강상원(姜相元) 교수
생명과학과[대학원] /의과대학 /생명과학과
강상원 교수는 생명과학전공 소속으로 활성산소와 관련한 생체신호전달 연구의 권위자다. 미국 국립보건원(NIH)에서 박사후 연구원시절부터 세계 최초로 활성산소의 신호전달 기능을 연구한 경력을 시작으로 지금까지 세포신호전달 분야에서 활성산소의 작용기전을 연구하고 있으며 특히 활성산소 기능 연구를 통해 사람의 다양한 만성 질환(암, 혈관질환)의 치료에 적용하려는 노력을 해 오고 있다. 2002년 생명과학과에 부임한 후로 <Nature>, <Cell> 자매지등에 획기적인 연구결과들을 발표하고 있다. 또한 국내외 Proteomics 학술 활동도 활발하게 해 오고 있다.
- 종합과학관 C동 504호
- 02-3277-3352
- 면담 가능시간
- 화 9 - 10시, 목 9 - 11시
연구실적
- A small molecule compound that inhibits blue light-induced retinal damage via activation of autophagy Biochemical Pharmacology, 2023, v.211, 115534
- Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation Cell Reports, 2023, v.42 no.11, 113361
- Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells Scientific reports, 2023, v.13 no.1, 2404
- Glucose Deprivation Induces Cancer Cell Death through Failure of ROS Regulation International Journal of Molecular Sciences, 2023, v.24 no.15, 11969
- Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells Redox Biology, 2022, v.51, 102293
- PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation Nature Communications, 2022, v.13 no.1, 1768
- RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis Molecules and Cells, 2022, v.45 no.4, 193-201
- CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication MOLECULES AND CELLS, 2021, v.44 no.2, 101-115
- GPx-1-encoded adenoviral vector attenuates dopaminergic impairments induced by methamphetamine in GPx-1 knockout mice through modulation of NF-KB transcription factor FOOD AND CHEMICAL TOXICOLOGY, 2021, v.154, 112313
- Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, v.53 no.6, 1080-1091
- Circulating lipidomic alterations in obese and non-obese subjects with non-alcoholic fatty liver disease ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, v.52 no.10, 1603-1614
- Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29, UNSP 101391
- Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink-dependent matrix assembly FASEB JOURNAL, 2020, v.34 no.8, 10228-10241
- Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation CANCERS, 2020, v.12 no.9, 2601
- SEZ6L2 Is an Important Regulator of Drug-Resistant Cells and Tumor Spheroid Cells in Lung Adenocarcinoma BIOMEDICINES, 2020, v.8 no.11, 500
- Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-alpha-Induced Apoptosis via Different Routes CELL REPORTS, 2019, v.26 no.8, 2194-
- Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51, 144
- Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres BIOMOLECULES, 2019, v.9 no.10, 595
- A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells SCIENTIFIC REPORTS, 2018, v.8, 16551
- Lipidomic profiling reveals free fatty acid alterations in plasma from patients with atrial fibrillation PLOS ONE, 2018, v.13 no.5
- OCT4 directly regulates sternness and extracellular matrix-related genes in human germ cell tumours BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, v.503 no.3, 1980-1986
- Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux AUTOPHAGY, 2018, v.14 no.1, 120-133
- Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, v.50
- INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis Oncotarget, 2017, v.8 no.70, 115041-115053
- Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells Nature Communications, 2017, v.8 no.1
- Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence BMB Reports, 2017, v.50 no.10, 528-533
- Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress Nature Communications, 2017, v.8
- Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II BMB Reports, 2017, v.50 no.8, 391-392
- A Decoy Peptide Targeted to Protein Phosphatase 1 Attenuates Degradation of SERCA2a in Vascular Smooth Muscle Cells PLOS ONE, 2016, v.11 no.10, e0165569
- Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway SCIENTIFIC REPORTS, 2016, v.6
- Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions-Targeted siRNA delivery to pro-atherogenic endothelium in vivo Scientific Reports, 2016, v.6
- NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells CANCER RESEARCH, 2016, v.76 no.4
- Ursodeoxycholic Acid (UDCA) exerts anti-Atherogenic effects by inhibiting RAGE signaling in diabetic atherosclerosis PLoS ONE, 2016, v.11 no.1
- ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair ONCOGENE, 2015, v.34 no.3, 351-361
- Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels Cardiovascular Research, 2015, v.106 no.3, 498-508
- ROS and energy metabolism in cancer cells: alliance for fast growth Archives of Pharmacal Research, 2015, v.38 no.3
- Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response PLOS ONE, 2015, v.10 no.8
- 2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks International Journal of Cell Biology, 2014, v. 2014
- Dominant Role of Peroxiredoxin/JNK Axis in Stemness Regulation During Neurogenesis from Embryonic Stem Cells STEM CELLS, 2014, v.32 no.4, 998-1011
- Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins ONCOTARGET, 2014, v.5 no.18, 8452-8465
