강수성 교수는 약학대학(원) 약학과 교수로 의약화학, 약품합성, 약화학 관련 강의를 하며 다양한 질병 타겟에 대한 신약개발을 하고 있다. 그는 Purdue 대학에서 유기화학/의약화학으로 박사학위를 받은후 Northwestern 대학에서 다양한 퇴행성 뇌질환 관련 약물개발 연구를 진행하였고 K-Med Hub 신약개발센터에서는 책임연구원으로 알츠하이머병, 염증성장질환, 및 항암관련 치료제개발 연구에 기여하였고, 2017년 부터는 본교 교수로 재직 중이다. 그는 주로 퇴행성 뇌질환에 관련된 단백질 및 미토콘드리아에 존재하거나 이의 산화적 스트레스와 연관된 단백질을 주된 약물 타겟으로하여 이와 관련된 질병의 치료제 개발 연구를 Medicinal Chemistry, Organic Chemistry, Computational chemistry 및 AI를 활용하여 진행하고 있다.
Drug Discovery, CNS disorders, Anticancers, Antibiotics, Mitochondrial protein specific drug delivery and modulation
연구실적
Employing Automated Machine Learning (AutoML) Methods to Facilitate the In Silico ADMET Properties PredictionJournal of Chemical Information and Modeling, 2025, v.65 no.7, 3215-3225
Targeting Autotaxin with imidazole-and Triazolyl-based inhibitors: Biological insights from in vitro and in vivo studies in pulmonary fibrosisBIOORGANIC CHEMISTRY, 2025, v.160, 108426
Development of a Fluorescence Probe for High-Throughput Screening of Allosteric Inhibitors Targeting TRAP1Journal of Medicinal Chemistry, 2024, v.67 no.23, 21421-21437
Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary FibrosisJournal of Medicinal Chemistry, 2023, v.66 no.23, 16342-16363
Meclizine, a piperazine-derivative antihistamine, binds to dimerized translationally controlled tumor protein and attenuates allergic reactions in a mouse modelBiomedicine and Pharmacotherapy, 2023, v.157, 114072
Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory ActivityMolecules (Basel, Switzerland), 2023, v.28 no.6
Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agentsEuropean Journal of Medicinal Chemistry, 2022, v.244, 114837
Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2021, v.64 no.2, 958-979
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding SiteJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, v.143 no.47, 19684-19696
A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca(v)1.3 L-Type Calcium ChannelsACS CHEMICAL BIOLOGY, 2020, v.15 no.9, 2539-2550
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft modelsBioorganic Chemistry, 2020, v.101, 103901
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, v.30 no.2, 126809
Practical direct synthesis of: N -aryl-substituted azacycles from N -alkyl protected arylamines using TiCl4and DBUOrganic and Biomolecular Chemistry, 2020, v.18 no.26, 5008-5016
Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo [1,5-a]pyrimidin-3-yl acetamideBIOORGANIC & MEDICINAL CHEMISTRY, 2019, v.27 no.18, 4069-4080
CF3-Substituted Mollugin 2-(4-Morpholinyl)-ethyl ester as a Potential Anti-inflammatory Agent with Improved Aqueous Solubility and Metabolic StabilityMOLECULES, 2018, v.23 no.8, 2030
Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditionsTETRAHEDRON LETTERS, 2018, v.59 no.39, 3541-3546
Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug DesignFRONTIERS IN PHARMACOLOGY, 2018, v.9
Facile direct synthesis of unsymmetrical ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines using DABAL-Me-3TETRAHEDRON, 2018, v.74 no.30, 4036-4046
2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and SelectivityJOURNAL OF MEDICINAL CHEMISTRY, 2015, v.58 no.14, 5548-5560
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide SynthaseJOURNAL OF MEDICINAL CHEMISTRY, 2015, v.58 no.21, 8694-8712
The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide SynthasesBIOCHEMISTRY, 2014, v.53 no.32, 5272-5279
[학술지논문] Employing Automated Machine Learning (AutoML) Methods to Facilitate the In Silico ADMET Properties Prediction
Journal of Chemical Information and Modeling, 2025, v.65
no.7
, 3215-3225
Scopus
[학술지논문] Targeting Autotaxin with imidazole-and Triazolyl-based inhibitors: Biological insights from in vitro and in vivo studies in pulmonary fibrosis
BIOORGANIC CHEMISTRY, 2025, v.160
no.11
, 108426-108426
SCIE
[학술지논문] Development of a Fluorescence Probe for High-Throughput Screening of Allosteric Inhibitors Targeting TRAP1
JOURNAL OF MEDICINAL CHEMISTRY, 2024, v.67
no.23
, 21421-21437
SCIE
[학술지논문] Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis
JOURNAL OF MEDICINAL CHEMISTRY, 2023, v.66
no.23
, 16342-16363
SCIE
[학술지논문] Meclizine, a piperazine-derivative antihistamine, binds to dimerized translationally controlled tumor protein and attenuates allergic reactions in a mouse model
BIOMEDICINE & PHARMACOTHERAPY, 2023, v.157
no.157
, 114072-114072
SCIE
[학술지논문] 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRP alpha Checkpoint
ACS MEDICINAL CHEMISTRY LETTERS, 2022, v.13
no.9
, 1459-1467
SCIE
[학술지논문] Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, v.244
no.0
, 114837-114837
SCI
[학술지논문] Palladium-Catalyzed alpha-Arylation of Cyclic beta-Dicarbonyl Compounds for the Synthesis of Ca(V)1.3 Inhibitors
ACS OMEGA, 2022, v.7
no.16
, 14252-14263
SCIE
[학술지논문] Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1
JOURNAL OF MEDICINAL CHEMISTRY, 2022, v.65
no.24
, 16155-16172
SCI
[학술지논문] Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6--chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity
BIOORGANIC CHEMISTRY, 2022, v.126
no.126
, 105856-105856
SCI
[학술지논문] Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity
ACS MEDICINAL CHEMISTRY LETTERS, 2021, v.12
no.7
, 1173-1180
SCIE
[학술지논문] Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY, 2021, v.64
no.2
, 958-979
SCI
[학술지논문] A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca(v)1.3 L-Type Calcium Channels
ACS CHEMICAL BIOLOGY, 2020, v.15
no.9
, 2539-2550
SCIE
[학술지논문] Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics
CELLS, 2020, v.9
no.11
, 2447-2447
SCIE
[학술지논문] Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models
BIOORGANIC CHEMISTRY, 2020, v.101
no.0
, 103901-103901
SCI
[학술지논문] Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, v.30
no.2
, 126809-126809
SCI
[학술지논문] Physiological involvement of presynaptic L-type voltage-dependent calcium channels in GABA release of cerebellar molecular layer interneurons
JOURNAL OF NEUROCHEMISTRY, 2020, v.155
no.4
, 390-402
SCI
[학술지논문] Practical direct synthesis of N-aryl-substituted azacycles from N-alkyl protected arylamines using TiCl4 and DBU
ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, v.18
no.26
, 5008-5016