Jihee Lee Professor
College of Medicine
Dr. Lee, Jihee is a professor at Department of Physiology School of Medicine. She is a leading authority in the field of lung injury diseases and resolution of inflammation. She graduated from Ewha Womans University College of Medicine (MD) and then obtained PhD at West Virginia University School of Medicine, USA. She has made international cooperation research with National Jewish Health and National Institute Occupational and Safety Health, USA. She acted as a director of Tissue Injury Defense Research Center (TIDRC-MRC) in 2010. At present, she acts as a director of Inflammation-Cancer Microenvironment Research (ICMRC) which was re-selected as a Leading Research Center-MRC by National Research Foundation of Korea (NRF) in 2020. She has received awards of 2008 and 2010 year Basic Research Best Products from Ministry of Education and Science Technology (MEST) and NRF. As major research products, she has published as a corresponding author in the top journals in the filed of respiratory system, such as American J. of Respiratory and Critical Care Medicine, European Respiratory J. and many other journals, including Mucosal Immunol, Sci Signaling, Cell Death & Disease, J. of Immunology, Critical Care Medicine, etc.
- Director, Inflammation-Cancer Microenvironment Research Center
- Esther Building #408
- 02-6986-6175
- Office hours
- 월,수,금 오후 4-6시
Research Record
- Lethal effects of mitochondria via microfluidics Bioengineering and Translational Medicine, 2023, v.8 no.3, e10461
- RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models Cells, 2023, v.12 no.3, 417
- Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an α7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson’s Disease Mouse Models International Journal of Molecular Sciences, 2022, v.23 no.8, 4420
- Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation Molecules and Cells, 2022, v.45 no.12, 950-962
- Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute Inflammation in Mice Biomolecules, 2022, v.12 no.3, 447
- Procollagen C-Endopeptidase Enhancer 2 Secreted by Tonsil-Derived Mesenchymal Stem Cells Increases the Oxidative Burst of Promyelocytic HL-60 Cells BIOLOGY-BASEL, 2022, v.11 no.2, 255
- Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling Cellular and Molecular Immunology, 2022, v.19 no.12, 1373-1391
- Shrimp miR-965 transfers tumoricidal mitochondria Biological Procedures Online, 2022, v.24 no.1, 16
- Aging effects on the diurnal patterns of gut microbial composition in male and female mice KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021, v.25 no.6, 575-583
- Apoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activation Cell Death and Disease, 2021 , 19
- Cancer-associated fibroblasts activated by miR-196a promote the migration and invasion of lung cancer cells Cancer Letters, 2021, v.508, 92-103
- Gas6 Ameliorates Inflammatory Response and Apoptosis in Bleomycin-Induced Acute Lung Injury BIOMEDICINES, 2021, v.9 no.11, 1674
- STAT6 Signaling Mediates PPAR gamma Activation and Resolution of Acute Sterile Inflammation in Mice CELLS, 2021, v.10 no.3, 501
- Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice NEUROBIOLOGY OF AGING, 2020, v.96, 33-42
- Motion microscopy for label-free detection of circulating breast tumor cells Biosensors and Bioelectronics, 2020, v.158, 112131
- Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease Biomedicine and Pharmacotherapy, 2020, v.130, 110576
- Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE(2), PGD(2) and Their Receptors CELLS, 2019, v.8 no.7, 643
- Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis Cellular and Molecular Immunology, 2019, v.16 no.11, 851-867
- RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial-Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells BIOMOLECULES, 2019, v.9 no.10, 565
- The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models JOURNAL OF NEUROINFLAMMATION, 2019, v.16 no.1, 246
