Jihee Lee Professor

College of Medicine

이지희 프로필 사진
Dr. Lee, Jihee is a professor at Department of Physiology School of Medicine.  She is a leading authority in the field of lung injury diseases and resolution of inflammation. She graduated from Ewha Womans University College of Medicine (MD) and  then obtained PhD at West Virginia University School of Medicine, USA. She has made international cooperation research with National Jewish Health and National Institute Occupational and Safety Health, USA. She acted as a director of Tissue Injury Defense Research Center (TIDRC-MRC)  in 2010.   At present, she acts as a director of  Inflammation-Cancer Microenvironment Research (ICMRC) which was re-selected as a Leading Research Center-MRC by National Research Foundation of Korea (NRF) in 2020. She has received awards of  2008 and 2010 year Basic Research Best Products  from Ministry of Education and Science Technology (MEST) and NRF. As major research products, she has published as a corresponding author in the top journals in the filed of respiratory system, such as American J. of Respiratory and Critical Care Medicine, European Respiratory J. and many other journals, including Mucosal Immunol, Sci Signaling, Cell Death & Disease, J. of Immunology, Critical Care Medicine, etc.
  • Director, Inflammation-Cancer Microenvironment Research Center
  • Esther Building #408
  • 02-6986-6175
  • Office hours
    • 월,수,금 오후 4-6시
Research Record
  • Lethal effects of mitochondria via microfluidics Bioengineering and Translational Medicine, 2023, v.8 no.3, e10461
    SCIE Scopus dColl.
  • RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models Cells, 2023, v.12 no.3, 417
    SCIE Scopus dColl.
  • Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an α7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson’s Disease Mouse Models International Journal of Molecular Sciences, 2022, v.23 no.8, 4420
    SCIE Scopus dColl.
  • Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation Molecules and Cells, 2022, v.45 no.12, 950-962
    SCIE Scopus KCI dColl.
  • Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute Inflammation in Mice Biomolecules, 2022, v.12 no.3, 447
    SCIE Scopus dColl.
  • Procollagen C-Endopeptidase Enhancer 2 Secreted by Tonsil-Derived Mesenchymal Stem Cells Increases the Oxidative Burst of Promyelocytic HL-60 Cells BIOLOGY-BASEL, 2022, v.11 no.2, 255
    SCIE Scopus dColl.
  • Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling Cellular and Molecular Immunology, 2022, v.19 no.12, 1373-1391
    SCIE Scopus dColl.
  • Shrimp miR-965 transfers tumoricidal mitochondria Biological Procedures Online, 2022, v.24 no.1, 16
    SCIE Scopus dColl.
  • Aging effects on the diurnal patterns of gut microbial composition in male and female mice KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021, v.25 no.6, 575-583
    SCIE Scopus KCI dColl.
  • Apoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activation Cell Death and Disease, 2021 , 19
    SCIE Scopus dColl.
  • Cancer-associated fibroblasts activated by miR-196a promote the migration and invasion of lung cancer cells Cancer Letters, 2021, v.508, 92-103
    SCIE Scopus dColl.
  • Gas6 Ameliorates Inflammatory Response and Apoptosis in Bleomycin-Induced Acute Lung Injury BIOMEDICINES, 2021, v.9 no.11, 1674
    SCIE Scopus dColl.
  • STAT6 Signaling Mediates PPAR gamma Activation and Resolution of Acute Sterile Inflammation in Mice CELLS, 2021, v.10 no.3, 501
    SCIE Scopus dColl.
  • Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice NEUROBIOLOGY OF AGING, 2020, v.96, 33-42
    SCIE Scopus dColl.
  • Motion microscopy for label-free detection of circulating breast tumor cells Biosensors and Bioelectronics, 2020, v.158, 112131
    SCIE Scopus dColl.
  • Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease Biomedicine and Pharmacotherapy, 2020, v.130, 110576
    SCIE Scopus dColl.
  • Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE(2), PGD(2) and Their Receptors CELLS, 2019, v.8 no.7, 643
    SCIE Scopus dColl.
  • Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis Cellular and Molecular Immunology, 2019, v.16 no.11, 851-867
    SCIE Scopus dColl.
  • RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial-Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells BIOMOLECULES, 2019, v.9 no.10, 565
