김완규(金浣奎) 교수

생명과학과[대학원] /생명과학전공

김완규 프로필 사진
김완규 교수는 학부 생명과학 전공/바이오정보학 대학원 협동과정 소속 교수로 영국 캠브리지 대학교에서 박사 학위를 수여하였다. 전공 분야는 전산 시스템생물학 및 생명정보학이고,  최근에는 주로 AI 및 빅데이터 기반 신약개발 관련 연구를 수행하고 있으며, 랩 동료와 함께 Spin-off 벤처기업인 주식회사 카이팜을 설립하였다. 지난 15년 간 시스템약물학, 화학유전체학, 빅데이터 마이닝, 암 유전체 및 생체 네트워크 등 다양한 생명정보학 관련 연구를 수행하였고, Genome Biology, Nucleic Acids Research, Molecular Cancer, Nat. Comm, Nature Biotech. 등 ~40편의 SCI(E) 논문 및 다수의 국내외 특허를 출원/등록한 바 있다.
  • 대학원바이오정보학협동과정주임교수/바이오인포매틱스연계전공주임교수
  • 종합과학관 A동 A208호
  • 02-3277-4132
연구실적
  • Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer Molecular Cancer, 2018, v.17 no.1, 175
    SCIE Scopus dColl.
  • BEAR: A Novel Virtual Screening Method Based on Large-Scale Bioactivity Data JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, v.63 no.5
    SCIE Scopus dColl.
  • NecroX Improves Polyhexamethylene Guanidine-induced Lung Injury by Regulating Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress American journal of respiratory cell and molecular biology, 2023, v.69 no.1, 57-72
    Scopus dColl.
  • Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial Clinical and Molecular Hepatology, 2022, v.28 no.3, 497-509
    SCIE Scopus KCI dColl.
  • Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance CANCER RESEARCH, 2021, v.81 no.13, 3539-3553
    SCIE Scopus dColl.
  • Comprehensive Survey of Recent Drug Discovery Using Deep Learning INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, v.22 no.18, 9983
    SCIE Scopus dColl.
  • Enhanced Sensitivity of Nonsmall Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors to Phenformin: The Roles of a Metabolic Shift to Oxidative Phosphorylation and Redox Balance Oxidative Medicine and Cellular Longevity, 2021, v.2021, 5428364
    SCIE Scopus dColl.
  • Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer Oncogene, 2020, v.39 no.23, 4567-4580
    SCIE Scopus dColl.
  • Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation Proceedings of the National Academy of Sciences of the United States of America, 2020, v.117 no.33, 19982-19993
    Scopus dColl.
  • MiR-4435 is an UQCRB-related circulating miRNA in human colorectal cancer Scientific Reports, 2020, v.10 no.1, 2833
    SCIE Scopus dColl.
  • Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020 , 1831-1844
    SCIE Scopus KCI dColl.
  • Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation Nature Communications, 2020, v.11 no.1, 4343
    SCIE Scopus dColl.
  • Safe scarless cassette-free selection of genome-edited human pluripotent stem cells using temporary drug resistance Biomaterials, 2020, v.262, 120295
    SCIE Scopus dColl.
  • Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis Redox Biology, 2020, v.37, 101719
    SCIE Scopus dColl.
  • CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures Molecules and cells, 2019, v.42 no.3, 237-244
    SCIE Scopus KCI dColl.
  • CSgator: an integrated web platform for compound set analysis JOURNAL OF CHEMINFORMATICS, 2019, v.11, 17
    SCIE Scopus dColl.
  • Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data PHARMACEUTICS, 2019, v.11 no.8, 377
    SCIE Scopus dColl.
  • In silico drug repositioning: from large-scale transcriptome data to therapeutics ARCHIVES OF PHARMACAL RESEARCH, 2019, v.42 no.10, 879-889
    SCIE Scopus KCI dColl.
  • Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells FRONTIERS IN CHEMISTRY, 2019, v.7, 298
    SCIE Scopus dColl.
  • Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway SCIENTIFIC REPORTS, 2018, v.8, 12407
