이화여자대학교

Sang Won Kang Professor

Life Sciences/Life Sciences/College of Medicine

강상원 프로필 사진 
Prof. Sang Won Kang in Department of Life Sciences is a leading scientist in the field of reactive oxygen species-mediated signal transduction. He began to study the ROS signaling in NIH, U.S., with postdoctoral career, as a pioneer in the field. He is particularly interested in the mechanism of ROS function in the signal transduction and furthermore tries to apply the research result to the medical aspects to find a clue for human chronic diseases, such as cancer and vascular diseases. Since he joined the department, he published the important results on the high-impact journals (e.g. Nature, Molecular Cell, etc). He is also actively involved in the proteomics society.
  • Science Building C #504
  • 02-3277-3352
  • Office hours
    • 화 9 - 10시, 목 9 - 11시
Research Record
  • A small molecule compound that inhibits blue light-induced retinal damage via activation of autophagy Biochemical Pharmacology, 2023, v.211, 115534
    SCIE Scopus dColl.
  • Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation Cell Reports, 2023, v.42 no.11, 113361
    SCIE Scopus dColl.
  • Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells Scientific reports, 2023, v.13 no.1, 2404
    SCIE Scopus dColl.
  • Glucose Deprivation Induces Cancer Cell Death through Failure of ROS Regulation International Journal of Molecular Sciences, 2023, v.24 no.15, 11969
    SCIE Scopus dColl.
  • Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells Redox Biology, 2022, v.51, 102293
    SCIE Scopus dColl.
  • PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation Nature Communications, 2022, v.13 no.1, 1768
    SCIE Scopus dColl.
  • RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis Molecules and Cells, 2022, v.45 no.4, 193-201
    SCIE Scopus KCI dColl.
  • CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication MOLECULES AND CELLS, 2021, v.44 no.2, 101-115
    SCIE Scopus KCI dColl.
  • GPx-1-encoded adenoviral vector attenuates dopaminergic impairments induced by methamphetamine in GPx-1 knockout mice through modulation of NF-KB transcription factor FOOD AND CHEMICAL TOXICOLOGY, 2021, v.154, 112313
    SCIE Scopus dColl.
  • Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, v.53 no.6, 1080-1091
    SCIE Scopus KCI dColl.
  • Circulating lipidomic alterations in obese and non-obese subjects with non-alcoholic fatty liver disease ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, v.52 no.10, 1603-1614
    SCIE Scopus dColl.
  • Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29, UNSP 101391
    SCIE Scopus dColl.
  • Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink-dependent matrix assembly FASEB JOURNAL, 2020, v.34 no.8, 10228-10241
    SCIE Scopus dColl.
  • Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation CANCERS, 2020, v.12 no.9, 2601
    SCIE Scopus dColl.
  • SEZ6L2 Is an Important Regulator of Drug-Resistant Cells and Tumor Spheroid Cells in Lung Adenocarcinoma BIOMEDICINES, 2020, v.8 no.11, 500
    SCIE Scopus dColl.
  • Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-alpha-Induced Apoptosis via Different Routes CELL REPORTS, 2019, v.26 no.8, 2194-
    SCIE Scopus dColl.
  • Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51, 144
    SCIE Scopus KCI dColl.
  • Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres BIOMOLECULES, 2019, v.9 no.10, 595
    SCIE Scopus dColl.
  • A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells SCIENTIFIC REPORTS, 2018, v.8, 16551
    SCIE Scopus dColl.
  • Lipidomic profiling reveals free fatty acid alterations in plasma from patients with atrial fibrillation PLOS ONE, 2018, v.13 no.5
    SCIE Scopus dColl.
  • OCT4 directly regulates sternness and extracellular matrix-related genes in human germ cell tumours BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, v.503 no.3, 1980-1986
    SCIE Scopus dColl.
  • Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux AUTOPHAGY, 2018, v.14 no.1, 120-133
    SCIE Scopus dColl.
  • Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, v.50
    SCIE Scopus KCI dColl.
  • INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis Oncotarget, 2017, v.8 no.70, 115041-115053
    SCIE Scopus dColl.
  • Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells Nature Communications, 2017, v.8 no.1
    SCIE Scopus dColl.
  • Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence BMB Reports, 2017, v.50 no.10, 528-533
    SCIE Scopus KCI dColl.
  • Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress Nature Communications, 2017, v.8
    SCIE Scopus dColl.
  • Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II BMB Reports, 2017, v.50 no.8, 391-392
    SCIE Scopus KCI dColl.
  • A Decoy Peptide Targeted to Protein Phosphatase 1 Attenuates Degradation of SERCA2a in Vascular Smooth Muscle Cells PLOS ONE, 2016, v.11 no.10, e0165569
    SCIE Scopus dColl.
  • Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway SCIENTIFIC REPORTS, 2016, v.6
    SCIE Scopus dColl.
  • Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions-Targeted siRNA delivery to pro-atherogenic endothelium in vivo Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells CANCER RESEARCH, 2016, v.76 no.4
    SCIE Scopus dColl.
  • Ursodeoxycholic Acid (UDCA) exerts anti-Atherogenic effects by inhibiting RAGE signaling in diabetic atherosclerosis PLoS ONE, 2016, v.11 no.1
    SCIE Scopus dColl.
  • ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair ONCOGENE, 2015, v.34 no.3, 351-361
    SCIE Scopus dColl.
  • Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels Cardiovascular Research, 2015, v.106 no.3, 498-508
    SCIE Scopus dColl.
  • ROS and energy metabolism in cancer cells: alliance for fast growth Archives of Pharmacal Research, 2015, v.38 no.3
    SCIE KCI Scopus dColl.
  • Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response PLOS ONE, 2015, v.10 no.8
    SCIE Scopus dColl.
  • 2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks International Journal of Cell Biology, 2014, v. 2014
    Scopus dColl.
  • Dominant Role of Peroxiredoxin/JNK Axis in Stemness Regulation During Neurogenesis from Embryonic Stem Cells STEM CELLS, 2014, v.32 no.4, 998-1011
    SCIE Scopus dColl.
  • Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins ONCOTARGET, 2014, v.5 no.18, 8452-8465
    SCIE Scopus dColl.
  • [학술지논문] Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation CELL REPORTS, 2023, v.42 no.11 , 1-13
    SCIE
  • [학술지논문] Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-Kappa B survival machinery in cancer cells REDOX BIOLOGY, 2022, v.51 no.102293 , 1-14
    SCIE
  • [학술지논문] PI3K gamma stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation NATURE COMMUNICATIONS, 2022, v.13 no.1 , 1768-1768
    SCI
  • [학술지논문] RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-alpha-Induced Necroptosis MOLECULES AND CELLS, 2022, v.45 no.4 , 193-201
    SCI
  • [학술지논문] Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29 no.0 , 101391-101391
    SCIE
Read More
Courses