    SCIE Scopus dColl.
  • The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models JOURNAL OF NEUROINFLAMMATION, 2019, v.16 no.1, 246
    SCIE Scopus dColl.
  • A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARy CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, v.45 no.5, 1863-1877
    SCIE Scopus dColl.
  • Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-B, Nrf2, and PPAR- signaling pathways JOURNAL OF NEUROINFLAMMATION, 2018, v.15, 326
    SCIE Scopus dColl.
  • Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR- expression and activation in macrophages JOURNAL OF LEUKOCYTE BIOLOGY, 2018, v.103 no.5, 885-895
    SCIE Scopus dColl.
  • Association between genetic variations of MERTK and chronic obstructive pulmonary disease in Koreans Journal of Korean Medical Science, 2018, v.33 no.7, e56
    SCIE Scopus KCI dColl.
  • Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain NEUROPHARMACOLOGY, 2018, v.133, 202-215
    SCIE Scopus dColl.
  • MCP-1 and MIP-3 alpha Secreted from Necrotic Cell-Treated Glioblastoma Cells Promote Migration/Infiltration of Microglia CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, v.48 no.3, 1332-1346
    SCIE Scopus dColl.
  • Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation PHARMACOLOGICAL RESEARCH, 2017, v.119, 431-442
    SCIE Scopus dColl.
  • Exogenous Hydrogen Peroxide Induces Lipid Raft-Mediated STAT-6 Activation in T Cells CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, v.42 no.6, 2467-2480
    SCIE Scopus dColl.
  • Extracellular matrix-derived extracellular vesicles promote cardiomyocyte growth and electrical activity in engineered cardiac atria BIOMATERIALS, 2017, v.146, 49-59
    SCIE Scopus dColl.
  • Interaction of macrophages with apoptotic cells inhibits transdifferentiation and invasion of lung fibroblasts Oncotarget, 2017, v.8 no.68, 112297-112312
    SCIE Scopus dColl.
  • Simvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis CELL DEATH & DISEASE, 2017, v.8
    SCIE Scopus dColl.
  • Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages SCIENTIFIC REPORTS, 2016, v.6
    SCIE Scopus dColl.
  • Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE(2), PGD(2), and HGF EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, v.46, 434-434
    SCIE Scopus dColl.
  • Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • Mer signaling leads to transactivation of anti-inflammatory target gene arginase 2 of liver X receptor via STAT1 transcription factor in macrophages EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, v.46, 435-435
    SCIE Scopus dColl.
  • Necrotic cells influence migration and invasion of glioblastoma via NF-γ° B/AP-1-mediated IL-8 regulation Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice NEUROBIOLOGY OF AGING, 2016, v.44, 74-84
    SCIE Scopus dColl.
  • Sulforaphane exerts its anti-inflammatory effect against amyloid-b peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages NEUROBIOLOGY OF AGING, 2016, v.38, 1-10
    SCIE Scopus dColl.
  • Anti-inflammatory Mechanism of Ginseng Saponin Metabolite Rh3 in Lipopolysaccharide-Stimulated Microglia: Critical Role of 5′-Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway Journal of Agricultural and Food Chemistry, 2015, v.63 no.13, 3472-3480
    SCIE Scopus dColl.
  • Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1) PLOS ONE, 2015, v.10 no.6
    SCIE Scopus dColl.
  • Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells SCIENTIFIC REPORTS, 2015, v.5
    SCIE Scopus dColl.
  • Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation SCIENCE SIGNALING, 2015, v.8 no.365
    SCIE dColl.
  • PPAR gamma activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines MUCOSAL IMMUNOLOGY, 2015, v.8 no.5, 1031-1046
    SCIE Scopus dColl.
  • Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2 BMB Reports, 2015, v.48 no.3, 184-189
    SCIE KCI Scopus dColl.
  • Comparison of experimental mouse models of inflammatory bowel disease INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, v.33 no.2, 333-340
    SCIE Scopus dColl.
  • Interaction of Apoptotic Cells with Macrophages Upregulates COX-2/PGE(2) and HGF Expression via a Positive Feedback Loop MEDIATORS OF INFLAMMATION, 2014 , Article ID 463524
