EWHA WOMANS UNIVERSITY

Jae Hyang Lim Professor

College of Medicine

Prof. Jae Hyang Lim is a faculty member of Dept. of Microbiology at Ewha Womans University School of Medicine. Research field of Prof. Lim is Cellular Microbiology, and her researches have been focused on the understanding the innate immune responses during pneumococcal and influenza infections to develop therapeutic strategies for treating respiratory infections. In particular, reseraches published in Immunity and Nature Communications significantly contributed to our understanding on the molecular pathogenesis of acute lung injury and fibrotic scar formation follwoing pneumococcal infections.

Chair, Department of Microbiology
Esther Building #704
02-6986-6277
Research Interests

Research Record

Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic toxicity via regulating ER stress and 13-cell apoptosis MOLECULES AND CELLS, 2025, v.48 no.1, 100168
SCIE Scopus KCI dColl.
miR-616-3p alleviates inflammatory response by targeting C-X-C motif chemokine ligand 5 Biochemical and Biophysical Research Communications, 2024, v.691, 149335
SCIE Scopus dColl.
CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses ANTIOXIDANTS, 2023, v.12 no.2, 458
SCIE Scopus dColl.
Characterization of humoral and cellular immune features of gamma-irradiated influenza vaccine HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2021, v.17 no.2, 485-496
SCIE Scopus dColl.
Molecular Characteristics of IS1216 Carrying Multidrug Resistance Gene Cluster in Serotype III/Sequence Type 19 Group B Streptococcus MSPHERE, 2021, v.6 no.4, e00543-21
SCIE Scopus dColl.
Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion REDOX BIOLOGY, 2021, v.46, 102077
SCIE Scopus dColl.
Radiation-Inactivated S. gallinarum Vaccine Provides a High Protective Immune Response by Activating Both Humoral and Cellular Immunity FRONTIERS IN IMMUNOLOGY, 2021, v.12, 0
SCIE Scopus dColl.
Salmonella Vaccine Vector System for Foot-and-Mouth Disease Virus and Evaluation of Its Efficacy with Virus-Like Particles VACCINES, 2021 , 22
SCIE Scopus dColl.
Development of Oxytolerant Salmonella typhimurium Using Radiation Mutation Technology (RMT) for Cancer Therapy Scientific Reports, 2020, v.10 no.1, 3764
SCIE Scopus dColl.
Promotion of Cellular and Humoral Immunity against Foot-and-Mouth Disease Virus by Immunization with Virus-Like Particles Encapsulated in Monophosphoryl Lipid A and Liposomes VACCINES, 2020, v.8 no.4, 633
SCIE Scopus dColl.
Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis Yeungnam University Journal of Medicine, 2020, v.37 no.4, 269-276
KCI dColl.
p90RSK Inhibition Ameliorates TGF-β1 Signaling and Pulmonary Fibrosis by Inhibiting Smad3 Transcriptional Activity Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2020, v.54 no.2, 195-210
Scopus dColl.
C/EBP homologous protein deficiency inhibits statin-induced myotoxicity BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, v.508 no.3, 857-863
SCIE Scopus dColl.
Serotype-Independent Protection Against Invasive Pneumococcal Infections Conferred by Live Vaccine With lgt Deletion FRONTIERS IN IMMUNOLOGY, 2019, v.10, 1212
SCIE Scopus dColl.
A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARy CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, v.45 no.5, 1863-1877
SCIE Scopus dColl.
Development of a multiplexed opsonophagocytic killing assay (MOPA) for group B Streptococcus Human Vaccines and Immunotherapeutics, 2018, v.14 no.1, 67-73
SCIE Scopus dColl.
PAR-1 is a novel mechano-sensor transducing laminar flow-mediated endothelial signaling SCIENTIFIC REPORTS, 2018, v.8, 15172
SCIE Scopus dColl.
Progress toward a group B streptococcal vaccine HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2018, v.14 no.11, 2669-2681
SCIE Scopus dColl.
Vaccination With a Latch Peptide Provides Serotype-Independent Protection Against Group B Streptococcus Infection in Mice JOURNAL OF INFECTIOUS DISEASES, 2018, v.217 no.1, 93-102
SCIE Scopus dColl.
CHOP deficiency ameliorates ERK5 inhibition-mediated exacerbation of streptozotocin-induced hyperglycemia and pancreatic β-cell apoptosis Molecules and Cells, 2017, v.40 no.7, 457-465
SCIE Scopus KCI dColl.
Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells PLOS ONE, 2017, v.12 no.5
SCIE Scopus dColl.