    SCIE Scopus dColl.
  • Selective Elimination of Culture-Adapted Human Embryonic Stem Cells with BH3 Mimetics STEM CELL REPORTS, 2018, v.11 no.5, 1244-1256
    SCIE Scopus dColl.
  • Drug Repositioning for Cancer Therapy Based on Large-Scale Drug-Induced Transcriptional Signatures PLOS ONE, 2016, v.11 no.3
    SCIE Scopus dColl.
  • Modulation of mRNA and lncRNA expression dynamics by the Set2-Rpd3S pathway Nature Communications, 2016, v.7
    SCIE Scopus dColl.
  • A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity PLOS ONE, 2015, v.10 no.10, e0141045
    SCIE Scopus dColl.
  • miRseqViewer: multi-panel visualization of sequence, structure and expression for analysis of microRNA sequencing data BIOINFORMATICS, 2015, v.31 no.4, 596-598
    SCIE Scopus dColl.
  • A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma NATURE GENETICS, 2014, v.46 no.4, 371-
    SCIE Scopus dColl.
  • Exome and transcriptome profiling of lung adenocarcinoma in female never-smokers CANCER RESEARCH, 2014, v.74 no.19
    SCIE Scopus dColl.
  • GEPdb: a database for investigating the ternary association of genotype, gene expression and phenotype BIOINFORMATICS, 2014, v.30 no.17, 2540-2542
    SCIE Scopus dColl.
  • IncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs BIOINFORMATICS, 2014, v.30 no.17, 2480-2485
    SCIE Scopus dColl.
  • gsGator : an integrated web platform for cross-species gene set analysis BMC BIOINFORMATICS, 2014, v.15, 13
    SCIE Scopus dColl.
  • [학술지논문] SARS-CoV-2 infection in severe asthma is associated with worsening of COVID-19 through respiratory NLRP3 inflammasome activation ALLERGY, 2023, v.10 no.1111 , 15452-15452
    SCIE
  • [학술지논문] Targeting Na-H exchanger 1 overcomes nuclear factor kappa B-mediated tumor resistance to radiotherapy NEOPLASIA, 2023, v.35 no.1 , 100862-100862
    SCIE
  • [학술지논문] Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial Clinical and molecular hepatology, 2022, v.28 no.3 , 497-509
    SCIE
  • [학술지논문] Crosstalk between YAP and TGF beta regulates SERPINE1 expression in mesenchymal lung cancer cells INTERNATIONAL JOURNAL OF ONCOLOGY, 2021, v.58 no.1 , 111-121
    SCI
  • [학술지논문] Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, v.117 no.33 , 19982-19993
    SCI
  • [학술지논문] MiR-4435 is an UQCRB-related circulating miRNA in human colorectal cancer SCIENTIFIC REPORTS, 2020, v.10 no.1 , 2833-2833
    SCI
  • [학술지논문] Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.11 , 1831-1844
    SCI
  • [학술지논문] Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation NATURE COMMUNICATIONS, 2020, v.11 no.1 , 4343-4343
    SCI
  • [학술지논문] CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures MOLECULES AND CELLS, 2019, v.42 no.3 , 237-244
    SCI
  • [학술지논문] CSgator: an integrated web platform for compound set analysis JOURNAL OF CHEMINFORMATICS, 2019, v.11 no.0 , 17-17
    SCIE
  • [학술지논문] Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data PHARMACEUTICS, 2019, v.11 no.8 , 377-377
    SCIE
  • [학술지논문] In silico drug repositioning: from large-scale transcriptome data to therapeutics ARCHIVES OF PHARMACAL RESEARCH, 2019, v.42 no.10 , 879-889
    SCIE
  • [학술지논문] Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells FRONTIERS IN CHEMISTRY, 2019, v.7 no.0 , 298-298
    SCIE
  • [학술발표] Assay Repositioning - Mining Drug Screening Big Data for Virtual Screening & Target Discovery KSBMB International Conference 2019, 대한민국, 제주, 2019-06-04 KSBMB International Conference 2019, 2019
강의
  • 2023-1학기