    SCIE Scopus dColl.
  • Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-alpha Activation JOURNAL OF IMMUNOLOGY, 2014, v.193 no.5, 2384-2393
    SCIE Scopus dColl.
  • Noggin improves ischemic brain tissue repair and promotes alternative activation of microglia in mice Brain, Behavior, and Immunity, 2014, v.40
    SCIE Scopus dColl.
  • RhoA/Phosphatidylinositol 3-Kinase/Protein Kinase B/Mitogen-Activated Protein Kinase Signaling after Growth Arrest-Specific Protein 6/Mer Receptor Tyrosine Kinase Engagement Promotes Epithelial Cell Growth and Wound Repair via Upregulation of Hepatocyte Growth Factor in Macrophages JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, v.350, 563-577
    SCIE Scopus dColl.
  • [학술지논문] Lethal effects of mitochondria via microfluidics BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023, v.8 no.3 , 461-474
    SCIE
  • [학술지논문] RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson's Disease Mouse Models CELLS, 2023, v.12 no.3 , 1-20
    SCIE
  • [학술지논문] Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an alpha 7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson's Disease Mouse Models INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, v.23 no.8 , 4420-4420
    SCIE
  • [학술지논문] Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation MOLECULES AND CELLS, 2022, v.45 no.12 , 950-962
    SCI
  • [학술지논문] Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPAR gamma in Macrophages to Resolve Acute Inflammation in Mice BIOMOLECULES, 2022, v.12 no.3 , 447-447
    SCIE
  • [학술지논문] Procollagen C-Endopeptidase Enhancer 2 Secreted by Tonsil-Derived Mesenchymal Stem Cells Increases the Oxidative Burst of Promyelocytic HL-60 Cells Biology-Basel, 2022, v.11 no.2 , 255-255
    SCIE
  • [학술지논문] Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling CELLULAR & MOLECULAR IMMUNOLOGY, 2022, v.19 no.12 , 1373-1391
    SCIE
  • [학술지논문] Shrimp miR-965 transfers tumoricidal mitochondria BIOLOGICAL PROCEDURES ONLINE, 2022, v.24 no.1 , 16-16
    SCIE
  • [학술지논문] Aging effects on the diurnal patterns of gut microbial composition in male and female mice KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021, v.25 no.6 , 575-583
    SCIE
  • [학술지논문] Apoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activation CELL DEATH & DISEASE, 2021, v.12 no.1 , 19-19
    SCIE
  • [학술지논문] Cancer-associated fibroblasts activated by miR-196a promote the migration and invasion of lung cancer cells CANCER LETTERS, 2021, v.508 no.2021 , 92-103
    SCI
  • [학술지논문] Gas6 Ameliorates Inflammatory Response and Apoptosis in Bleomycin-Induced Acute Lung Injury Biomedicines, 2021, v.9 no.11 , 1674-1674
    SCIE
  • [학술지논문] STAT6 Signaling Mediates PPAR gamma Activation and Resolution of Acute Sterile Inflammation in Mice CELLS, 2021, v.10 no.3 , 501-501
    SCIE
  • [학술지논문] Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE(2), PGD(2) and Their Receptors CELLS, 2019, v.8 no.7 , 643-643
    SCIE
  • [학술지논문] Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis CELLULAR & MOLECULAR IMMUNOLOGY, 2019, v.16 no.11 , 851-867
    SCIE
  • [학술지논문] RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial-Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells BIOMOLECULES, 2019, v.9 no.10 , 565-565
    SCIE
  • [학술발표] Apoptotic cancer cells stimulate WISP-1 secretion from cancer-associated fibroblasts (CAFs) to inhibit migration and invasion of lung cancer cells and CAFs 대한생리학회 학술대회, 대한민국, 서울, 2022-10-28 Korean Journal of Physiology and Pharmacology, 2022
  • [학술발표] Enhancement of the Notch ligand Dll1 expression in UV-irradiated apoptotic cancer cells activates Notch1 signaling in cancer-associated fibroblasts (CAFs) 대한생리학회 학술대회, 대한민국, 서울, 2022-10-28 Korean Journal of Physiology and Pharmacology, 2022
  • [학술발표] In vivo administration of Gas6 inhibits epithelial-mesenchymal transition and enhances PGE2 and PGD2 in alveolar type II epithelial cells following bleomycin treatment 대한생리학회 학술대회, 대한민국, 서울, 2022-10-27 Korean Journal of Physiology and Pharmacology, 2022
  • [학술발표] In vivo injection of apoptotic cancer cells inhibits CAF activation and lung metastasis via Notch1-WISP-1 signaling 대한생리학회 학술대회, 대한민국, 서울, 2022-10-27 Korean Journal of Physiology and Pharmacology, 2022
Courses
  • 2024-1st