Long pentraxin PTX3 mediates acute inflammatory responses against pneumococcal infection Biochemical and Biophysical Research Communications, 2017, v.493 no.1, 671-676
SCIE Scopus dColl.
Molecular characterization of pneumococcal surface protein K, a potential pneumococcal vaccine antigen VIRULENCE, 2017, v.8 no.6, 875-890
SCIE Scopus dColl.
Activated protein C prevents methylglyoxal-induced endoplasmic reticulum stress and cardiomyocyte apoptosis via regulation of the AMP-activated protein kinase signaling pathway BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, v.480 no.4, 622-628
SCIE Scopus dColl.
Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, v.113 no.2, E165-E171
SCIE Scopus dColl.
Role of Coagulation Factor 2 Receptor during Respiratory Pneumococcal Infections Journal of Bacteriology and Virology, 2016, v.46 no.4, 319
Scopus KCI dColl.
CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction Journal of Molecular and Cellular Cardiology, 2015, v.85, 168-177
SCIE Scopus dColl.
ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts Life Sciences, 2015, v.135 no.1, 1-8
SCIE Scopus dColl.
Interleukin-1β participates in the development of pneumococcal acute lung injury and death by promoting alveolar microvascular leakage Journal of Bacteriology and Virology, 2015, v.45 no.2, 93-103
KCI Scopus dColl.
Itch E3 Ubiquitin Ligase Positively Regulates TGF-beta Signaling to EMT via Smad7 Ubiquitination MOLECULES AND CELLS, 2015, v.38 no.1, 20-25
SCIE KCI Scopus dColl.
PPAR gamma activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines MUCOSAL IMMUNOLOGY, 2015, v.8 no.5, 1031-1046
SCIE Scopus dColl.
PRMT3 Regulates Hepatic Lipogenesis Through Direct Interaction With LXR alpha DIABETES, 2015, v.64 no.1, 60-71
SCIE Scopus dColl.
Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, v.769, 257-265
SCIE Scopus dColl.
Statin-Conferred Enhanced Cellular Resistance against Bacterial Pore-Forming Toxins in Airway Epithelial Cells AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2015, v.53 no.5, 689-702
SCIE Scopus dColl.
ITCH E3 ubiquitin ligase positively regulates TGF-beta signaling to EMT via Smad7 ubiquitination FASEB JOURNAL, 2014, v.28 no.1
SCIE Scopus dColl.
PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media ACTA OTO-LARYNGOLOGICA, 2014, v.134 no.12, 1231-1238
SCIE dColl.
TBX21 participates in innate immune response by regulating Toll-like receptor 2 expression in Streptococcus pneumoniae infections MOLECULAR ORAL MICROBIOLOGY, 2014, v.29 no.5, 233-243
SCIE Scopus dColl.
The in vivo and in vitro roles of epithelial pattern recognition receptors in pneumococcal infections Journal of Bacteriology and Virology, 2014, v.44 no.2, 121-132
KCI Scopus dColl.
Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy Cellular Signalling, 2014, v.26 no.9, 1774-1782
Scopus dColl.
[학술지논문] Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic toxicity via regulating ER stress and β-cell apoptosis Molecules and Cells, 2025, v.48 no.1 , 1-8
SCIE
[학술지논문] CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses ANTIOXIDANTS, 2023, v.12 no.2 , 1-18
SCIE
[학술지논문] Molecular Characteristics of IS1216 Carrying Multidrug Resistance Gene Cluster in Serotype III/Sequence Type 19 Group B Streptococcus MSPHERE, 2021, v.6 no.4 , 543-543
SCIE
[학술지논문] Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion REDOX BIOLOGY, 2021, v.46 no.0 , 102077-102077
SCIE
[학술지논문] Radiation-Inactivated S. gallinarum Vaccine Provides a High Protective Immune Response by Activating Both Humoral and Cellular Immunity FRONTIERS IN IMMUNOLOGY, 2021, v.12 no.0 , 717556-717556
SCIE
[학술지논문] Development of Oxytolerant Salmonella typhimurium Using Radiation Mutation Technology (RMT) for Cancer Therapy SCIENTIFIC REPORTS, 2020, v.10 no.1 , 3764-3764
SCI
[학술지논문] Promotion of Cellular and Humoral Immunity against Foot-and-Mouth Disease Virus by Immunization with Virus-Like Particles Encapsulated in Monophosphoryl Lipid A and Liposomes VACCINES, 2020, v.8 no.4 , 633-633
SCIE
[학술지논문] Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis Yeungnam University Journal of Medicine, 2020, v.37 no.4 , 269-276
KCI
[학술지논문] p90RSK inhibition ameliorates TGF-b1 signaling and pulmonary fibrosis by inhibiting Smad3 transcriptional activity CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2020, v.54 no.2 , 195-210
Scopus

