EWHA WOMANS UNIVERSITY | Undergraduate/Graduate | Undergraduate | College of Pharmacy

Dong Hae Shin Professor

Pharmaceutical Sciences/Industrial Pharmaceutical Science/Division of Pharmacy

Prof. Dong Hae Shin, a professor at the College of Pharmacy, is an expert in the field of structural genomics. He had received a Ph. D at Seoul National University and became a staff scientist at the Berkeley Lawrence National Laboratory. He was involved in the Protein Structure Initiative I Project and proved the superiority of Protein X-ray crystallography for identification of molecular functions of hypothetical proteins compared with traditional methods. Until now, he has published approximately 60 scientific papers. His group focuses on the development of druggable compounds applicable to Parkinson's disease, allergy and melioidosis using the combined approach of X-ray crystallography, modeling and in-silico screening.

Science Building C #408
02-3277-4502

Research Record

A tryptophan-based assay method to search regulatory compounds for transcriptionally controlled tumor protein Biochemical and Biophysical Research Communications, 2024, v.692, 149363
SCIE Scopus dColl.
Meclizine, a piperazine-derivative antihistamine, binds to dimerized translationally controlled tumor protein and attenuates allergic reactions in a mouse model Biomedicine and Pharmacotherapy, 2023, v.157, 114072
SCIE Scopus dColl.
A Study of Drug Repurposing to Identify SARS-CoV-2 Main Protease (3CLpro) Inhibitors International Journal of Molecular Sciences, 2022, v.23 no.12, 6468
SCIE Scopus dColl.
Dimerization Tendency of 3CLpros of Human Coronaviruses Based on the X-ray Crystal Structure of the Catalytic Domain of SARS-CoV-2 3CLpro International Journal of Molecular Sciences, 2022, v.23 no.9, 5268
SCIE Scopus dColl.
A study of 3clpros as promising targets against sars-cov and sars-cov-2 Microorganisms, 2021, v.9 no.4, 756
SCIE Scopus dColl.
A study of inhibitors of d-glycero-beta-d-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei as a potential antibiotic target JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, v.36 no.1, 776-784
SCIE Scopus dColl.
A triple-targeting inhibitory activity of Rose Bengal on polysaccharide biosynthesis of Burkholderia pseudomallei Archiv der Pharmazie, 2021, v.354 no.6, 2000360
SCIE Scopus dColl.
Crystal structure of pharmaceutical-grade human serum albumin INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021 , 221-228
SCIE Scopus dColl.
Inhibition of D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase from Burkholderia pseudomallei by epigallocatechin gallate and myricetin Biochemical Journal, 2021, v.478 no.1, 235-245
SCIE Scopus dColl.
Stepwise oxidations play key roles in the structural and functional regulations of DJ-1 BIOCHEMICAL JOURNAL, 2021, v.478 no.19, 3505-3525
SCIE Scopus dColl.
A Study of a Potent Inhibitor against a GDP-6-Deoxy-α-d-Manno-Heptose Biosynthesis Pathway as Antibiotic Candidates Microbial Drug Resistance, 2020, v.26 no.4, 385-390
SCIE Scopus dColl.
A study of Rose Bengal against a 2-keto-3-deoxy-d-manno-octulosonate cytidylyltransferase as an antibiotic candidate Journal of enzyme inhibition and medicinal chemistry, 2020, v.35 no.1, 1414-1421
Scopus dColl.
Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, v.35 no.1, 1539-1544
SCIE Scopus dColl.
Flexible loop and helix 2 domains of TCTP are the functional domains of dimerized TCTP Scientific Reports, 2020, v.10 no.1, 197
SCIE Scopus dColl.
GTP Preference of D-Glycero-alpha-D-manno-Heptose-1-Phosphate Guanylyltransferase from Yersinia pseudotuberculosis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, v.21 no.1, 280
SCIE Scopus dColl.
