이윤실 교수는 약학대학 약학과 소속 교수로 방사선연구분야 전문가이다. 이화여대 약학과에서 박사학위를 받았고 미국 암연구소에서 박사후연구원을 거쳐 2010년까지 18여년간 한국원자력의학원에서 방사선관련 연구를 수행하였다. 2010년에 이화여대로 부임하여 강의와 연구활동을 지속하고 있으며 여성원자력전문인협회 부회장, 방사선생명과학회 회장, 약학회 학술위원장등을 맡아 활동하고 있으며 현재까지 SCI 논문 200여편 게재 및 특허 20여건을 등록했다.
Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cellsCancer Science, 2024, v.115 no.6, 2036-2048
Transcriptional Changes in Radiation-Induced Lung Injury: A Comparative Analysis of Two Radiation Doses for Preclinical ResearchInternational Journal of Molecular Sciences, 2024, v.25 no.7, 3766
Design, synthesis, and biological evaluation of novel HSP27 inhibitors to sensitize lung cancer cells to clinically available anticancer agentsBioorganic Chemistry, 2023, v.130, 106260
Engineered Lipid Nanoparticles for the Treatment of Pulmonary Fibrosis by Regulating Epithelial-Mesenchymal Transition in the LungsAdvanced Functional Materials, 2023, v.33 no.7, 2209432
Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary FibrosisJournal of Medicinal Chemistry, 2023, v.66 no.23, 16342-16363
Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutationsCellular Oncology, 2022, v.45 no.5, 913-930
Efferocytosis and enhanced FPR2 expression following apoptotic cell instillation attenuate radiation-induced lung inflammation and fibrosisBiochemical and Biophysical Research Communications, 2022, v.601, 38-44
Drug-like small molecule HSP27 functional inhibitor sensitizes lung cancer cells to gefitinib or cisplatin by inducing altered cross-linked Hsp27 dimersPharmaceutics, 2021, v.13 no.5, 630
HSPB1 inhibitor J2 attenuates lung inflammation through direct modulation of Ym1 production and paracrine signalingBIOMEDICINE & PHARMACOTHERAPY, 2021, v.143, 112225
The protective effects of emf‐lte against dna double‐strand break damage in vitro and in vivoInternational Journal of Molecular Sciences, 2021, v.22 no.10, 5134
Behavioral changes and gene profile alterations after chronic 1,950-MHz radiofrequency exposure: An observation in C57BL/6 miceBrain and Behavior, 2020, v.10 no.11, e01815
Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1CELL DEATH & DISEASE, 2020, v.11 no.5
Effects of Radiofrequency Electromagnetic Fields and Ionizing Radiation on Amyloid Precursor Protein Processing and Cell DeathJournal of Electromagnetic Engineering and Science, 2020, v.20 no.4, 307-319
Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivoENVIRONMENTAL RESEARCH, 2019, v.173, 124-134
Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivoFood and Chemical Toxicology, 2019, v.124, 265-272
Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 MiceINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, v.19 no.7, 2103
Submicromolar bisphenol A induces proliferation and DNA damage in human hepatocyte cell lines in vitro and in juvenile rats in vivoFOOD AND CHEMICAL TOXICOLOGY, 2018, v.111, 125-132
Assessment of ionizing radiation induced dicentric chromosome and micronuclei in human peripheral blood lymphocytes for preliminary reconstruction of cytogenetic biodosimetryAtom Indonesia, 2017, v.43 no.1, 47-54
Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27European Journal of Medicinal Chemistry, 2017, v.139, 892-900
The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated CytotoprotectionJOURNAL OF NATURAL PRODUCTS, 2017, v.80 no.8, 2379-2383
The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanomaONCOTARGET, 2017, v.8 no.15, 24932-24948
The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable responseStem Cell Research and Therapy, 2017, v.8 no.1
The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3 beta and decreasing the expression of cyclinD1ONCOTARGET, 2017, v.8 no.8, 13632-13651
