이혁진 교수는 약학대학 소속 약제학 및 물리약학 전공 교수이다. Johns Hopkins University (미), Columbia University (미) 및 KAIST에서 학/석/박사학위를 받았으며, 모더나 창업주인 MIT 대학의 Robert Langer 교수 지도 하에 siRNA 치료제 (Patisiran) 개발 및 핵산 구조체와 지질나노입자(LNP) 연구를 진행하였다. 2012년 본교 임용 후, 핵산 나노기술을 기반으로 한 차세대 RNA 핵산 치료제 (Dicer substrate RNA and IVT mRNA) 개발 및 체내 유전자 의약품 전달을 위한 3세대 지질나노입자(lipid nanoparticle) 발굴에 대한 연구를 진행하고 있다. 2013년 ~ 2014년 대한약학회 영문지 편집위원으로 활동하였으며, 2015년 ~ 2020년 공업화학회 영문지 편집위원, 그리고 2021년 Journal of Controlled Release 편집위원으로 활동 중이다. 현재까지 총 85여편의 논문을 SCI 국제학술지에 발표했다.
[학술지논문] Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver
SCIENCE ADVANCES, 2021, v.7
no.9
, 4398-4398
SCI
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Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liverSCIENCE ADVANCES, 2021, v.7 no.9, eabf4398
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[학술지논문] Engineered Lipid Nanoparticles for the Treatment of Pulmonary Fibrosis by Regulating Epithelial-Mesenchymal Transition in the Lungs
ADVANCED FUNCTIONAL MATERIALS, 2023, v.33
no.7
, 2209432-2209432
SCIE
[지적재산권] TCTP-PTD를 포함하는 유전자 전달체 국내 : 특허, 등록, 10-1595152, 2016
[지적재산권] 생분해성 중합체, 이의 제조 방법, 이를 포함하는 유전자 전달 시스템 국내 : 특허, 등록, 10-1577893, 2015
[지적재산권] 표적 유전자 검출용 미세 유동 장치, 이의 제조방법 및 이를 이용한 검출 방법국내 : 특허, 출원
[지적재산권] 핵산 나노구조체의 대량생산방법 및 이의 약물전달체로서의 활용국내 : 특허, 출원
Massachusetts Institute of Technology, Post-doc.2010-03-01 ~ 2012-02-29
연구분야
Advanced Biomaterials and Drug Delivery
We are interested in developing novel biomaterials for drug delivery and tissue engineering. Some of the projects that we are most interested in are
1. Sustained release of protein drugs, 2. Novel regio-specific PEGylation for therapeutic proteins, 3. Natural polymer based hydrogels for cell therapy and drug delivery. 4. Preparation of Induced Pluripotent Stem (IPS) cells by non-viral gene delivery systems
It is important that our materials are designed to be non-cytotoxic, non-immunogenic, and biodegradable.
We are developing multi-functional nanoparticles for various applications. Drug, imaging, or biosensor molecules are incorporated within our nanoparticles. We aim to develop Nanobiotechnolgy that can efficiently and safely target particular tissues and organs to give therapeutic effects
1. Gene Delivery System (pDNA, mRNA, and siRNA delivery) 2. Anti-Cancer Drug Delivery System (water insoluble small molecule delivery) 3. Molecular Imaging System (ROS sensing, ECM degrading enzyme sensitive imaging probe) 4. Inorganic nanoparticles for biomedical sensors and probes
We are motivated by the potential of DNA Nanotechnology to improve the fields of drug delivery. Not only the structural interests of DNA nano-assembly, we want to move forward to apply this novel materials and approaches to treat various diseases. Of particular interest to us is the targeting of cancer and stem cells
1. Programmable Self-assembly of DNA/RNA Nanoparticles 2. Self-replicating Nucleic Acid Nanoparticles 3. Screening of Targeting Ligands as well as evaluating Cell Penetrating Peptides 4. Dip-pen Nano-lithography using DNA/RNA molecular ink