연구실적

• EW-7197, transforming growth factor β inhibitor, combined with irreversible electroporation for improving skin wound in a rat excisional model Scientific Reports, 2024, v.14 no.1, 12779
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• Beneficial Effects of a Curcumin Derivative and Transforming Growth Factor-β Receptor I Inhibitor Combination on Nonalcoholic Steatohepatitis DIABETES & METABOLISM JOURNAL, 2023, v.47 no.4, 500-513
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• Different routes of administering EW-7197 versus EW-7197?HBr for preventing peritoneal adhesion in a rat model SURGERY, 2023, v.173 no.4, 1008-1014
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• Discovery of (E)-3-(3-((2-Cyano-4' -dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis JOURNAL OF MEDICINAL CHEMISTRY, 2022, v.65 no.14, 9974-10000
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• EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation Endocrinology and Metabolism, 2022, v.37 no.1, 96-111
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• Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, v.35 no.1, 702-712
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• Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie's Disease WORLD JOURNAL OF MENS HEALTH, 2020, v.38 no.4, 552-563
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• EW-7197 eluting nano-fiber covered self-expandable metallic stent to prevent granulation tissue formation in a canine urethral model PLoS ONE, 2018, v.13 no.2, e0192430
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• EW-7197, an oral transforming growth factor beta type I receptor kinase inhibitor, for preventing peritoneal adhesion formation in a rat model SURGERY, 2018, v.164 no.5, 1100-1108
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• Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF-β signaling Oncotarget, 2017, v.8 no.3, 5092-5110
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• EW-7197, an activin-like kinase 5 inhibitor, suppresses granulation tissue after stent placement in rat esophagus GASTROINTESTINAL ENDOSCOPY, 2017, v.86 no.1, 219-228
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• Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells Cancer Science, 2016, 26 JAN 2016
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• TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition Cellular Physiology and Biochemistry, 2016, v.38 no.2, 571-588
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• Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives Bulletin of the Korean Chemical Society, 2015, v.36 no.1, 43-51
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• Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells Oncotarget, 2015, v.6 no.35, 37526-37543
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• EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling Cellular and molecular life sciences : CMLS, 2015, v.72 no.10, 2023-2039
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• Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation Nature Communications, 2015, v.6
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• Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type i receptor kinase Bioorganic and Medicinal Chemistry Letters, 2015, v.25 no.22, 5228-5231
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• 4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-beta type I receptor kinase BIOORGANIC & MEDICINAL CHEMISTRY, 2014, v.22 no.9, 2724-2732
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• An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition Cancer Letters, 2014, v.351 no.1, 72-80
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• Discovery of N-((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197) : A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF-beta Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic Agent JOURNAL OF MEDICINAL CHEMISTRY, 2014, v.57 no.10, 4213-4238
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• EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis Molecular Cancer Therapeutics, 2014, v.13 no.7, 1704-1716
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• [학술지논문] Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, v.35 no.1 , 702-712
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