- [학술지논문] Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation CELL REPORTS, 2023, v.42 no.11 , 1-13
- [학술지논문] Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-Kappa B survival machinery in cancer cells REDOX BIOLOGY, 2022, v.51 no.102293 , 1-14
- [학술지논문] PI3K gamma stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation NATURE COMMUNICATIONS, 2022, v.13 no.1 , 1768-1768
- [학술지논문] RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-alpha-Induced Necroptosis MOLECULES AND CELLS, 2022, v.45 no.4 , 193-201
- [학술지논문] Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29 no.0 , 101391-101391
강의
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2025-1학기
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일반생물학
- 학수번호 20412분반 04
- 1학년 ( 3학점 , 3시간) 월 5~5 (포453) , 수 4~4 (포453)
- 공대(휴먼기계바이오공학)1, 공대(건축학)1, 인공지능대(컴퓨터공학)1, 인공지능대(인공지능데이터사이언스학부)1
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생물화학Ⅰ
- 학수번호 33716분반 01
- 2학년 ( 3학점 , 3시간) 월 3~3 (포361) , 수 2~2 (포361)
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생명과학실험Ⅰ
- 학수번호 35309분반 01
- 2학년 ( 2학점 , 3시간) 월 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 02
- 2학년 ( 2학점 , 3시간) 화 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 03
- 2학년 ( 2학점 , 3시간) 수 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 04
- 2학년 ( 2학점 , 3시간) 목 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 05
- 2학년 ( 2학점 , 3시간) 금 6~7 (종A205)
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생명과학연구개론
- 학수번호 36337분반 01
- 3학년 ( 3학점 , 3시간) 화 4~4 (포452) , 금 5~5 (포452)
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21C바이오산업
- 학수번호 37713분반 01
- 4학년 ( 1학점 , 1시간) 금 6~6 (포363)
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생명공학
- 학수번호 G16974분반 01
- 학년 ( 3학점 , 3시간) 금 5~6 (종C)
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신호전달과신약개발
- 학수번호 G16982분반 01
- 학년 ( 3학점 , 3시간) 월 5~6 (종C)
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2024-2학기
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생물화학Ⅱ
- 학수번호 35824분반 02
- 2학년 ( 3학점 , 3시간) 화 4~4 (포362) , 금 5~5 (포362)
- 팀티칭
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분자의생물학
- 학수번호 36336분반 01
- 4학년 ( 3학점 , 3시간) 월 4~4 (종A) , 목 5~5 (102)
- 팀티칭
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세포신호전달개론
- 학수번호 38212분반 01
- 3학년 ( 3학점 , 3시간) 화 5~5 (포361) , 목 6~6 (포361)
- 팀티칭
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생명과학연구Ⅳ
- 학수번호 G16935분반 01
- 학년 ( 3학점 , 3시간)
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활성산소생물학Ⅱ
- 학수번호 G16943분반 01
- 학년 ( 3학점 , 3시간) 금 2~3 (종C)
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2024-1학기
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일반생물학
- 학수번호 20412분반 04
- 1학년 ( 3학점 , 3시간) 월 5~5 (포453) , 수 4~4 (포453)
- 공대
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생물화학Ⅰ
- 학수번호 33716분반 01
- 2학년 ( 3학점 , 3시간) 월 3~3 (포361) , 수 2~2 (포361)
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생명과학실험Ⅰ
- 학수번호 35309분반 01
- 2학년 ( 2학점 , 3시간) 월 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 02
- 2학년 ( 2학점 , 3시간) 화 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 03
- 2학년 ( 2학점 , 3시간) 수 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 04
- 2학년 ( 2학점 , 3시간) 목 6~7 (종A205)
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생명과학실험Ⅰ
- 학수번호 35309분반 05
- 2학년 ( 2학점 , 3시간) 금 6~7 (종A205)
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활성산소생물학Ⅰ
- 학수번호 G16942분반 01
- 학년 ( 3학점 , 3시간) 화 3~4 (종C)
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고급생화학특론Ⅰ
- 학수번호 G16946분반 01
- 학년 ( 3학점 , 3시간) 월 5~6 (종C)
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2022-2학기
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생물화학II
- 학수번호 35824분반 01
- 2학년 ( 3학점 , 3시간) 월 4~4 (포361) , 목 5~5 (포361)
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세포신호전달개론
- 학수번호 38212분반 01
- 3학년 ( 3학점 , 3시간) 화 5~5 (포361) , 목 6~6 (포361)
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생명과학연구Ⅱ
- 학수번호 G16933분반 01
- 학년 ( 3학점 , 3시간)
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활성산소생물학Ⅱ
- 학수번호 G16943분반 01
- 학년 ( 3학점 , 3시간) 수 2~3 (종C)
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2022-1학기
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일반생물학I
- 학수번호 20413분반 04
- 1학년 ( 3학점 , 3시간) 화 2~2 (포453) , 금 3~3 (포453)
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생물화학I
- 학수번호 33716분반 01
- 2학년 ( 3학점 , 3시간) 월 3~3 (포361) , 수 2~2 (포361)
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생명과학실험I
- 학수번호 35309분반 01
- 2학년 ( 2학점 , 3시간) 월 6~7 (종A205)
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생명과학실험I
- 학수번호 35309분반 02
- 2학년 ( 2학점 , 3시간) 화 6~7 (종A205)
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생명과학실험I
- 학수번호 35309분반 03
- 2학년 ( 2학점 , 3시간) 수 6~7 (종A205)
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생명과학실험I
- 학수번호 35309분반 04
- 2학년 ( 2학점 , 3시간) 목 6~7 (종A205)
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생명과학실험I
- 학수번호 35309분반 05
- 2학년 ( 2학점 , 3시간) 금 6~7 (종A205)
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학력
연세대학교(서울) 이학박사(생화학과)