    • Introduction to Medicine

      • Subject No 37588Class No 01
      • 1Year ( 2.5Credit , 48Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅠ

      • Subject No 37592Class No 01
      • 1Year ( 3Credit , 57Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅡ

      • Subject No 37593Class No 01
      • 1Year ( 2Credit , 44Hour)
      • Major Requisite
    • Metabolism and Nutrition

      • Subject No 37594Class No 01
      • 1Year ( 2.5Credit , 52Hour)
      • Major Requisite
    • Current Topics in Pathophysiology 강의 계획서 상세보기

      • Subject No G15713Class No 01
      • Year ( 3Credit , 3Hour) Mon 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기

      • Subject No G18114Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기

      • Subject No G18116Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기

      • Subject No G18121Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기

      • Subject No G18123Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
  • 2023-2nd

  • 2023-1st

    • Introduction to Medicine

      • Subject No 37588Class No 01
      • 1Year ( 2.5Credit , 48Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅠ

      • Subject No 37592Class No 01
      • 1Year ( 3Credit , 57Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅡ

      • Subject No 37593Class No 01
      • 1Year ( 2Credit , 44Hour)
      • Major Requisite
    • Metabolism and Nutrition

      • Subject No 37594Class No 01
      • 1Year ( 2.5Credit , 52Hour)
      • Major Requisite
    • Pulmonary cell Biology 강의 계획서 상세보기

      • Subject No G15714Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기

      • Subject No G18116Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기

      • Subject No G18121Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기

      • Subject No G18123Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
  • 2022-2nd

  • 2022-1st

    • Introduction to Medicine

      • Subject No 37588Class No 01
      • 1Year ( 2.5Credit , 48Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅠ

      • Subject No 37592Class No 01
      • 1Year ( 3Credit , 57Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅡ

      • Subject No 37593Class No 01
      • 1Year ( 2Credit , 44Hour)
      • Major Requisite
    • Metabolism and Nutrition

      • Subject No 37594Class No 01
      • 1Year ( 2.5Credit , 52Hour)
      • Major Requisite
    • Current Topics in Pathophysiology 강의 계획서 상세보기

      • Subject No G15713Class No 01
      • Year ( 3Credit , 3Hour) Mon 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기

      • Subject No G18121Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기

      • Subject No G18123Class No 01
      • Year ( 3Credit , 3Hour) Wed 7~8
  • 2021-2nd

  • 2021-1st

    • Introduction to Medicine

      • Subject No 37588Class No 01
      • 1Year ( 2.5Credit , 48Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅠ

      • Subject No 37592Class No 01
      • 1Year ( 3Credit , 57Hour)
      • Major Requisite
    • Human Histology and PhysiologyⅡ

      • Subject No 37593Class No 01
      • 1Year ( 2Credit , 45Hour)
      • Major Requisite
    • Metabolism and Nutrition

      • Subject No 37594Class No 01
      • 1Year ( 2.5Credit , 52Hour)
      • Major Requisite
    • Pulmonary cell Biology 강의 계획서 상세보기

      • Subject No G15714Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8
    • Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기

      • Subject No G18114Class No 01
      • Year ( 3Credit , 3Hour) Wed 5~6
    • Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기

      • Subject No G18121Class No 01
      • Year ( 3Credit , 3Hour) Wed 5~6
Academic Background

West Virginia University Ph.D.(생리학)

Ewha Womans University 의학사(의학)