Focal exposure of limited lung volumes to high-dose irradiation down-regulated organ development-related functions and up-regulated the immune response in mouse pulmonary tissuesBMC GENETICS, 2016, v.17
Identification of radiation response genes and proteins from mouse pulmonary tissues after high-dose per fraction irradiation of limited lung volumesInternational Journal of Radiation Biology, 2016, 25 Oct 2016, 1-10
A hypoxia-induced vascular endothelial-to-mesenchymal transition in development of radiation-induced pulmonary fibrosisClinical Cancer Research, 2015, v.21 no.16, 3716-3726
DIFFERENTIAL EXPRESSION OF RADIATION RESPONSE GENES IN SPLEEN, LUNG, AND LIVER OF RATS FOLLOWING ACUTE OR CHRONIC RADIATION EXPOSURE방사선방어학회지, 2015, v.40 no.1, 25-35
Effect of whole-body exposure to the 848.5 MHz code division multiple access (CDMA) electromagnetic field on adult neurogenesis in the young, healthy rat brainINTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2015, v.91 no.4, 354-359
Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial CellsKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2015, v.19 no.2, 119-124
Eight hours of nocturnal 915 MHz radiofrequency identification (RFID) exposure reduces urinary levels of melatonin and its metabolite via pineal arylalkylamine N-acetyltransferase activity in male ratsInternational Journal of Radiation Biology, 2015, v.91 no.11, 898-907
MicroRNA-26a/-26b-COX-2-MIP-2 loop regulates allergic inflammation and allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cellsJournal of Biological Chemistry, 2015, v.290 no.22, 14245-14266
Pyruvate metabolism: A therapeutic opportunity in radiation-induced skin injuryBiochemical and Biophysical Research Communications, 2015, v.460 no.3, 504-510
The inflammasome accelerates radiation-induced lung inflammation and fibrosis in miceENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2015, v.39 no.2, 917-926
Absence of DNA damage after 60-Hz electromagnetic field exposure combined with ionizing radiation, hydrogen peroxide, or c-Myc overexpressionRADIATION AND ENVIRONMENTAL BIOPHYSICS, 2014, v.53 no.1, 93-101
Combined Effects of 60 Hz Electromagnetic Field Exposure With Various Stress Factors on Cellular Transformation in NIH3T3 Cells (vol 33, pg 207, 2012)BIOELECTROMAGNETICS, 2014, v.35 no.1, 76-77
Effect of 915 MHz RFID exposure on changes of body temperature in ratsIEEE International Symposium on Electromagnetic Compatibility, 2014, v.2014-December, 170-173
Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cellsJOURNAL OF RADIATION RESEARCH, 2014, v.55 no.2, 265-276
Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiationONCOLOGY REPORTS, 2014, v.31 no.5, 2229-2235
Increased gamma-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell linesINTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2014, v.90 no.4, 291-298
miR-326-Histone Deacetylase-3 Feedback Loop Regulates the Invasion and Tumorigenic and Angiogenic Response to Anti-cancer DrugsJOURNAL OF BIOLOGICAL CHEMISTRY, 2014, v.289 no.40, 28019-28039
[학술지논문] GTSE1 driven ZEB1 stabilization promotes pulmonary fibrosis through the epithelial-to-mesenchymal transition
MOLECULAR THERAPY, 2024, v.32
no.11
, 1-20
SCIE
[학술지논문] Low Dose Radiation Therapy for Neurological Disorders: A Double-Edged Sword
DISCOVERY MEDICINE, 2024, v.36
no.184
, 898-912
SCIE
[학술지논문] Phosphorylation of BRCA1 at serine 1387 plays a critical role in cathepsin S-mediated radiation resistance via BRCA1 degradation and BCL2 stabilization
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2024, v.1871
no.0
, 167523-167534
SCIE
[학술지논문] Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple negative breast cancer cells