  • 2022-2학기

    • 분자생물학 I

      • 학수번호 20600분반 03
      • 2학년 ( 3학점 , 3시간) 월 2~2 (포362) , 목 3~3 (포362)
      • 영어강의
    • 생명과학실험II

      • 학수번호 35312분반 01
      • 2학년 ( 2학점 , 3시간) 월 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 02
      • 2학년 ( 2학점 , 3시간) 화 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 03
      • 2학년 ( 2학점 , 3시간) 수 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 04
      • 2학년 ( 2학점 , 3시간) 목 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 05
      • 2학년 ( 2학점 , 3시간) 금 6~7 (종A203)
    • 융합생물학세미나Ⅱ

      • 학수번호 G16967분반 01
      • 학년 ( 3학점 , 3시간) 월 3~4 (종C515)
  • 2022-1학기

    • 일반생물학실험I

      • 학수번호 33332분반 01
      • 1학년 ( 1학점 , 1.5시간) 월 6~6 (종A203)
    • 일반생물학실험I

      • 학수번호 33332분반 02
      • 1학년 ( 1학점 , 1.5시간) 화 6~6 (종A203)
    • 일반생물학실험I

      • 학수번호 33332분반 03
      • 1학년 ( 1학점 , 1.5시간) 수 6~6 (종A203)
    • 일반생물학실험I

      • 학수번호 33332분반 04
      • 1학년 ( 1학점 , 1.5시간) 금 6~6 (종A203)
    • 분자생물학II

      • 학수번호 35825분반 03
      • 3학년 ( 3학점 , 3시간) 화 5~5 , 목 6~6
      • 영어강의
    • 시스템생물학

      • 학수번호 36338분반 01
      • 4학년 ( 3학점 , 3시간) 화 3~3 , 목 2~2
    • 고급분자생물학

      • 학수번호 G16977분반 01
      • 학년 ( 3학점 , 3시간) 화 5~6 (종C)
  • 2021-2학기

    • 분자생물학 I

      • 학수번호 20600분반 03
      • 2학년 ( 3학점 , 3시간) 월 2~2 (포453) , 목 3~3 (포453)
      • 영어강의
    • 생명과학실험II

      • 학수번호 35312분반 01
      • 2학년 ( 2학점 , 3시간) 월 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 02
      • 2학년 ( 2학점 , 3시간) 화 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 03
      • 2학년 ( 2학점 , 3시간) 수 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 04
      • 2학년 ( 2학점 , 3시간) 목 6~7 (종A203)
    • 생명과학실험II

      • 학수번호 35312분반 05
      • 2학년 ( 2학점 , 3시간) 금 6~7 (종A203)
    • 유전체정보학

      • 학수번호 G17016분반 01
      • 학년 ( 3학점 , 3시간) 월 3~4 (종C515)
  • 2021-1학기

    • 생명의신비

      • 학수번호 10066분반 01
      • 학년 ( 3학점 , 3시간) 화 3~3 , 금 3~3
      • 수강불가:자연대,엘텍공대,의대,간호대,약대 재학생 및 일반생물학, 일반생물학I,II 수강생
    • 일반생물학실험I

      • 학수번호 33332분반 01
      • 1학년 ( 1학점 , 1.5시간) 월 6~6 (종A202)
      • 자연대,호크마대1,팀티칭
    • 일반생물학실험I

      • 학수번호 33332분반 02
      • 1학년 ( 1학점 , 1.5시간) 화 6~6 (종A202)
      • 자연대,호크마대1,팀티칭
    • 일반생물학실험I

      • 학수번호 33332분반 03
      • 1학년 ( 1학점 , 1.5시간) 수 6~6 (종A202)
    • 일반생물학실험I

      • 학수번호 33332분반 04
      • 1학년 ( 1학점 , 1.5시간) 금 6~6 (종A202)
    • 분자생물학II

      • 학수번호 35825분반 03
      • 3학년 ( 3학점 , 3시간) 화 3~3 (포453) , 목 2~2 (포453)
      • 영어강의
    • 시스템생물학

      • 학수번호 36338분반 01
      • 4학년 ( 3학점 , 3시간) 월 3~3 (포363) , 수 2~2 (포363)
    • 고급분자생물학

      • 학수번호 G16977분반 01
      • 학년 ( 3학점 , 3시간) 화 5~6 (종C)
학력

University of Cambridge Ph.D.(생명정보학)

서울대학교 이학석사(미생물학과)

서울대학교 이학사(미생물학과)