2025-1st
- Thesis Writing
  - Subject No G14764Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Immunology
  - Subject No G14769Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Aging and Geriatrics
  - Subject No G14772Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8
- Seminars in Biomedical Science Ⅰ
  - Subject No G14773Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Seminars in Biomedical Science Ⅲ
  - Subject No G14774Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Thesis Writing
  - Subject No G15683Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Immunology
  - Subject No G15687Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Aging and Geriatrics
  - Subject No G15690Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8
- Seminars in Biomedical Science Ⅰ
  - Subject No G15691Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Seminars in Biomedical Science Ⅲ
  - Subject No G15692Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Medical Immunology
  - Subject No G15729Class No 01
  - Year ( 3Credit , 3Hour) Fri 5~6
- Comprehension of Medicine Ⅰ 강의 계획서 상세보기
  - Subject No G17672Class No 01
  - Year ( 3Credit , 3Hour) Thu 5~6
2024-2nd
- Basics of Creative Research 강의 계획서 상세보기
  - Subject No 37494Class No 01
  - 1Year ( 2Credit , 2Hour) Mon 3~4 (D)
  - Major Requisite
- Writing and Presentation of Research Paper 강의 계획서 상세보기
  - Subject No 37495Class No 01
  - 2Year ( 2Credit , 2Hour) Tue 5~6 (D)
- Immunology
  - Subject No 37604Class No 01
  - 1Year ( 2Credit , 39Hour)
  - Major Requisite
- Techniques of Animal Research 강의 계획서 상세보기
  - Subject No G14778Class No 01
  - Year ( 3Credit , 3Hour) Thu 8~9
- Techniques of Animal Research 강의 계획서 상세보기
  - Subject No G15693Class No 01
  - Year ( 3Credit , 3Hour) Thu 8~9
- Current Topics in Microbiology
  - Subject No G15792Class No 01
  - Year ( 3Credit , 3Hour) Fri 5~6
2024-1st
- Thesis Writing
  - Subject No G14764Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Immunology
  - Subject No G14769Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Aging and Geriatrics
  - Subject No G14772Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8
- Thesis Writing
  - Subject No G15683Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Cell Biology
  - Subject No G15686Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8 (-)
- Immunology
  - Subject No G15687Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Aging and Geriatrics
  - Subject No G15690Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8
- Seminars in Microbiology
  - Subject No G15725Class No 01
  - Year ( 3Credit , 3Hour) Mon 3~4
- Comprehension of Medicine Ⅰ
  - Subject No G17672Class No 01
  - Year ( 3Credit , 3Hour) Thu 5~6
2023-2nd
- Basic Laboratory Skills 강의 계획서 상세보기
  - Subject No 37494Class No 01
  - 1Year ( 2Credit , 2Hour) Mon 3~4 (D)
  - Major Requisite
- Immunology
  - Subject No 37604Class No 01
  - 1Year ( 2Credit , 39Hour)
  - Major Requisite
- Human Pathogens
  - Subject No 37605Class No 01
  - 1Year ( 3Credit , 62Hour)
  - Major Requisite
- Infectious Diseases
  - Subject No 37607Class No 01
  - 1Year ( 3Credit , 63Hour)
  - Major Requisite
- Techniques of Animal Research 강의 계획서 상세보기
  - Subject No G15693Class No 01
  - Year ( 3Credit , 3Hour) Thu 8~9
2023-1st
