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College of Pharmacy

Jae-Sang Ryu Professor

Pharmaceutical Sciences/Industrial Pharmaceutical Science/Division of Pharmacy

류재상 프로필 사진 
Jae-Sang Ryu is a professor of college of pharmacy, and an expert in the field of medicinal chemistry and organic chemistry. He got his PhD degree from the department of chemistry, Northwestern Univ. USA, and he finished his post-doc training in Memorial Sloan-Kettering Cancer Center, NY, USA. His research area covers a lead discovery through natural product-mimetic library synthesis, a mechanism-based drug discovery, and anti-allergic drug discovery using peptidomimetic library. He has published a lot of research articles and applied for patents about "anti-allergic drug discovery using peptidomimetics" and "anticancer drug discovery targeting kinase & Hsp90".
  • Associate Dean, The College of Pharmacy/Assistant Director, Center for Pharmacy Healthcare Communication
  • Pharmaceutical Science Building A(Appenzeller Hall) #212-1
  • 02-3277-3008
  • Research Interests
Research Record
  • Sulfamidate-Based Stereoselective Total Synthesis of (+)-Preussin Using Gold(I)-Catalyzed Intramolecular Dehydrative Amination: Dead End and Detour Journal of Organic Chemistry, 2023, v.88 no.14, 9902-9909
    Scopus dColl.
  • Formal synthesis of (±)-sedamine through gold(I)-catalyzed intramolecular dehydrative amination of sulfamate esters tethered to allylic alcohols Tetrahedron Letters, 2021, v.71, 153024
    SCIE Scopus dColl.
  • Gold(I)-Catalyzed Intramolecular Dehydrative Amination of Sulfamate Esters Tethered to Allylic Alcohols: A Strategy for the Synthesis of Cyclic Sulfamidates Advanced Synthesis and Catalysis, 2021, v.363 no.8, 2183-2188
    SCIE Scopus dColl.
  • Gold(I)-catalyzed tandem synthesis of polycyclic dihydroquinazolinones Catalysts, 2021, v.11 no.12, 1436
    SCIE Scopus dColl.
  • A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles Synthesis (Germany), 2020, v.52 no.5, 744-754
    SCIE Scopus dColl.
  • Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction MOLECULES, 2019, v.24 no.18, 3349
    SCIE Scopus dColl.
  • One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(I) acetylides RSC ADVANCES, 2018, v.8 no.5, 2759-2767
    SCIE Scopus dColl.
  • General assay for enzymes in the heptose biosynthesis pathways using electrospray ionization mass spectrometry APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2017, v.101 no.11, 4521-4532
    SCIE Scopus dColl.
  • A concise synthesis of tubuphenylalanine and epi-tubuphenylalanine via a diastereoselective Mukaiyama aldol reaction of silyl ketene acetal Organic and Biomolecular Chemistry, 2016, v.14 no.3, 913-919
    SCIE Scopus dColl.
  • Design, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors Bioorganic and Medicinal Chemistry, 2016, v.24 no.9
    SCIE Scopus dColl.
  • Stereoselective Synthesis of a Ceramide Transporter Protein (CERT)-Dependent Ceramide-Trafficking Inhibitor, (1R,3S)-HPA-12, via Gold(I)-Catalyzed Cyclization of a Propargylic N-Hydroxylamine Synthesis (Germany), 2016, vol. 49 no. 7
    SCIE Scopus dColl.
  • Synthesis of 4-Isoxazolines through Gold(I)-Catalyzed Cyclization of Propargylic N-Hydroxylamines JOURNAL OF ORGANIC CHEMISTRY, 2016, v.81 no.15, 6740-6749
    SCIE Scopus dColl.
  • Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation FREE RADICAL BIOLOGY AND MEDICINE, 2015, v.83, 41-53
    SCIE Scopus dColl.
  • Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2 Free Radical Biology and Medicine, 2015, v.89, 842-851
    SCIE Scopus dColl.
  • Synthesis of a Cyclic Analogue of Tuv N-Methyl Tubulysin SYNLETT, 2015, v.26 no.8, 1063-1068
    SCIE Scopus dColl.
  • Synthesis of stereochemically diverse cyclic analogs of tubulysins Bioorganic and Medicinal Chemistry, 2015, v.23 no.21, 6827-6843
    SCIE Scopus dColl.
  • Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors BIOORGANIC & MEDICINAL CHEMISTRY, 2014, v.22 no.17, 4855-4866
    SCIE Scopus dColl.
  • Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors Bioorganic and Medicinal Chemistry Letters, 2014, v.24 no.15, 3600-3604
    SCIE Scopus dColl.
  • Direct Synthesis of 4-Fluoroisoxazoles through Gold-Catalyzed Cascade Cyclization-Fluorination of 2-Alkynone O-Methyl Oximes JOURNAL OF ORGANIC CHEMISTRY, 2014, v.79, 6444-6455
    SCIE Scopus dColl.
  • Synthesis of 3,4,5-Trisubstituted Isoxazoles through Gold-Catalyzed Cascade Cyclization Oxidative Alkynylation and Cyclization-Fluorination of 2-Alkynone O-Methyloximes BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2014, v.35 no.9, 2635-2644
    SCIE KCI Scopus dColl.
  • [학술지논문] Gold(I)-Catalyzed Intramolecular Dehydrative Amination of Sulfamate Esters Tethered to Allylic Alcohols: A Strategy for the Synthesis of Cyclic Sulfamidates ADVANCED SYNTHESIS & CATALYSIS, 2021, v.363 no.8 , 2183-2188
    SCI
  • [학술지논문] Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction MOLECULES, 2019, v.24 no.18 , 3349-3349
    SCIE
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Courses