Inhibition of African swine fever virus protease by myricetin and myricitrin JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, v.35 no.1, 1045-1049
SCIE Scopus dColl.
Inhibition of SARS-CoV 3CL protease by flavonoids Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, v.35 no.1, 145-151
SCIE Scopus dColl.
Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors Chemical Biology and Drug Design, 2019, v.94 no.6, 2023-2030
SCIE Scopus dColl.
Tyrosine 51 residue of the syndecan-2 extracellular domain is involved in the interaction with and activation of pro-matrix metalloproteinase-7 Scientific Reports, 2019, v.9 no.1, 10625
SCIE Scopus dColl.
An artificially constructed dimer through deformation of a short zinc-binding loop BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2018, v.1866 no.2, 205-213
SCIE Scopus dColl.
Crystal structure of D-glycero-B-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2018, v.86 no.1, 124-131
SCIE Scopus dColl.
Crystal structure of D-glycero-α-D-manno-heptose-1-phosphate guanylyltransferase from Yersinia pseudotuberculosis Biochimica et Biophysica Acta - Proteins and Proteomics, 2018, v.1866 no.3, 482-487
SCIE Scopus dColl.
Small molecule activator of Nm23/NDPK as an inhibitor of metastasis SCIENTIFIC REPORTS, 2018, v.8, 10909
SCIE Scopus dColl.
Calcium Ion Induced Structural Changes Promote Dimerization of Secretagogin, Which is Required for Its Insulin Secretory Function Scientific Reports, 2017, v.7 no.1
SCIE Scopus dColl.
Dimerized translationally controlled tumor protein-binding peptide ameliorates atopic dermatitis in NC/NGA mice International Journal of Molecular Sciences, 2017, v.18 no.2
Scopus dColl.
Expression and crystallographic studies of D-glycero-b-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei Acta Crystallographica Section:F Structural Biology Communications, 2017, v.73 no.2, 90-94
SCIE Scopus dColl.
General assay for enzymes in the heptose biosynthesis pathways using electrospray ionization mass spectrometry APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2017, v.101 no.11, 4521-4532
SCIE Scopus dColl.
The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin Scientific Reports, 2017, v.7 no.1
SCIE Scopus dColl.
Crystal Structure of Hypothetical Fructose-Specific EIIB from Escherichia coli MOLECULES AND CELLS, 2016, v.39 no.6, 495-500
SCIE Scopus KCI dColl.
Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination SCIENTIFIC REPORTS, 2016, v.6
SCIE Scopus dColl.
A preliminary X-ray study of 3-deoxy-D-manno-oct-2-ulosonic acid 8-phosphate phosphatase (YrbI) from Burkholderia pseudomallei ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2015, v.71, 790-793
SCIE Scopus dColl.
A search for anti-melioidosis drug candidates targeted to D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase from Burkholderia pseudomallei PROTEIN SCIENCE, 2015, v.24, 297-297
SCIE Scopus dColl.
A search for anti-melioidosis drug candidates targeted to sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei PROTEIN SCIENCE, 2015, v.24, 295-295
SCIE Scopus dColl.
Crystal structure of dimeric D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase from Burkholderia thailandensis PROTEIN SCIENCE, 2015, v.24, 297-298
SCIE Scopus dColl.
Refined crystal structure of predicted fructose-specific enzyme IIB(fruc) from E. coli PROTEIN SCIENCE, 2015, v.24, 298-298
SCIE Scopus dColl.
A Preliminary X-ray Study of Murine Tnfaip8/Oxi-alpha INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, v.15 no.3, 4523-4530
SCIE Scopus dColl.
Interaction of translationally controlled tumor protein with Apaf-1 is involved in the development of chemoresistance in HeLa cells BMC CANCER, 2014, v.14, Article ID 165
SCIE Scopus dColl.

