이화정 교수는 대학원 약학과/약학대학 약학과 교수로 생물약제학과 약물동태학 분야 전문가이다. 미국 버팔로 뉴욕주립대학교 약학대학 약제학부에서 박사학위를 받았으며, 신약 및 개량신약의 약물동태학, 배출수송체 저해제 발굴 등의 연구를 수행하고 있다. 현재까지 SCI급 국제전문학술지에 약 90여편, 국내전문학술지에 약 20여편의 논문을 게재하였다.
COVID-19 drugs: potential interaction with ATP-binding cassette transporters P-glycoprotein and breast cancer resistance proteinJournal of Pharmaceutical Investigation, 2023, v.53 no.2, 191-212
Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancersJournal of Advanced Research, 2023, v.47, 173-187
Population pharmacokinetics and model-based dosing optimization of teicoplanin in elderly critically ill patients with pneumoniaJournal of Critical Care, 2023, v.78, 154402
Development and evaluation of a digestive formulation using a microbial enzyme for treatment of dyspepsiaJournal of Pharmaceutical Investigation, 2022, v.52 no.5, 601-609
Development and evaluation of a digestive formulation using a microbial enzyme for treatment of dyspepsiaJournal of Pharmaceutical Investigation, 2022, v.52 no.5, 601-609
Discovery of (E)-3-(3-((2-Cyano-4' -dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic SteatohepatitisJOURNAL OF MEDICINAL CHEMISTRY, 2022, v.65 no.14, 9974-10000
Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's diseaseEuropean Journal of Medicinal Chemistry, 2022, v.244, 114854
Drug-like small molecule HSP27 functional inhibitor sensitizes lung cancer cells to gefitinib or cisplatin by inducing altered cross-linked Hsp27 dimersPharmaceutics, 2021, v.13 no.5, 630
Optimization, validation, and comparison of a rapid method for the quantification of insulin-like growth factor 1 in serum using liquid chromatography–high-resolution mass spectrometryDrug Testing and Analysis, 2021, v.13 no.2, 451-459
Quantification of teicoplanin using the hplc-uv method for clinical applications in critically ill patients in KoreaPharmaceutics, 2021, v.13 no.4, 572
Design of a Novel Theranostic Nanomedicine (III): Synthesis and Physicochemical Properties of Tumor-Targeting Cisplatin Conjugated to a Hydrophilic PolyphosphazeneINTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, v.15, 981-990
Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitorsJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, v.35 no.1, 702-712
Menopausal hormone therapy and the risk of breast cancer by histological type and race: a meta-analysis of randomized controlled trials and cohort studiesBREAST CANCER RESEARCH AND TREATMENT, 2018, v.170 no.3, 667-675
Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomicsCHEMISTRY AND PHYSICS OF LIPIDS, 2018, v.214, 69-83
Design of theranostic nanomedicine (II): synthesis and physicochemical properties of a biocompatible polyphosphazene-docetaxel conjugateINTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, v.12
Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitorEuropean Journal of Medicinal Chemistry, 2017, v.127, 318-333
1H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in ratsJournal of Pharmaceutical and Biomedical Analysis, 2016, v.129, 492-501
Design of a novel theranostic nanomedicine: Synthesis and physicochemical properties of a biocompatible Polyphosphazene–platinum(II) conjugateInternational Journal of Nanomedicine, 2016, v.11, 837-851
Development of simultaneous analysis of tryptophan metabolites in serum and gastric juice - an investigation towards establishing a biomarker test for gastric cancer diagnosisBiomedical Chromatography, 2016, 12 July 2016
Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin IANTIOXIDANTS & REDOX SIGNALING, 2016, v.24 no.8, 453-469
Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damageFree Radical Biology and Medicine, 2016, v.91, 264-274
Development of lipidomic platform and phosphatidylcholine retention time index for lipid profiling of rosuvastatin treated human plasmaJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2014, v.944, 157-165
Discovery of N-((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197) : A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF-beta Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic AgentJOURNAL OF MEDICINAL CHEMISTRY, 2014, v.57 no.10, 4213-4238
Effect of coumarin derivative-mediated inhibition of P-glycoprotein on oral bioavailability and therapeutic efficacy of paclitaxelEUROPEAN JOURNAL OF PHARMACOLOGY, 2014, v.723, 381-388
Na+/H+ Exchanger Regulatory Factor 3 Is Critical for Multidrug Resistance Protein 4-Mediated Drug Efflux in the KidneyJOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, v.25 no.4, 726-736
Preclinical evaluation of efficacy and stability of docetaxel micelle-encapsulated by a tripodal cyclotriphosphazene amphiphileBIOMEDICINE & PHARMACOTHERAPY, 2014, v.68 no.5, 649-655
Aripiprazole-montmorillonite: A new organic-inorganic nanohybrid material for biomedical applicationsChemistry - A European Journal, 2013, v.19 no.15, 4869-4875
Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in ratsXenobiotica, 2013, v.43 no.3, 303-310
Identification of a New Hexenoic Acid Glycoside and the RSV Principles from Vitis vinifera cv. Muscat of AlexandriaBulletin of the Korean Chemical Society, 2013, v.34 no.6, 1906-1908
Synthesis and physicochemical properties of new tripodal amphiphiles bearing fatty acids as a hydrophobic groupBioorganic and Medicinal Chemistry Letters, 2013, v.23 no.6, 1763-1767
Effects of silymarin and formulation on the oral bioavailability of paclitaxel in ratsEuropean Journal of Pharmaceutical Sciences, 2012, v.45 no.3, 296-301
Nuclear magnetic resonance-based metabolomics for prediction of gastric damage induced by indomethacin in ratsAnalytica Chimica Acta, 2012, v.722, 87-94
Preclinical study of a potent P-glycoprotein and cytochrome P450 enzyme inducer rifampicin changing pharmacokinetic parameters of risperidone and its metabolite, 9-hydroxyrisperidone, using a rat modelJournal of Pharmaceutical Investigation, 2012, v.42 no.6, 345-351
Quantitative analysis of acetaminophen and its six metabolites in rat plasma using liquid chromatography/tandem mass spectrometryBiomedical Chromatography, 2012, v.26 no.12, 1596-1604
Stable and efficient delivery of docetaxel by micelle-encapsulation using a tripodal cyclotriphosphazene amphiphileInternational Journal of Pharmaceutics, 2012, v.422 no.41276, 374-380
[학술지논문] Population pharmacokinetics and model-based dosing optimization of teicoplanin in elderly critically ill patients with pneumonia
JOURNAL OF CRITICAL CARE, 2023, v.78
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[지적재산권] 알콕시페닐프로펜온 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 다약제 내성 억제용 약학적 조성물국내 : 특허, 등록, 10-1427291, 2014