- A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARy CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, v.45 no.5, 1863-1877
- Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-B, Nrf2, and PPAR- signaling pathways JOURNAL OF NEUROINFLAMMATION, 2018, v.15, 326
- Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR- expression and activation in macrophages JOURNAL OF LEUKOCYTE BIOLOGY, 2018, v.103 no.5, 885-895
- Association between genetic variations of MERTK and chronic obstructive pulmonary disease in Koreans Journal of Korean Medical Science, 2018, v.33 no.7, e56
- Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain NEUROPHARMACOLOGY, 2018, v.133, 202-215
- MCP-1 and MIP-3 alpha Secreted from Necrotic Cell-Treated Glioblastoma Cells Promote Migration/Infiltration of Microglia CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, v.48 no.3, 1332-1346
- Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation PHARMACOLOGICAL RESEARCH, 2017, v.119, 431-442
- Exogenous Hydrogen Peroxide Induces Lipid Raft-Mediated STAT-6 Activation in T Cells CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, v.42 no.6, 2467-2480
- Extracellular matrix-derived extracellular vesicles promote cardiomyocyte growth and electrical activity in engineered cardiac atria BIOMATERIALS, 2017, v.146, 49-59
- Interaction of macrophages with apoptotic cells inhibits transdifferentiation and invasion of lung fibroblasts Oncotarget, 2017, v.8 no.68, 112297-112312
- Simvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis CELL DEATH & DISEASE, 2017, v.8
- Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages SCIENTIFIC REPORTS, 2016, v.6
- Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE(2), PGD(2), and HGF EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, v.46, 434-434
- Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF Scientific Reports, 2016, v.6
- Mer signaling leads to transactivation of anti-inflammatory target gene arginase 2 of liver X receptor via STAT1 transcription factor in macrophages EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, v.46, 435-435
- Necrotic cells influence migration and invasion of glioblastoma via NF-γ° B/AP-1-mediated IL-8 regulation Scientific Reports, 2016, v.6
- Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice NEUROBIOLOGY OF AGING, 2016, v.44, 74-84
- Sulforaphane exerts its anti-inflammatory effect against amyloid-b peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages NEUROBIOLOGY OF AGING, 2016, v.38, 1-10
- Anti-inflammatory Mechanism of Ginseng Saponin Metabolite Rh3 in Lipopolysaccharide-Stimulated Microglia: Critical Role of 5′-Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway Journal of Agricultural and Food Chemistry, 2015, v.63 no.13, 3472-3480
- Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1) PLOS ONE, 2015, v.10 no.6
- Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells SCIENTIFIC REPORTS, 2015, v.5
- Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation SCIENCE SIGNALING, 2015, v.8 no.365
- PPAR gamma activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines MUCOSAL IMMUNOLOGY, 2015, v.8 no.5, 1031-1046
- Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2 BMB Reports, 2015, v.48 no.3, 184-189
- Comparison of experimental mouse models of inflammatory bowel disease INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, v.33 no.2, 333-340
- Interaction of Apoptotic Cells with Macrophages Upregulates COX-2/PGE(2) and HGF Expression via a Positive Feedback Loop MEDIATORS OF INFLAMMATION, 2014 , Article ID 463524
- Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-alpha Activation JOURNAL OF IMMUNOLOGY, 2014, v.193 no.5, 2384-2393
- Noggin improves ischemic brain tissue repair and promotes alternative activation of microglia in mice Brain, Behavior, and Immunity, 2014, v.40
