Jongbum Kwon
Professor
Life Sciences/Life Sciences
Professor Jongbum Kwon obtained his Ph.D. from the University of Alabama in Birmingham and did his postdoctoral training at Harvard Medical School. Since appointed as a faculty at Ewha in 2001, his research interest has been mainly focused on understanding the molecular mechanisms governing the genome stability and tumorigenesis. He has published many papers on this topic in high impact SCI journals. He has served as a chief of the Epigenetic and Cell Cycle Sections of the Korean Society for Molecular and Cellular Biology. He is currently an Editorial Board Member of Molecules and Cells and an Advisory Panel Member of the Biochemical Journal (UK).
Science Building C #308
02-3277-4334
Office hours
Research Interests
Research Record
BAP1 as a guardian of genome stability: implications in human cancer
Experimental and Molecular Medicine, 2023, v.55 no.4, 745-754
Targeting BAP1 with small compound inhibitor for colon cancer treatment
Scientific Reports, 2023, v.13 no.1, 2264
BAP1 promotes the repair of UV-induced DNA damage via PARP1-mediated recruitment to damage sites and control of activity and stability
Cell Death and Differentiation, 2022
CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication
MOLECULES AND CELLS, 2021, v.44 no.2, 101-115
The bromodomain inhibitor PFI-3 sensitizes cancer cells to DNA damage by targeting SWI/SNF
Molecular Cancer Research, 2021, v.19 no.5, 900-912
Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells
Scientific Reports, 2020, v.10 no.1, 16330
Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-alpha-Induced Apoptosis via Different Routes
CELL REPORTS, 2019, v.26 no.8, 2194-
BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress
Biochemical Journal, 2019, v.476 no.20, 3053-3066
INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis
Oncotarget, 2017, v.8 no.70, 115041-115053
The role of BAP1 and INO80 in genome stability and cancer
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, v.38, S38-S38
ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair
ONCOGENE, 2015, v.34 no.3, 351-361
Targeting BRG1 chromatin remodeler via its bromodomain for enhanced tumor cell radiosensitivity in vitro and in vivo
Molecular Cancer Therapeutics, 2015, v.14 no.2, 597-607
Genome-wide reorganization of histone H2AX toward particular fragile sites on cell activation
NUCLEIC ACIDS RESEARCH, 2014, v.42 no.2, 1016-1025
Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis
NATURE COMMUNICATIONS, 2014, v.5
[학술지논문] BAP1 as a guardian of genome stability: implications in human cancer
EXPERIMENTAL AND MOLECULAR MEDICINE, 2023, v.55
no.4
, 745-754
SCIE
[학술지논문] Targeting BAP1 with small compound inhibitor for colon cancer treatment
SCIENTIFIC REPORTS, 2023, v.13
no.1
, 2264-2264
SCIE
[학술지논문] BAP1 promotes the repair of UV-induced DNA damage via PARP1-mediated recruitment to damage sites and control of activity and stability
CELL DEATH AND DIFFERENTIATION, 2022, v.29
no.12
, 2381-2398
SCI
[학술지논문] CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication
MOLECULES AND CELLS, 2021, v.44
no.2
, 101-115
SCI
[학술지논문] The Bromodomain Inhibitor PFI-3 Sensitizes Cancer Cells to DNA Damage by Targeting SWI/SNF
MOLECULAR CANCER RESEARCH, 2021, v.19
no.5
, 900-912
SCI
[학술지논문] Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells
SCIENTIFIC REPORTS, 2020, v.10
no.1
, 16330-16330
SCI
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