular NAD(+) Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation FRONTIERS IN IMMUNOLOGY, 2021, v.12, 765477
    SCIE Scopus dColl.
  • Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway ELIFE, 2021, v.10, e65952
    SCIE Scopus dColl.
  • Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for beta-catenin or MITF in colon cancer and melanoma cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.7, 1075-1089
    SCIE Scopus KCI dColl.
  • Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020 , 1831-1844
    SCIE Scopus KCI dColl.
  • Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory NEUROCHEMICAL RESEARCH, 2019, v.44 no.3, 676-682
    SCIE Scopus dColl.
  • Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation BMB REPORTS, 2019, v.52 no.3, 190-195
    SCIE Scopus KCI dColl.
  • SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions Autophagy, 2019, v.15 no.8, 1356-1375
    SCIE Scopus dColl.
  • Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain MOLECULAR BRAIN, 2018, v.11, 49
    SCIE Scopus dColl.
  • NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling Scientific Reports, 2017, v.7 no.1
    SCIE Scopus dColl.
  • Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • Nitric Oxide Induction of Parkin Translocation in PTEN-induced Putative Kinase 1 (PINK1) Deficiency FUNCTIONAL ROLE OF NEURONAL NITRIC OXIDE SYNTHASE DURING MITOPHAGY JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, v.290 no.16, 10325-10335
    SCIE Scopus dColl.
  • WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis ONCOGENE, 2015, v.34 no.23, 3023-3035
    SCIE Scopus dColl.
  • SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient-and exercise-induced stress Antioxidants and Redox Signaling, 2014, v.21 no.4, 551-564
    SCIE Scopus dColl.
  • Telomere length and telomerase activity are related with immortalization frequency but not with replicative senescence in mammalian embryonic fibroblasts, except human embryonic fibroblasts ANIMAL CELLS AND SYSTEMS, 2014, v.18 no.6, 387-393
    SCIE KCI Scopus dColl.
  • Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts MOLECULAR BIOLOGY REPORTS, 2014, v.41 no.4, 2397-2408
    SCIE Scopus dColl.
  • [학술지논문] Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory NEUROCHEMICAL RESEARCH, 2019, v.44 no.3 , 676-682
    SCI
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Courses

  • 2024-2nd

    • General Biology

      • Subject No 20412Class No 01
      • 1Year ( 3Credit , 3Hour) Wed 3~3 (SCI-AA) , Fri 2~2 (102)
        • Syllabus(File)

    • General Biology : Laboratory Work Ⅱ

      • Subject No 33333Class No 01
      • 1Year ( 1Credit , 1.5Hour) Tue 7~7 (SCI-AA203)
        • Syllabus(File)

    • General Biology : Laboratory Work Ⅱ

      • Subject No 33333Class No 02
      • 1Year ( 1Credit , 1.5Hour) Mon 7~7 (SCI-AA203)
        • Syllabus(File)

    • Biochemistry Ⅱ

      • Subject No 35824Class No 01
      • 2Year ( 3Credit , 3Hour) Tue 4~4 (POSCO361) , Fri 5~5 (POSCO361)
        • Syllabus(File)

    • Research for Life Science Ⅳ

    • Biology of Reactive Oxygen Species Ⅱ

      • Subject No G16943Class No 01
      • Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
        • Syllabus(File)

    • Special Topics in Advanced Biochemistry Ⅱ

      • Subject No G16947Class No 01
      • Year ( 3Credit , 3Hour) Tue 2~3 (SCI-C)
        • Syllabus(File)

  • 2024-1st

    • Biochemistry Ⅰ

      • Subject No 33716Class No 02
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO362) , Wed 2~2 (POSCO362)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
        • Syllabus(File)

    • Research for Life Science Ⅰ

    • Special Topics in Advanced Biochemistry Ⅰ

      • Subject No G16946Class No 01
      • Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)
        • Syllabus(File)

    • Advanced Biochemistry

      • Subject No G16976Class No 01
      • Year ( 3Credit , 3Hour) Tue 7~8 (SCI-C)
        • Syllabus(File)

  • 2023-2nd

  • 2023-1st

  • 2022-2nd

    • General Biology

      • Subject No 20412Class No 03
      • 1Year ( 3Credit , 3Hour) Tue 4~4 (SCI-AA) , Fri 5~5 (101)
        • Syllabus(File)

    • Biochemistry II

      • Subject No 35824Class No 03
      • 2Year ( 3Credit , 3Hour) Mon 4~4 (POSCO366) , Thu 5~5 (POSCO366)
        • Syllabus(File)

    • Human Disease Model Phenomics

      • Subject No G17003Class No 01
      • Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
        • Syllabus(File)

  • 2022-1st

    • Biochemistry

      • Subject No 21963Class No 01
      • 3Year ( 3Credit , 3Hour) Wed 5~5 (EDU-) , Fri 6~6 (461)
        • Syllabus(File)

    • Biochemistry I

      • Subject No 33716Class No 02
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO362) , Wed 2~2 (POSCO362)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
        • Syllabus(File)

    • Life Science SeminarⅠ

      • Subject No G16928Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (-)
        • Syllabus(File)

    • Advanced Biochemistry

      • Subject No G16976Class No 01
      • Year ( 3Credit , 3Hour) Mon 7~8 (-)
        • Syllabus(File)

  • 2021-2nd

    • General Biology

      • Subject No 20412Class No 02
      • 1Year ( 3Credit , 3Hour) Tue 4~4 , Fri 5~5
        • Syllabus(File)

    • Biochemistry II

      • Subject No 35824Class No 03
      • 2Year ( 3Credit , 3Hour) Mon 4~4 , Thu 5~5
        • Syllabus(File)

    • Human Disease Model Phenomics

      • Subject No G17003Class No 01
      • Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
        • Syllabus(File)

  • 2021-1st

    • General Biology I

      • Subject No 20413Class No 03
      • 1Year ( 3Credit , 3Hour) Tue 2~2 , Fri 3~3
        • Syllabus(File)

    • Biochemistry I

      • Subject No 33716Class No 02
      • 2Year ( 3Credit , 3Hour) Wed 3~3 , Fri 2~2
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Thu 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Fri 6~7
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Thu 4~5 (SCI-AA205)

    • Advanced Biochemistry

      • Subject No G16976Class No 01
      • Year ( 3Credit , 3Hour) Mon 2~3
        • Syllabus(File)
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Academic Background

Hallym Univ. 의학박사(의학)