  • 2025-1st

    • General Biology

      • Subject No 20412Class No 04
      • 1Year ( 3Credit , 3Hour) Mon 5~5 (POSCO453) , Wed 4~4 (POSCO453)

    • Biochemistry Ⅰ

      • Subject No 33716Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO361) , Wed 2~2 (POSCO361)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)

    • Colloquium of Life Science Research

      • Subject No 36337Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 4~4 (POSCO452) , Fri 5~5 (POSCO452)

    • Bioindustury in the 21st Century

      • Subject No 37713Class No 01
      • 4Year ( 1Credit , 1Hour) Fri 6~6 (POSCO363)

    • Bio Technology

      • Subject No G16974Class No 01
      • Year ( 3Credit , 3Hour) Fri 5~6 (SCI-C)

    • Signal Transduction and Drug Discovery

      • Subject No G16982Class No 01
      • Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)

  • 2024-2nd

    • Biochemistry Ⅱ

      • Subject No 35824Class No 02
      • 2Year ( 3Credit , 3Hour) Tue 4~4 (POSCO362) , Fri 5~5 (POSCO362)
        • Syllabus(File)

    • Molecular Medical Science

      • Subject No 36336Class No 01
      • 4Year ( 3Credit , 3Hour) Mon 4~4 (SCI-AA) , Thu 5~5 (102)
        • Syllabus(File)

    • Introduction to Cell Signaling

      • Subject No 38212Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO361) , Thu 6~6 (POSCO361)
        • Syllabus(File)

    • Research for Life Science Ⅳ

    • Biology of Reactive Oxygen Species Ⅱ

      • Subject No G16943Class No 01
      • Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
        • Syllabus(File)

  • 2024-1st

    • General Biology

      • Subject No 20412Class No 04
      • 1Year ( 3Credit , 3Hour) Mon 5~5 (POSCO453) , Wed 4~4 (POSCO453)
        • Syllabus(File)

    • Biochemistry Ⅰ

      • Subject No 33716Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO361) , Wed 2~2 (POSCO361)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences Ⅰ

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
        • Syllabus(File)

    • Biology of Reactive Oxygen Species Ⅰ

      • Subject No G16942Class No 01
      • Year ( 3Credit , 3Hour) Tue 3~4 (SCI-C)
        • Syllabus(File)

    • Special Topics in Advanced Biochemistry Ⅰ

      • Subject No G16946Class No 01
      • Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)
        • Syllabus(File)

  • 2022-2nd

    • Biochemistry II

      • Subject No 35824Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 4~4 (POSCO361) , Thu 5~5 (POSCO361)
        • Syllabus(File)

    • Introduction to Cell Signaling

      • Subject No 38212Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO361) , Thu 6~6 (POSCO361)
        • Syllabus(File)

    • Research for Life ScienceⅡ

    • Biology of Reactive Oxygen SpeciesⅡ

      • Subject No G16943Class No 01
      • Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C)
        • Syllabus(File)

  • 2022-1st

    • General Biology I

      • Subject No 20413Class No 04
      • 1Year ( 3Credit , 3Hour) Tue 2~2 (POSCO453) , Fri 3~3 (POSCO453)
        • Syllabus(File)

    • Biochemistry I

      • Subject No 33716Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO361) , Wed 2~2 (POSCO361)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 01
      • 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 02
      • 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 03
      • 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 04
      • 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
        • Syllabus(File)

    • Experiments in Life Sciences I

      • Subject No 35309Class No 05
      • 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
        • Syllabus(File)
Read More
Academic Background

YONSEI UNIVERSITY 이학박사(생화학과)