Cancer Science, 2024, v.115
no.2
, 2036-2048
SCIE
[학술지논문] Rutaecarpine, Isolated from Evodia rutaecarpa, Inhibits Epithelial-Mesenchymal Transition and Cellular Senescence in a Mouse Model of Pulmonary Fibrosis
Natural Product Sciences, 2024, v.30
no.3
, 190-197
Scopus
[학술지논문] Transcirptional Changes in Radiation-induced LUng Injry: A Comparative Analysis of Two Radiation Doses for Preclinical Research
International Journal of Molecular Sciences, 2024, v.25
no.0
, 3766-3772
SCIE
[학술지논문] BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy
BIOMEDICINE & PHARMACOTHERAPY, 2023, v.158
no.0
, 114090-114090
SCIE
[학술지논문] Design, synthesis, and biological evaluation of novel HSP27 inhibitors to sensitize lung cancer cells to clinically available anticancer agents
BIOORGANIC CHEMISTRY, 2023, v.130
no.1062600
, 1-11
SCIE
[학술지논문] Drug like HSP27 cross linkers with chromenone structure ameliorates pulmonary fibrosis
FRONTIERS IN PHARMACOLOGY, 2023, v.14
no.0
, 1203033-1203033
SCIE
[학술지논문] Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis
JOURNAL OF MEDICINAL CHEMISTRY, 2023, v.66
no.23
, 16342-16363
SCIE
[학술지논문] NXC736 Attenuates Radiation-Induced Lung Fibrosis via Regulating NLRP3/IL-1β Signaling Pathway
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, v.24
no.22
, 16265-16265
SCIE
[학술지논문] The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis
JOURNAL OF BIOMEDICAL SCIENCE, 2023, v.30
no.1
, 2-2
SCIE
[학술지논문] Efferocytosis and enhanced FPR2 expression following apoptotic cell instillation attenuate radiation-induced lung inflammation and fibrosis
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, v.601
no.0
, 38-44
SCI
[학술지논문] Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
NATURE COMMUNICATIONS, 2022, v.13
no.1
, 6732-6732
SCI
[학술지논문] Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers
PHARMACEUTICS, 2021, v.13
no.5
, 630-649
SCIE
[학술지논문] The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, v.22
no.10
, 5134-5134
SCIE
[학술지논문] Behavioral changes and gene profile alterations after chronic 1,950-MHz radiofrequency exposure: An observation in C57BL/6 mice
BRAIN AND BEHAVIOR, 2020, v.10
no.11
, 01815-01815
SCIE
[학술지논문] Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1
CELL DEATH & DISEASE, 2020, v.11
no.5
, 395-409
SCIE
[학술지논문] Effects of Radiofrequency Electromagnetic Fields and Ionizing Radiation on Amyloid Precursor Protein Processing and Cell Death
Journal of Electromagnetic Engineering and Science, 2020, v.20
no.4
, 307-319
Scopus
[학술지논문] LXA(4)-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-beta/Smad signaling
CELL DEATH & DISEASE, 2020, v.11
no.8
, 653-653
SCIE
[학술지논문] Lung-targeted delivery of TGF-beta antisense oligonucleotides to treat pulmonary fibrosis
JOURNAL OF CONTROLLED RELEASE, 2020, v.322
no.0
, 108-121
[학술지논문] Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance
CANCERS, 2020, v.12
no.6
, 1-24
SCIE
[학술지논문] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo
ENVIRONMENTAL RESEARCH, 2019, v.173
no.0
, 124-134
SCI
[학술지논문] Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo
FOOD AND CHEMICAL TOXICOLOGY, 2019, v.124
no.2
, 265-272
SCI
[학술지논문] Radiosensitivity of Cancer Cells Is Regulated by Translationally Controlled Tumor Protein
CANCERS, 2019, v.11
no.3
, 386-386
SCIE
[학술지논문] Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation
CELL DEATH AND DIFFERENTIATION, 2019, v.26
no.5
, 812-825
SCI
[학술지논문] Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?
CANCERS, 2019, v.11
no.8
, 1195-1195
SCIE
[학술지논문] The Hsp27-Mediated IkB alpha-NF kappa B Signaling Axis Promotes Radiation-Induced Lung Fibrosis
CLINICAL CANCER RESEARCH, 2019, v.25
no.17
, 5364-5375