권영주 교수는 약학대학 소속 교수로서 휴스턴대학 화학과에서 분석화학을 전공하였으며, 베일러의대 생화학·분자생물학과에서 박사후연구원으로 화학유전체학 분야의 연구를 수행한 후, 현재 '화학·구조 생물학 연구실(http://ykwon.ewha.ac.kr/)'을 운영하면서, 여성 난치성 암 치료제 개발을 위해 신규 타겟 발굴 및 화학요법제와 표적항암제 개발 및 약물내성 유발 기전 연구 수행, 퇴행성 뇌질환 관련 효소의 이성체 특이적 기능 규명 및 이성체 선택적 억제제 개발 연구 수행, 그리고 비정상적 암 대사와 간질환과의 상관성 규명을 위한 연구를 수행 중이다. 현재까지 총 150여편의 논문을 SCI급 국제학술지에 발표하였고, 11건의 국내외 특허를 등록하였다.
Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cellsCancer Science, 2024, v.115 no.6, 2036-2048
Design, synthesis, and biological evaluation of novel HSP27 inhibitors to sensitize lung cancer cells to clinically available anticancer agentsBioorganic Chemistry, 2023, v.130, 106260
Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancersJournal of Advanced Research, 2023, v.47, 173-187
Original Article BR101801 enhances the radiosensitivity of p53-deficient colorectal cancer cells by inducing G2/M arrest, apoptosis, and senescence in a p53-independent mannerAMERICAN JOURNAL OF CANCER RESEARCH, 2023, v.13 no.12, 0
Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cellsEuropean journal of medicinal chemistry, 2023, v.246, 114999
Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutationsCellular Oncology, 2022, v.45 no.5, 913-930
Discovery of (E)-3-(3-((2-Cyano-4' -dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic SteatohepatitisJOURNAL OF MEDICINAL CHEMISTRY, 2022, v.65 no.14, 9974-10000
Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitorsEuropean Journal of Medicinal Chemistry, 2022, v.227, 113916
Topologically-Interlocked Minicircles as Probes of DNA Topology and DNA-Protein InteractionsChemistry - A European Journal, 2022, v.28 no.22, e202200108
Ak-i-190, a new catalytic inhibitor of topoisomerase ii with anti-proliferative and pro-apoptotic activity on androgen-negative prostate cancer cellsInternational Journal of Molecular Sciences, 2021, v.22 no.20, 11246
Anticancer Activity of Indeno[1,2-b]-Pyridinol Derivative as a New DNA Minor Groove Binding Catalytic Inhibitor of Topoisomerase II alphaBIOMOLECULES & THERAPEUTICS, 2021, v.29 no.5, 562-570
COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential developmentArchives of Pharmacal Research, 2021, v.44 no.5, 499-513
Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poisonEuropean Journal of Medicinal Chemistry, 2021, v.226, 113860
Drug-like small molecule HSP27 functional inhibitor sensitizes lung cancer cells to gefitinib or cisplatin by inducing altered cross-linked Hsp27 dimersPharmaceutics, 2021, v.13 no.5, 630
Synthesis and structure-activity relationships of hydroxylated and halogenated 2,4-diaryl benzofuro[3,2-b]pyridin-7-ols as selective topoisomerase IIα inhibitorsBioorganic Chemistry, 2021, v.111, 104884
Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila GutCELL HOST & MICROBE, 2020, v.27 no.3, 345-
Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agentCHEMICAL COMMUNICATIONS, 2020, v.56 no.68, 9795-9798
Synthesis, Biological Evaluation and Molecular Docking Study of Cyclic Diarylheptanoids as Potential Anticancer TherapeuticsANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, v.20 no.4, 464-475
A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoformCHEMICAL COMMUNICATIONS, 2019, v.55 no.85, 12857-12860
Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-b]pyridinol Derivatives as Potent Topoisomerase II alpha-Targeted Chemotherapeutic Agents for Breast CancerJOURNAL OF MEDICINAL CHEMISTRY, 2019, v.62 no.17, 8194-8234
A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationshipsBIOORGANIC & MEDICINAL CHEMISTRY, 2018, v.26 no.18, 5212-5223
Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitorsEuropean Journal of Medicinal Chemistry, 2018, v.143, 200-215
Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitorsBioorganic and Medicinal Chemistry Letters, 2018, v.28 no.4, 566-571
Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/II alpha inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY, 2018, v.26 no.18, 5181-5193
Hyperactivated m-calpain affects acquisition of doxorubicin resistance in breast cancer cellsBiochimica et Biophysica Acta - General Subjects, 2018, v.1862 no.5, 1126-1133
Linear diarylheptanoids as potential anticancer therapeutics: synthesis, biological evaluation, and structure-activity relationship studiesARCHIVES OF PHARMACAL RESEARCH, 2018, v.41 no.12, 1131-1148
Modification of translationally controlled tumor protein-derived protein transduction domain for improved intranasal delivery of insulinDRUG DELIVERY, 2018, v.25 no.1, 1025-1032
Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase II alpha-targeting anticancer agentsBIOORGANIC & MEDICINAL CHEMISTRY, 2018, v.26 no.8, 1909-1919
2-Chlorophenyl-substituted benzofuro[3,2-b] pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituentBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, v.27 no.15, 3279-3283
A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase II alpha catalytic inhibitor, for caspase 3-independent anticancer activityCHEMICAL COMMUNICATIONS, 2017, v.53 no.51
Antiepileptic and Neuroprotective Effects of Oleamide in Rat Striatum on Kainate-Induced Behavioral Seizure and Excitotoxic Damage via Calpain InhibitionFRONTIERS IN PHARMACOLOGY, 2017, v.8, 817
Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and II alpha dual inhibitors with DNA non-intercalative catalytic activityEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, v.133, 69-84
Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cellsEuropean Journal of Medicinal Chemistry, 2017, v.125, 49-67
Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitorEuropean Journal of Medicinal Chemistry, 2017, v.127, 318-333
Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, v.139, 892-900
The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated CytotoprotectionJournal of Natural Products, 2017, v.80 no.8, 2379-2383
The synthesis of tamoxifen-loaded albumin nanoparticles by homogenizers: Optimization and in vitro characterizationJournal of Drug Delivery Science and Technology, 2017, v.41, 20-30
A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR studyEuropean Journal of Medicinal Chemistry, 2016, v.113, 228-245
Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathwayONCOTARGET, 2016, v.7 no.21, 30831-30844
Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitorBioorganic and Medicinal Chemistry, 2016, v.24 no.8
Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against μ-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formationEuropean Journal of Medicinal Chemistry, 2016, v.121, 433-444
Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agentsBIOORGANIC CHEMISTRY, 2016, v.66, 145-159
Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase II alpha catalytic inhibitorsEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, v.123, 211-225
A Series of Novel Terpyridine-Skeleton Molecule Derivants Inhibit Tumor Growth and Metastasis by Targeting TopoisomerasesJOURNAL OF MEDICINAL CHEMISTRY, 2015, v.58 no.3, 1100-1122
Benzo[b]Tryptanthrin Inhibits MDR1, Topoisomerase Activity, and Reverses Adriamycin Resistance in Breast Cancer CellsChemMedChem, 2015, v.10 no.5, 827-835
Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agentsBioorganic and Medicinal Chemistry, 2015, v.23 no.19, 6454-6466
Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicityBioorganic and Medicinal Chemistry, 2015, v.23 no.1, 160-173
Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibitionEuropean Journal of Medicinal Chemistry, 2015, v.92, 583-607
Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerasesEuropean Journal of Medicinal Chemistry, 2015, v.103, 69-79
Synthesis and biological activity of 2,4-di- p -phenolyl-6- 2 -furanyl-pyridine as a potent topoisomerase II poisonEuropean Journal of Medicinal Chemistry, 2015, v.90, 360-378
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridinesBioorganic and Medicinal Chemistry, 2015, v.23 no.13
Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridinesBioorganic and Medicinal Chemistry, 2015, 2015
Cobalt-albumin binding (CAB) assay: An advantageous and flaw free testing of albumin-cobalt bindingJournal of Pharmaceutical and Biomedical Analysis, 2014, v.99, 79-82
Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitorsEuropean Journal of Medicinal Chemistry, 2014, v.82, 181-194
Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitorEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, v.80 no., 428-438
Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3, 2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitorBIOORGANIC & MEDICINAL CHEMISTRY, 2014, v.22 no.17, 4553-4565
Evaluation of albumin structural modifications through cobalt-albumin binding (CAB) assayJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, v.91, 17-23
Fluorescein Hydrazones as Novel Nonintercalative Topoisomerase Catalytic Inhibitors with Low DNA ToxicityJOURNAL OF MEDICINAL CHEMISTRY, 2014, v.57 no.21, 9139-9151
Reply to the Letter to the Editor "Cobalt-albumin binding (CAB) assay: An advantageous and flaw free testing of albumin-cobalt binding"JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, v.99, 81-82
Synthesis, antitumor,activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitorsEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, v.84, 555-565
[학술지논문] A novel A2a adenosine receptor inhibitor effectively mitigates hepatic fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2024, v.20
no.5
, 1855-1870
[학술지논문] Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells
CANCER SCIENCE, 2024, v.115
no.6
, 2036-2048
SCIE
[학술지논문] Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 Interaction
ELIFE, 2024, v.13
no.97051
, 1-25
SCIE
[학술지논문] Cannabidiol, a Regulator of Intracellular Calcium and Calpain
CANNABIS AND CANNABINOID RESEARCH , 2023, v.11
no.111
, 1-7
SCIE
[학술지논문] Design, synthesis, and biological evaluation of novel HSP27 inhibitors to sensitize lung cancer cells to clinically available anticancer agents
BIOORGANIC CHEMISTRY, 2023, v.130
no.1062600
, 1-11
[학술지논문] Editorial: Small organic molecules with anticancer activity
FRONTIERS IN CHEMISTRY, 2023, v.11
no.2023
, 1-2
SCIE
[학술지논문] Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers
JOURNAL OF ADVANCED RESEARCH, 2023, v.47
no.0
, 173-187
SCIE
[학술지논문] Original Article BR101801 enhances the radiosensitivity of p53-deficient colorectal cancer cells by inducing G2/M arrest, apoptosis, and senescence in a p53-independent manner
AMERICAN JOURNAL OF CANCER RESEARCH, 2023, v.13
no.12
, 5887-5900
SCIE
[학술지논문] Roles of Coffee and Its Components in Liver Diseases
Drug Targets and Therapeutics, 2023, v.2
no.2
, 133-144
KCI
[학술지논문] Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, v.246
no.114999
, 1-16
SCIE
[학술지논문] An In-Silico Identification of Potential Flavonoids against Kidney Fibrosis Targeting TGF beta R-1
LIFE-BASEL, 2022, v.12
no.11
, 1764-1764
SCIE
[학술지논문] Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3-f]quinoline Derivatives
Pharmaceuticals, 2022, v.15
no.4
, 399-399
SCIE
[학술지논문] Epigenetic regulator Cfp1 safeguards male meiotic progression by regulating meiotic gene expression
EXPERIMENTAL AND MOLECULAR MEDICINE, 2022, v.54