  • 2024-1st

    • Medicinal Chemistry Ⅰ 강의 계획서 상세보기

      • Subject No 36202Class No 01
      • 5Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A400) , Fri 6~6 (PHM-A400)
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ 강의 계획서 상세보기

      • Subject No 36202Class No 02
      • 5Year ( 3Credit , 3Hour) Tue 3~3 (PHM-A400) , Fri 3~3 (PHM-A400)
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ 강의 계획서 상세보기

      • Subject No 36202Class No 03
      • 5Year ( 3Credit , 3Hour) Mon 5~5 (PHM-A400) , Thu 3~3 (PHM-A400)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 01
      • 4Year ( 1.5Credit , 3Hour) Tue 6~9 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 02
      • 4Year ( 1.5Credit , 3Hour) Wed 6~9 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 03
      • 4Year ( 1.5Credit , 3Hour) Mon 6~9 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Organic Chemistry Ⅰ

      • Subject No 38931Class No 01
      • 2Year ( 3Credit , 3Hour) Mon 4~4 (PHM-A400) , Thu 4~4 (PHM-A100-1)
      • Major Requisite,Language Changed
        • Syllabus(File)

    • Pharmaceutical Organic Chemistry Ⅰ

      • Subject No 38931Class No 02
      • 2Year ( 3Credit , 3Hour) Tue 2~2 (POSCO451) , Fri 2~2 (PHM-A104)
      • Major Requisite,Language Changed
        • Syllabus(File)

    • Introduction to Pharmaceutical Research

      • Subject No 38940Class No 01
      • 2Year ( 1.5Credit , 1.5Hour) Thu 6~6 (PHM-A404)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Ⅰ

      • Subject No 38963Class No 01
      • 3Year ( 2Credit , 3Hour) Mon 6~9 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Ⅰ

      • Subject No 38963Class No 02
      • 3Year ( 2Credit , 3Hour) Tue 6~9 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Organic Chemistry Ⅰ

      • Subject No 39036Class No 01
      • 2Year ( 3Credit , 3Hour) Tue 2~2 (POSCO451) , Fri 2~2 (PHM-A104)
      • Major Requisite,Language Changed
        • Syllabus(File)

    • Pharmaceutical Experiment Ⅰ

      • Subject No 39068Class No 01
      • 3Year ( 2Credit , 3Hour) Wed 6~9 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Seminar for Pharmaceutical Sciences Ⅲ 강의 계획서 상세보기

      • Subject No G16849Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A-400)
        • Syllabus(File)

    • Advanced Medicinal Chemistry Ⅰ

      • Subject No G16861Class No 01
      • Year ( 3Credit , 3Hour) Wed 4~5 (PHM-A204)
        • Syllabus(File)

    • Seminar for Pharmaceutical Sciences Ⅲ 강의 계획서 상세보기

      • Subject No G18240Class No 01
      • Year ( 3Credit , 3Hour) Thu 7~8 (PHM-A-400)
        • Syllabus(File)

  • 2023-2nd

  • 2023-1st

  • 2022-2nd

    • Medicinal Chemistry II

      • Subject No 36210Class No 01
      • 5Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A104) , Thu 4~4 (PHM-A104)
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry II

      • Subject No 36210Class No 02
      • 5Year ( 3Credit , 3Hour) Wed 5~5 (PHM-A104) , Fri 5~5 (PHM-A400)
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry II

      • Subject No 36210Class No 03
      • 5Year ( 3Credit , 3Hour) Wed 3~3 (PHM-A400) , Fri 4~4 (PHM-A400)
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry II

      • Subject No 36210Class No 04
      • 5Year ( 3Credit , 3Hour) Wed 3~3 (PHM-A400) , Fri 4~4 (PHM-A400)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 01
      • 4Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 02
      • 4Year ( 1.5Credit , 3Hour) Tue 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 03
      • 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research I

      • Subject No 37154Class No 01
      • 6Year ( 4Credit , 200Hour)
      • Major Requisite
        • Syllabus(File)