2024-1st
- Introduction to Pharmaceutical Research
  - Subject No 38940Class No 01
  - 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
  - Major Requisite
- Advanced Pharmaceutical Analysis
  - Subject No G16831Class No 01
  - Year ( 3Credit , 3Hour) Tue 6~7 (PHM-A204)
2023-2nd
- Pharmaceutical Synthesis Ⅰ 강의 계획서 상세보기
  - Subject No 36198Class No 01
  - 3Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A100-1) , Fri 5~5 (PHM-A100-1)
  - Major Requisite
- Pharmaceutical Synthesis Ⅰ 강의 계획서 상세보기
  - Subject No 36198Class No 02
  - 3Year ( 3Credit , 3Hour) Wed 4~4 (PHM-A100-1) , Fri 4~4 (PHM-A100-1)
  - Major Requisite
- Advanced Pharmacy Practice and Research I 강의 계획서 상세보기
  - Subject No 37154Class No 02
  - 6Year ( 4Credit , 200Hour)
  - Major Requisite
- Advanced Pharmacy Practice and Research Ⅱ 강의 계획서 상세보기
  - Subject No 37155Class No 02
  - 6Year ( 4Credit , 200Hour)
  - Major Requisite
- Advanced Pharmacy Practice and Research Ⅲ 강의 계획서 상세보기
  - Subject No 37156Class No 02
  - 6Year ( 4Credit , 200Hour)
  - Major Requisite
- Inorganic and radiopharmaceuticals 강의 계획서 상세보기
  - Subject No 38939Class No 01
  - 2Year ( 3Credit , 3Hour) Mon 4~4 (PHM-A104) , Wed 2~2 (PHM-A104)
  - Major Requisite
- Inorganic and radiopharmaceuticals 강의 계획서 상세보기
  - Subject No 38939Class No 02
  - 2Year ( 3Credit , 3Hour) Mon 3~3 (PHM-A104) , Thu 5~5 (PHM-A104)
  - Major Requisite
- Inorganic and radiopharmaceuticals 강의 계획서 상세보기
  - Subject No 39044Class No 01
  - 2Year ( 3Credit , 3Hour) Mon 3~3 (PHM-A104) , Thu 5~5 (PHM-A104)
  - Major Requisite
- Understanding and application of Bioinformatics and Chemoinformatics
  - Subject No G18091Class No 01
  - Year ( 3Credit , 3Hour) Fri 7~8 (PHM-)
2023-1st
- Bioethical issues in health care and emerging technologies
  - Subject No 37801Class No 01
  - 4Year ( 1.5Credit , 1.5Hour) Wed 4~4 (POSCO552)
- Introduction to Pharmaceutical Research 강의 계획서 상세보기
  - Subject No 39045Class No 01
  - 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-)
- Advanced Pharmaceutical Analysis
  - Subject No G16831Class No 01
  - Year ( 3Credit , 3Hour) Wed 6~7 (PHM-)
2022-2nd
- Pharmaceutical Synthesis Ⅰ
  - Subject No 36198Class No 01
  - 3Year ( 3Credit , 3Hour) Tue 3~3 (POSCO551) , Thu 4~4 (POSCO552)
  - Major Requisite
- Pharmaceutical Synthesis Ⅰ
  - Subject No 36198Class No 02
  - 3Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A100-1) , Fri 3~3 (PHM-A100-1)
  - Major Requisite
- Pharmaceutical Synthesis Ⅰ
  - Subject No 36198Class No 03
  - 3Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A100-1) , Fri 4~4 (PHM-A100-1)
  - Major Requisite
- Advanced Pharmacy Practice and Research I
  - Subject No 37154Class No 02
  - 6Year ( 4Credit , 200Hour)
  - Major Requisite
- Understanding and application of Bioinformatics and Chemoinformatics
  - Subject No G18091Class No 01
  - Year ( 3Credit , 3Hour) Mon 2~3 (PHM-)
2022-1st
- Bioethical issues in health care and emerging technologies
  - Subject No 37801Class No 01
  - 4Year ( 1.5Credit , 1.5Hour) Thu 5~5
- Advanced Pharmaceutical Analysis
  - Subject No G16831Class No 01
  - Year ( 3Credit , 3Hour) Mon 5~6 (PHM-)
2021-2nd
- Pharmaceutical Synthesis Ⅰ
  - Subject No 36198Class No 01
  - 3Year ( 3Credit , 3Hour) Tue 5~5 , Thu 4~4
  - Major Requisite
- Pharmaceutical Synthesis Ⅰ
  - Subject No 36198Class No 02
  - 3Year ( 3Credit , 3Hour) Tue 3~3 , Fri 3~3
  - Major Requisite
- Pharmaceutical Synthesis Ⅰ
  - Subject No 36198Class No 03
  - 3Year ( 3Credit , 3Hour) Wed 5~5 , Fri 4~4
  - Major Requisite
- Pharmaceutical Synthesis Ⅰ
  - Subject No 36198Class No 04
  - 3Year ( 3Credit , 3Hour) Wed 5~5 , Fri 4~4
  - Major Requisite
- Advanced Pharmacy Practice and Research I
  - Subject No 37154Class No 02
  - 6Year ( 4Credit
  - Major Requisite
- Honors research
  - Subject No 37803Class No 01
  - 4Year ( 1Credit , 1Hour)
- Seminar for Pharmaceutical Sciences II
  - Subject No G16888Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A400)
2021-1st
- Bioethical issues in health care and emerging technologies
  - Subject No 37801Class No 01
  - 4Year ( 1.5Credit , 1.5Hour) Tue 4~4
- Honors research
  - Subject No 37803Class No 01
  - 4Year ( 1Credit , 1Hour)
- Advanced Pharmaceutical Analysis
  - Subject No G16831Class No 01
  - Year ( 3Credit , 3Hour) Thu 2~3
- Seminar for Pharmaceutical Sciences I
  - Subject No G16848Class No 01
  - Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A400)

Academic Background

Seoul Nat'l Univ. 이학박사(화학)

List

College of Pharmacy

Dong Hae Shin Professor

Research Record

Courses

Academic Background