no.8
, 1098-1108
[학술지논문] Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, v.227
no.2022
, 113916-113934
SCI
[학술지논문] The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days
JOURNAL OF KOREAN MEDICAL SCIENCE, 2022, v.37
no.30
, 235-235
SCI
[학술지논문] Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, v.60
no.0
, 128606-128606
SCI
[학술지논문] Topologically-Interlocked Minicircles as Probes of DNA Topology and DNA-Protein Interactions
CHEMISTRY-A EUROPEAN JOURNAL, 2022, v.28
no.22
, 202200108-202200108
SCI
[학술지논문] 4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase II alpha inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships
BIOORGANIC CHEMISTRY, 2021, v.116
no.2021
, 105349-105360
SCI
[학술지논문] AK-I-190, a New Catalytic Inhibitor of Topoisomerase II with Anti-Proliferative and Pro-Apoptotic Activity on Androgen-Negative Prostate Cancer Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, v.22
no.20
, 11246-11246
SCIE
[학술지논문] An Insight into Pathophysiological Features and Therapeutic Advances on Ependymoma
CANCERS, 2021, v.13
no.13
, 3221-3246
SCIE
[학술지논문] Anticancer Activity of Indeno[1,2-b]-Pyridinol Derivative as a New DNA Minor Groove Binding Catalytic Inhibitor of Topoisomerase II alpha
BIOMOLECULES & THERAPEUTICS, 2021, v.29
no.5
, 562-570
SCIE
[학술지논문] COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential development
ARCHIVES OF PHARMACAL RESEARCH, 2021, v.44
no.5
, 499-513
SCIE
[학술지논문] Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase II alpha poison
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, v.226
no.0
, 113860-113860
SCI
[학술지논문] Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers
PHARMACEUTICS, 2021, v.13
no.5
, 630-649
SCIE
[학술지논문] Identification of Indicators for Preterm Birth Using Retinoid Metabolites
METABOLITES, 2021, v.11
no.7
, 443-443
SCIE
[학술지논문] Synthesis and structure-activity relationships of hydroxylated and halogenated 2,4-diaryl benzofuro[3,2-b]pyridin-7-ols as selective topoisomerase II alpha inhibitors
BIOORGANIC CHEMISTRY, 2021, v.111
no.2021
, 104884-104898
SCI
[학술지논문] Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila Gut
CELL HOST & MICROBE, 2020, v.27
no.3
, 345-345
SCI
[학술지논문] Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent
CHEMICAL COMMUNICATIONS, 2020, v.56
no.68
, 9795-9798
SCI
[학술지논문] Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance
CANCERS, 2020, v.12
no.6
, 1-24
SCIE
[학술지논문] Synthesis, Biological Evaluation and Molecular Docking Study of Cyclic Diarylheptanoids as Potential Anticancer Therapeutics
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, v.20
no.4
, 464-475
SCIE
[학술지논문] Recent therapeutic trends and promising targets in triple negative breast cancer
PHARMACOLOGY & THERAPEUTICS, 2019, v.199
no.0
, 30-57
SCI
[학술지논문] The synthesis and anticancer activities of chiral epoxy-substituted chromone analogs
BIOORGANIC CHEMISTRY, 2019, v.84
no.2019
, 347-354
SCI
[저역서] 의약품기기분석학
동명사, 2023, 496
[학술발표] Oncogenic Protein and Its Protein-Protein Interactions: Drug Targetability and Overcoming Therapeutic Resistance Strategies2023 Annual Meeting and Symposium of The Korea Society of Applied Pharmacology, 대한민국, 2023-10-06
Exploring Novel Therapeutic Approaches for Intractable Diseases through Organoid Models, 2023
[학술발표] Targeting the oncogenic role of E74 Like ETS transcription factor 3 (ELF3) through modulation of its protein-protein interactionTargeting the oncogenic role of E74 Like ETS transcription factor 3 (ELF3) through modulation of its, 대한민국, 2023-10-26
Exploring the Frontiers of Pharmaceutical Sciences, 2023
[지적재산권] 할로겐 함유 2,4-디페닐 인데노피리딘-5-온 유도체 및 이의 제조방법국내 : 특허, 등록, 10-2629173, 2024
[지적재산권] 신규 화합물 및 그를 유효성분으로 포함하는 약학 조성물국내 : 특허, 등록, 10-2409583, 2022