  • 2022-1st

    • Medicinal Chemistry Ⅰ

      • Subject No 36202Class No 01
      • 5Year ( 3Credit , 3Hour) Tue 5~5 (PHM-A104) , Thu 5~5 (PHM-A100-1)
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ

      • Subject No 36202Class No 02
      • 5Year ( 3Credit , 3Hour) Tue 3~3 , Thu 2~2
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ

      • Subject No 36202Class No 03
      • 5Year ( 3Credit , 3Hour) Mon 4~4 , Thu 4~4
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ

      • Subject No 36202Class No 04
      • 5Year ( 3Credit , 3Hour) Mon 4~4 , Thu 4~4
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 01
      • 4Year ( 1.5Credit , 3Hour) Tue 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 02
      • 4Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 03
      • 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 04
      • 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Advanced Medicinal Chemistry I

      • Subject No G16861Class No 01
      • Year ( 3Credit , 3Hour) Fri 5~6 (PHM-)
        • Syllabus(File)

  • 2021-2nd

    • Pharmaceutical Synthesis Ⅲ

      • Subject No 33948Class No 01
      • 4Year ( 1.5Credit , 1.5Hour) Tue 4~4
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Synthesis Ⅲ

      • Subject No 33948Class No 02
      • 4Year ( 1.5Credit , 1.5Hour) Thu 2~2
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Synthesis Ⅲ

      • Subject No 33948Class No 03
      • 4Year ( 1.5Credit , 1.5Hour) Thu 5~5
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Synthesis Ⅲ

      • Subject No 33948Class No 04
      • 4Year ( 1.5Credit , 1.5Hour) Thu 5~5
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry II

      • Subject No 36210Class No 01
      • 5Year ( 3Credit , 3Hour) Tue 5~5 , Thu 4~4
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry II

      • Subject No 36210Class No 02
      • 5Year ( 3Credit , 3Hour) Wed 5~5 , Fri 4~4
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry II

      • Subject No 36210Class No 03
      • 5Year ( 3Credit , 3Hour) Wed 3~3 , Fri 5~5
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 01
      • 4Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 02
      • 4Year ( 1.5Credit , 3Hour) Tue 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 03
      • 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Advanced Pharmacy Practice and Research Ⅱ

      • Subject No 37155Class No 01
      • 6Year ( 4Credit
      • Major Requisite
        • Syllabus(File)

    • Synthetic Medicinal Chemistry

      • Subject No G16901Class No 01
      • Year ( 3Credit , 3Hour) Fri 6~7
        • Syllabus(File)

  • 2021-1st

    • Pharmaceutical Synthesis Ⅱ

      • Subject No 33947Class No 01
      • 4Year ( 3Credit , 3Hour) Tue 2~2 , Fri 3~3
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Synthesis Ⅱ

      • Subject No 33947Class No 02
      • 4Year ( 3Credit , 3Hour) Wed 4~4 , Fri 4~4
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Synthesis Ⅱ

      • Subject No 33947Class No 03
      • 4Year ( 3Credit , 3Hour) Mon 4~4 , Thu 4~4
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Synthesis Ⅱ

      • Subject No 33947Class No 04
      • 4Year ( 3Credit , 3Hour) Mon 4~4 , Thu 4~4
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ

      • Subject No 36202Class No 01
      • 5Year ( 3Credit , 3Hour) Mon 5~5 , Wed 5~5
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ

      • Subject No 36202Class No 02
      • 5Year ( 3Credit , 3Hour) Tue 5~5 , Thu 5~5
      • Major Requisite
        • Syllabus(File)

    • Medicinal Chemistry Ⅰ

      • Subject No 36202Class No 03
      • 5Year ( 3Credit , 3Hour) Mon 3~3 , Thu 3~3
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 01
      • 4Year ( 1.5Credit , 3Hour) Mon 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 02
      • 4Year ( 1.5Credit , 3Hour) Tue 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 03
      • 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Pharmaceutical Experiment Laboratory IV

      • Subject No 37127Class No 04
      • 4Year ( 1.5Credit , 3Hour) Wed 6~7 (PHM-A309)
      • Major Requisite
        • Syllabus(File)

    • Honors research

      • Subject No 37803Class No 01
      • 4Year ( 1Credit , 1Hour)
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Academic Background

Northwestern University Ph.D.(화학과)

Seoul Nat'l Univ. 약학석사(약학과)

Seoul Nat'l Univ. 약학사(제약학과)

Work Experience

Menorial Sloan-Kettering Cancer Center 연구원 2003-05-01 ~ 2005-08-15

2005-09-01 ~

2007-01-01 ~ 2008-12-31

Board Member, Korean Society of Organic Synthesis 2014-01-01 ~ 2015-12-31

Board Member, Korean Society of Organic Synthesis 2021-01-01 ~ 2021-12-31

List