강수성 교수는 약학대학(원) 약학과 교수로 의약화학, 약품합성, 약화학 관련 강의를 하며 다양한 질병 타겟에 대한 신약개발을 하고 있다. 그는 Purdue 대학에서 유기화학/의약화학으로 박사학위를 받은후 Northwestern 대학에서 다양한 퇴행성 뇌질환 관련 약물개발 연구를 진행하였고 K-Med Hub 신약개발센터에서는 책임연구원으로 알츠하이머병, 염증성장질환, 및 항암관련 치료제개발 연구에 기여하였고, 2017년 부터는 본교 교수로 재직 중이다. 그는 주로 퇴행성 뇌질환에 관련된 단백질 및 미토콘드리아에 존재하거나 이의 산화적 스트레스와 연관된 단백질을 주된 약물 타겟으로하여 이와 관련된 질병의 치료제 개발 연구를 Medicinal Chemistry, Organic Chemistry, Computational chemistry 및 AI를 활용하여 진행하고 있다.
Drug Discovery, CNS disorders, Anticancers, Antibiotics, Mitochondrial protein specific drug delivery and modulation
연구실적
Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary FibrosisJournal of Medicinal Chemistry, 2023, v.66 no.23, 16342-16363
Meclizine, a piperazine-derivative antihistamine, binds to dimerized translationally controlled tumor protein and attenuates allergic reactions in a mouse modelBiomedicine and Pharmacotherapy, 2023, v.157, 114072
Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory ActivityMolecules (Basel, Switzerland), 2023, v.28 no.6
Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agentsEuropean Journal of Medicinal Chemistry, 2022, v.244, 114837
Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2021, v.64 no.2, 958-979
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding SiteJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, v.143 no.47, 19684-19696
A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca(v)1.3 L-Type Calcium ChannelsACS CHEMICAL BIOLOGY, 2020, v.15 no.9, 2539-2550
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft modelsBioorganic Chemistry, 2020, v.101, 103901
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, v.30 no.2, 126809
Practical direct synthesis of: N -aryl-substituted azacycles from N -alkyl protected arylamines using TiCl4and DBUOrganic and Biomolecular Chemistry, 2020, v.18 no.26, 5008-5016
Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo [1,5-a]pyrimidin-3-yl acetamideBIOORGANIC & MEDICINAL CHEMISTRY, 2019, v.27 no.18, 4069-4080
CF3-Substituted Mollugin 2-(4-Morpholinyl)-ethyl ester as a Potential Anti-inflammatory Agent with Improved Aqueous Solubility and Metabolic StabilityMOLECULES, 2018, v.23 no.8, 2030
Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditionsTETRAHEDRON LETTERS, 2018, v.59 no.39, 3541-3546
Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug DesignFRONTIERS IN PHARMACOLOGY, 2018, v.9
Facile direct synthesis of unsymmetrical ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines using DABAL-Me-3TETRAHEDRON, 2018, v.74 no.30, 4036-4046
2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and SelectivityJOURNAL OF MEDICINAL CHEMISTRY, 2015, v.58 no.14, 5548-5560
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide SynthaseJOURNAL OF MEDICINAL CHEMISTRY, 2015, v.58 no.21, 8694-8712
The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide SynthasesBIOCHEMISTRY, 2014, v.53 no.32, 5272-5279
[학술지논문] Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis
JOURNAL OF MEDICINAL CHEMISTRY, 2023, v.66
no.23
, 16342-16363
SCIE
[학술지논문] Meclizine, a piperazine-derivative antihistamine, binds to dimerized translationally controlled tumor protein and attenuates allergic reactions in a mouse model
BIOMEDICINE & PHARMACOTHERAPY, 2023, v.157
no.157
, 114072-114072
SCIE
[학술지논문] 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRP alpha Checkpoint
ACS MEDICINAL CHEMISTRY LETTERS, 2022, v.13
no.9
, 1459-1467
SCIE
[학술지논문] Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, v.244
no.0
, 114837-114837
SCI
[학술지논문] Palladium-Catalyzed alpha-Arylation of Cyclic beta-Dicarbonyl Compounds for the Synthesis of Ca(V)1.3 Inhibitors
ACS OMEGA, 2022, v.7
no.16
, 14252-14263
SCIE
[학술지논문] Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1
JOURNAL OF MEDICINAL CHEMISTRY, 2022, v.65
no.24
, 16155-16172
SCI
[학술지논문] Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6--chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity
BIOORGANIC CHEMISTRY, 2022, v.126
no.126
, 105856-105856
SCI
[학술지논문] Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity
ACS MEDICINAL CHEMISTRY LETTERS, 2021, v.12
no.7
, 1173-1180
SCIE
[학술지논문] Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY, 2021, v.64
no.2
, 958-979
SCI
[학술지논문] A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca(v)1.3 L-Type Calcium Channels
ACS CHEMICAL BIOLOGY, 2020, v.15
no.9
, 2539-2550
SCIE
[학술지논문] Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics
CELLS, 2020, v.9
no.11
, 2447-2447
SCIE
[학술지논문] Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models
BIOORGANIC CHEMISTRY, 2020, v.101
no.0
, 103901-103901
SCI
[학술지논문] Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, v.30
no.2
, 126809-126809
SCI
[학술지논문] Physiological involvement of presynaptic L-type voltage-dependent calcium channels in GABA release of cerebellar molecular layer interneurons
JOURNAL OF NEUROCHEMISTRY, 2020, v.155
no.4
, 390-402
SCI
[학술지논문] Practical direct synthesis of N-aryl-substituted azacycles from N-alkyl protected arylamines using TiCl4 and DBU
ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, v.18
no.26
, 5008-5016
SCI
[학술지논문] Casein kinase-1 gamma 1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3
CELL DEATH & DISEASE, 2019, v.10
no.0
, 923-923
SCIE
[학술지논문] Metal-Free Synthesis of N-Aryl-Substituted Azacycles from Cyclic Ethers Using POCI3
JOURNAL OF ORGANIC CHEMISTRY, 2019, v.84
no.11
, 6689-6696
SCI
[학술지논문] Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo [1,5-a]pyrimidin-3-yl acetamide
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, v.27
no.18
, 4069-4080
SCI
[지적재산권] JAK 저해제 화합물, 및 이를 포함하는 의약 조성물국내 : 특허, 출원
[지적재산권] JAK 저해제 화합물, 및 이의 제조방법국내 : 특허, 등록, 제10-2034538호, 2019