- RhoA/Phosphatidylinositol 3-Kinase/Protein Kinase B/Mitogen-Activated Protein Kinase Signaling after Growth Arrest-Specific Protein 6/Mer Receptor Tyrosine Kinase Engagement Promotes Epithelial Cell Growth and Wound Repair via Upregulation of Hepatocyte Growth Factor in Macrophages JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, v.350, 563-577
- [학술지논문] Lethal effects of mitochondria via microfluidics BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023, v.8 no.3 , 461-474
- [학술지논문] RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson's Disease Mouse Models CELLS, 2023, v.12 no.3 , 1-20
- [학술지논문] Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an alpha 7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson's Disease Mouse Models INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, v.23 no.8 , 4420-4420
- [학술지논문] Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation MOLECULES AND CELLS, 2022, v.45 no.12 , 950-962
- [학술지논문] Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPAR gamma in Macrophages to Resolve Acute Inflammation in Mice BIOMOLECULES, 2022, v.12 no.3 , 447-447
- [학술지논문] Procollagen C-Endopeptidase Enhancer 2 Secreted by Tonsil-Derived Mesenchymal Stem Cells Increases the Oxidative Burst of Promyelocytic HL-60 Cells Biology-Basel, 2022, v.11 no.2 , 255-255
- [학술지논문] Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling CELLULAR & MOLECULAR IMMUNOLOGY, 2022, v.19 no.12 , 1373-1391
- [학술지논문] Shrimp miR-965 transfers tumoricidal mitochondria BIOLOGICAL PROCEDURES ONLINE, 2022, v.24 no.1 , 16-16
- [학술지논문] Aging effects on the diurnal patterns of gut microbial composition in male and female mice KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021, v.25 no.6 , 575-583
- [학술지논문] Apoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activation CELL DEATH & DISEASE, 2021, v.12 no.1 , 19-19
- [학술지논문] Cancer-associated fibroblasts activated by miR-196a promote the migration and invasion of lung cancer cells CANCER LETTERS, 2021, v.508 no.2021 , 92-103
- [학술지논문] Gas6 Ameliorates Inflammatory Response and Apoptosis in Bleomycin-Induced Acute Lung Injury Biomedicines, 2021, v.9 no.11 , 1674-1674
- [학술지논문] STAT6 Signaling Mediates PPAR gamma Activation and Resolution of Acute Sterile Inflammation in Mice CELLS, 2021, v.10 no.3 , 501-501
- [학술지논문] Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE(2), PGD(2) and Their Receptors CELLS, 2019, v.8 no.7 , 643-643
- [학술지논문] Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis CELLULAR & MOLECULAR IMMUNOLOGY, 2019, v.16 no.11 , 851-867
- [학술지논문] RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial-Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells BIOMOLECULES, 2019, v.9 no.10 , 565-565
- [학술발표] Apoptotic cancer cells stimulate WISP-1 secretion from cancer-associated fibroblasts (CAFs) to inhibit migration and invasion of lung cancer cells and CAFs 대한생리학회 학술대회, 대한민국, 서울, 2022-10-28 Korean Journal of Physiology and Pharmacology, 2022
- [학술발표] Enhancement of the Notch ligand Dll1 expression in UV-irradiated apoptotic cancer cells activates Notch1 signaling in cancer-associated fibroblasts (CAFs) 대한생리학회 학술대회, 대한민국, 서울, 2022-10-28 Korean Journal of Physiology and Pharmacology, 2022
- [학술발표] In vivo administration of Gas6 inhibits epithelial-mesenchymal transition and enhances PGE2 and PGD2 in alveolar type II epithelial cells following bleomycin treatment 대한생리학회 학술대회, 대한민국, 서울, 2022-10-27 Korean Journal of Physiology and Pharmacology, 2022
- [학술발표] In vivo injection of apoptotic cancer cells inhibits CAF activation and lung metastasis via Notch1-WISP-1 signaling 대한생리학회 학술대회, 대한민국, 서울, 2022-10-27 Korean Journal of Physiology and Pharmacology, 2022
Courses
-
2024-1st
-
Introduction to Medicine
- Subject No 37588Class No 01
- 1Year ( 2.5Credit , 48Hour)
- Major Requisite
-
Human Histology and PhysiologyⅠ
- Subject No 37592Class No 01
- 1Year ( 3Credit , 57Hour)
- Major Requisite
-
Human Histology and PhysiologyⅡ
- Subject No 37593Class No 01
- 1Year ( 2Credit , 44Hour)
- Major Requisite
-
Metabolism and Nutrition
- Subject No 37594Class No 01