- Microbiology 강의 계획서 상세보기
  - Subject No 35613Class No 01
  - 2Year ( 1.5Credit , 1.5Hour) Thu 5~5 (HELEN116)
  - Not open to exchange student
- Thesis Writing
  - Subject No G14764Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Immunology
  - Subject No G14769Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Aging and geriatrics
  - Subject No G14772Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8
- Seminars in Biomedical Science I
  - Subject No G14773Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Seminars in Biomedical Science III
  - Subject No G14774Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Thesis Writing
  - Subject No G15683Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Immunology
  - Subject No G15687Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Aging and Geriatrics
  - Subject No G15690Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8
- Seminars in Biomedical Science I
  - Subject No G15691Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Seminars in Biomedical Science III
  - Subject No G15692Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Medical Immunology
  - Subject No G15729Class No 01
  - Year ( 3Credit , 3Hour) Tue 2~3
- Comprehension of Medicine Ⅰ
  - Subject No G17672Class No 01
  - Year ( 3Credit , 3Hour) Thu 5~6
- Comprehension of Medicine Ⅰ
  - Subject No G18435Class No 01
  - Year ( 3Credit , 3Hour) Thu 5~6
2022-2nd
- Basic Laboratory Skills 강의 계획서 상세보기
  - Subject No 37494Class No 01
  - 1Year ( 2Credit , 2Hour) Mon 3~4 (D)
  - Major Requisite
- Immunology
  - Subject No 37604Class No 01
  - 1Year ( 2Credit , 39Hour)
  - Major Requisite
- Human Pathogens
  - Subject No 37605Class No 01
  - 1Year ( 3Credit , 62Hour)
  - Major Requisite
- Infectious Diseases
  - Subject No 37607Class No 01
  - 1Year ( 3Credit , 63Hour)
  - Major Requisite
- Techniques of Animal Research 강의 계획서 상세보기
  - Subject No G14778Class No 01
  - Year ( 3Credit , 3Hour) Thu 8~9
- Techniques of Animal Research 강의 계획서 상세보기
  - Subject No G15693Class No 01
  - Year ( 3Credit , 3Hour) Thu 8~9
2022-1st
- Microbiology
  - Subject No 35613Class No 01
  - 2Year ( 1.5Credit , 1.5Hour) Fri 2~2
- Basic Laboratory Skills
  - Subject No 37494Class No 01
  - 2Year ( 2Credit , 2Hour) Wed 6~7
  - Major Requisite
- Thesis Writing
  - Subject No G14764Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Immunology
  - Subject No G14769Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Seminars in Biomedical Science I
  - Subject No G14773Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Seminars in Biomedical Science III
  - Subject No G14774Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Thesis Writing
  - Subject No G15683Class No 01
  - Year ( 3Credit , 3Hour) Tue 8~9
- Immunology
  - Subject No G15687Class No 01
  - Year ( 3Credit , 3Hour) Fri 8~9
- Seminars in Biomedical Science I
  - Subject No G15691Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Seminars in Biomedical Science III
  - Subject No G15692Class No 01
  - Year ( 3Credit , 3Hour) Mon 7~8
- Comprehension of Medicine Ⅰ
  - Subject No G17672Class No 01
  - Year ( 3Credit , 3Hour) Thu 5~6

Academic Background

Chonnam Nat'l Univ. 수의학박사(수의학)

Jae Hyang Lim Professor

Research Record

Courses

Academic Background