- 1Year ( 2.5Credit , 52Hour)
- Major Requisite
-
Current Topics in Pathophysiology 강의 계획서 상세보기
- Subject No G15713Class No 01
- Year ( 3Credit , 3Hour) Mon 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기
- Subject No G18116Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기
- Subject No G18121Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기
- Subject No G18123Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
-
2023-2nd
-
Inflammation-Cancer Microenvironment Seminar Ⅱ 강의 계획서 상세보기
- Subject No G18115Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅱ 강의 계획서 상세보기
- Subject No G18122Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅳ 강의 계획서 상세보기
- Subject No G18124Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
-
2023-1st
-
Introduction to Medicine
- Subject No 37588Class No 01
- 1Year ( 2.5Credit , 48Hour)
- Major Requisite
-
Human Histology and PhysiologyⅠ
- Subject No 37592Class No 01
- 1Year ( 3Credit , 57Hour)
- Major Requisite
-
Human Histology and PhysiologyⅡ
- Subject No 37593Class No 01
- 1Year ( 2Credit , 44Hour)
- Major Requisite
-
Metabolism and Nutrition
- Subject No 37594Class No 01
- 1Year ( 2.5Credit , 52Hour)
- Major Requisite
-
Pulmonary cell Biology 강의 계획서 상세보기
- Subject No G15714Class No 01
- Year ( 3Credit , 3Hour) Thu 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기
- Subject No G18116Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기
- Subject No G18121Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기
- Subject No G18123Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
-
2022-2nd
-
Innate Immunoty Research Technology 강의 계획서 상세보기
- Subject No G15781Class No 01
- Year ( 3Credit , 3Hour) Mon 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅱ 강의 계획서 상세보기
- Subject No G18115Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅱ 강의 계획서 상세보기
- Subject No G18122Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅳ 강의 계획서 상세보기
- Subject No G18124Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
-
2022-1st
-
Introduction to Medicine
- Subject No 37588Class No 01
- 1Year ( 2.5Credit , 48Hour)
- Major Requisite
-
Human Histology and PhysiologyⅠ
- Subject No 37592Class No 01
- 1Year ( 3Credit , 57Hour)
- Major Requisite
-
Human Histology and PhysiologyⅡ
- Subject No 37593Class No 01
- 1Year ( 2Credit , 44Hour)
- Major Requisite
-
Metabolism and Nutrition
- Subject No 37594Class No 01
- 1Year ( 2.5Credit , 52Hour)
- Major Requisite
-
Current Topics in Pathophysiology 강의 계획서 상세보기
- Subject No G15713Class No 01
- Year ( 3Credit , 3Hour) Mon 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기
- Subject No G18121Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅲ 강의 계획서 상세보기
- Subject No G18123Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
-
2021-2nd
-
Innate Immunoty Research Technology 강의 계획서 상세보기
- Subject No G15781Class No 01
- Year ( 3Credit , 3Hour) Mon 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅱ 강의 계획서 상세보기
- Subject No G18115Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅱ 강의 계획서 상세보기
- Subject No G18122Class No 01
- Year ( 3Credit , 3Hour) Wed 7~8
-
-
2021-1st
-
Introduction to Medicine
- Subject No 37588Class No 01
- 1Year ( 2.5Credit , 48Hour)
- Major Requisite
-
Human Histology and PhysiologyⅠ
- Subject No 37592Class No 01
- 1Year ( 3Credit , 57Hour)
- Major Requisite
-
Human Histology and PhysiologyⅡ
- Subject No 37593Class No 01
- 1Year ( 2Credit , 45Hour)
- Major Requisite
-
Metabolism and Nutrition
- Subject No 37594Class No 01
- 1Year ( 2.5Credit , 52Hour)
- Major Requisite
-
Pulmonary cell Biology 강의 계획서 상세보기
- Subject No G15714Class No 01
- Year ( 3Credit , 3Hour) Thu 7~8
-
Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기
- Subject No G18114Class No 01
- Year ( 3Credit , 3Hour) Wed 5~6
-
Inflammation-Cancer Microenvironment Seminar Ⅰ 강의 계획서 상세보기
- Subject No G18121Class No 01
- Year ( 3Credit , 3Hour) Wed 5~6
-
Academic Background
West Virginia University Ph.D.(생리학)
Ewha Womans University 의학사(의학)